Thi H. O. Nguyen
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View article: Dysregulated inflammation in solid tumor malignancy patients shapes polyfunctional antibody responses to COVID-19 vaccination
Dysregulated inflammation in solid tumor malignancy patients shapes polyfunctional antibody responses to COVID-19 vaccination Open
View article: HLA-B*15:01-positive severe COVID-19 patients lack CD8 <sup>+</sup> T cell pools with highly expanded public clonotypes
HLA-B*15:01-positive severe COVID-19 patients lack CD8 <sup>+</sup> T cell pools with highly expanded public clonotypes Open
Understanding host factors driving asymptomatic versus severe disease outcomes is of key importance if we are to control emerging and re-emerging viral infections. HLA-B*15:01 has been associated with asymptomatic SARS-CoV-2 infection in n…
View article: Historic 1994 influenza vaccine cohorts reveal breadth of antibody and B cell responses towards three decades of future influenza A and B viruses
Historic 1994 influenza vaccine cohorts reveal breadth of antibody and B cell responses towards three decades of future influenza A and B viruses Open
Influenza vaccination is the best way to combat annual influenza epidemics, yet the breadth of vaccine-induced humoral immunity towards decades of future differentially-evolving influenza A and B viruses is unclear. Using historic 1994 inf…
View article: Central memory T cells with key TCR repertoires and gene expression profiles dominate influenza CD8+ T cell pools across the human lifespan
Central memory T cells with key TCR repertoires and gene expression profiles dominate influenza CD8+ T cell pools across the human lifespan Open
Central memory CD8 + T cells (T cm ) represent the prominent memory T cell subset in human blood, yet the persistence of T cell receptor (TCR) clonotypic and transcriptional features of epitope-specific T cm pools across the human lifespan…
View article: Genetic markers of enhanced functional antibody responses to COVID-19 vaccination
Genetic markers of enhanced functional antibody responses to COVID-19 vaccination Open
Primary COVID-19 vaccination induced increased S2-specific IgG in G1m1,17+/+ vaccinees, facilitating enhanced anti-viral FcγR engagement and suggesting immunogenetics may be a valuble consideration for next-generation vaccine de…
View article: Dysregulated inflammation in solid tumor malignancy patients shapes polyfunctional antibody responses to COVID-19 vaccination
Dysregulated inflammation in solid tumor malignancy patients shapes polyfunctional antibody responses to COVID-19 vaccination Open
Solid tumor malignancy (STM) patients experience increased risk of breakthrough SARS-CoV-2 infection owing to reduced COVID-19 vaccine immunogenicity. However, the underlying immunological causes of impaired neutralization remain poorly ch…
View article: Gradual changes within long-lived influenza virus-specific CD8+ T cells are associated with the loss of public TCR clonotypes in older adults
Gradual changes within long-lived influenza virus-specific CD8+ T cells are associated with the loss of public TCR clonotypes in older adults Open
View article: Single-cell immune profiling of third trimester pregnancies defines importance of chemokine receptors and prevalence of CMV-induced NK cells in the periphery and decidua
Single-cell immune profiling of third trimester pregnancies defines importance of chemokine receptors and prevalence of CMV-induced NK cells in the periphery and decidua Open
Human pregnancy presents a unique physiological state that allows for growth of an antigenically dissimilar foetus and requires specific adaptations of the immune system. The immune system plays an important role in establishing and mainta…
View article: Increased SARS-CoV-2 IgG4 has variable consequences dependent upon Fc function, Fc receptor polymorphism, and viral variant
Increased SARS-CoV-2 IgG4 has variable consequences dependent upon Fc function, Fc receptor polymorphism, and viral variant Open
Repeated mRNA COVID-19 vaccination increases spike-specific immunoglobulin G4 (IgG4) titers. Here, we characterized the influence of increased IgG4 titers on a range of Fc-mediated responses. Elevated spike-specific IgG4 reduced binding to…
View article: SARS-CoV-2-specific CD8 <sup>+</sup> T cells from people with long COVID establish and maintain effector phenotype and key TCR signatures over 2 years
