Scott M. Nelson
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View article: Precision functional imaging in infants using multi-echo fMRI at 7T
Precision functional imaging in infants using multi-echo fMRI at 7T Open
Personalized functional brain developmental trajectories can be studied with Precision Functional Mapping (PFM). Our previous work has demonstrated that PFM can be achieved in infants despite rapid brain growth. However, even with extensiv…
View article: Association between prenatal exposure to antihypertensive medication and neurodevelopmental and educational outcomes in children
Association between prenatal exposure to antihypertensive medication and neurodevelopmental and educational outcomes in children Open
View article: Examining the heritability of functional brain networks in adolescence
Examining the heritability of functional brain networks in adolescence Open
Understanding the mechanisms underlying mental illness requires disentangling the roles of genetic and environmental factors. The brain has been proposed as a key intermediate biomarker linking these factors, yet the extent to which geneti…
View article: Development of a Machine Learning Model for Predicting Treatment-Related Amenorrhea in Young Women with Breast Cancer
Development of a Machine Learning Model for Predicting Treatment-Related Amenorrhea in Young Women with Breast Cancer Open
Treatment-induced ovarian function loss is a significant concern for many young patients with breast cancer. Accurately predicting this risk is crucial for counselling young patients and informing their fertility-related decision-making. H…
View article: Image-based meta- and mega-analysis (IBMMA): A unified framework for large-scale, multi-site, neuroimaging data analysis
Image-based meta- and mega-analysis (IBMMA): A unified framework for large-scale, multi-site, neuroimaging data analysis Open
The increasing scale and complexity of neuroimaging datasets aggregated from multiple study sites present substantial analytic challenges, as existing statistical analysis tools struggle to handle missing voxel-data, suffer from limited co…
View article: Interpretation of the association between thyroid peroxidase antibodies and thyroid function during pregnancy: An individual participant data meta-analysis
Interpretation of the association between thyroid peroxidase antibodies and thyroid function during pregnancy: An individual participant data meta-analysis Open
During pregnancy, TPOAbs were dose-dependently associated with TSH, FT4, and the risk of abnormal thyroid function. With concentrations below currently used positivity cut-offs, TPOAbs could be associated with lower maternal thyroid functi…
View article: Development of a Machine Learning Model for Predicting Treatment-Related Amenorrhea in Young Women with Breast Cancer
Development of a Machine Learning Model for Predicting Treatment-Related Amenorrhea in Young Women with Breast Cancer Open
Treatment-induced ovarian function loss is a significant concern for many young patients with breast cancer. Accurately predicting this risk is crucial for counselling young patients and informing their fertility-related decision-making. H…
View article: Volumetric Differences of Thalamic Nuclei are Associated with Post-Trauma Psychopathology
Volumetric Differences of Thalamic Nuclei are Associated with Post-Trauma Psychopathology Open
Whole thalamus volume and volumes of the sensorimotor and limbic thalamus may play an important role in the development of PTSD and MDD in the aftermath of trauma exposure. The interaction between PTSD and MDD symptoms and contrasting effe…
View article: Modelling Follicular Growth During Ovarian Stimulation Using Agent-based Artificial Intelligence
Modelling Follicular Growth During Ovarian Stimulation Using Agent-based Artificial Intelligence Open
Context Ovarian stimulation is a key step in medically assisted reproduction (MAR), whereby supraphysiological doses of FSH extend the “FSH window” and induce multifollicular growth. However, only limited data exist that examine individual…
View article: Gynecologic surgery for benign disease: Preserving reproductive potential
Gynecologic surgery for benign disease: Preserving reproductive potential Open
Preserving fertility is essential when managing benign gynecologic disorders in reproductive‐aged women. Surgical interventions can impact future fertility, therefore requiring an evidence‐based, individualized approach. The FIGO Committee…
View article: <scp>FIGO</scp> Fertility Passport: A tool for patients and their healthcare providers
