Nenad Bogdanović
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View article: Find-DLB: a naturalistic cohort of patients presenting with clinical features of dementia with Lewy bodies to a specialized cognitive clinic
Find-DLB: a naturalistic cohort of patients presenting with clinical features of dementia with Lewy bodies to a specialized cognitive clinic Open
Purpose Dementia with Lewy bodies (DLB) is a common neurodegenerative disorder, yet difficult to diagnose. Carefully selected research cohorts may not represent the clinical reality. We aimed to characterize a naturalistic cohort of patien…
View article: Educational Needs in Geriatric Medicine Among Health Care Professionals and Medical Students in COST Action 21122 PROGRAMMING: Mixed-Methods Survey Protocol
Educational Needs in Geriatric Medicine Among Health Care Professionals and Medical Students in COST Action 21122 PROGRAMMING: Mixed-Methods Survey Protocol Open
Background The European Cooperation in Science and Technology (COST) Action 21122, PROmoting GeRiAtric Medicine in countries where it is still eMergING (PROGRAMMING) developed an online open survey to assess the educational interests and n…
View article: Alzheimer mimicry: LATE and PART
Alzheimer mimicry: LATE and PART Open
Alzheimer’s disease (AD) is the main cause of dementia and accounts for 60% of dementia syndromes in people older than 75 years. The correct classification of AD and non-AD cases is mandatory to study disease mechanisms or new treatment po…
View article: Building a pan-European network to bridge gaps in geriatric medicine education: the PROGRAMMING COST Action 21,122—a call for endorsement
Building a pan-European network to bridge gaps in geriatric medicine education: the PROGRAMMING COST Action 21,122—a call for endorsement Open
Background The growing challenges of population aging create a pressing need for specialized geriatric medicine services to effectively address the complex health needs of older adults and influence supportive healthcare policies. Older pa…
View article: Altered Empathy Processing in Frontotemporal Dementia
Altered Empathy Processing in Frontotemporal Dementia Open
This case-control study examines differences in empathetic response of patients experiencing behavioral variant frontotemporal dementia using functional magnetic resonance imaging.
View article: Altered empathy processing in frontotemporal dementia A task-based fMRI study
Altered empathy processing in frontotemporal dementia A task-based fMRI study Open
A lack of empathy, and particularly its affective components, is a core symptom of behavioural variant frontotemporal dementia (bvFTD). Visual exposure to images of a needle pricking a hand (pain condition) and Q-tips touching a hand (cont…
View article: Alzheimer’s disease biomarker profiling in a memory clinic cohort without common comorbidities
Alzheimer’s disease biomarker profiling in a memory clinic cohort without common comorbidities Open
Background Comorbidities such as hypertension, hypercholesterolemia and diabetes are known contributors to Alzheimer disease (AD) progression. However, their mechanistic contribution to pathology and neurodegeneration has not been clarifie…
View article: Stress, depression, and risk of dementia – a cohort study in the total population between 18 and 65 years old in Region Stockholm
Stress, depression, and risk of dementia – a cohort study in the total population between 18 and 65 years old in Region Stockholm Open
Background Chronic stress and depression are potential risk factors for mild cognitive impairment and dementia, including Alzheimer disease. The aim was to investigate whether any such risk is additive. Methods Cohort study including 1 362…
View article: Clinical Effect of Early vs Late Amyloid Positron Emission Tomography in Memory Clinic Patients
Clinical Effect of Early vs Late Amyloid Positron Emission Tomography in Memory Clinic Patients Open
Importance Amyloid positron emission tomography (PET) allows the direct assessment of amyloid deposition, one of the main hallmarks of Alzheimer disease. However, this technique is currently not widely reimbursed because of the lack of app…
View article: Analysis of Psychological Symptoms Following Disclosure of Amyloid–Positron Emission Tomography Imaging Results to Adults With Subjective Cognitive Decline
Analysis of Psychological Symptoms Following Disclosure of Amyloid–Positron Emission Tomography Imaging Results to Adults With Subjective Cognitive Decline Open
Importance Individuals who are amyloid-positive with subjective cognitive decline and clinical features increasing the likelihood of preclinical Alzheimer disease (SCD+) are at higher risk of developing dementia. Some individuals with SCD+…
View article: Alzheimer’s disease biomarker profiling in a memory clinic cohort without common comorbidities
Alzheimer’s disease biomarker profiling in a memory clinic cohort without common comorbidities Open
Alzheimer’s disease is a multifactorial disorder with large heterogeneity. Comorbidities such as hypertension, hypercholesterolaemia and diabetes are known contributors to disease progression. However, less is known about their mechanistic…
View article: Associations Between Intrathecal Levels of Vitamin D, Cytokines, and Core Biomarkers of Alzheimer’s Disease: A Cross-Sectional Study
