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View article: Trypanosoma brucei Acyl-Protein Thioesterase-like (TbAPT-L) Is a Lipase with Esterase Activity for Short and Medium-Chain Fatty Acids but Has No Depalmitoylation Activity
Trypanosoma brucei Acyl-Protein Thioesterase-like (TbAPT-L) Is a Lipase with Esterase Activity for Short and Medium-Chain Fatty Acids but Has No Depalmitoylation Activity Open
Dynamic post-translational modifications allow the rapid, specific, and tunable regulation of protein functions in eukaryotic cells. S-acylation is the only reversible lipid modification of proteins, in which a fatty acid, usually palmitat…
View article: Selective activation of PFKL suppresses the phagocytic oxidative burst
Selective activation of PFKL suppresses the phagocytic oxidative burst Open
In neutrophils, nicotinamide adenine dinucleotide phosphate (NADPH) generated via the pentose phosphate pathway fuels NADPH oxidase NOX2 to produce reactive oxygen species for killing invading pathogens. However, excessive NOX2 activity ca…
View article: Toxoplasma gondii serine hydrolases regulate parasite lipid mobilization during growth and replication within the host
Toxoplasma gondii serine hydrolases regulate parasite lipid mobilization during growth and replication within the host Open
View article: <i>Toxoplasma gondii</i>serine hydrolases regulate parasite lipid mobilization during growth and replication within the host
<i>Toxoplasma gondii</i>serine hydrolases regulate parasite lipid mobilization during growth and replication within the host Open
Summary The intracellular protozoan parasite Toxoplasma gondii must scavenge cholesterol and other lipids from the host to facilitate intracellular growth and replication. Enzymes responsible for neutral lipid synthesis have been identifie…
View article: <i>Toxoplasma gondii</i>&nbsp;Serine Hydrolases Regulate Parasite Lipid Mobilization During Growth and Replication within the Host
<i>Toxoplasma gondii</i> Serine Hydrolases Regulate Parasite Lipid Mobilization During Growth and Replication within the Host Open
View article: Synthetic Fluorogenic Peptides Reveal Dynamic Substrate Specificity of Depalmitoylases
Synthetic Fluorogenic Peptides Reveal Dynamic Substrate Specificity of Depalmitoylases Open
View article: Erratum for Foe et al., “The Toxoplasma gondii Active Serine Hydrolase 4 Regulates Parasite Division and Intravacuolar Parasite Architecture”
Erratum for Foe et al., “The Toxoplasma gondii Active Serine Hydrolase 4 Regulates Parasite Division and Intravacuolar Parasite Architecture” Open
[This corrects the article DOI: 10.1128/mSphere.00393-18.].
View article: The <i>Toxoplasma gondii</i> Active Serine Hydrolase 4 Regulates Parasite Division and Intravacuolar Parasite Architecture
The <i>Toxoplasma gondii</i> Active Serine Hydrolase 4 Regulates Parasite Division and Intravacuolar Parasite Architecture Open
This work defines the function of an enzyme in the obligate intracellular parasite Toxoplasma gondii . We show that this previously uncharacterized enzyme is critical for aspects of cellular division by the parasite and that loss of this e…
View article: Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation
Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation Open
Tubulin carboxypeptidase identity revealed Enzymes of the α-tubulin detyrosination/tyrosination cycle create landmarks on microtubules that are essential for their multiple cellular functions and are altered in disease. Tubulin carboxypept…
View article: Cover Picture: Fine‐Tuning Covalent Inhibition of Bacterial Quorum Sensing (ChemBioChem 9/2016)
Cover Picture: Fine‐Tuning Covalent Inhibition of Bacterial Quorum Sensing (ChemBioChem 9/2016) Open
The cover picture shows schematically how the important quorum-sensing regulator LasR of the human pathogen Pseudomonas aeruginosa can be targeted with tailor-made covalent probes. A diverse array of electrophile-containing N-acylated homo…