L. Nelson Sanchez‐Pinto
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View article: Derivation and Validation of Pediatric Sepsis-Associated Acute Kidney Injury Subphenotypes With Prognostic Relevance
Derivation and Validation of Pediatric Sepsis-Associated Acute Kidney Injury Subphenotypes With Prognostic Relevance Open
OBJECTIVES: Sepsis-associated acute kidney injury (SAKI) is a heterogeneous syndrome associated with poor outcomes. Subphenotypes of SAKI with prognostic and therapeutic relevance have been identified in adults, but not in children. We sou…
View article: Association of Dynamic Arterial Elastance With Fluid Responsiveness in Critically Ill Children
Association of Dynamic Arterial Elastance With Fluid Responsiveness in Critically Ill Children Open
OBJECTIVES: Cardiac mechanical efficiency has been shown to be a predictor of fluid responsiveness (FR) in adults. Our goal was to assess the association between mechanical efficiency as measured by dynamic arterial elastance (Ea dyn ) and…
View article: Machine Learning for Predicting Critical Events Among Hospitalized Children
Machine Learning for Predicting Critical Events Among Hospitalized Children Open
Importance Unrecognized deterioration among hospitalized children is associated with a high risk of mortality and morbidity. The current approach to pediatric risk stratification is fragmented, as each hospital unit (emergency, ward, or in…
View article: The Recent Increase in Invasive Bacterial Infections A Report From the National COVID Cohort Collaborative
The Recent Increase in Invasive Bacterial Infections A Report From the National COVID Cohort Collaborative Open
Background: When coronavirus disease 2019 (COVID-19) mitigation efforts waned, viral respiratory infections (VRIs) surged, potentially increasing the risk of postviral invasive bacterial infections (IBIs). We sought to evaluate the change …
View article: Development of a Core Critical Care Data Dictionary With Common Data Elements to Characterize Critical Illness and Injuries Using a Modified Delphi Method
Development of a Core Critical Care Data Dictionary With Common Data Elements to Characterize Critical Illness and Injuries Using a Modified Delphi Method Open
OBJECTIVES: To develop the first core Critical Care Data Dictionary (C2D2) with common data elements (CDEs) to characterize critical illness and injuries. DESIGN: Group consensus process using modified Delphi approach. SETTING: Electronic …
View article: External Validation, Re-Calibration, and Extension of a Prediction Model of Early Acute Kidney Injury in Critically Ill Children using Multi-Center Data
External Validation, Re-Calibration, and Extension of a Prediction Model of Early Acute Kidney Injury in Critically Ill Children using Multi-Center Data Open
Background Acute kidney injury (AKI) is common among children with critical illness and is associated with high morbidity and mortality. Risk prediction models designed for clinical decision support implementation offer an opportunity to i…
View article: Phoenix Sepsis Criteria in Critically Ill Children: Retrospective Validation Using a United States Nine-Center Dataset, 2012–2018
Phoenix Sepsis Criteria in Critically Ill Children: Retrospective Validation Using a United States Nine-Center Dataset, 2012–2018 Open
Objectives: To perform: 1) external validation of the Phoenix Sepsis Score and Phoenix sepsis criteria in a multicenter cohort of critically ill children with infection and a comparison with the 2005 International Pediatric Sepsis Consensu…
View article: The Resuscitation, Equilibrium and De-escalation (RED) strategy: a phased, personalized hemodynamic support in children with sepsis
The Resuscitation, Equilibrium and De-escalation (RED) strategy: a phased, personalized hemodynamic support in children with sepsis Open
Hemodynamic support in critically ill children with septic shock is a pervasive challenge in the intensive care settings. Cardiovascular involvement in sepsis entails both macro- and microcirculation abnormalities, with the main treatment …
View article: The Recent Increase in Invasive Bacterial Infections: A Report From the National COVID Cohort Collaborative
The Recent Increase in Invasive Bacterial Infections: A Report From the National COVID Cohort Collaborative Open
Background: When coronavirus disease 2019 (COVID-19) mitigation efforts waned, viral respiratory infections (VRIs) surged, potentially increasing the risk of postviral invasive bacterial infections (IBIs). We sought to evaluate the change …
View article: A matched analysis of the use of high flow nasal cannula for pediatric severe acute asthma
A matched analysis of the use of high flow nasal cannula for pediatric severe acute asthma Open
Rationale The high‐flow nasal cannula (HFNC) device is commonly used to treat pediatric severe acute asthma. However, there is little evidence regarding its effectiveness in real‐world practice. Objectives We sought to compare the physiolo…
