Neil Keshvani
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View article: Dapagliflozin versus empagliflozin in patients with heart failure with preserved ejection fraction
Dapagliflozin versus empagliflozin in patients with heart failure with preserved ejection fraction Open
Background and Purpose Current guidelines for managing heart failure with preserved ejection fraction (HFpEF) focus on controlling volume overload as needed and adding an SGLT-2 inhibitor. Because SGLT-2 inhibitors are thought to have a cl…
View article: Procedural Volume and Outcomes in Lower‐Extremity Peripheral Vascular Interventions: Insights From the NCDR Peripheral Vascular Intervention Registry
Procedural Volume and Outcomes in Lower‐Extremity Peripheral Vascular Interventions: Insights From the NCDR Peripheral Vascular Intervention Registry Open
Background Lower‐extremity peripheral vascular interventions (PVIs) are increasingly used for treatment of peripheral artery disease. However, the relationship between hospital and operator PVI volume with in‐hospital major adverse limb ev…
View article: Transcatheter vs. surgical aortic valve replacement in bicuspid aortic valve stenosis
Transcatheter vs. surgical aortic valve replacement in bicuspid aortic valve stenosis Open
Aims Patients with bicuspid aortic valve (BAV) stenosis were excluded from major TAVR trials, and data comparing TAVR and SAVR in this population remain limited. To compare real-world, risk-adjusted outcomes of TAVR vs. SAVR in patients wi…
View article: Diuretic resistance and the efficacy of hydrochlorothiazide in acute decompensated heart failure: A post‐hoc analysis of the <scp>CLOROTIC</scp> trial
Diuretic resistance and the efficacy of hydrochlorothiazide in acute decompensated heart failure: A post‐hoc analysis of the <span>CLOROTIC</span> trial Open
Aims Diuretic resistance (DR) in acute decompensated heart failure (ADHF) is associated with poor outcomes. The CLOROTIC trial demonstrated hydrochlorothiazide (HCTZ) with intravenous furosemide improved weight loss in ADHF. We assessed pe…
View article: Diuretic efficiency of a single dose of subcutaneous versus oral furosemide after heart failure hospitalization across diuretic resistance strata: A pilot randomized controlled trial
Diuretic efficiency of a single dose of subcutaneous versus oral furosemide after heart failure hospitalization across diuretic resistance strata: A pilot randomized controlled trial Open
Aims Diuretic resistance (DR) in heart failure (HF) is associated with worse outcomes. Furoscix®, a self‐administered subcutaneous (sc) furosemide injection administered via on‐body infusor, is approved for HF congestion relief. However, i…
View article: Frailty, age, and treatment effect of surgical coronary revascularization in ischemic cardiomyopathy: a post hoc analysis of the STICHES trial
Frailty, age, and treatment effect of surgical coronary revascularization in ischemic cardiomyopathy: a post hoc analysis of the STICHES trial Open
View article: Electronic health Literacy gaps among adults with diabetes in the United States: Role of socioeconomic and demographic factors
Electronic health Literacy gaps among adults with diabetes in the United States: Role of socioeconomic and demographic factors Open
View article: Electronic Health Record Alert With Heart Failure Risk and Sodium Glucose Cotransporter 2 Inhibitor Prescriptions in Diabetes: A Randomized Clinical Trial
Electronic Health Record Alert With Heart Failure Risk and Sodium Glucose Cotransporter 2 Inhibitor Prescriptions in Diabetes: A Randomized Clinical Trial Open
Background: Sodium glucose cotransporter 2 inhibitors (SGLT2i) prevent heart failure (HF) in patients with type 2 diabetes mellitus (T2DM) but prescription rates are low. The effect of an electronic health record (EHR) alert notifying prov…
View article: Temporal trends and racial/ethnic- and sex-differences in LDL cholesterol control among US adults with self-reported atherosclerotic cardiovascular disease
Temporal trends and racial/ethnic- and sex-differences in LDL cholesterol control among US adults with self-reported atherosclerotic cardiovascular disease Open
LDL-C control modestly improved between 2005 and 2008 and 2017-March 2020; however, only ∼1/4 of individuals met guideline-directed LDL-C treatment targets by 2017-March 2020. Women had lower LDL-C control and lesser magnitude of improveme…
View article: Sex Disparities in Longitudinal Use and Intensification of Guideline-Directed Medical Therapy Among Patients With Newly Diagnosed Heart Failure With Reduced Ejection Fraction
Sex Disparities in Longitudinal Use and Intensification of Guideline-Directed Medical Therapy Among Patients With Newly Diagnosed Heart Failure With Reduced Ejection Fraction Open
