Explanipedia

Prospective analysis on the outcomes of histotripsy for primary and metastatic liver tumours Open

Albert Chan, Vince Lau, Gordon Wong, Kwan Man, L.C.K. Ng , et al. · 2025

Background: Histotripsy was an innovative, non-invasive ultrasound-based technology that mechanically disrupts liver tumour tissues at cellular level through acoustic cavitation. It offered precise swith minimal collateral damage. This stu…

Targeting sterol O-acyltransferase 1 rewires fatty acid metabolism and uncovers immune vulnerability in hepatocellular carcinoma Open

Huanhuan Ma, Xin Zhang, Yu Man Tsui, Joyce Man‐Fong Lee, Eva Lee , et al. · 2025

Background and Aims: The development of hepatocellular carcinoma (HCC) is intricately linked to metabolic processes and immune evasion strategies. As an emerging metabolic vulnerability in HCC, the detailed molecular mechanisms of sterol O…

Nurse‐coordinated multidisciplinary comprehensive heart failure management programme: A propensity‐matched trial Open

Christina K. Chan, Polly W.C. Li, D Lee, Esmond Yan‐Hang Fong, Irene Oi‐Lin Ng , et al. · 2025

Aims Despite therapeutic advancements, the prognosis of heart failure (HF) remains poor, with high rates of mortality and readmission, particularly following a HF exacerbation. This study aimed to evaluate the effects of a nurse‐coordinate…

The growth and pathogenesis of <i>Citrobacter rodentium</i> is compromised by disrupted mucin sugar pathways that accumulate N-acetylglucosamine 6-phosphate Open

Zhi-quan Huang, M Mslati, Caixia Ma, Hyungjun Yang, Qiaochu Liang , et al. · 2025

Many enteric bacterial pathogens, including the attaching/effacing (A/E) Escherichia coli strains, cause acute gastroenteritis in humans. Considering the highly competitive nature of the mammalian gastrointestinal (GI) tract, these pathoge…

Secreted lumican from the tumor microenvironment potentiates HCC stemness and progression Open

Kristy Kwan‐Shuen Chan, Cheuk‐Yan Wong, K.K. Au, Long-Hin Suen, W.Y.Celia Yip , et al. · 2025

Background: Extracellular matrix proteins are tightly linked to cancer progression. HCC frequently arises from chronic liver diseases with varying degrees of parenchymal fibrosis. Herein, we aimed to investigate the roles of secreted lumic…

MASLD/MASH—New mechanisms and treatments Open

Xin Zhang, Yu‐Man Tsui, Irene Oi‐Lin Ng · 2025

Mevalonate pathway promotes liver cancer by suppressing ferroptosis through CoQ10 production and selenocysteine-tRNA modification Open

Yi‐Ling Chen, Derek Lee, Kenneth Kin‐Leung Kwan, Mengjie Wu, Gengchao Wang , et al. · 2025

Current therapies show limited efficacy for advanced hepatocellular carcinoma (HCC). This study demonstrates that targeting the mevalonate pathway induces ferroptosis in HCC by disrupting CoQ10 biosynthesis and selenoprotein translation. C…

Apobec1 complementation factor overexpression promotes hepatic steatosis, fibrosis, and hepatocellular cancer Open

Valérie Blanc, Jesse D. Riordan, Saeed Soleymanjahi, Joseph H. Nadeau, ILKe Nalbantoglu , et al. · 2025

GPD1L supports glycerol-3-phosphate and triacylglycerol synthesis and promotes tumor progression in HCC Open

Tiffany Ching-Yun Yu, Luqing Zhao, Karen Man‐Fong Sze, Lü Tian, Xin Zhang , et al. · 2025

Background and Aims: Research on metabolic reprogramming in HCC has increased; however, studies on the metabolism of glycerolipids or interactions between different pathways remain scarce. Enzymes of the glycerol phosphate dehydrogenase (G…

Multimodal sequencing of neoadjuvant nivolumab treatment in hepatocellular carcinoma reveals cellular and molecular immune landscape for drug response Open

Fanhong Zeng, Qingyang Zhang, Yu-Man Tsui, Huanhuan Ma, Lü Tian , et al. · 2025

A striking characteristic of liver cancer is its extensive heterogeneity, particularly with regard to its varied response to immunotherapy. In this study, we employed multimodal sequencing approaches to explore the various aspects of neoad…

Lipid Metabolism and Immune Response in Hepatocellular Carcinoma: Interplay Driving Tumor Progression Open

