Nathan W. Levin
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View article: Enhanced Reactivity and Selectivity in Organocatalysis via In-Situ Proline-Boronic Acid Complex Modification
Enhanced Reactivity and Selectivity in Organocatalysis via In-Situ Proline-Boronic Acid Complex Modification Open
The aldol reaction is a pivotal carbon-carbon bond-forming process integral to the biosynthesis of natural compounds. Yet, its application remains limited due to the challenges of selectivity, stereochemistry, and reaction efficiency. Here…
View article: More Frequent On-Site Dialysis May Hasten Return to Home for Nursing Home Patients with End-Stage Kidney Disease
More Frequent On-Site Dialysis May Hasten Return to Home for Nursing Home Patients with End-Stage Kidney Disease Open
Key Points Prior efficacy study—established that more frequent dialysis achieved better outcomes than CONVENTIONAL dialysis in outpatients. We undertook an effectiveness observational on-site nursing home study ( N =195) comparing on-site …
View article: #500 Monitoring relative blood volume and calf bioimpedance in hemodialysis patients
#500 Monitoring relative blood volume and calf bioimpedance in hemodialysis patients Open
Background and Aims Measurements of relative blood volume (RBV, %) are used to monitor the relative change in blood plasm during hemodialysis (HD). Continuous measurement of calf extracellular volume (cECV) during HD allows the calculation…
View article: Improved nursing home end‐stage renal disease patient participation in physical therapy with onsite, more frequent dialysis
Improved nursing home end‐stage renal disease patient participation in physical therapy with onsite, more frequent dialysis Open
Introduction For end‐stage renal disease (ESRD) patients residing in skilled nursing facilities (SNFs), the logistics and physical exhaustion of life‐saving hemodialysis therapy often conflict with rehabilitation goals. Integration of dial…
View article: Data from Specifically Targeting Angiopoietin-2 Inhibits Angiogenesis, Tie2-Expressing Monocyte Infiltration, and Tumor Growth
Data from Specifically Targeting Angiopoietin-2 Inhibits Angiogenesis, Tie2-Expressing Monocyte Infiltration, and Tumor Growth Open
Purpose: Angiopoietin-1 (Ang1) plays a key role in maintaining stable vasculature, whereas in a tumor Ang2 antagonizes Ang1's function and promotes the initiation of the angiogenic switch. Specifically targeting Ang2 is a promising antican…
View article: Supplementary Data from Specifically Targeting Angiopoietin-2 Inhibits Angiogenesis, Tie2-Expressing Monocyte Infiltration, and Tumor Growth
Supplementary Data from Specifically Targeting Angiopoietin-2 Inhibits Angiogenesis, Tie2-Expressing Monocyte Infiltration, and Tumor Growth Open
Supplementary Figures S1-S3.
View article: Data from Specifically Targeting Angiopoietin-2 Inhibits Angiogenesis, Tie2-Expressing Monocyte Infiltration, and Tumor Growth
Data from Specifically Targeting Angiopoietin-2 Inhibits Angiogenesis, Tie2-Expressing Monocyte Infiltration, and Tumor Growth Open
Purpose: Angiopoietin-1 (Ang1) plays a key role in maintaining stable vasculature, whereas in a tumor Ang2 antagonizes Ang1's function and promotes the initiation of the angiogenic switch. Specifically targeting Ang2 is a promising antican…
View article: Supplementary Data from Specifically Targeting Angiopoietin-2 Inhibits Angiogenesis, Tie2-Expressing Monocyte Infiltration, and Tumor Growth
Supplementary Data from Specifically Targeting Angiopoietin-2 Inhibits Angiogenesis, Tie2-Expressing Monocyte Infiltration, and Tumor Growth Open
Supplementary Figures S1-S3.
View article: Evaluating Gaming Detector Model Robustness Over Time
Evaluating Gaming Detector Model Robustness Over Time Open
Research into "gaming the system" behavior in intelligent tutoring systems (ITS) has been around for almost two decades, and detection has been developed for many ITSs. Machine learning models can detect this behavior in both real-time and…
View article: A MATHEMATICAL MODEL OF OPTIMIZATION FOR GEARS WITH CONVEX-CONCAVE CONTACT
A MATHEMATICAL MODEL OF OPTIMIZATION FOR GEARS WITH CONVEX-CONCAVE CONTACT Open
Стаття присвячена оптимальному проектуванню зубчастих передач з опукло-увігнутим контактом зубців. Побудовано математичну модель оптимізації за критеріями мінімальних контактних напружень або відносних швидкостей ковзання. У якості об'єкта…
View article: <scp>Post‐dialysis</scp> recovery time in <scp>ESRD</scp> patients receiving more frequent hemodialysis in skilled nursing facilities
<span>Post‐dialysis</span> recovery time in <span>ESRD</span> patients receiving more frequent hemodialysis in skilled nursing facilities Open
Introduction Post‐dialysis recovery time ( DRT ) has an important relationship to quality of life and survival, as identified in studies of ESRD patients on conventional dialysis. ESRD patients are often discharged from hospitals to skille…
View article: Long-Term Sustainability of Using Hemodialyzers to Inexpensively Provide Pathogen-Free Water to Remote Villages Lacking Electricity
Long-Term Sustainability of Using Hemodialyzers to Inexpensively Provide Pathogen-Free Water to Remote Villages Lacking Electricity Open
The provision of clean water to remote communities is a major goal of both the World Health Organization and the United Nations. We report on the long-term sustainability of filter-sterilizing polluted water in remote villages in Ghana tha…
View article: Edelman Revisited: Concepts, Achievements, and Challenges
Edelman Revisited: Concepts, Achievements, and Challenges Open