BACKGROUND: Guideline-directed medical therapies (GDMTs) are the mainstay of treatment for heart failure with reduced ejection fraction (HFrEF), but they are underused. Whether sex differences exist in the initiation and intensification of…
View article: Prevalence and Predictors of Subclinical Cardiomyopathy in Patients With Type 2 Diabetes in a Health System
Prevalence and Predictors of Subclinical Cardiomyopathy in Patients With Type 2 Diabetes in a Health System Open
Introduction: Diabetic cardiomyopathy (DbCM) is characterized by subclinical abnormalities in cardiac structure/function and is associated with a higher risk of overt heart failure (HF). However, there are limited data on optimal strategie…
View article: Empowering telemetry technicians and enhancing communication to improve in-hospital cardiac arrest survival
Empowering telemetry technicians and enhancing communication to improve in-hospital cardiac arrest survival Open
Delays in treatment of in-hospital cardiac arrests (IHCAs) are associated with worsened survival. We sought to assess the impact of a bundled intervention on IHCA survival in patients on centralised telemetry. A retrospective quality impro…
View article: SOCIAL DETERMINANTS IN A LOW-INCOME POPULATION WITH HEART FAILURE
SOCIAL DETERMINANTS IN A LOW-INCOME POPULATION WITH HEART FAILURE Open
Therapeutic Area: Heart Failure Background: The association of social determinants of health (SDOH) and heart failure (HF) outcomes is well-established. However, most HF SDOH measures are obtained in the ambulatory setting, and the distrib…
View article: Sex differences in long‐term outcomes following acute heart failure hospitalization: Findings from the Get With The Guidelines‐Heart Failure registry
Sex differences in long‐term outcomes following acute heart failure hospitalization: Findings from the Get With The Guidelines‐Heart Failure registry Open
Aims Sex differences in long‐term outcomes following hospitalization for heart failure (HF) across ejection fraction (EF) subtypes are not well described. In this study, we evaluated the risk of mortality and rehospitalization among males …
View article: Historical Redlining, Socioeconomic Distress, and Risk of Heart Failure Among Medicare Beneficiaries
Historical Redlining, Socioeconomic Distress, and Risk of Heart Failure Among Medicare Beneficiaries Open
BACKGROUND: The association of historical redlining policies, a marker of structural racism, with contemporary heart failure (HF) risk among White and Black individuals is not well established. METHODS: We aimed to evaluate the association…
View article: Patterns of Referral and Postdischarge Utilization of Cardiac Rehabilitation Among Patients Hospitalized With Heart Failure: An Analysis From the GWTG-HF Registry
Patterns of Referral and Postdischarge Utilization of Cardiac Rehabilitation Among Patients Hospitalized With Heart Failure: An Analysis From the GWTG-HF Registry Open
BACKGROUND: Coverage for cardiac rehabilitation (CR) for patients with heart failure with reduced ejection fraction was expanded in 2014, but contemporary referral and participation rates remain unknown. METHODS: Patients hospitalized for …
View article: Achieving Equity in Hospital Performance Assessments Using Composite Race-Specific Measures of Risk-Standardized Readmission and Mortality Rates for Heart Failure
Achieving Equity in Hospital Performance Assessments Using Composite Race-Specific Measures of Risk-Standardized Readmission and Mortality Rates for Heart Failure Open
Background: The contemporary measures of hospital performance for heart failure hospitalization and 30-day risk-standardized readmission rate (RSRR) and risk-standardized mortality rate (RSMR) are estimated using the same risk adjustment m…
View article: Race, Social Determinants of Health, and Length of Stay Among Hospitalized Patients With Heart Failure: An Analysis From the Get With The Guidelines-Heart Failure Registry
Race, Social Determinants of Health, and Length of Stay Among Hospitalized Patients With Heart Failure: An Analysis From the Get With The Guidelines-Heart Failure Registry Open
Background: Racial disparities in heart failure hospitalization and mortality are well established; however, the association between different social determinants of health (SDOH) and length of stay (LOS) and the extent to which this assoc…
View article: Ninety-Day Risk-Standardized Home Time as a Performance Metric for Cardiac Surgery Hospitals in the United States
Ninety-Day Risk-Standardized Home Time as a Performance Metric for Cardiac Surgery Hospitals in the United States Open
Background: Assessing hospital performance for cardiac surgery necessitates consistent and valid care quality metrics. The association of hospital-level risk-standardized home time for cardiac surgeries with other performance metrics such …
View article: Should Polypills Be Used for Heart Failure With Reduced Ejection Fraction?