<span>FIGO</span> Fertility Passport: A tool for patients and their healthcare providers Open
Infertility is a condition with significant psychological, economic, and health implications. Investigations are generally conducted by a primary healthcare provider who then refers to a specialist; however, multidisciplinary care is often…
View article: Effect of comprehensive tobacco control policies on maternal and child outcomes: a population-based linkage study
Effect of comprehensive tobacco control policies on maternal and child outcomes: a population-based linkage study Open
Objectives To assess the impact of comprehensive tobacco control policies on maternal smoking during pregnancy and perinatal outcomes over a 20-year period. Design Population-based cohort study using linked Scottish National Health Service…
View article: Prenatal exposure to maternal asthma and asthma medication and neurodevelopmental outcomes: a population cohort study of 179,024 children
Prenatal exposure to maternal asthma and asthma medication and neurodevelopmental outcomes: a population cohort study of 179,024 children Open
ObjectivesTo investigate the associations between treated and untreated asthma during pregnancy and neurodevelopmental outcomes in the offspring, including autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD) and…
View article: Educational outcomes associated with prenatal exposure to antiseizure medications: A systematic literature review and meta-Analysis
Educational outcomes associated with prenatal exposure to antiseizure medications: A systematic literature review and meta-Analysis Open
Prenatal exposure to first-generation ASMs, especially sodium valproate, was associated with increased educational support needs. Newer-generation ASMs appear to have a more favourable risk profile, though evidence remains limited, undersc…
View article: Examining the heritability of functional brain networks in adolescence
Examining the heritability of functional brain networks in adolescence Open
Discovering mechanisms underlying mental illness requires disentangling genetic and environmental factors influencing mental health. Researchers have started investigating the brain’s role as a potential intermediate biomarker linking gene…
View article: Personalized Adaptive Cortical Electro-stimulation (PACE) in Treatment-Resistant Depression
Personalized Adaptive Cortical Electro-stimulation (PACE) in Treatment-Resistant Depression Open
Treatment-resistant depression (TRD) is a leading cause of premature death. For decades investigators have assessed the clinical efficacy of direct brain stimulation for TRD. Outcomes have been inconsistent due to imprecise brain targeting…
View article: Precision Functional Neuroimaging Reveals Individually Specific Auditory Responses in Infants
Precision Functional Neuroimaging Reveals Individually Specific Auditory Responses in Infants Open
Adaptively responding to salient stimuli in the environment is a fundamental feature of cognitive development in early life, which is enabled by the developing brain. Understanding individual variability in how the brain supports this fund…
View article: Data‐Driven Approach to Dynamic Resting State Functional Connectivity in Post‐Traumatic Stress Disorder: An <scp>ENIGMA</scp>‐<scp>PGC PTSD</scp> Study
Data‐Driven Approach to Dynamic Resting State Functional Connectivity in Post‐Traumatic Stress Disorder: An <span>ENIGMA</span>‐<span>PGC PTSD</span> Study Open
Using functional magnetic resonance imaging (fMRI), symptoms of posttraumatic stress disorder (PTSD) have been associated with aberrations in brain networks in the absence of a given cognitive demand or task, called resting‐state networks.…
View article: Volumetric Differences of Thalamic Nuclei are Associated with Post-Trauma Psychopathology
Volumetric Differences of Thalamic Nuclei are Associated with Post-Trauma Psychopathology Open
Previous investigations of whole thalamus and thalamic nuclei volumes in post-trauma psychopathology have been sparse, limited in scope, and yielded inconsistent results. To address this, volumetric estimates of whole thalamus and thalamic…
View article: Alcohol consumption during pregnancy in Scotland following public health interventions: population-based study
Alcohol consumption during pregnancy in Scotland following public health interventions: population-based study Open
Introduction Alcohol consumption during pregnancy is associated with adverse maternal and perinatal outcomes, with no safe lower limit established. We evaluated the individual and cumulative impact of three alcohol-related interventions on…
