Nga Yan Tse
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View article: Unveiling the Multifaceted Networks of the Left DLPFC for Precision TMS Targeting
Unveiling the Multifaceted Networks of the Left DLPFC for Precision TMS Targeting Open
The left dorsolateral prefrontal cortex (lDLPFC) is the standard target for transcranial magnetic stimulation (TMS) to ameliorate treatment-resistant depression (TRD), yet non-response rates remain high. TMS efficacy has been linked to the…
View article: Behavioral subtypes impact prognosis and survival in amyotrophic lateral sclerosis: a clustering-based approach
Behavioral subtypes impact prognosis and survival in amyotrophic lateral sclerosis: a clustering-based approach Open
Extending previous cross-sectional work, current findings offer delineation of the trajectory of clinical outcomes associated with classic behavioral phenotypes of ALS. Converging with past evidence of unique disease and progression profil…
View article: Fourteen years later: Reviewing the diagnostic criteria for behavioral‐variant frontotemporal dementia
Fourteen years later: Reviewing the diagnostic criteria for behavioral‐variant frontotemporal dementia Open
INTRODUCTION Diagnosis of behavioral‐variant frontotemporal dementia (bvFTD) requires the presence of at least three of six core features. The contribution of each criterion toward diagnosis, however, remains unclear. We aimed to determine…
View article: Clinical and Neurophysiological Effects of Robotically Delivered fMRI-Guided Personalized Transcranial Magnetic Stimulation Therapy for Depression
Clinical and Neurophysiological Effects of Robotically Delivered fMRI-Guided Personalized Transcranial Magnetic Stimulation Therapy for Depression Open
Introduction: Repetitive transcranial magnetic stimulation (rTMS) of the left dorsolateral prefrontal cortex (DLPFC) is an established treatment for refractory major depressive disorder (MDD), but treatment outcomes vary substantially from…
View article: A scoping review of the unique landscape and challenges associated with dementia in the Western Pacific region
A scoping review of the unique landscape and challenges associated with dementia in the Western Pacific region Open
FightMND Mid-Career Fellowship, NHMRC EL1 Fellowship, NHMRC Practitioner Fellowship (1156093), NHMRC Postgraduate scholarship (2022387).
View article: An attentional and working memory theory of hallucination vulnerability in frontotemporal dementia
An attentional and working memory theory of hallucination vulnerability in frontotemporal dementia Open
The rate and prevalence of hallucinations in behavioural variant frontotemporal dementia is well established. The mechanisms for underlying vulnerability however are the least well described in FTD compared with other neuropsychiatric cond…
View article: Functional dysconnectivity in youth depression: Systematic review, meta‐analysis, and network-based integration
Functional dysconnectivity in youth depression: Systematic review, meta‐analysis, and network-based integration Open
Youth depression has been associated with heterogenous patterns of aberrant brain connectivity. To make sense of these divergent findings, we conducted a systematic review encompassing 19 resting-state fMRI seed-to-whole-brain studies (140…
View article: Distinct hypothalamic involvement in the amyotrophic lateral sclerosis-frontotemporal dementia spectrum
Distinct hypothalamic involvement in the amyotrophic lateral sclerosis-frontotemporal dementia spectrum Open
These findings revealed that subdivisions of the hypothalamus are differentially affected in the ALS-FTD spectrum and contribute to canonical cognitive and behavioural disturbances beyond eating abnormalities. The anterior superior and sup…
View article: 2424 Hallucinations in non-parkinson’s neurodegenerative disorders: cognitive and neuroimaging evidence for a trans-diagnostic attentional theory of hallucination generation
2424 Hallucinations in non-parkinson’s neurodegenerative disorders: cognitive and neuroimaging evidence for a trans-diagnostic attentional theory of hallucination generation Open
Objective To determine the rate of hallucinations across non-Parkinson's neurodegenerative disorders including Frontotemporal Dementia and explore the underlying cognitive and neural basis for the development of these symptoms Methods Pati…
View article: 2374 A decade on: examining the frequency of diagnostic criteria in behavioural variant frontotemporal dementia
2374 A decade on: examining the frequency of diagnostic criteria in behavioural variant frontotemporal dementia Open
Objectives A diagnosis of behavioural variant frontotemporal dementia (bvFTD) requires the presence of at least three of the six core (five behavioural, one cognitive) criteria. The contribution of each criterion towards the clinical diagn…
View article: Thalamic and Cerebellar Regional Involvement across the ALS–FTD Spectrum and the Effect of C9orf72
Thalamic and Cerebellar Regional Involvement across the ALS–FTD Spectrum and the Effect of C9orf72 Open
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are part of the same disease spectrum. While thalamic–cerebellar degeneration has been observed in C9orf72 expansion carriers, the exact subregions involved across the c…
View article: Factors That Influence Non-Motor Impairment Across the ALS-FTD Spectrum: Impact of Phenotype, Sex, Age, Onset and Disease Stage
Factors That Influence Non-Motor Impairment Across the ALS-FTD Spectrum: Impact of Phenotype, Sex, Age, Onset and Disease Stage Open
Objective: This study aimed to establish (1) the pattern and severity of neuropsychiatric symptoms and other non-motor symptoms of sleep and mood, across ALS phenotypes in comparison to bvFTD and (2) the contribution of non-modifiable fact…
View article: Tackling clinical heterogeneity across the amyotrophic lateral sclerosis–frontotemporal dementia spectrum using a transdiagnostic approach
Tackling clinical heterogeneity across the amyotrophic lateral sclerosis–frontotemporal dementia spectrum using a transdiagnostic approach Open
The disease syndromes of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) display considerable clinical, genetic and pathological overlap, yet mounting evidence indicates substantial differences in progression and surv…
View article: Neural correlates of fat preference in frontotemporal dementia: translating insights from the obesity literature
Neural correlates of fat preference in frontotemporal dementia: translating insights from the obesity literature Open
Objective Alterations in eating behaviour are one of the diagnostic features of behavioural variant frontotemporal dementia (bvFTD). It is hypothesised that underlying brain network disturbances and atrophy to key structures may affect mac…
View article: Cerebellar contributions to cognition in corticobasal syndrome and progressive supranuclear palsy
Cerebellar contributions to cognition in corticobasal syndrome and progressive supranuclear palsy Open
Mounting evidence suggests an association between cerebellar atrophy and cognitive impairment in the main frontotemporal dementia syndromes. In contrast, whether cerebellar atrophy is present in the motor syndromes associated with frontote…
View article: The effect of stimulation interval on plasticity following repeated blocks of intermittent theta burst stimulation
The effect of stimulation interval on plasticity following repeated blocks of intermittent theta burst stimulation Open
Introduction Theta burst stimulation (TBS) is a non-invasive brain stimulation paradigm capable of influencing cortical circuits in humans by inducing neural plasticity. Applying spaced blocks of TBS can affect both the direction and magni…