Neil J. Perkins
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View article: Ambient air pollution during developmental windows of spermatogenesis and semen quality among an infertility treatment seeking population
Ambient air pollution during developmental windows of spermatogenesis and semen quality among an infertility treatment seeking population Open
Prior studies have observed impacts of air pollution on semen quality, but timing of exposure during developmental windows of spermatogenesis and impacts of low-to-moderate air pollution is less well understood. We examined the relation be…
View article: Niemann Pick C1 mistargeting disrupts lysosomal cholesterol homeostasis contributing to neurodegeneration in a Batten disease model
Niemann Pick C1 mistargeting disrupts lysosomal cholesterol homeostasis contributing to neurodegeneration in a Batten disease model Open
Neurodegeneration is a devastating manifestation in most lysosomal storage disorders (LSDs). Loss-of-function mutations in CLN1 , encoding palmitoyl-protein thioesterase-1 (PPT1), cause CLN1 disease, a devastating neurodegenerative LSD tha…
View article: A Study of Short-Chain Fatty Acids During the Canalicular and Early Saccular Phases of Fetal Lung Development and Childhood Asthma
A Study of Short-Chain Fatty Acids During the Canalicular and Early Saccular Phases of Fetal Lung Development and Childhood Asthma Open
Background: Emerging literature indicates that the microbiome and its byproducts, such as short-chain fatty acids (SCFAs), play an important role in childhood diseases such as allergies and asthma. Specifically, there is evidence suggestin…
View article: Socioeconomic mobility, metabolic health, and diet: mediation via subjective socioeconomic status
Socioeconomic mobility, metabolic health, and diet: mediation via subjective socioeconomic status Open
Objective Socioeconomic mobility, i.e., changing socioeconomic status (SES) between adolescence and adulthood, may impact health through changing resources, social status, and health‐related behaviors. This analysis examined whether subjec…
View article: How is tailored implementation undertaken using a self-guided toolkit? Qualitative study of the ItFits-toolkit in the ImpleMentAll project
How is tailored implementation undertaken using a self-guided toolkit? Qualitative study of the ItFits-toolkit in the ImpleMentAll project Open
View article: How is tailored implementation undertaken using a self-guided toolkit? Qualitative study of the ItFits-toolkit in the ImpleMentAll project
How is tailored implementation undertaken using a self-guided toolkit? Qualitative study of the ItFits-toolkit in the ImpleMentAll project Open
Background.The process of tailored implementation is ill-defined and under-explored. The ItFits-toolkit was developed and subsequently tested as a self-guided online platform to facilitate implementation of tailored strategies for internet…
View article: Preconception Phthalate Exposure and Women’s Reproductive Health: Pregnancy, Pregnancy Loss, and Underlying Mechanisms
Preconception Phthalate Exposure and Women’s Reproductive Health: Pregnancy, Pregnancy Loss, and Underlying Mechanisms Open
Women's preconception exposure to phthalates was associated with lower fecundability, changes in reproductive hormones, and increased inflammation and oxidative stress. The pre- and periconception periods may represent sensitive windows fo…
View article: Towards an Implementation‐STakeholder Engagement Model (I‐STEM) for improving health and social care services
Towards an Implementation‐STakeholder Engagement Model (I‐STEM) for improving health and social care services Open
Background The implementation science literature acknowledges a need for engagement of key stakeholders when designing, delivering and evaluating implementation work. To date, the literature reports minimal or focused stakeholder engagemen…
View article: The Relationship of Preconception and Early Pregnancy Isoprostanes with Fecundability and Pregnancy Loss
The Relationship of Preconception and Early Pregnancy Isoprostanes with Fecundability and Pregnancy Loss Open
Background: Although redox stress likely plays an important role in reproductive health, the utility of peripheral biomarkers of oxidative stress, such as isoprostanes, during the periconception period remains underexplored. We evaluated t…
View article: Pregnancy Complications and Long-Term Mortality in a Diverse Cohort
Pregnancy Complications and Long-Term Mortality in a Diverse Cohort Open
Background: Pregnancy complications are associated with increased risk of development of cardiometabolic diseases and earlier mortality. However, much of the previous research has been limited to White pregnant participants. We aimed to in…
View article: The Role of Maternal Preconception Adiposity in Human Offspring Sex and Sex Ratio
The Role of Maternal Preconception Adiposity in Human Offspring Sex and Sex Ratio Open
We evaluated relationships between preconception adiposity and human offspring sex and sex ratio. Using data from a prospective preconception cohort nested within a randomized controlled trial based at 4 US clinical sites (2006–2012), we u…
View article: Longitudinal semen parameter assessments and live birth: variability and implications for treatment strategies
Longitudinal semen parameter assessments and live birth: variability and implications for treatment strategies Open
View article: Exposure to ambient temperature extremes during peri-conception and fecundability
Exposure to ambient temperature extremes during peri-conception and fecundability Open
Background and Aim: Ambient temperature extremes, particularly high heat, have been associated with adverse pregnancy outcomes; however, fecundity has been little examined. We assessed the relationship of exposure to ambient temperature ex…
View article: A multistate competing risks framework for preconception prediction of pregnancy outcomes
A multistate competing risks framework for preconception prediction of pregnancy outcomes Open
View article: The Implementation of Whole-School Approaches to Transform Mental Health in UK Schools: A Realist Evaluation Protocol