Should Polypills Be Used for Heart Failure With Reduced Ejection Fraction? Open
View article: Heart failure quality of care and <scp>in‐hospital</scp> outcomes during the <scp>COVID</scp>‐19 pandemic: findings from the Get With The <scp>Guidelines‐Heart</scp> Failure registry
Heart failure quality of care and <span>in‐hospital</span> outcomes during the <span>COVID</span>‐19 pandemic: findings from the Get With The <span>Guidelines‐Heart</span> Failure registry Open
Aims To assess heart failure (HF) in‐hospital quality of care and outcomes before and during the COVID‐19 pandemic. Methods and results Patients hospitalized for HF with ejection fraction (EF) <40% in the American Heart Association Get Wit…
View article: Risk-Adjusted, 30-Day Home Time After Transcatheter Aortic Valve Replacement as a Hospital-Level Performance Metric
Risk-Adjusted, 30-Day Home Time After Transcatheter Aortic Valve Replacement as a Hospital-Level Performance Metric Open
View article: Association of readmission penalty amount with subsequent 30-day risk standardized readmission and mortality rates among patients hospitalized with heart failure: An analysis of get with the guidelines – heart failure participating centers
Association of readmission penalty amount with subsequent 30-day risk standardized readmission and mortality rates among patients hospitalized with heart failure: An analysis of get with the guidelines – heart failure participating centers Open
Financial penalties based on 30-day RSRR are not associated with declines in 30-day RSRR or RSMR from 2012 to 2015 among patients hospitalized with HF. Financially penalizing hospitals based on current Hospital Readmissions Reduction Progr…
View article: Beyond Physical Impairment: The Role of Social Frailty in Heart Failure
Beyond Physical Impairment: The Role of Social Frailty in Heart Failure Open
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View article: Medicaid expansion and provision of prescription contraception to Medicaid beneficiaries
Medicaid expansion and provision of prescription contraception to Medicaid beneficiaries Open
View article: Evaluation of Risk-Adjusted Home Time After Hospitalization for Heart Failure as a Potential Hospital Performance Metric
Evaluation of Risk-Adjusted Home Time After Hospitalization for Heart Failure as a Potential Hospital Performance Metric Open
In this study, 30-day home time among patients discharged after a hospitalization for HF was objectively assessed as a hospital-level quality metric using Medicare claims data and was associated with readmission and mortality outcomes and …
View article: Adalimumab-associated psoriasiform rash in an African-American patient
Adalimumab-associated psoriasiform rash in an African-American patient Open
A 72-year-old African-American man with a history of biopsy-proven pulmonary and hepatic sarcoidosis presented to primary care clinic with a pruritic rash. The lesions first appeared over his right lateral trunk 3 months ago before spreadi…
View article: A case of chemotherapy-induced coronary vasospasm in a patient with colorectal cancer
A case of chemotherapy-induced coronary vasospasm in a patient with colorectal cancer Open
View article: Evaluation of Risk-Adjusted Home Time After Acute Myocardial Infarction as a Novel Hospital-Level Performance Metric for Medicare Beneficiaries
Evaluation of Risk-Adjusted Home Time After Acute Myocardial Infarction as a Novel Hospital-Level Performance Metric for Medicare Beneficiaries Open
Background: The utility of 30-day risk-standardized readmission rate (RSRR) as a hospital performance metric has been a matter of debate. Home time is a patient-centered outcome measure that accounts for rehospitalization, mortality, and p…