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Ddx61-enriched condensates refine heart regeneration programs Open

Mira I. Pronobis, Sophia DeLuca, Siyun Lee, L. Pérez García, Jianhong Ou , et al. · 2025

Gene regulatory mechanisms that underlie tissue regeneration have been largely studied at the level of transcription. Here, proximity labeling methods identify increased presence of the RNA helicase and P-body marker Ddx61 in adult zebrafi…

Organ-specific rewiring of mitochondrial integrity through COX7A dictates cellular ploidy control Open

Archan Chakraborty, Sophia DeLuca, Meera Gangasani, Stephen L. Rogers, Nenad Bursac , et al. · 2025

To achieve proper cell and tissue size, cytoplasmic and nuclear growth must be coordinated. Disrupting this coordination causes birth defects and disease. In nature’s largest cells, nuclear growth occurs through polyploidization (whole-gen…

Author response: Spatial and longitudinal tracking of enhancer-AAV vectors that target transgene expression to injured mouse myocardium Open

David Wolfson, Joshua A. Hull, Yongwu Li, Trevor Gonzalez, Makkuni Jayaram , et al. · 2025

Spatial and longitudinal tracking of enhancer-AAV vectors that target transgene expression to injured mouse myocardium Open

David Wolfson, Joshua A. Hull, Yongwu Li, Trevor Gonzalez, Makkuni Jayaram , et al. · 2025

Tissue regeneration enhancer elements (TREEs) direct expression of target genes in injured and regenerating tissues. Additionally, TREEs of zebrafish origin were shown to direct expression of transgenes in border zone regions after cardiac…

Spatial and longitudinal tracking of enhancer-AAV vectors that target transgene expression to injured mouse myocardium Open

David Wolfson, Joshua A. Hull, Yongwu Li, Trevor Gonzalez, Makkuni Jayaram , et al. · 2025

Tissue regeneration enhancer elements (TREEs) direct expression of target genes in injured and regenerating tissues. Additionally, TREEs of zebrafish origin were shown to direct the expression of transgenes in border zone regions after car…

Author response: Spatial and longitudinal tracking of enhancer-AAV vectors that target transgene expression to injured mouse myocardium Open

David Wolfson, Joshua A. Hull, Yongwu Li, Trevor Gonzalez, Makkuni Jayaram , et al. · 2025

Effects of Pharmacological Polyploidization in Human iPSC‐Derived Cardiomyocytes Open

Nicholas Strash, Marisa Patsy, Sophia DeLuca, Abbigail Helfer, Xixian Jiang , et al. · 2025

BacNa <sub>v</sub> Gene Therapy Improves Function of Infarcted Engineered Human Myocardium and NHPs Open

Tianyu Wu, Nicole Tee, Yiu Yan Siu, Anna Tornatore, Abhishek Bhattacharjee , et al. · 2025

Spatial and longitudinal tracking of enhancer-AAV vectors that target transgene expression to injured mouse myocardium Open

David Wolfson, Joshua A. Hull, Yongwu Li, Trevor Gonzalez, Makkuni Jayaram , et al. · 2025

Tissue regeneration enhancer elements (TREEs) direct expression of target genes in injured and regenerating tissues. Additionally, TREEs of zebrafish origin were shown to direct the expression of transgenes in border zone regions after car…

Spatial and longitudinal tracking of enhancer-AAV vectors that target transgene expression to injured mouse myocardium Open

David Wolfson, Joshua A. Hull, Yongwu Li, Trevor Gonzalez, Makkuni Jayaram , et al. · 2025

Tissue regeneration enhancer elements (TREEs) direct expression of target genes in injured and regenerating tissues. Additionally, TREEs of zebrafish origin were shown to direct expression of transgenes in border zone regions after cardiac…

Spatial and longitudinal tracking of enhancer-AAV vectors that target transgene expression to injured mouse myocardium Open

David Wolfson, Joshua A. Hull, Yongwu Li, Trevor Gonzalez, Makkuni Jayaram , et al. · 2025

Tissue regeneration enhancer elements (TREEs) direct expression of target genes in injured and regenerating tissues. Additionally, TREEs of zebrafish origin were shown to direct the expression of transgenes in border zone regions after car…

Long-term editing of brain circuits in mice using an engineered electrical synapse Open

Elizabeth Ransey, Gwenaëlle E. Thomas, Elias M. Wisdom, Agustin Almoril-Porras, Ryan Bowman , et al. · 2025

Electrical signaling across distinct populations of brain cells underpins cognitive and emotional function; however, approaches that selectively regulate electrical signaling between two cellular components of a mammalian neural circuit re…

Human Myobundle Platform for Studying the Role of Notch Signaling in Satellite Cell Phenotype and Function Open

Torie Broer, Nick Tsintolas, Stewart Hammond, Abbigail Helfer, Joonbum Lee , et al. · 2025

Notch signaling plays a pivotal role in regulating satellite cell (SC) behavior during skeletal muscle development, homeostasis, and repair. While well‐characterized in mouse models, the impact of Notch signaling in human muscle tissues re…

Fibroblast growth factor 23 and fibroblast growth factor receptor 4 promote cardiac metabolic remodeling in chronic kidney disease Open

Michaela Fuchs, Emily J. Burke, Nejla Latic, Susan Murray, Hanjun Li , et al. · 2025

Chronic kidney disease (CKD) is a global health epidemic that greatly increases mortality due to cardiovascular disease. Left ventricular hypertrophy (LVH) is an important mechanism of cardiac injury in CKD. High serum levels of fibroblast…

Bioengineered Model of Human LGMD2B Skeletal Muscle Reveals Roles of Intracellular Calcium Overload in Contractile and Metabolic Dysfunction in Dysferlinopathy Open