Tiffany Ching-Yun Yu, Yu‐Man Tsui, Xin Zhang, Huanhuan Ma, Irene Oi‐Lin Ng · 2025

With the rising incidence of metabolic dysfunction-associated steatotic liver disease (MASLD), it has become a significant risk factor for hepatocellular carcinoma (HCC). This review focuses on the roles of lipid metabolism aberrations and…

Small Extracellular Vesicle‐Derived Nicotinamide Phosphoribosyltransferase (NAMPT) Induces Acyl‐Coenzyme A Synthetase SLC27A4‐Mediated Glycolysis to Promote Hepatocellular Carcinoma Open

Cherlie Lot Sum Yeung, Tung Him Ng, C. Lai, Tingmao Xue, Xiao Wen Mao , et al. · 2025

Tumour‐derived small extracellular vesicles (sEV) are critical mediators within the tumour microenvironment (TME) and are known to regulate various metabolic pathways. In metastatic hepatocellular carcinoma (HCC), mass spectrometry protein…

LiverSCA 2.0: An Enhanced Comprehensive Cell Atlas for Human Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma Open

Tina Suoangbaji, Renwen Long, Irene Oi‐Lin Ng, Lung‐Yi Mak, Daniel Wai‐Hung Ho · 2025

Background: Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) are two distinct types of primary liver cancer (PLC) characterized by considerable extents of cellular and molecular heterogeneities. We recently develope…

AVID enables sensitive and accurate viral integration detection across human cancers Open

Xueying Lyu, Russell Wing-Yeung Mok, H. T. Claude Chan, Tina Suoangbaji, Qian Li , et al. · 2025

Nuclear localization of BRCA1-associated protein 1 is important in suppressing hepatocellular carcinoma metastasis via CTCF and NRF1/OGT axis Open

Xiaoyu Xie, Yu‐Man Tsui, Xin Zhang, Tiffany Ching-Yun Yu, Abdullah Husain , et al. · 2025

Germline mutations of the deubiquitinase BRCA1-associated protein 1 (BAP1) lead to the “BAP1 cancer syndrome” characterized by development of cancers. However, the role of BAP1 in hepatocellular carcinoma (HCC) is unclear. We found that BA…

A5 USING AIR-LIQUID INTERFACE ORGANOID MONOLAYERS TO DEFINE MUCOSAL-MICROBE DYSFUNCTION IN PATIENTS WITH ULCERATIVE COLITIS Open

Ashley Gilliland, Y Chen, Irene Oi‐Lin Ng, Xiao Han, I Kalisky , et al. · 2025

NOT PUBLISHED AT AUTHOR’S REQUEST Please acknowledge all funding agencies listed below Funding Agencies: CCC, CIHRWeston Family Foundation

Human Circovirus in Patients with Hepatitis, Hong Kong Open

Shusheng Wu, Cyril Chik‐Yan Yip, Jianwen Situ, Zhiyu Li, Sara Ho , et al. · 2024

Circovirus human is a new viral species that includes the human circovirus (HCirV), which has been linked to hepatitis in immunocompromised persons. We investigated prevalence of HCirV infection in 278 patients with hepatitis and 184 asymp…

Transcription factor AP-4 reactivates telomerase reverse transcriptase independently of genome alteration in non-HBV associated hepatocellular carcinoma Open

Huiju Lim, Trevor Kwan-Hung Wu, Eliana Mary Senires Suarez, Tiffany Ching-Yun Yu, Joyce Man‐Fong Lee , et al. · 2024

Recurrent genome alterations have been identified in the telomerase reverse transcriptase (TERT) promoter region, a common occurrence in various types of cancer. In addition to epigenetic alterations at the TERT promoter region, the recrui…

APASL clinical practice guidelines on systemic therapy for hepatocellular carcinoma-2024 Open

George Lau, Shuntaro Obi, Jian Zhou, Ryosuke Tateishi, Shukui Qin , et al. · 2024

Disparity landscapes of viral-induced structural variations in HCC: Mechanistic characterization and functional implications Open

Xueying Lyu, Karen Man‐Fong Sze, Joyce Man‐Fong Lee, Abdullah Husain, Lü Tian , et al. · 2024

Background and Aims: HCC is the most common type of primary liver cancer and is a common malignancy worldwide. About half of all new liver cancers worldwide each year occur in China, including Hong Kong, due to a high prevalence of HBV inf…