Associations Between Intrathecal Levels of Vitamin D, Cytokines, and Core Biomarkers of Alzheimer’s Disease: A Cross-Sectional Study Open
Background: Several studies have examined association between vitamin D levels in serum and cognition, but little is known of vitamin D levels in cerebrospinal fluid (CSF) and association with Alzheimer’s disease (AD). Objective: In this c…
View article: Alzheimer’s disease biomarker profiling in a memory clinic cohort without common comorbidities
Alzheimer’s disease biomarker profiling in a memory clinic cohort without common comorbidities Open
Alzheimer’s disease is a multifactorial disorder with a heterogeneous patient population. Comorbidities such as hypertension, hypercholesterolemia and diabetes are known contributors to the disease progression. Indeed, therapies targeting …
View article: Autophagy Impairment in App Knock-in Alzheimer’s Model Mice
Autophagy Impairment in App Knock-in Alzheimer’s Model Mice Open
Alzheimer’s disease (AD) is characterized by impaired protein homeostasis leading to amyloid-β peptide (Aβ) amyloidosis. Amyloid precursor protein (APP) knock-in mice exhibit robust Aβ pathology, providing possibilities to determine its ef…
View article: Serum Amyloidogenic Nanoplaques and Cytokines in Alzheimer’s Disease: Pilot Study in a Small Naturalistic Memory Clinic Cohort
Serum Amyloidogenic Nanoplaques and Cytokines in Alzheimer’s Disease: Pilot Study in a Small Naturalistic Memory Clinic Cohort Open
Background: Neuroinflammation is a central component of Alzheimer’s disease (AD) and correlates closely with amyloid pathology. Markers of inflammation such as cytokines, and amyloidogenic aggregates, so-called nanoplaques, are both promis…
View article: Microdissected Pyramidal Cell Proteomics of Alzheimer Brain Reveals Alterations in Creatine Kinase B-Type, 14-3-3-γ, and Heat Shock Cognate 71
Microdissected Pyramidal Cell Proteomics of Alzheimer Brain Reveals Alterations in Creatine Kinase B-Type, 14-3-3-γ, and Heat Shock Cognate 71 Open
Novel insights on proteins involved in Alzheimer’s disease (AD) are needed. Since multiple cell types and matrix components are altered in AD, bulk analysis of brain tissue maybe difficult to interpret. In the current study, we isolated py…
View article: Confusion, cognitive impairment, and spinal cord compression caused by plasmacytoma: a case report
Confusion, cognitive impairment, and spinal cord compression caused by plasmacytoma: a case report Open
Background Plasmacytomas are rare tumors comprised of neoplastic monoclonal plasma cells and can be found anywhere in the body. Plasmacytomas that involve the nervous system can give rise to diffuse symptoms depending on their location. Pa…
View article: Decorin is an early CSF biomarker of Alzheimer’s Aβ amyloidosis
Decorin is an early CSF biomarker of Alzheimer’s Aβ amyloidosis Open
Alzheimer’s disease (AD) is characterized by impaired protein homeostasis leading to amyloid-beta (Aβ) amyloidosis. Here, we show that autophagy is similarly inhibited in AD brains and App knock-in AD mouse models. To determine how patholo…
View article: Comparison of Cerebrospinal Fluid Amyloidogenic Nanoplaques With Core Biomarkers of Alzheimer’s Disease
Comparison of Cerebrospinal Fluid Amyloidogenic Nanoplaques With Core Biomarkers of Alzheimer’s Disease Open
Accurate biomarkers of Alzheimer’s disease (AD) are essential for early diagnosis and intervention. Available biomarkers are not sufficient to permit the monitoring of AD progression over time, and additional biomarkers are required. Measu…
View article: Amyloidogenic nanoplaque levels are increased in the cerebrospinal fluid in Alzheimer’s disease
Amyloidogenic nanoplaque levels are increased in the cerebrospinal fluid in Alzheimer’s disease Open
Background The aggregation of amyloid β (Aβ) is a central step in Alzheimer’s disease (AD) pathogenesis according to the amyloid cascade hypothesis. Measures of misfolded or aggregated Aβ are attractive biomarkers for AD, as they could pot…
View article: Insulin-Independent and Dependent Glucose Transporters in Brain Mural Cells in CADASIL
Insulin-Independent and Dependent Glucose Transporters in Brain Mural Cells in CADASIL Open
Typical cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is caused by mutations in the human NOTCH3 gene. Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencep…
View article: Amyloidogenic Nanoplaques in Cerebrospinal Fluid: Relationship to Amyloid Brain Uptake and Clinical Alzheimer’s Disease in a Memory Clinic Cohort
Amyloidogenic Nanoplaques in Cerebrospinal Fluid: Relationship to Amyloid Brain Uptake and Clinical Alzheimer’s Disease in a Memory Clinic Cohort Open
Background: Aggregation of amyloid-β (Aβ) is an early pathological event in Alzheimer’s disease (AD). Consequently, measures of pathogenic aggregated Aβ are attractive biomarkers for AD. Here, we use a recently developed Thioflavin-T-Fluor…
View article: Amyloid, tau, and astrocyte pathology in autosomal-dominant Alzheimer’s disease variants: AβPParc and PSEN1DE9
Amyloid, tau, and astrocyte pathology in autosomal-dominant Alzheimer’s disease variants: AβPParc and PSEN1DE9 Open
Autosomal-dominant Alzheimer’s disease (ADAD) may be associated with atypical amyloid beta deposits in the brain. In vivo amyloid imaging using 11 C-Pittsburgh compound B (PiB) tracer has shown differences in binding between brains from AD…