Alastair Khodabukus, Neel K. Prabhu, Taylor Roberts, Meghan Buldo, Amber Detwiler , et al. · 2024

Dysferlin is a multi‐functional protein that regulates membrane resealing, calcium homeostasis, and lipid metabolism in skeletal muscle. Genetic loss of dysferlin results in limb girdle muscular dystrophy 2B/2R (LGMD2B/2R) and other dysfer…

Time-dependent effects of BRAF-V600E on cell cycling, metabolism, and function in engineered myocardium Open

Nicholas Strash, Sophia DeLuca, Geovanni L. Janer Carattini, Yifan Chen, Tianyu Wu , et al. · 2024

Candidate cardiomyocyte (CM) mitogens such as those affecting the extracellular signal–regulated kinase (ERK) signaling pathway represent potential targets for functional heart regeneration. We explored whether activating ERK via a constit…

Fibroblast Growth Factor (FGF) 23 and FGF Receptor 4 promote cardiac metabolic remodeling in chronic kidney disease Open

Alexander Grabner, Michaela Fuchs, Emily Burke, Nejla Latic, Susan Murray , et al. · 2023

Author Correction: Engineered bacterial voltage-gated sodium channel platform for cardiac gene therapy Open

Hung Nguyen, Tianyu Wu, Daniel Needs, Hengtao Zhang, Robin M. Perelli , et al. · 2023

Prokaryotic voltage-gated sodium channels are more effective than endogenous Na<sub>v</sub>1.5 channels in rescuing cardiac action potential conduction: an in silico study Open

Daniel Needs, Tianyu Wu, Hung Nguyen, Craig S. Henriquez, Nenad Bursac · 2023

Slow action potential conduction is a common cause of various cardiac arrhythmias; yet, current pharmacotherapies cannot augment cardiac conduction. This in silico study compared the efficacy of recently proposed antiarrhythmic gene therap…

Differential Response of Engineered Human Cardiac Tissues to Delta and Omicron COVID‐19 Virus Open

Qiao Zhang, Ren‐Zhi Zhan, Marisa Patsy, Binjie Li, Yifan Chen , et al. · 2023

Conserved Chamber-Specific Polyploidy Maintains Heart Function in<i>Drosophila</i> Open

Archan Chakraborty, Nora G. Peterson, Juliet S. King, Ryan Gross, Michelle Mendiola , et al. · 2023

SUMMARY Developmentally programmed polyploidy (whole-genome-duplication) of cardiomyocytes is common across evolution. Functions of such polyploidy are essentially unknown. Here, we reveal roles for precise polyploidy levels in cardiac tis…

An enhancer-based gene-therapy strategy for spatiotemporal control of cargoes during tissue repair Open

Ruorong Yan, Valentina Cigliola, Kelsey A Oonk, Zachary Petrover, Sophia DeLuca , et al. · 2022

Meteorin-like is an injectable peptide that can enhance regeneration in aged muscle through immune-driven fibro/adipogenic progenitor signaling Open

David E. Lee, Lauren K. McKay, Akshay Bareja, Yongwu Li, Alastair Khodabukus , et al. · 2022

Translating musculoskeletal bioengineering into tissue regeneration therapies Open

Alastair Khodabukus, Tyler Guyer, Axel C. Moore, Molly M. Stevens, Robert E. Guldberg , et al. · 2022

Musculoskeletal injuries and disorders are the leading cause of physical disability worldwide and a considerable socioeconomic burden. The lack of effective therapies has driven the development of novel bioengineering approaches that have …

Differential microRNA profiles of intramuscular and secreted extracellular vesicles in human tissue-engineered muscle Open

Christopher G. Vann, Xin Zhang, Alastair Khodabukus, Melissa C. Orenduff, Yu‐Hsiu Chen , et al. · 2022

Exercise affects the expression of microRNAs (miR/s) and muscle-derived extracellular vesicles (EVs). To evaluate sarcoplasmic and secreted miR expression in human skeletal muscle in response to exercise-mimetic contractile activity, we ut…

BRG1 is a biomarker of hypertrophic cardiomyopathy in human heart specimens Open

Jacob C. Scherba, Marc K. Halushka, Nicholas D. Andersen, Joseph J. Maleszewski, Andrew P. Landstrom , et al. · 2022

Myoblast deactivation within engineered human skeletal muscle creates a transcriptionally heterogeneous population of quiescent satellite-like cells Open

Jason Wang, Torie Broer, Taylor Chavez, Chris J. Zhou, Sabrina Tran , et al. · 2022

BRAF-V600E-Mediated Erk Activation Promotes Sustained Cell Cycling and Broad Transcriptional Changes in Neonatal Cardiomyocytes Open

Nicholas Strash, Sophia DeLuca, Geovanni L. Janer Carattini, Yifan Chen, Jacob C. Scherba , et al. · 2022

Mitogens capable of promoting cardiomyocyte proliferation represent important targets for functional heart regeneration following myocardial infarction. We previously described an ERK-dependent pro-proliferative tissue phenotype following …

Targeted Delivery for Cardiac Regeneration: Comparison of Intra-coronary Infusion and Intra-myocardial Injection in Porcine Hearts Open

Andrew M. Vekstein, David C. Wendell, Sophia DeLuca, Ruorong Yan, Yifan Chen , et al. · 2022

Background The optimal delivery route to enhance effectiveness of regenerative therapeutics to the human heart is poorly understood. Direct intra-myocardial (IM) injection is the gold standard, however, it is relatively invasive. We thus c…

Engineered bacterial voltage-gated sodium channel platform for cardiac gene therapy Open

Hung Nguyen, Tianyu Wu, Daniel Needs, Hengtao Zhang, Robin M. Perelli , et al. · 2022

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