Neil J. Stone
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View article: Secondary Prevention for Atherosclerotic Cardiovascular Disease: Comparing Recent US and European Guidelines on Dyslipidemia
Secondary Prevention for Atherosclerotic Cardiovascular Disease: Comparing Recent US and European Guidelines on Dyslipidemia Open
The 2018 American Heart Association (AHA)/American College of Cardiology (ACC) Multisociety Guideline on the Management of Blood Cholesterol divides patients with clinical atherosclerotic cardiovascular disease (ASCVD) into high-risk and v…
View article: Four Cases of Cholesterol Management Informed by the 2018 American Heart Association/American College of Cardiology Multisociety Guideline on the Management of Blood Cholesterol
Four Cases of Cholesterol Management Informed by the 2018 American Heart Association/American College of Cardiology Multisociety Guideline on the Management of Blood Cholesterol Open
These 4 hypothetical cases highlight some of the new features in the 2018 American Heart Association/American College of Cardiology multisociety cholesterol management guidelines. Topics include management issues in a secondary prevention …
View article: Department of Veterans Affairs (VA) and U.S. Department of Defense (DoD) guidelines for management of dyslipidemia and cardiovascular disease risk reduction: Putting evidence in context
Department of Veterans Affairs (VA) and U.S. Department of Defense (DoD) guidelines for management of dyslipidemia and cardiovascular disease risk reduction: Putting evidence in context Open
Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of morbidity and mortality in the United States (U.S.) and incurs significant cost to the healthcare system. Management of cholesterol remains central for ASCVD preve…
View article: Understanding Lipid Measurement Error to Improve Cardiovascular Risk
Understanding Lipid Measurement Error to Improve Cardiovascular Risk Open
Journal Article Understanding Lipid Measurement Error to Improve Cardiovascular Risk Get access Neil J Stone, Neil J Stone Departments of Medicine (Cardiology) and Preventive Medicine, Northwestern University, Feinberg School of Medicine, …
View article: Antifungal susceptibility profiles for fungal isolates from corneas and contact lenses in the United Kingdom
Antifungal susceptibility profiles for fungal isolates from corneas and contact lenses in the United Kingdom Open
Objective To report the identification and results of susceptibility testing for fungal isolates from the cornea or contact lens care systems.Materials and methods In this retrospective epidemiological study, we searched the results of fun…
View article: Presacral malakoplakia presenting as foot drop: a case report
Presacral malakoplakia presenting as foot drop: a case report Open
Background Malakoplakia is a rare condition characterized by inflammatory masses with specific histological characteristics. These soft tissue masses can mimic tumors and tend to develop in association with chronic or recurrent infections,…
View article: Antimicrobial resistance in topical treatments for microbial keratitis: protocol for a systematic review and meta-analysis
Antimicrobial resistance in topical treatments for microbial keratitis: protocol for a systematic review and meta-analysis Open
Introduction There is evidence for increased resistance against the antimicrobials used to treat keratitis. This review aims to provide global and regional prevalence estimates of antimicrobial resistance in corneal isolates and the range …
View article: RACING to judgement: weighing the value of pre-specified subgroup analyses
RACING to judgement: weighing the value of pre-specified subgroup analyses Open
Optimizing what we get from subgroup analyses.
View article: Statin-Associated Muscle Symptoms Among New Statin Users Randomly Assigned to Vitamin D or Placebo
Statin-Associated Muscle Symptoms Among New Statin Users Randomly Assigned to Vitamin D or Placebo Open
Importance Statin-associated muscle symptoms (SAMS) are common and may lead to discontinuation of indicated statin therapy. Observational studies suggest that vitamin D therapy is associated with reduced statin intolerance, but no randomiz…
View article: Chest radiograph classification and severity of suspected COVID-19 by different radiologist groups and attending clinicians: multi-reader, multi-case study
Chest radiograph classification and severity of suspected COVID-19 by different radiologist groups and attending clinicians: multi-reader, multi-case study Open
Objectives To quantify reader agreement for the British Society of Thoracic Imaging (BSTI) diagnostic and severity classification for COVID-19 on chest radiographs (CXR), in particular agreement for an indeterminate CXR that could instigat…
View article: Cardiology clinic visit increases likelihood of <scp>evidence‐based</scp> cholesterol prescribing in severe hypercholesterolemia
Cardiology clinic visit increases likelihood of <span>evidence‐based</span> cholesterol prescribing in severe hypercholesterolemia Open
Background Patients with phenotypic severe hypercholesterolemia (SH), low‐density lipoprotein‐cholesterol (LDL‐c) ≥ 190 mg/dl, atherosclerotic cardiovascular disease (ASCVD) or adults 40–75 years with diabetes with risk factors or 10‐year …
View article: How low is safe? The frontier of very low (&lt;30 mg/dL) LDL cholesterol
How low is safe? The frontier of very low (<30 mg/dL) LDL cholesterol Open
Low-density lipoprotein cholesterol (LDL-C) is a proven causative factor for developing atherosclerotic cardiovascular disease. Individuals with genetic conditions associated with lifelong very low LDL-C levels can be healthy. We now posse…
View article: Same evidence, varying viewpoints: Three questions illustrating important differences between United States and European cholesterol guideline recommendations
Same evidence, varying viewpoints: Three questions illustrating important differences between United States and European cholesterol guideline recommendations Open
In 2018, the AHA/ACC Multisociety Guideline on the Management of Blood Cholesterol was released. Less than one year later, the 2019 ESC/EAS Dyslipidemia Guideline was published. While both provide important recommendations for managing ath…
View article: Shared Decisions: A Qualitative Study on Clinician and Patient Perspectives on Statin Therapy and Statin‐Associated Side Effects
Shared Decisions: A Qualitative Study on Clinician and Patient Perspectives on Statin Therapy and Statin‐Associated Side Effects Open
Background Despite guideline recommendations and clinical trial data suggesting benefit, statin therapy use in patients with atherosclerotic cardiovascular disease remains suboptimal. The aim of this study was to understand clinician and p…
View article: Clinical implications of the log linear association between LDL-C lowering and cardiovascular risk reduction: Greatest benefits when LDL-C >100 mg/dl
Clinical implications of the log linear association between LDL-C lowering and cardiovascular risk reduction: Greatest benefits when LDL-C >100 mg/dl Open
Greater cardiovascular and mortality risk reduction benefits from intensifying LDL-C lowering therapy may be expected in those with LDL-C ≥100 mg/dl, or in extremely high risk patient groups. When baseline LDL-C <100 mg/dl, the log linear …
View article: Nondietary Cardiovascular Health Metrics With Patient Experience and Loss of Productivity Among US Adults Without Cardiovascular Disease: The Medical Expenditure Panel Survey 2006 to 2015
Nondietary Cardiovascular Health Metrics With Patient Experience and Loss of Productivity Among US Adults Without Cardiovascular Disease: The Medical Expenditure Panel Survey 2006 to 2015 Open
Background The American Heart Association 2020 Impact Goals aimed to promote population health through emphasis on cardiovascular health (CVH). We examined the association between nondietary CVH metrics and patient‐reported outcomes among …