Neza Alfazema
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View article: DDDR-48. An AAV-1 mediated dual-payload gene therapy for high grade glioma
DDDR-48. An AAV-1 mediated dual-payload gene therapy for high grade glioma Open
BACKGROUND There have been few advances in glioblastoma treatment in recent decades. Treatments fail due to tumour heterogeneity (genetic, epigenetic, cell-state) and persistence of GBM stem-like cells (GSCs) within the tumour margin. SOX2…
View article: Elevated FOXG1 in glioblastoma stem cells cooperates with Wnt/β-catenin to induce exit from quiescence
Elevated FOXG1 in glioblastoma stem cells cooperates with Wnt/β-catenin to induce exit from quiescence Open
Glioblastoma (GBM) stem cells (GSCs) display phenotypic and molecular features reminiscent of normal neural stem cells and exhibit a spectrum of cell cycle states (dormant, quiescent, proliferative). However, mechanisms controlling the tra…
View article: Lrig1 regulates the balance between proliferation and quiescence in glioblastoma stem cells
Lrig1 regulates the balance between proliferation and quiescence in glioblastoma stem cells Open
Patients with glioblastoma (GBM) face a dismal prognosis. GBMs are driven by glioblastoma stem cells (GSCs) that display a neural stem cell (NSC)-like phenotype. These glioblastoma stem cells are often in a quiescent state that evades curr…
View article: Simultaneous disruption of PRC2 and enhancer function underlies histone H3.3-K27M oncogenic activity in human hindbrain neural stem cells
Simultaneous disruption of PRC2 and enhancer function underlies histone H3.3-K27M oncogenic activity in human hindbrain neural stem cells Open
View article: LRIG1 is a gatekeeper to exit from quiescence in adult neural stem cells
LRIG1 is a gatekeeper to exit from quiescence in adult neural stem cells Open
View article: Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion
Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion Open
View article: Regional identity of human neural stem cells determines oncogenic responses to histone H3.3 mutants
Regional identity of human neural stem cells determines oncogenic responses to histone H3.3 mutants Open
View article: <i>Camk2n1</i> Is a Negative Regulator of Blood Pressure, Left Ventricular Mass, Insulin Sensitivity, and Promotes Adiposity
<i>Camk2n1</i> Is a Negative Regulator of Blood Pressure, Left Ventricular Mass, Insulin Sensitivity, and Promotes Adiposity Open
Metabolic syndrome is a cause of coronary artery disease and type 2 diabetes mellitus. Camk2n1 resides in genomic loci for blood pressure, left ventricle mass, and type 2 diabetes mellitus, and in the spontaneously hypertensive rat model o…
View article: Complement Factor B Is a Determinant of Both Metabolic and Cardiovascular Features of Metabolic Syndrome
Complement Factor B Is a Determinant of Both Metabolic and Cardiovascular Features of Metabolic Syndrome Open
CFB (complement factor B) is elevated in adipose tissue and serum from patients with type 2 diabetes mellitus and cardiovascular disease, but the causal relationship to disease pathogenesis is unclear. Cfb is also elevated in adipose tissu…
View article: Genetic, physiological and comparative genomic studies of hypertension and insulin resistance in the spontaneously hypertensive rat
Genetic, physiological and comparative genomic studies of hypertension and insulin resistance in the spontaneously hypertensive rat Open
We previously mapped hypertension-related insulin resistance quantitative trait loci (QTL) to rat chromosomes 4, 12 and 16 using adipocytes from F2 crosses between spontaneously hypertensive (SHR) and Wistar Kyoto (WKY) rats, and subsequen…
View article: New Wistar Kyoto and Spontaneously Hypertensive rat transgenic models with ubiquitous expression of green fluorescent protein
New Wistar Kyoto and Spontaneously Hypertensive rat transgenic models with ubiquitous expression of green fluorescent protein Open
The Wistar Kyoto rat (WKY) and the Spontaneously Hypertensive Rat (SHR) inbred strains are well-established models for human crescentic glomerulonephritis (CRGN) and metabolic syndrome respectively. Novel transgenic (Tg) strains add resear…