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View article: Temporal Trajectories in Sleep, Temperature Trends, Cardiorespiratory, and Activity Metrics Measured via Oura Ring During Pregnancy: Large-Scale Observational Analysis
Temporal Trajectories in Sleep, Temperature Trends, Cardiorespiratory, and Activity Metrics Measured via Oura Ring During Pregnancy: Large-Scale Observational Analysis Open
Background Pregnancy and childbirth involve significant health challenges, including preventable maternal deaths, severe complications, and disparities tied to social determinants, emphasizing the need for improved maternal care. Pregnancy…
View article: GraftIQ: Hybrid multi-class neural network integrating clinical insight for multi-outcome prediction in liver transplant recipients
GraftIQ: Hybrid multi-class neural network integrating clinical insight for multi-outcome prediction in liver transplant recipients Open
View article: Comparative analysis of treatment modalities for solitary, small (≤3 cm) hepatocellular carcinoma: A systematic review and network meta-analysis of oncologic outcomes
Comparative analysis of treatment modalities for solitary, small (≤3 cm) hepatocellular carcinoma: A systematic review and network meta-analysis of oncologic outcomes Open
View article: GraftIQ: A Hybrid Multi-Class Neural Network Integrating Clinical Insight for Multi-Outcome Prediction in Liver Transplant Recipients
GraftIQ: A Hybrid Multi-Class Neural Network Integrating Clinical Insight for Multi-Outcome Prediction in Liver Transplant Recipients Open
Background and Aims Liver transplant recipients (LTRs) are at risk of developing graft injury, leading to cirrhosis and reduced survival. Liver biopsy remains the gold standard method for the diagnosis of graft pathology but is invasive an…
View article: Predicting labor onset relative to the estimated date of delivery using smart ring physiological data
Predicting labor onset relative to the estimated date of delivery using smart ring physiological data Open
View article: Association between lean muscle mass and treatment-resistant late-life depression in the IRL-GRey randomized controlled trial
Association between lean muscle mass and treatment-resistant late-life depression in the IRL-GRey randomized controlled trial Open
As expected, older age and female sex were associated with lower lean muscle mass in TR-LLD. However, contrary to prior results in LLD, lean muscle mass was not associated with depression severity or outcome. This suggests that aripiprazol…
View article: A Multi-Class Neural Network Machine Learning Algorithm to Diagnose Graft Pathology in Liver Transplant Recipients
A Multi-Class Neural Network Machine Learning Algorithm to Diagnose Graft Pathology in Liver Transplant Recipients Open
View article: The promise of machine learning applications in solid organ transplantation
The promise of machine learning applications in solid organ transplantation Open
View article: Impact of Chronic Prenatal Stress on Maternal Neuroendocrine Function and Embryo and Placenta Development During Early-to-Mid-Pregnancy in Mice
Impact of Chronic Prenatal Stress on Maternal Neuroendocrine Function and Embryo and Placenta Development During Early-to-Mid-Pregnancy in Mice Open
Psychological stress, both leading up to and during pregnancy, is associated with increased risk for negative pregnancy outcomes. Although the neuroendocrine circuits that link the stress response to reduced sexual motivation and mating ar…
View article: Machine Learning Approach to Classify Cardiovascular Disease in Patients With Nonalcoholic Fatty Liver Disease in the UK Biobank Cohort
Machine Learning Approach to Classify Cardiovascular Disease in Patients With Nonalcoholic Fatty Liver Disease in the UK Biobank Cohort Open
Background Nonalcoholic fatty liver disease (NAFLD) is the most prevalent liver disease worldwide. Cardiovascular disease (CVD) is the leading cause of mortality among patients with NAFLD. The aim of our study was to develop a machine lear…
View article: Longitudinal decrease in platelet counts as a surrogate marker of liver fibrosis
Longitudinal decrease in platelet counts as a surrogate marker of liver fibrosis Open
In the preceding years before the diagnosis of cirrhosis, there is a progressive decline in PTC, within the normal range, matched to a gradual increase in fibrosis scores.
