Nengyi Hou
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View article: Burden of gastroesophageal reflux disease among women of childbearing age, with projections to 2050: an analysis of the Global Burden of Disease study 2021
Burden of gastroesophageal reflux disease among women of childbearing age, with projections to 2050: an analysis of the Global Burden of Disease study 2021 Open
Background Gastroesophageal reflux disease (GERD) is a common chronic digestive disorder characterized by the reflux of gastroduodenal contents into the esophagus, causing uncomfortable symptoms and potential tissue damage. It affects over…
View article: TRPV1 Induced Apoptosis of Colorectal Cancer Cells by Activating Calcineurin-NFAT2-p53 Signaling Pathway
TRPV1 Induced Apoptosis of Colorectal Cancer Cells by Activating Calcineurin-NFAT2-p53 Signaling Pathway Open
Background/Aims. TRPV1 is a nonselective Ca 2+ channel which has recently been observed in many cancers, while its effect on cell proliferation, apoptosis, metabolism, and cancer development in colorectal cancer (CRC) is still unclear. In …
View article: A novel APC mutation identified in a large Chinese family with familial adenomatous polyposis and a brief literature review
A novel APC mutation identified in a large Chinese family with familial adenomatous polyposis and a brief literature review Open
Familial adenomatous polyposis (FAP), an autosomal dominant disease, is a colon cancer predisposition syndrome that manifests as a large number of adenomatous polyps. Mutations in the Adenomatous polyposis coli (APC) gene are responsible f…
View article: Genome-Wide Network-Based Analysis of Colorectal Cancer Identifies Novel Prognostic Factors and an Integrative Prognostic Index
Genome-Wide Network-Based Analysis of Colorectal Cancer Identifies Novel Prognostic Factors and an Integrative Prognostic Index Open
Background/Aims: Colorectal cancer (CRC) is one of leading cancers in both incidence and mortality rate. The 5-year survival rate varies considerably depending on the pathological stage of the tumor. Although prominent progress has been ma…
View article: CT volumetry for gastric adenocarcinoma: association with lymphovascular invasion and T-stages
CT volumetry for gastric adenocarcinoma: association with lymphovascular invasion and T-stages Open
Gross tumor volume of resectable gastric adenocarcinoma at multidetector computed tomography demonstrated capability in predicting lymphovascular invasion and distinguishing T-stages.
View article: MiR‑370 promotes apoptosis in colon cancer by directly targeting MDM4
MiR‑370 promotes apoptosis in colon cancer by directly targeting MDM4 Open
MicroRNA (miR)-370 functions as a tumor suppressor or promoter in several cancers. However, the expression and biological role of miR-370 in colon cancer remains undefined. In the present study, miR-370 expression in both normal and malign…
View article: ATP-Dependent Lon Protease Contributes to Helicobacter pylori-Induced Gastric Carcinogenesis
ATP-Dependent Lon Protease Contributes to Helicobacter pylori-Induced Gastric Carcinogenesis Open
Helicobacter pylori infection is the strongest risk factor for development of gastric cancer. Host cellular stress responses, including inflammatory and immune responses, have been reported highly linked to H. pylori-induced carcinogenesis…