Nele Tamberg
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View article: A conserved phosphorylation mechanism for regulating the interaction between the CMG replicative helicase and its forked DNA substrate
A conserved phosphorylation mechanism for regulating the interaction between the CMG replicative helicase and its forked DNA substrate Open
The CMG helicase is a crucial enzyme complex that plays a vital role in the replication of genomic DNA in eukaryotes. Besides unwinding the DNA template and coordinating the replisome's structure, it is also a key target for signaling path…
View article: Keap1–MCM3 interaction is a potential coordinator of molecular machineries of antioxidant response and genomic DNA replication in metazoa
Keap1–MCM3 interaction is a potential coordinator of molecular machineries of antioxidant response and genomic DNA replication in metazoa Open
Coordination of DNA replication and cellular redox homeostasis mechanisms is essential for the sustained genome stability due to the sensitivity of replicating DNA to oxidation. However, substantial gaps remain in our knowledge of underlyi…