View article: Corrigendum to “Disentangling the systems contributing to changes in learning during adolescence” [Dev. Cogn. Neurosci. 41, 2020, 100732]
Corrigendum to “Disentangling the systems contributing to changes in learning during adolescence” [Dev. Cogn. Neurosci. 41, 2020, 100732] Open
View article: Longitudinal assessment of progressive decrease in platelet counts as a surrogate marker of liver fibrosis and portal hypertension
Longitudinal assessment of progressive decrease in platelet counts as a surrogate marker of liver fibrosis and portal hypertension Open
View article: MON-016 Neural Circuits and Hormonal Mechanisms Underlying the Negative Impact of Stress on Pregnancy Outcomes
MON-016 Neural Circuits and Hormonal Mechanisms Underlying the Negative Impact of Stress on Pregnancy Outcomes Open
Despite numerous findings detailing the negative impact of stress on female reproductive health, the means by which stress acts on the CNS and periphery to compromise reproductive success remains poorly understood. As a result, the current…
View article: Effects of Tumor Necrosis Factor Antagonists in Patients With Primary Sclerosing Cholangitis
Effects of Tumor Necrosis Factor Antagonists in Patients With Primary Sclerosing Cholangitis Open
View article: Disentangling the systems contributing to changes in learning during adolescence
Disentangling the systems contributing to changes in learning during adolescence Open
View article: Time‐of‐day‐dependent sensitivity of the reproductive axis to RFamide‐related peptide‐3 inhibition in female Syrian hamsters
Time‐of‐day‐dependent sensitivity of the reproductive axis to RFamide‐related peptide‐3 inhibition in female Syrian hamsters Open
In spontaneously ovulating rodent species, the timing of the luteinising hormone (LH) surge is controlled by the master circadian pacemaker in the suprachiasmatic nucleus (SCN). The SCN initiates the LH surge via the coordinated control of…
View article: Attentional Networks during the Menstrual Cycle
Attentional Networks during the Menstrual Cycle Open
The menstrual cycle is characterized partially by fluctuations of the ovarian hormones estradiol (E2) and progesterone (P4), which are implicated in the regulation of cognition. Research on attention in the different stages of the menstrua…
View article: Hepatitis A and E – Differences and commonalities
Hepatitis A and E – Differences and commonalities Open
View article: Distentangling the systems contributing to changes in learning during adolescence
Distentangling the systems contributing to changes in learning during adolescence Open
Multiple neurocognitive systems contribute simultaneously to learning. For example, dopamine and basal ganglia (BG) systems are thought to support reinforcement learning (RL) by incrementally updating the value of choices, while the prefro…
View article: Hepatitis B virus downregulates vitamin D receptor levels in hepatoma cell lines, thereby preventing vitamin D-dependent inhibition of viral transcription and production
Hepatitis B virus downregulates vitamin D receptor levels in hepatoma cell lines, thereby preventing vitamin D-dependent inhibition of viral transcription and production Open
These findings indicate that VDR expression is downregulated in HBV-transfected cells, thereby preventing vitamin D from inhibiting transcription and translation of HBV in vitro. HBV might use this mechanism to avoid the immunological defe…
View article: Pregnancy stage determines the effect of chronic stress on ovarian progesterone synthesis
Pregnancy stage determines the effect of chronic stress on ovarian progesterone synthesis Open
Although stress-induced glucocorticoid release is thought to be a primary driver by which maternal stress negatively impacts pregnancy outcomes, the downstream neuroendocrine targets mediating these adverse outcomes are less well understoo…
View article: Characteristics, Outcomes and Predictors of Mortality in Patients Undergoing Transjugular Intrahepatic Portosystemic Shunt
Characteristics, Outcomes and Predictors of Mortality in Patients Undergoing Transjugular Intrahepatic Portosystemic Shunt Open
Background: Transjugular intrahepatic portosystemic shunt (TIPS) is a procedure for hepatic decompression and lowering of portal hypertension. The procedure is performed angiographically by inserting a metal stent between the hepatic and p…
View article: Regeneration of Functional Adrenal Tissue Following Bilateral Adrenalectomy
Regeneration of Functional Adrenal Tissue Following Bilateral Adrenalectomy Open
It is assumed that after complete bilateral adrenalectomy (ADX), no adrenal tissue will redevelop and adrenal hormone levels will remain low and unaffected by stress. However, anecdotal observations in animals and in patients suggest that …
View article: Perioperative treatment with the new synthetic <scp>TLR</scp>‐4 agonist <scp>GLA‐SE</scp> reduces cancer metastasis without adverse effects
Perioperative treatment with the new synthetic <span>TLR</span>‐4 agonist <span>GLA‐SE</span> reduces cancer metastasis without adverse effects Open
The use of TLR agonists as an anti‐cancer treatment is gaining momentum given their capacity to activate various host cellular responses through the secretion of inflammatory cytokines and type‐I interferons. It is now also recognized that…