Resolution of Optimal Mitochondrial and Nuclear DNA Enrichment in Target-Panel Sequencing and Physiological Mitochondrial DNA Copy Number Estimation in Liver Cancer and Non-Liver Cancer Subjects Open

Xueying Lyu, Yu‐Man Tsui, Ivan Ka-Kit Tam, Po-Man Li, Gary Cheuk-Hang Cheung , et al. · 2024

Mitochondria generate energy to support cells. They are important organelles that engage in key biological pathways. The dysfunction of mitochondria can be linked to hepatocarcinogenesis, which has been actively explored in recent years. T…

Interplay among extracellular vesicles, cancer stemness and immune regulation in driving hepatocellular carcinoma progression Open

Yu‐Man Tsui, Lü Tian, Jingyi Lu, Huanhuan Ma, Irene Oi‐Lin Ng · 2024

The intricate interplay among extracellular vesicles, cancer stemness properties, and the immune system significantly impacts hepatocellular carcinoma (HCC) progression, treatment response, and patient prognosis. Extracellular vesicles (EV…

LiverSCA: A comprehensive and user-friendly cell atlas in human hepatocellular carcinoma Open

Renwen Long, Suoangbaji, Irene Oi‐Lin Ng, Daniel Wai‐Hung Ho · 2024

Targeting the oncogenic m6A demethylase FTO suppresses tumourigenesis and potentiates immune response in hepatocellular carcinoma Open

Ao Chen, Xin Zhang, Qingyang Zhang, Karen Man‐Fong Sze, Lü Tian , et al. · 2024

Objective Fat mass and obesity-associated protein (FTO), an eraser of N 6 -methyadenosine (m6A), plays oncogenic roles in various cancers. However, its role in hepatocellular carcinoma (HCC) is unclear. Furthermore, small extracellular ves…

Abstract 433: BCAT1 promotes HCC metabolic reprogramming and survival through HIF-1α stabilization Open

Misty Shuo Zhang, Kenneth Kin‐Leung Kwan, Weixing Li, Adonia E. Papathanassiu, Irene Oi‐Lin Ng , et al. · 2024

Hepatocellular carcinoma (HCC) is a highly lethal primary liver malignancy characterized by hypoxia, a common feature of solid tumors, particularly in HCC. Hypoxia-inducible factors (HIFs) play a pivotal role in mediating various cellular …

Extracellular vesicles and cancer stemness in hepatocellular carcinoma – is there a link? Open

Lü Tian, Jingyi Lu, Irene Oi‐Lin Ng · 2024

Hepatocellular carcinoma (HCC) is a highly aggressive malignancy, with high recurrence rates and notorious resistance to conventional chemotherapy. Cancer stemness refers to the stem-cell-like phenotype of cancer cells and has been recogni…

Reciprocal interactions between malignant cells and macrophages enhance cancer stemness and M2 polarization in HBV-associated hepatocellular carcinoma Open

Qingyang Zhang, Yu‐Man Tsui, Xin Zhang, Anna Jingyi Lu, Joyce Man‐Fong Lee , et al. · 2024

Background: The tumor microenvironment of cancers has emerged as a crucial component in regulating cancer stemness and plays a pivotal role in cell-cell communication. However, the specific mechanisms underlying these phenomena rema…

Sorted-Cell Sequencing on HCC Specimens Reveals EPS8L3 as a Key Player in CD24/CD13/EpCAM-Triple Positive, Stemness-Related HCC Cells Open

Yu‐Man Tsui, Daniel Wai‐Hung Ho, Karen Man‐Fong Sze, Joyce Man‐Fong Lee, Eva Lee , et al. · 2024

Our findings suggest that Akt signaling-driven SP1 promotes EPS8L3 expression, which is critical in maintaining the downstream expression of CD24, CD13, and EpCAM. The findings provide insight into potential LCSC-targeting therapeutic stra…

Issue Information Open

David J. Pinato, Edoardo G. Giannini, Yi‐Hsiang Huang, Lorenza Rimassa, Stephen Y. Chan , et al. · 2023

LANCL1, a cell surface protein, promotes liver tumor initiation through FAM49B-Rac1 axis to suppress oxidative stress Open

Hongyang Huang, Yu‐Man Tsui, Daniel Wai‐Hung Ho, Clive Yik‐Sham Chung, Karen Man‐Fong Sze , et al. · 2023

Background and Aims: HCC is an aggressive cancer with a poor clinical outcome. Understanding the mechanisms that drive tumor initiation is important for improving treatment strategy. This study aimed to identify functional cell membrane pr…

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