The key message from the 1958 Edelman study states that combinations of external gains or losses of sodium, potassium and water leading to an increase of the fraction (total body sodium plus total body potassium) over total body water will…
View article: Periodontal disease adversely affects the survival of patients with end-stage renal disease
Periodontal disease adversely affects the survival of patients with end-stage renal disease Open
Periodontal disease is associated with cardiovascular disease and is thought to accelerate systemic atherosclerosis. Here we examined the relationship between periodontitis and cardiovascular disease mortality in outpatients on hemodialysi…
View article: Epidemiology of nursing home dialysis patients—A hidden population
Epidemiology of nursing home dialysis patients—A hidden population Open
Introduction Dialysis patients are often discharged from hospitals to skilled nursing facilities (SNFs), but little has been published about their natural history. Methods Using electronic medical record data, we conducted a retrospective …
View article: Recognition and management of community-acquired acute kidney injury in low-resource settings in the ISN 0by25 trial: A multi-country feasibility study
Recognition and management of community-acquired acute kidney injury in low-resource settings in the ISN 0by25 trial: A multi-country feasibility study Open
Background Acute kidney injury (AKI) is increasingly encountered in community settings and contributes to morbidity, mortality, and increased resource utilization worldwide. In low-resource settings, lack of awareness of and limited access…
View article: The Predialysis Serum Sodium Level Modifies the Effect of Hemodialysis Frequency on Left-Ventricular Mass: The Frequent Hemodialysis Network Trials
The Predialysis Serum Sodium Level Modifies the Effect of Hemodialysis Frequency on Left-Ventricular Mass: The Frequent Hemodialysis Network Trials Open
Introduction: The Frequent Hemodialysis Network (FHN) Daily and Nocturnal trials aimed to compare the effects of hemodialysis (HD) given 6 versus 3 times per week. More frequent in-center HD significantly reduced left-ventricular mass (LVM…
View article: Predictors of heart rate variability and its prognostic significance in chronic kidney disease
Predictors of heart rate variability and its prognostic significance in chronic kidney disease Open
Heart rate variability (HRV), a noninvasive measure of autonomic dysfunction and a risk factor for cardiovascular disease (CVD), has not been systematically studied in nondialysis chronic kidney disease (CKD).
View article: Association of carotid intima-media thickness with cardiovascular risk factors and patient outcomes in advanced chronic kidney disease: the RRI-CKD study
Association of carotid intima-media thickness with cardiovascular risk factors and patient outcomes in advanced chronic kidney disease: the RRI-CKD study Open
Background: Chronic kidney disease (CKD) is associated with accelerated atherosclerosis and an increased risk of adverse cardiovascular disease (CVD) outcomes. The relationships of intima-media thickness (IMT), a measure of subclinical ath…
View article: Relationship between heart rate variability and pulse wave velocity and their association with patient outcomes in chronic kidney disease
Relationship between heart rate variability and pulse wave velocity and their association with patient outcomes in chronic kidney disease Open
Background: Arterial stiffness and low heart rate variability (HRV) have each been associated with increased cardiovascular risk in a variety of patient populations. We explored the relationship between HRV and pulse wave velocity (PWV mea…
View article: Purifying polluted water through hemodialysis filters for poor villages without electricity: the Easy Water for Everyone approach and experience
Purifying polluted water through hemodialysis filters for poor villages without electricity: the Easy Water for Everyone approach and experience Open
Given the need for treating polluted drinking water, our NGO Easy Water for Everyone has produced pure water in remote villages without power and achieved health benefits. With the goal of reaching more needy populations we report our expe…
View article: Diagnostic performance of a point-of-care saliva urea nitrogen dipstick to screen for kidney disease in low-resource settings where serum creatinine is unavailable
Diagnostic performance of a point-of-care saliva urea nitrogen dipstick to screen for kidney disease in low-resource settings where serum creatinine is unavailable Open
Background Kidney disease is prevalent in low-resource settings worldwide, but tests for its diagnosis are often unavailable. The saliva urea nitrogen (SUN) dipstick is a laboratory and electricity independent tool, which may be used for t…
View article: SUN-034 DOES SALIVARY UREA NITROGEN DIPSTICK ALLOW PEDIATRIC ACUTE INJURY DETECTION IN SUB-SAHARAN AFRICA?
SUN-034 DOES SALIVARY UREA NITROGEN DIPSTICK ALLOW PEDIATRIC ACUTE INJURY DETECTION IN SUB-SAHARAN AFRICA? Open
Acute Kidney Injury in pediatric populations (pAKI) results in significant morbidity and mortality in developing countries. Point of care (POC) devices providing the required diagnostic accuracy to diagnose AKI and may increase diagnosis a…
View article: Decentralized Water Purification Using Novel Membrane Filtration Technology Approach to Improve Community Health
Decentralized Water Purification Using Novel Membrane Filtration Technology Approach to Improve Community Health Open
Introduction: In rural communities in regions with limited resources the provision of clean water remains challenging. Fecal contamination of water is very common and results in a high incidence of diarrhea, subsequent acute kidney injury …