Nell Klimpert
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View article: A spatial code governs olfactory receptor choice and aligns sensory maps in the nose and brain
A spatial code governs olfactory receptor choice and aligns sensory maps in the nose and brain Open
Although topographical maps organize many peripheral sensory systems, it remains unclear whether olfactory sensory neurons (OSNs) choose which of the ∼1100 odor receptors (ORs) to express based upon their spatial location in the olfactory …
View article: 3D spatial transcriptomics reveals the molecular structure of input and output pathways in the mouse olfactory bulb
3D spatial transcriptomics reveals the molecular structure of input and output pathways in the mouse olfactory bulb Open
SUMMARY A core organizing principle of the vertebrate brain is its symmetry along multiple axes. However, the precision with which neurons, circuit modules, and brain regions align to these axes remains poorly understood. Here, we used 3D …
View article: Odors in space
Odors in space Open
As an evolutionarily ancient sense, olfaction is key to learning where to find food, shelter, mates, and important landmarks in an animal’s environment. Brain circuitry linking odor and navigation appears to be a well conserved multi-regio…
View article: Opposing, spatially-determined epigenetic forces impose restrictions on stochastic olfactory receptor choice
Opposing, spatially-determined epigenetic forces impose restrictions on stochastic olfactory receptor choice Open
Olfactory receptor (OR) choice represents an example of genetically hardwired stochasticity, where every olfactory neuron expresses one out of ~2000 OR alleles in the mouse genome in a probabilistic, yet stereotypic fashion. Here, we propo…
View article: Reviewer #2 (Public Review): Opposing, spatially-determined epigenetic forces impose restrictions on stochastic olfactory receptor choice
Reviewer #2 (Public Review): Opposing, spatially-determined epigenetic forces impose restrictions on stochastic olfactory receptor choice Open
Olfactory receptor (OR) choice represents an example of genetically hardwired stochasticity, where every olfactory neuron expresses one out of ∼2000 OR alleles in a probabilistic, yet stereotypic fashion. Here, we propose that topographic …
View article: Opposing, spatially-determined epigenetic forces impose restrictions on stochastic olfactory receptor choice
Opposing, spatially-determined epigenetic forces impose restrictions on stochastic olfactory receptor choice Open
Olfactory receptor (OR) choice represents an example of genetically hardwired stochasticity, where every olfactory neuron expresses one out of ∼2000 OR alleles in a probabilistic, yet stereotypic fashion. Here, we propose that topographic …
View article: Reviewer #1 (Public Review): Opposing, spatially-determined epigenetic forces impose restrictions on stochastic olfactory receptor choice
Reviewer #1 (Public Review): Opposing, spatially-determined epigenetic forces impose restrictions on stochastic olfactory receptor choice Open
Olfactory receptor (OR) choice represents an example of genetically hardwired stochasticity, where every olfactory neuron expresses one out of ∼2000 OR alleles in a probabilistic, yet stereotypic fashion. Here, we propose that topographic …
View article: Reviewer #3 (Public Review): Opposing, spatially-determined epigenetic forces impose restrictions on stochastic olfactory receptor choice
Reviewer #3 (Public Review): Opposing, spatially-determined epigenetic forces impose restrictions on stochastic olfactory receptor choice Open
Olfactory receptor (OR) choice represents an example of genetically hardwired stochasticity, where every olfactory neuron expresses one out of ∼2000 OR alleles in a probabilistic, yet stereotypic fashion. Here, we propose that topographic …
View article: Author Response: Opposing, spatially-determined epigenetic forces impose restrictions on stochastic olfactory receptor choice
Author Response: Opposing, spatially-determined epigenetic forces impose restrictions on stochastic olfactory receptor choice Open
Olfactory receptor (OR) choice represents an example of genetically hardwired stochasticity, where every olfactory neuron expresses one out of ∼2000 OR alleles in a probabilistic, yet stereotypic fashion. Here, we propose that topographic …
View article: Opposing, spatially-determined epigenetic forces impose restrictions on stochastic olfactory receptor choice
Opposing, spatially-determined epigenetic forces impose restrictions on stochastic olfactory receptor choice Open
Olfactory receptor (OR) choice represents an example of genetically hardwired stochasticity, where every olfactory neuron expresses one out of ~2000 OR alleles in a probabilistic, yet stereotypic fashion. Here, we show that topographic res…
View article: Opposing, spatially-determined epigenetic forces impose restrictions on stochastic olfactory receptor choice
Opposing, spatially-determined epigenetic forces impose restrictions on stochastic olfactory receptor choice Open
Olfactory receptor (OR) choice represents an example of genetically hardwired stochasticity, where every olfactory neuron expresses one out of ~2000 OR alleles in the mouse genome in a probabilistic, yet stereotypic fashion. Here, we propo…
View article: Opposing, spatially-determined epigenetic forces impose restrictions on stochastic olfactory receptor choice
Opposing, spatially-determined epigenetic forces impose restrictions on stochastic olfactory receptor choice Open
Olfactory receptor (OR) choice represents an example of genetically hardwired stochasticity, where every olfactory neuron expresses one out of ∼2000 OR alleles in a probabilistic, yet stereotypic fashion. Here, we propose that topographic …
View article: Molecular characterization of projection neuron subtypes in the mouse olfactory bulb
Molecular characterization of projection neuron subtypes in the mouse olfactory bulb Open
Projection neurons (PNs) in the mammalian olfactory bulb (OB) receive input from the nose and project to diverse cortical and subcortical areas. Morphological and physiological studies have highlighted functional heterogeneity, yet no mole…
View article: Molecular characterization of projection neuron subtypes in the mouse olfactory bulb
Molecular characterization of projection neuron subtypes in the mouse olfactory bulb Open
Projection neurons (PNs) in the mammalian olfactory bulb (OB) receive direct input from the nose and project to diverse cortical and subcortical areas. Morphological and physiological studies have highlighted functional heterogeneity, yet …