SARS-CoV-2-specific CD8 <sup>+</sup> T cells from people with long COVID establish and maintain effector phenotype and key TCR signatures over 2 years Open
Long COVID occurs in a small but important minority of patients following COVID-19, reducing quality of life and contributing to healthcare burden. Although research into underlying mechanisms is evolving, immunity is understudied. SARS-Co…
View article: Mapping the immunopeptidome of seven SARS-CoV-2 antigens across common HLA haplotypes
Mapping the immunopeptidome of seven SARS-CoV-2 antigens across common HLA haplotypes Open
View article: High expression of oleoyl-ACP hydrolase underpins life-threatening respiratory viral diseases
High expression of oleoyl-ACP hydrolase underpins life-threatening respiratory viral diseases Open
Respiratory infections cause significant morbidity and mortality, yet it is unclear why some individuals succumb to severe disease. In patients hospitalized with avian A(H7N9) influenza, we investigated early drivers underpinning fatal dis…
View article: CD8+ T-cell responses towards conserved influenza B virus epitopes across anatomical sites and age
CD8+ T-cell responses towards conserved influenza B virus epitopes across anatomical sites and age Open
View article: Immunogenicity and protective efficacy of a co-formulated two-in-one inactivated whole virus particle COVID-19/influenza vaccine
Immunogenicity and protective efficacy of a co-formulated two-in-one inactivated whole virus particle COVID-19/influenza vaccine Open
Due to the synchronous circulation of seasonal influenza viruses and severe acute respiratory coronavirus 2 (SARS-CoV-2) which causes coronavirus disease 2019 (COVID-19), there is need for routine vaccination for both COVID-19 and influenz…
View article: Immunoglobulin G genetic variation can confound assessment of antibody levels via altered binding to detection reagents
Immunoglobulin G genetic variation can confound assessment of antibody levels via altered binding to detection reagents Open
Objectives Amino acid variations across more than 30 immunoglobulin (Ig) allotypes may introduce structural changes that influence recognition by anti‐Ig detection reagents, consequently confounding interpretation of antibody responses, pa…
View article: Interim results from a phase I randomized, placebo-controlled trial of novel SARS-CoV-2 beta variant receptor-binding domain recombinant protein and mRNA vaccines as a 4th dose booster
Interim results from a phase I randomized, placebo-controlled trial of novel SARS-CoV-2 beta variant receptor-binding domain recombinant protein and mRNA vaccines as a 4th dose booster Open
View article: Mapping the immunopeptidome of seven SARS-CoV-2 antigens across common HLA haplotypes
Mapping the immunopeptidome of seven SARS-CoV-2 antigens across common HLA haplotypes Open
Most COVID-19 vaccines have been designed to elicit immunity against the SARS-CoV-2 Spike protein. However, the repeated occurrence of new strains harbouring Spike protein mutations demonstrates ready immune evasion by the SARS-CoV-2 virus…
View article: Evolution of Humoral and Cellular Immunity Post–Breakthrough Coronavirus Disease 2019 in Vaccinated Patients With Hematologic Malignancy Receiving Tixagevimab-Cilgavimab
Evolution of Humoral and Cellular Immunity Post–Breakthrough Coronavirus Disease 2019 in Vaccinated Patients With Hematologic Malignancy Receiving Tixagevimab-Cilgavimab Open
Background In-depth immunogenicity studies of tixagevimab-cilgavimab (T-C) are lacking, including following breakthrough coronavirus disease 2019 (COVID-19) in vaccinated patients with hematologic malignancy (HM) receiving T-C as pre-expos…
View article: Cyclodextrin-loaded nanobubbles reduce cholesterol and atherosclerosis in vivo
Cyclodextrin-loaded nanobubbles reduce cholesterol and atherosclerosis in vivo Open
Background Ischemic heart disease (IHD) is the leading cause of mortality and morbidity worldwide. Atherosclerosis, a chronic inflammatory disease, is the main contributor to IHD. However, atherosclerosis is commonly left undiagnosed and u…
View article: Long-term safety and immunogenicity of an MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2 in adults aged 18–55 years or ≥56 years: 12-month results from a randomised, double-blind, placebo-controlled, phase 1 trial