The Implementation of Whole-School Approaches to Transform Mental Health in UK Schools: A Realist Evaluation Protocol Open
Evidence suggests that mental health interventions are more effective when they consider the whole context of schools; addressing the needs of all students, their families, and staff; otherwise known as a whole-school approach (WSA). The U…
View article: Preconception hemoglobin A1c concentration in healthy women is not associated with fecundability or pregnancy loss
Preconception hemoglobin A1c concentration in healthy women is not associated with fecundability or pregnancy loss Open
View article: Preconception caffeine metabolites, caffeinated beverage intake, and fecundability
Preconception caffeine metabolites, caffeinated beverage intake, and fecundability Open
View article: Determining the Clinical Course of Asthma in Pregnancy
Determining the Clinical Course of Asthma in Pregnancy Open
View article: Life is a rollercoaster: an exploration of a support group for parents and carers of those with children and young people with mental health difficulties
Life is a rollercoaster: an exploration of a support group for parents and carers of those with children and young people with mental health difficulties Open
NHS Digital reported that one in eight children aged 5 to 19-year-old in England were identified with a mental illness, the most prevalent being emotional disorders. A diagnosis of a mental illness has a clear impact on children or young p…
View article: The role of reproductive hormones and anovulation in moderating the relationship of phthalates with fecundability
The role of reproductive hormones and anovulation in moderating the relationship of phthalates with fecundability Open
BACKGROUND AND AIM: Phthalates are endocrine disruptors that may inhibit folliculogenesis and we previously observed a relationship of metabolites of DEHP, DEP and BzBP with reduced fecundability. Estrogen supplementation may additionally …
View article: The role of maternal preconception vitamin D status in human offspring sex ratio
The role of maternal preconception vitamin D status in human offspring sex ratio Open
View article: Markers of vitamin D metabolism and premenstrual symptoms in healthy women with regular cycles
Markers of vitamin D metabolism and premenstrual symptoms in healthy women with regular cycles Open
STUDY QUESTION Are insufficient 25-hydroxyvitamin D (25(OH)D) concentrations, and other markers of vitamin D metabolism, associated with premenstrual symptoms in healthy women with regular menstrual cycles? SUMMARY ANSWER 25(OH)D insuffici…
View article: Low Intake of Vegetable Protein is Associated With Altered Ovulatory Function Among Healthy Women of Reproductive Age
Low Intake of Vegetable Protein is Associated With Altered Ovulatory Function Among Healthy Women of Reproductive Age Open
Context Diets high in plant-based protein have gained popularity due to increasing health concerns regarding consumption of animal products. Though links between intakes of certain protein-rich foods and reproductive disorders have been su…
View article: Serum antioxidant vitamin concentrations and oxidative stress markers associated with symptoms and severity of premenstrual syndrome: a prospective cohort study
Serum antioxidant vitamin concentrations and oxidative stress markers associated with symptoms and severity of premenstrual syndrome: a prospective cohort study Open
View article: The Effect of Preconception-Initiated Low-Dose Aspirin on Human Chorionic Gonadotropin–Detected Pregnancy, Pregnancy Loss, and Live Birth
The Effect of Preconception-Initiated Low-Dose Aspirin on Human Chorionic Gonadotropin–Detected Pregnancy, Pregnancy Loss, and Live Birth Open
National Institutes of Health.
View article: Cannabis use while trying to conceive: a prospective cohort study evaluating associations with fecundability, live birth and pregnancy loss
Cannabis use while trying to conceive: a prospective cohort study evaluating associations with fecundability, live birth and pregnancy loss Open
STUDY QUESTION Is cannabis use assessed via urinary metabolites and self-report during preconception associated with fecundability, live birth and pregnancy loss? SUMMARY ANSWER Preconception cannabis use was associated with reduced fecund…
View article: Circulating Vascular Endothelial Growth Factor and Soluble fms-Like Tyrosine Kinase-1 as Biomarkers for Endometrial Remodeling Across the Menstrual Cycle
Circulating Vascular Endothelial Growth Factor and Soluble fms-Like Tyrosine Kinase-1 as Biomarkers for Endometrial Remodeling Across the Menstrual Cycle Open
OBJECTIVE: To characterize variation in circulating vascular endothelial growth factor (VEGF) and its receptor, soluble fms-like tyrosine kinase-1 (sFLT-1), across the menstrual cycle in normal ovulating women in relation to reproductive h…
View article: Adiposity is associated with anovulation independent of serum free testosterone: A prospective cohort study
Adiposity is associated with anovulation independent of serum free testosterone: A prospective cohort study Open
Background Obesity, a body mass index (BMI) ≥30 kg/m 2 , is linked to infertility, potentially through a greater risk of anovulation due to elevated androgens. Yet, previous studies have not directly assessed the impact of adiposity, or bo…
View article: Prenatal exposure to trichlorinated biphenyls (PCB 18 and 28) is associated with child hyperactivity 8 years later
Prenatal exposure to trichlorinated biphenyls (PCB 18 and 28) is associated with child hyperactivity 8 years later Open
Background: Polychlorinated biphenyl (PCB) exposure may be associated with neurodevelopmental problems, particularly hyperactivity and attention deficit/hyperactivity disorder (ADHD). In animal studies, exposure to PCBs increased hyperacti…
View article: Preconception telomere length and pregnancy outcomes: a new marker of reproductive aging?
Preconception telomere length and pregnancy outcomes: a new marker of reproductive aging? Open
Background: Telomere length is influenced by a variety of endogenous and exogenous factors, including environmental chemicals, inflammation, and oxidative stress, and is therefore considered a marker of cumulative cellular aging or biologi…