View article: Identification of severe acute pediatric asthma phenotypes using unsupervised machine learning
Identification of severe acute pediatric asthma phenotypes using unsupervised machine learning Open
Rationale More targeted management of severe acute pediatric asthma could improve clinical outcomes. Objectives To identify distinct clinical phenotypes of severe acute pediatric asthma using variables obtained in the first 12 h of hospita…
View article: <tt>phoenix</tt>: an R package and Python module for calculating the Phoenix pediatric sepsis score and criteria
phoenix: an R package and Python module for calculating the Phoenix pediatric sepsis score and criteria Open
Objectives The publication of the Phoenix criteria for pediatric sepsis and septic shock initiates a new era in clinical care and research of pediatric sepsis. Tools to consistently and accurately apply the Phoenix criteria to electronic h…
View article: Accuracy and Interpretation of Transcutaneous Carbon Dioxide Monitoring in Critically Ill Children
Accuracy and Interpretation of Transcutaneous Carbon Dioxide Monitoring in Critically Ill Children Open
OBJECTIVES: Transcutaneous carbon dioxide (Tc co 2 ) monitoring can noninvasively assess ventilation by estimating carbon dioxide ( CO 2 ) levels in the blood. We aimed to evaluate the accuracy of Tc co 2 monitoring in critically ill child…
View article: Phoenix Criteria for Pediatric Sepsis and Septic Shock—Reply
Phoenix Criteria for Pediatric Sepsis and Septic Shock—Reply Open
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View article: Medical Complexity, Language Use, and Outcomes in the Pediatric ICU
Medical Complexity, Language Use, and Outcomes in the Pediatric ICU Open
OBJECTIVES To determine whether use of a language other than English (LOE) would be associated with medical complexity, and whether medical complexity and LOE together would be associated with worse clinical outcomes. METHODS The primary o…
View article: Northwestern University resource and education development initiatives to advance collaborative artificial intelligence across the learning health system
Northwestern University resource and education development initiatives to advance collaborative artificial intelligence across the learning health system Open
Introduction The rapid development of artificial intelligence (AI) in healthcare has exposed the unmet need for growing a multidisciplinary workforce that can collaborate effectively in the learning health systems. Maximizing the synergy a…
View article: 316 Machine Learning to Predict Fluid Responsiveness in Hypotensive Children
316 Machine Learning to Predict Fluid Responsiveness in Hypotensive Children Open
OBJECTIVES/GOALS: Fluid boluses are administered to hypotensive, critically ill children but may not reverse hypotension, leading to delay of vasoactive infusion, end-organ damage, and mortality. We hypothesize that a machine learning-base…
View article: Biomarker Assessment of a High-Risk, Data-Driven Pediatric Sepsis Phenotype Characterized by Persistent Hypoxemia, Encephalopathy, and Shock
Biomarker Assessment of a High-Risk, Data-Driven Pediatric Sepsis Phenotype Characterized by Persistent Hypoxemia, Encephalopathy, and Shock Open
OBJECTIVES: Identification of children with sepsis-associated multiple organ dysfunction syndrome (MODS) at risk for poor outcomes remains a challenge. We sought to the determine reproducibility of the data-driven “persistent hypoxemia, en…
View article: International Consensus Criteria for Pediatric Sepsis and Septic Shock
International Consensus Criteria for Pediatric Sepsis and Septic Shock Open
Importance Sepsis is a leading cause of death among children worldwide. Current pediatric-specific criteria for sepsis were published in 2005 based on expert opinion. In 2016, the Third International Consensus Definitions for Sepsis and Se…
View article: Development and Validation of the Phoenix Criteria for Pediatric Sepsis and Septic Shock
Development and Validation of the Phoenix Criteria for Pediatric Sepsis and Septic Shock Open
Importance The Society of Critical Care Medicine Pediatric Sepsis Definition Task Force sought to develop and validate new clinical criteria for pediatric sepsis and septic shock using measures of organ dysfunction through a data-driven ap…
View article: Machine learning-driven identification of the gene-expression signature associated with a persistent multiple organ dysfunction trajectory in critical illness
Machine learning-driven identification of the gene-expression signature associated with a persistent multiple organ dysfunction trajectory in critical illness Open
H.R.W.'s NIHR35GM126943 award supported the work detailed in this manuscript. Upon his death, the award was transferred to M.N.A. M.R.A., N.S.P, and R.K were supported by NIHR21GM151703. R.K. was supported by R01GM139967.