K.A.N. Esievo
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View article: Preliminary Observations on the Efficacy of Antidiabetic Plant, Tithonia Diversifolia (Hemsl.) A Gray (Tree Marigold) on Alloxan-Induced Diabetic Wistar Rats
Preliminary Observations on the Efficacy of Antidiabetic Plant, Tithonia Diversifolia (Hemsl.) A Gray (Tree Marigold) on Alloxan-Induced Diabetic Wistar Rats Open
Aim and Objectives: The world-threatening increases of types 1 and 2 diabetes mellitus and their pressure on insulin and other drugs led to the continued search for non-conventional drugs as remedy particularly in countries with reduced ec…
View article: Mitigating Effects of Jimsonweed (Datura Stramonium) on Chronic Chlorpyrifos-Induced Toxicity in Wistar Rats
Mitigating Effects of Jimsonweed (Datura Stramonium) on Chronic Chlorpyrifos-Induced Toxicity in Wistar Rats Open
Chlorpyrifos (CFS), a widely used organophosphorus pesticides for agricultural, industrial and residential purposes, caused accidental poisoning in non-target mammals and other living organisms, including labourerers tasked with spraying e…
View article: The Medicinal Properties of Anogeissus leiocarpus (African Birch Tree) and the Development of a Drug for Diabetes Mellitus and its Complications: A Review
The Medicinal Properties of Anogeissus leiocarpus (African Birch Tree) and the Development of a Drug for Diabetes Mellitus and its Complications: A Review Open
The antidiabetic, sialoglycoconjugates, antidyslipidemic, antioxidant, anti-inflammatory, haematopoietic and wound-healing properties of Anogeissus leiocarpus are highlighted. Its purification and structure using nuclear magnetic resonance…
View article: Identification of Betulinic Acid and Trimethoxyellagic Acid as the Antidiabetic Compounds in Anogeissus leiocarpus Stem Bark Purified Extract
Identification of Betulinic Acid and Trimethoxyellagic Acid as the Antidiabetic Compounds in Anogeissus leiocarpus Stem Bark Purified Extract Open
Objectives: The study aimed to identify the antidiabetic compounds purified from stem bark of Anogeissus leiocarpus and propose the mechanisms of action. Design: Anogeissus leiocarpus stem bark was purified through ethyl acetate and n-hexa…
View article: Contrasting Evidences Between High Cholesterol Levels and The Risk of Cardiovascular Disease: A Review
Contrasting Evidences Between High Cholesterol Levels and The Risk of Cardiovascular Disease: A Review Open
Introduction: The cholesterol hypothesis had been kept alive for decades by reviewers who used statistics that excluded the results from unsuccessful trials and ignored numerous contradictory observations. High dietary cholesterol intake h…
View article: Antiinflammatory Lupeol and Antidiabetic Compound Coexist in Ethyl Acetate and n-Hexane Extracts from Stem Bark of Anogeissus leiocarpus (African Birch Tree): The Therapeutic Advantages
Antiinflammatory Lupeol and Antidiabetic Compound Coexist in Ethyl Acetate and n-Hexane Extracts from Stem Bark of Anogeissus leiocarpus (African Birch Tree): The Therapeutic Advantages Open
Objectives: Anogeissus leiocarpus stem bark is endowed with numerous antidiabetic properties, such as its prognostic value, treatment of organic damages, dyslipidaemia and enhancement of haematopoiesis. In addition to its antioxidant activ…
View article: Effect of Extract (Interface) from Stem Bark of Antidiabetic Anogeissus leiocarpus (African Birch Tree) on Random Blood Glucose Levels of Adult Female Wistar Rats: Optimisation for Therapeutic Hypoglycaemic Dose
Effect of Extract (Interface) from Stem Bark of Antidiabetic Anogeissus leiocarpus (African Birch Tree) on Random Blood Glucose Levels of Adult Female Wistar Rats: Optimisation for Therapeutic Hypoglycaemic Dose Open
The LD50 of the interface portion of ethyl acetate and n-hexane extract from antidiabetic Anogeissus leiocarpus stem bark was greater than 2000mg/kg.bd.wt., with a wide range of safety value. In addition it caused no death 24hours and ther…
View article: Acute and Delayed Oral Toxicity Studies and Observations on Pregnancy, Gestation and Reproductive Performance of Wistar Rats Administered Limit Dose of Purified Extract from Stem Bark of Antidiabetic Anogeissus leiocarpus (African Birch Tree)
Acute and Delayed Oral Toxicity Studies and Observations on Pregnancy, Gestation and Reproductive Performance of Wistar Rats Administered Limit Dose of Purified Extract from Stem Bark of Antidiabetic Anogeissus leiocarpus (African Birch Tree) Open
Objectives: The maximum purification of the extracts of antidiabetic Anogeissus leiocarpus stem bark led to a quest for its lethal dose (LD50) and effects on pregnancy, gestation, pups (kitten) and reproductive performance of Wistar rats. …
View article: Ethanolic extract of Anogeissus leiocarpus ameliorates hyperglycaemia, hepato-renal damage, deranged electrolytes and acid-base balance in alloxan-induced diabetes in dogs
Ethanolic extract of Anogeissus leiocarpus ameliorates hyperglycaemia, hepato-renal damage, deranged electrolytes and acid-base balance in alloxan-induced diabetes in dogs Open
Anti-diabetic effects of ethanolic extract of stem bark of Anogeissus leiocarpus were investigated in alloxan monohydrate-induced acute type 1 diabetes mellitus (TIDM) extending into chronicity and organic damages in 12 adult Nigerian indi…
View article: Clinicopathological Parameters and Sialyltransferase Activity in Trypanosoma Congolense-Infected Sheep
Clinicopathological Parameters and Sialyltransferase Activity in Trypanosoma Congolense-Infected Sheep Open