View article: Action-mode subnetworks for decision-making, action control, and feedback
Action-mode subnetworks for decision-making, action control, and feedback Open
The action-mode network (AMN) is a canonical functional brain network first identified using resting-state functional connectivity (RSFC). Based on animal and human data, we have proposed that AMN supports the brain’s action mode by contro…
View article: Image-Based Meta- and Mega-Analysis (IBMMA): A Unified Framework for Large-Scale, Multi-Site, Neuroimaging Data Analysis
Image-Based Meta- and Mega-Analysis (IBMMA): A Unified Framework for Large-Scale, Multi-Site, Neuroimaging Data Analysis Open
The increasing scale and complexity of neuroimaging datasets aggregated from multiple study sites present substantial analytic challenges, as existing statistical analysis tools struggle to handle missing voxel-data, suffer from limited co…
View article: Do lower antenatal blood pressure cut-offs in pregnant women with obesity identify those at greater risk of adverse maternal and perinatal outcomes? A secondary analysis of data from the UK Pregnancies Better Eating and Activity Trial (UPBEAT)
Do lower antenatal blood pressure cut-offs in pregnant women with obesity identify those at greater risk of adverse maternal and perinatal outcomes? A secondary analysis of data from the UK Pregnancies Better Eating and Activity Trial (UPBEAT) Open
View article: The impacts of sex and acute stress modalities on the interoceptive stimulus properties of cocaine in rats
The impacts of sex and acute stress modalities on the interoceptive stimulus properties of cocaine in rats Open
Stress impacts the behavioral effects of drugs including cocaine. However, the extent of these impacts may rely on the modality of stressor. One such measure of cocaine’s effects is the drug discrimination procedure where rats are trained …
View article: An action networks model for pain reveals cortical neuromodulation targets
An action networks model for pain reveals cortical neuromodulation targets Open
Chronic neuropathic pain is a debilitating condition, difficult to treat, and associated with poor outcomes, including addiction and suicide. Neuromodulation of primary motor cortex and dorsolateral prefrontal cortex (dlPFC) alleviates neu…
View article: Less is More: Lower Levels of Task-Induced Hippocampal Activation Predict Better Performance on a Separate Verbal Memory Evaluation
Less is More: Lower Levels of Task-Induced Hippocampal Activation Predict Better Performance on a Separate Verbal Memory Evaluation Open
Memories that differ in content or duration differ in the extent to which they depend on the hippocampus, and also the part of the hippocampus, posterior (pHPC) or anterior (aHPC), that they implicate. Inter-individual differences in learn…
View article: Stimulant medications affect arousal and reward, not attention
Stimulant medications affect arousal and reward, not attention Open
Prescription stimulants such as methylphenidate are being used by an increasing portion of the population, primarily children. These potent norepinephrine and dopamine reuptake inhibitors promote wakefulness, suppress appetite, enhance phy…
View article: fMRIPrep Lifespan: Extending A Robust Pipeline for Functional MRI Preprocessing to Developmental Neuroimaging
fMRIPrep Lifespan: Extending A Robust Pipeline for Functional MRI Preprocessing to Developmental Neuroimaging Open
The adoption of a standardized preprocessing workflow is vital for fostering community, sharing, and reproducibility. fMRIPrep has been a critical advancement towards this end, however, it is limited in its capacity to be applied to data a…
View article: Structural covariance of early visual cortex is negatively associated with PTSD symptoms: A Mega-Analysis from the ENIGMA PTSD workgroup
Structural covariance of early visual cortex is negatively associated with PTSD symptoms: A Mega-Analysis from the ENIGMA PTSD workgroup Open
Background Identifying robust neural signatures of posttraumatic stress disorder (PTSD) symptoms is important to facilitate precision psychiatry and help in understanding and treatment of the disorder. Emergent research suggests structural…
View article: Unintended bias in the pursuit of collinearity solutions in fMRI analysis
Unintended bias in the pursuit of collinearity solutions in fMRI analysis Open
In task functional magnetic resonance imaging (fMRI), collinearity between task regressors in time series models may impact power. When collinearity is identified after data collection, researchers often modify the model in an effort to re…