Nell E. Baumgarten
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View article: Identification of AMOTL2 as an antiviral factor that enhances the human type I interferon response against Zika virus
Identification of AMOTL2 as an antiviral factor that enhances the human type I interferon response against Zika virus Open
Zika virus (ZIKV) has caused multiple human outbreaks, with more recent epidemics associated with severe outcomes in infants. Today, ZIKV is endemic to many countries and presents a persistent threat for future epidemics. The host innate i…
View article: Host cell glycosylation selects for infection with CCR5- versus CXCR4-tropic HIV-1
Host cell glycosylation selects for infection with CCR5- versus CXCR4-tropic HIV-1 Open
HIV-1 infection involves a selection bottleneck that leads to transmission of one or a few HIV variants, which nearly always use CCR5 as the coreceptor (R5 viruses) for viral entry as opposed to CXCR4 (X4 viruses). The host properties that…