Nezih Karasu
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View article: Transcription induces context-dependent remodeling of chromatin architecture during differentiation
Transcription induces context-dependent remodeling of chromatin architecture during differentiation Open
Metazoan chromosomes are organized into discrete spatial domains (TADs), believed to contribute to the regulation of transcriptional programs. Despite extensive correlation between domain organization and gene activity, a direct mechanisti…
View article: <scp>RNA</scp> polymerase <scp>II CTD</scp> is dispensable for transcription and required for termination in human cells
<span>RNA</span> polymerase <span>II CTD</span> is dispensable for transcription and required for termination in human cells Open
View article: Context-dependent transcriptional remodeling of TADs during differentiation
Context-dependent transcriptional remodeling of TADs during differentiation Open
Summary Metazoan chromosomes are organized into discrete domains (TADs), believed to contribute to the regulation of transcriptional programs. Despite extensive correlation between TAD organization and gene activity, a direct mechanistic l…
View article: The histone variant macroH2A1.1 regulates RNA polymerase II-paused genes within defined chromatin interaction landscapes
The histone variant macroH2A1.1 regulates RNA polymerase II-paused genes within defined chromatin interaction landscapes Open
The histone variant macroH2A1.1 plays a role in cancer development and metastasis. To determine the underlying molecular mechanisms, we mapped the genome-wide localization of endogenous macroH2A1.1 in the human breast cancer cell line MDA-…
View article: Concurrent <i>CDX2 cis</i>-deregulation and <i>UBTF::ATXN7L3</i> fusion define a novel high-risk subtype of B-cell ALL
Concurrent <i>CDX2 cis</i>-deregulation and <i>UBTF::ATXN7L3</i> fusion define a novel high-risk subtype of B-cell ALL Open
Oncogenic alterations underlying B-cell acute lymphoblastic leukemia (B-ALL) in adults remain incompletely elucidated. To uncover novel oncogenic drivers, we performed RNA sequencing and whole-genome analyses in a large cohort of unresolve…
View article: Chromatin looping dynamics during the transition from hematopoietic stem cells to T-cells
Chromatin looping dynamics during the transition from hematopoietic stem cells to T-cells Open
Cell identity is reflected by a particular 3D genome organization which is linked to the expression of a specific transcriptional program. Enhancers are distal regulatory element causing transcriptional upregulation of their target genes. …
View article: Myod1 and GR coordinate myofiber-specific transcriptional enhancers
Myod1 and GR coordinate myofiber-specific transcriptional enhancers Open
Skeletal muscle is a dynamic tissue the size of which can be remodeled through the concerted actions of various cues. Here, we investigated the skeletal muscle transcriptional program and identified key tissue-specific regulatory genetic e…
View article: Age-related and disease locus-specific mechanisms contribute to early remodelling of chromatin structure in Huntington’s disease mice
Age-related and disease locus-specific mechanisms contribute to early remodelling of chromatin structure in Huntington’s disease mice Open
View article: Alternative Enhancer Usage and Targeted Polycomb Marking Hallmark Promoter Choice during T Cell Differentiation
Alternative Enhancer Usage and Targeted Polycomb Marking Hallmark Promoter Choice during T Cell Differentiation Open
During thymic development and upon peripheral activation, T cells undergo extensive phenotypic and functional changes coordinated by lineage-specific developmental programs. To characterize the regulatory landscape controlling T cell ident…
View article: The histone variant macroH2A1.1 regulates RNA Polymerase II paused genes within defined chromatin interaction landscapes
The histone variant macroH2A1.1 regulates RNA Polymerase II paused genes within defined chromatin interaction landscapes Open
The histone variant macroH2A1.1 (mH2A1.1) plays a role in cancer development and metastasis-related processes. To determine the underlying molecular mechanisms, we mapped genome-wide localization of endogenous mH2A1.1 in the human breast c…