Cleavage of erythrocyte surface sialic acid (SA) by the sialidase produced by trypanosomes is implicated in the pathogenesis of anaemia in African animal trypanosomiasis (AAT). Sialyltransferase (ST) mediates the attachment of SA to cell s…
View article: Pigeons (Columba livia domestica) Are Susceptible to Infectious Bursal Disease: A Comparative Study of Their Hematological and Serum Biochemical Alterations
Pigeons (Columba livia domestica) Are Susceptible to Infectious Bursal Disease: A Comparative Study of Their Hematological and Serum Biochemical Alterations Open
The hematological and serum biochemical alterations following very virulent infectious bursal disease virus (IBDV) infection in pigeons and chickens were evaluated in this study. Sixty IBDV seronegative birds comprising 30 (3–6 weeks old) …
View article: Comparative Pathological Changes Induced by Very Virulent Infectious Bursal Disease Virus Infection in Inoculated, Sentinel Pigeons and Chickens
Comparative Pathological Changes Induced by Very Virulent Infectious Bursal Disease Virus Infection in Inoculated, Sentinel Pigeons and Chickens Open
In this study, the authors determined whether vvIBDV could be transmitted from chickens to pigeons and vice versa, and the relative severity of the lesions in the two species. Thirty 3-to 6-week-old pigeons and thirty 3-week-old chickens w…
View article: Correlations of Reduced Glutathione and Glutathione Peroxidase Activities with Biochemical Markers of Liver and Kidney Damage in Trypanosoma brucei brucei Infected Rats
Correlations of Reduced Glutathione and Glutathione Peroxidase Activities with Biochemical Markers of Liver and Kidney Damage in Trypanosoma brucei brucei Infected Rats Open
The correlations of reduced glutathione (GSH) and glutathione peroxidase (GPx) levels with biochemical markers of liver and kidney damage in Trypanosoma brucei brucei infection were studied in rats. Forty adult male rats divided into 2 gro…
View article: Clinico-pathological and Immunohistochemistry of Newcastle Disease in Indigenous Chickens and Some Wild Birds in Plateau State, Nigeria
Clinico-pathological and Immunohistochemistry of Newcastle Disease in Indigenous Chickens and Some Wild Birds in Plateau State, Nigeria Open
Aim: Newcastle disease (ND) is one of the most important avian diseases. Virulent strains of Newcastle disease virus (NDV) have the potential of rapid spread, and may cause serious economic impact and international trade restrictions for t…
View article: Molecular characterization and phylogenetic studies of a virulent newcastle disease virus detected in indigenous chickens in plateau state, Nigeria
Molecular characterization and phylogenetic studies of a virulent newcastle disease virus detected in indigenous chickens in plateau state, Nigeria Open
A study of Newcastle disease virus (NDVs) using molecular characterization in indigenous chickens in Plateau State was carried out. The birds were obtained from three geographical locations in Plateau State. Three ribonucleic acids (RNAs) …
View article: Haematological and biochemical parameters of clinically dehydrated and euhydrated dogs
Haematological and biochemical parameters of clinically dehydrated and euhydrated dogs Open
Dehydration results in alterations in haematological and biochemical parameters of dogs. The aim of this study was to determine the haematological and biochemical parameters of clinically dehydrated and euhydrated dogs. A total of 109 samp…
View article: Some plasma biochemical changes in layers experimentally infection with Pasteurella multocida
Some plasma biochemical changes in layers experimentally infection with Pasteurella multocida Open
The present study was carried out to investigate some biochemical alterations in layers experimentally infected with Pasteurella multocida. A total of 20 eighteen-week old ISA Brown layers were used in the experiment. The birds were random…
View article: Some plasma biochemical changes in layers experimentally infected with Salmonella gallinarum
Some plasma biochemical changes in layers experimentally infected with Salmonella gallinarum Open
Aim: The study was conducted to investigate some plasma biochemical changes in layers experimentally infected with Salmonella Gallinarum Methods: A total of 20 eighteen-week- old ISA Brown layers were used in the experiment. The birds were…
View article: Potential impact of husbandry practices on the welfare and productivity of draught cattle in rural communities around Zaria, Nigeria
Potential impact of husbandry practices on the welfare and productivity of draught cattle in rural communities around Zaria, Nigeria Open
A survey of the draught cattle husbandry practices and the potential impact of such practices on the health and productivity as it relates to work hours of these cattle was carried out during the months of November – March (dry season) and…
View article: Haematological changes in layers experimentally infected with salmonella gallinarum
Haematological changes in layers experimentally infected with salmonella gallinarum Open
Aim: The present study was conducted to investigate the haematological changes in layers experimentally infected with Salmonella gallinarum. Methods: A total of 20 eighteen-week- old ISA Brown layers were used for the experiment. The birds…
View article: Early stage leucocytosis in Nigerian pigs experimentally infected with <i>Trypanosoma brucei</i>
Early stage leucocytosis in Nigerian pigs experimentally infected with <i>Trypanosoma brucei</i> Open
Sequential leukocyte changes associated with early phase of Trypanosoma brucei infection were investigated in indigenous Nigerian pigs. This was with the view to providing further hematological basis for effective chemotherapy of natural p…