Long-term safety and immunogenicity of an MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2 in adults aged 18–55 years or ≥56 years: 12-month results from a randomised, double-blind, placebo-controlled, phase 1 trial Open
View article: Newborn and child-like molecular signatures in older adults stem from TCR shifts across human lifespan
Newborn and child-like molecular signatures in older adults stem from TCR shifts across human lifespan Open
CD8 + T cells provide robust antiviral immunity, but how epitope-specific T cells evolve across the human lifespan is unclear. Here we defined CD8 + T cell immunity directed at the prominent influenza epitope HLA-A*02:01-M1 58–66 (A2/M1 58…
View article: Broad spectrum <scp>SARS‐CoV</scp>‐2‐specific immunity in hospitalized First Nations peoples recovering from <scp>COVID</scp>‐19
Broad spectrum <span>SARS‐CoV</span>‐2‐specific immunity in hospitalized First Nations peoples recovering from <span>COVID</span>‐19 Open
Indigenous peoples globally are at increased risk of COVID‐19‐associated morbidity and mortality. However, data that describe immune responses to SARS‐CoV‐2 infection in Indigenous populations are lacking. We evaluated immune responses in …
View article: Robust and prototypical immune responses toward COVID-19 vaccine in First Nations peoples are impacted by comorbidities
Robust and prototypical immune responses toward COVID-19 vaccine in First Nations peoples are impacted by comorbidities Open
View article: CD4+ T cell calibration of antigen-presenting cells optimizes antiviral CD8+ T cell immunity
CD4+ T cell calibration of antigen-presenting cells optimizes antiviral CD8+ T cell immunity Open
Antiviral CD8+ T cell immunity depends on the integration of various contextual cues, but how antigen-presenting cells (APCs) consolidate these signals for decoding by T cells remains unclear. Here, we describe gradual interfero…
View article: Immune profiling of SARS-CoV-2 infection during pregnancy reveals NK cell and γδ T cell perturbations
Immune profiling of SARS-CoV-2 infection during pregnancy reveals NK cell and γδ T cell perturbations Open
NK and T cells perturbations in pregnancy
View article: Robust SARS-CoV-2 T cell responses with common TCRαβ motifs toward COVID-19 vaccines in patients with hematological malignancy impacting B cells
Robust SARS-CoV-2 T cell responses with common TCRαβ motifs toward COVID-19 vaccines in patients with hematological malignancy impacting B cells Open
Immunocompromised hematology patients are vulnerable to severe COVID-19 and respond poorly to vaccination. Relative deficits in immunity are, however, unclear, especially after 3 vaccine doses. We evaluated immune responses in hematology p…
View article: SARS-CoV-2 breakthrough infection induces rapid memory and de novo T cell responses
SARS-CoV-2 breakthrough infection induces rapid memory and de novo T cell responses Open
View article: Robust SARS-CoV-2 antibody and T cell immunity following three COVID-19 vaccine doses in inflammatory bowel disease patients receiving anti-TNF or alternative treatments
Robust SARS-CoV-2 antibody and T cell immunity following three COVID-19 vaccine doses in inflammatory bowel disease patients receiving anti-TNF or alternative treatments Open
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View article: Circulating effector γδ T cell populations are associated with acute coronavirus disease 19 in unvaccinated individuals
Circulating effector γδ T cell populations are associated with acute coronavirus disease 19 in unvaccinated individuals Open
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection causes severe coronavirus disease 2019 (COVID‐19) in a small proportion of infected individuals. The immune system plays an important role in the defense against SARS‐C…
View article: Prospective comprehensive profiling of immune responses to COVID‐19 vaccination in patients on zanubrutinib therapy
Prospective comprehensive profiling of immune responses to COVID‐19 vaccination in patients on zanubrutinib therapy Open
Zanubrutinib‐treated and treatment‐naïve patients with chronic lymphocytic leukaemia (CLL) or Waldenstrom's macroglobulinaemia were recruited in this prospective study to comprehensively profile humoral and cellular immune responses to COV…