Explanipedia

Systems level analysis of B-cell development identifies BDNF as a driver for human B lymphopoiesis Open

Neta Nevo, Yuval Klein, Ayelet Alpert, Amir Grau, Doron Melamed , et al. · 2025

B-cell aplasia impairs the immune response to cancer, infections and vaccines. However, no B-cell accelerator is available in the clinic to date. Here, we utilized a system biology approach to discover drivers for B lymphopoiesis in the hu…

A personalized network framework reveals predictive axis of anti-TNF response across diseases Open

Shiran Gerassy-Vainberg, Elina Starosvetsky, Renaud Gaujoux, Alexandra Blatt, Naama Maimon , et al. · 2023

Reconstructing disease dynamics for mechanistic insights and clinical benefit Open

Amit Frishberg, Neta Milman, Ayelet Alpert, Hannah Spitzer, Ben Asani , et al. · 2023

Systematic mapping of neural signals in the periphery reveals a rich and specific alphabet for immune cell communication Open

Karen Regev Berman, Neta Milman, Meital Segev, Elina Stratovsky, Shai S. Shen-Orr · 2022

Summary Accumulating evidence indicate a strong link between neural signals and the immune system. Given neural signals constitute a large family that may be leveraged for communication, we systematically explored the neuro-immune regulati…

B cell-derived cfDNA after primary BNT162b2 mRNA vaccination anticipates memory B cells and SARS-CoV-2 neutralizing antibodies Open

Ilana Fox-Fisher, Sheina Piyanzin, Mayan Briller, Esther Oiknine‐Djian, Or Alfi , et al. · 2022

Mature neutrophils and a NF-κB-to-IFN transition determine the unifying disease recovery dynamics in COVID-19 Open

Amit Frishberg, Emma J. Kooistra, Melanie Nuesch-Germano, Tal Pecht, Neta Milman , et al. · 2022

Reconstructing disease dynamics for mechanistic insights and clinical benefit Open

Amit Frishberg, Neta Milman, Ayelet Alpert, Hannah Spitzer, Ben Asani , et al. · 2021

Diseases change over time, both phenotypically and in underlying driving molecular processes. Though understanding disease progression dynamics is critical for diagnostics and treatment, capturing these dynamics is difficult, due to their …

A personalized network framework reveals predictive axis of anti-TNF response across diseases Open

Shiran Gerassy-Vainberg, Elina Starosvetsky, Renaud Gaujoux, Alexandra Blatt, Naama Maimon , et al. · 2021

Personalized treatment of complex diseases has been mostly predicated on biomarker identification of one drug-disease combination at a time. Here, we used a novel computational approach termed Disruption Networks to generate a new data typ…

Collagenase Nanoparticles Enhance the Penetration of Drugs into Pancreatic Tumors Open

Assaf Zinger, Lilach Koren, Omer Adir, Maria Poley, Mohammed Alyan , et al. · 2019

Overexpressed extracellular matrix (ECM) in pancreatic ductal adenocarcinoma (PDAC) limits drug penetration into the tumor and is associated with poor prognosis. Here, we demonstrate that a pretreatment based on a proteolytic-enzyme nanopa…

MiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1 Open

Ying Yang, Mari B. Ishak Gabra, Eric A. Hanse, Xazmin H. Lowman, Thai Q. Tran , et al. · 2019

Plasmodium falciparum infected erythrocytes can bind to host receptors integrins αVβ3 and αVβ6 through DBLδ1_D4 domain of PFL2665c PfEMP1 protein Open

Olga Chesnokov, Jordan Merritt, Sergey Tcherniuk, Neta Milman, Andrew V. Oleinikov · 2018

Major complications and mortality from Plasmodium falciparum malaria are associated with cytoadhesion of parasite-infected erythrocytes (IE). The main parasite ligands for cytoadhesion are members of the P . falciparum erythrocyte membrane…

RET, a targetable driver of pancreatic adenocarcinoma Open

Moran Amit, Shorook Na’ara, Eran Fridman, Euvgeni Vladovski, Tanya Wasserman , et al. · 2018

Pancreatic ductal adenocarcinoma (PDA) remains a deadly disease, affecting about 40,000 individuals in the United States annually. We aimed to characterize the role of RET as a co‐driver of pancreas tumorigenesis. To assess the role of RET…

Transfer of miRNA in Macrophage-Derived Exosomes Induces Drug Resistance in Pancreatic Adenocarcinoma Open

Yoav Binenbaum, Eran Fridman, Zvi Yaari, Neta Milman, Avi Schroeder , et al. · 2018

Pancreatic ductal adenocarcinoma (PDAC) is known for its resistance to gemcitabine, which acts to inhibit cell growth by termination of DNA replication. Tumor-associated macrophages (TAM) were recently shown to contribute to gemcitabine re…

Correction: Identification of Novel Pre-Erythrocytic Malaria Antigen Candidates for Combination Vaccines with Circumsporozoite Protein Open

Cate Speake, Alexander Pichugin, Tejram Sahu, Vlad Malkov, Robert Morrison , et al. · 2016

[This corrects the article DOI: 10.1371/journal.pone.0159449.].

Identification of Novel Pre-Erythrocytic Malaria Antigen Candidates for Combination Vaccines with Circumsporozoite Protein Open

Cate Speake, Alexander Pichugin, Tejram Sahu, Vlad Malkov, Robert Morrison , et al. · 2016

[This corrects the article DOI: 10.1371/journal.pone.0159449.].

In Situ Detection of Regulatory T Cells in Human Genital Herpes Simplex Virus Type 2 (HSV-2) Reactivation and Their Influence on Spontaneous HSV-2 Reactivation Open

Neta Milman, Jia Zhu, Christine Johnston, Anqi Cheng, Amalia Magaret , et al. · 2016

The association of a high Treg to Tconv ratio with high viral shedding suggests that the balance between regulatory and effector T cells influences human HSV-2 disease.

Two separable functions of Ctp1 in the early steps of meiotic DNA double-strand break repair Open

Lijuan Ma, Neta Milman, Mridula Nambiar, Gerald R. Smith · 2015

Meiotic programmed DNA double-strand break (DSB) repair is essential for crossing-over and viable gamete formation and requires removal of Spo11-oligonucleotide complexes from 5' ends (clipping) and their resection to generate invasive 3'-…

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