Hui‐Ling Cao
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View article: A Style is Worth One Code: Unlocking Code-to-Style Image Generation with Discrete Style Space
A Style is Worth One Code: Unlocking Code-to-Style Image Generation with Discrete Style Space Open
Innovative visual stylization is a cornerstone of artistic creation, yet generating novel and consistent visual styles remains a significant challenge. Existing generative approaches typically rely on lengthy textual prompts, reference ima…
View article: Research Progress of traditional Chinese Medicine monomers in Vascular Protection
Research Progress of traditional Chinese Medicine monomers in Vascular Protection Open
Cardiovascular disease is seriously harmful to human health, and its mortality and disability rate are increasing, which brings heavy economic pressure to ordinary families.The pathogenesis of most cardiovascular diseases is derived from a…
View article: Pharmacological Research Progress of Novel Antihypertensive Drugs
Pharmacological Research Progress of Novel Antihypertensive Drugs Open
Cardiovascular disease stands as the leading cause of death globally, with hypertension emerging as an independent risk factor for its development. The worldwide prevalence of hypertension hovers around 30%, encompassing a staggering 1.2 b…
View article: Identification and Significance of the Novel MDR Relevant Hub Genes in Drug-Resistant Hepatocellular Carcinoma
Identification and Significance of the Novel MDR Relevant Hub Genes in Drug-Resistant Hepatocellular Carcinoma Open
View article: Research Advances on Anti-Cancer Natural Products
Research Advances on Anti-Cancer Natural Products Open
Malignant tumors seriously threaten people’s health and life worldwide. Natural products, with definite pharmacological effects and known chemical structures, present dual advantages of Chinese herbs and chemotherapeutic drug. Some of them…
View article: Table of Contents
Table of Contents Open
View article: Research advances of modern and traditional medicine on dry age-related macular degeneration
Research advances of modern and traditional medicine on dry age-related macular degeneration Open
Age-related macular degeneration(ARMD)is one of the main causes of irreversible visual impairment in the middle-aged and elderly people, which severely impacts the patient's life quality and poses a substantial health economic burden on so…
View article: Research Advances on Matrine
Research Advances on Matrine Open
Matrine is an alkaloid extracted from traditional Chinese herbs including Sophora flavescentis , Sophora alopecuroides , Sophora root, etc. It has the dual advantages of traditional Chinese herbs and chemotherapy drugs. It exhibits distinc…
View article: Complex Crystal Structure Determination of Hsp90N-NVP-AUY922 and In Vitro Anti-NSCLC Activity of NVP-AUY922
Complex Crystal Structure Determination of Hsp90N-NVP-AUY922 and In Vitro Anti-NSCLC Activity of NVP-AUY922 Open
New targeted chemotherapy agents greatly improved five-year survival in NSCLC patients, but which were susceptible to drug resistance. NVP-AUY922, terminated in phase II clinical trials, exhibited promising anti-NSCLC (non-small-cell lung …
View article: Rational Design and Synthesis of 3-Morpholine Linked Aromatic-Imino-1H-Indoles as Novel Kv1.5 Channel Inhibitors Sharing Vasodilation Effects
Rational Design and Synthesis of 3-Morpholine Linked Aromatic-Imino-1H-Indoles as Novel Kv1.5 Channel Inhibitors Sharing Vasodilation Effects Open
Atrial fibrillation (AF) is the most common clinical sustained arrhythmia; clinical therapeutic drugs have low atrial selectivity and might cause more severe ventricle arrhythmias while stopping AF. As an anti-AF drug target with high sele…
View article: Atheroprotective Effects and Molecular Mechanism of Berberine
Atheroprotective Effects and Molecular Mechanism of Berberine Open
Cardiovascular diseases remain the leading cause of morbidity and mortality worldwide. Atherosclerosis is the main pathological basis of cardiovascular diseases and it is closely associated with hyperlipidemia, endothelial injury, macropha…
View article: Multiple functions of autophagy in vascular calcification
Multiple functions of autophagy in vascular calcification Open
View article: Role of Long Non-coding RNAs on Bladder Cancer
Role of Long Non-coding RNAs on Bladder Cancer Open
Graphical Abstract LncRNAs interacted with proteins in BC. (A) UCA1 interacts with C/EBPα. (B) Lnc-LBCS directly binds to hnRNPK and EZH2, and inhibits SOX2 transcription. (C) XIST-TET1-p53 pathway in BC. (D) DGCR5 promotes P21 transcripti…
View article: Research progress of Chinese herb monomers in the treatment of diabetic retinopathy
Research progress of Chinese herb monomers in the treatment of diabetic retinopathy Open
Diabetic retinopathy(DR)is a common chronic complication of diabetes mellitus, which cause irreversible damage of microvessels in the retina. DR is a leading blindness eye disease among diabetes mellitus. The pathogenesis of DR is mainly r…
View article: Complex Crystal Structure Determination and in vitro Anti–non–small Cell Lung Cancer Activity of Hsp90N Inhibitor SNX-2112
Complex Crystal Structure Determination and in vitro Anti–non–small Cell Lung Cancer Activity of Hsp90N Inhibitor SNX-2112 Open
SNX-2112, as a promising anticancer lead compound targeting heat shock protein 90 (Hsp90), absence of complex crystal structure of Hsp90 N -SNX-2112 hindered further structural optimization and understanding on molecular interaction mechan…
View article: Nϵ-Carboxymethyl-Lysine Deteriorates Vascular Calcification in Diabetic Atherosclerosis Induced by Vascular Smooth Muscle Cell-Derived Foam Cells
Nϵ-Carboxymethyl-Lysine Deteriorates Vascular Calcification in Diabetic Atherosclerosis Induced by Vascular Smooth Muscle Cell-Derived Foam Cells Open
Nϵ-carboxymethyl-lysine (CML), an advanced glycation end product, is involved in vascular calcification (VC) in diabetic atherosclerosis. This study aimed to investigate the effects of CML on VC in diabetic atherosclerosis induced by vascu…
View article: Research Progress on PARP14 as a Drug Target
Research Progress on PARP14 as a Drug Target Open
Poly-adenosine diphosphate-ribose polymerase (PARP) implements posttranslational mono- or poly-ADP-ribosylation modification of target proteins. Among the known 18 members in the enormous family of PARP enzymes, several investigations abou…
View article: Table of Contents
Table of Contents Open