Phong Nguyen
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View article: NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT
NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT Open
Cells generate purine nucleotides through de novo purine biosynthesis (DNPB) and purine salvage. Purine salvage represses DNPB to prevent excessive purine nucleotide synthesis through mechanisms that are incompletely understood. We identif…
View article: TÁC DỤNG KHÁNG ALPHA-GLUCOSIDASE CỦA CÁC HỢP CHẤT TÁCH CHIẾT TỪ CÂY BỒ CÔNG ANH VIỆT NAM (LACTUCA INDICA L.) BẰNG TÍNH TOÁN HÓA LƯỢNG TỬ VÀ MÔ PHỎNG DOCKING PHÂN TỬ
TÁC DỤNG KHÁNG ALPHA-GLUCOSIDASE CỦA CÁC HỢP CHẤT TÁCH CHIẾT TỪ CÂY BỒ CÔNG ANH VIỆT NAM (LACTUCA INDICA L.) BẰNG TÍNH TOÁN HÓA LƯỢNG TỬ VÀ MÔ PHỎNG DOCKING PHÂN TỬ Open
Đái tháo đường gây ra tình trạng đường huyết cao quá mức và làm rối loạn chuyển hóa trong cơ thể. Ức chế các enzyme α-glucosidase là một trong những phương pháp điều trị bệnh tiểu đường. Trong nghiên cứu này, cao chiết n-hexane của cây Bồ …
View article: Kết quả áp dụng chiến lược hồi phục sớm sau phẫu thuật nội soi cắt bán phần dạ dày do ung thư
Kết quả áp dụng chiến lược hồi phục sớm sau phẫu thuật nội soi cắt bán phần dạ dày do ung thư Open
Mục tiêu: Khảo sát các biện pháp can thiệp bằng các tiêu chí nhằm đạt hiệu quả hồi phục sớm sau mổ nội soi cắt bán phần dạ dày do ung thư để giảm thiểu các biến chứng và rút ngắn thời gian nằm viện. Đối tượng và phương pháp nghiên cứu: Báo…
View article: NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT
NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT Open
Cells generate purine nucleotides through both de novo purine biosynthesis (DNPB) and purine salvage. Purine accumulation represses energetically costly DNPB through feedback inhibition of the enzymatic steps that produce the precursor pho…
View article: Năng lực chăm sóc người bệnh hồi sức tích cực của sinh viên Điều dưỡng Đại học Y Dược Thành phố Hồ Chí Minh và các yếu tố liên quan
Năng lực chăm sóc người bệnh hồi sức tích cực của sinh viên Điều dưỡng Đại học Y Dược Thành phố Hồ Chí Minh và các yếu tố liên quan Open
Mục tiêu: Chương trình đào tạo Điều dưỡng cần chuẩn bị cho sinh viên khi tốt nghiệp đạt được các năng lực, một trong các năng lực quan trọng chính là chăm sóc người bệnh hồi sức tích cực. Nghiên cứu đánh giá mức độ tự tin năng lực chăm sóc…
View article: TÌNH TRẠNG ĐỘT BIẾN BRAF V600E Ở BỆNH NHÂN UNG THƯ ĐẠI TRỰC TRÀNG DMMR TẠI BỆNH VIỆN BÌNH DÂN TỪ THÁNG 05/2021 ĐẾN THÁNG 10/2022
TÌNH TRẠNG ĐỘT BIẾN BRAF V600E Ở BỆNH NHÂN UNG THƯ ĐẠI TRỰC TRÀNG DMMR TẠI BỆNH VIỆN BÌNH DÂN TỪ THÁNG 05/2021 ĐẾN THÁNG 10/2022 Open
Giới thiệu: Ung thư đại trực tràng chiếm hàng đầu về tỷ lệ mắc và tử vong trên toàn thế giới với Hội chứng Lynch (LS) là dạng có liên quan tới yếu tố di truyền thường gặp nhất. Xét nghiệm sàng lọc LS bao gồm xét nghiệm sự mất ổn định vi vệ…
View article: Discovery of Pyrazolopyrazines as Selective, Potent, and Mutant-Active MET Inhibitors with Intracranial Efficacy
Discovery of Pyrazolopyrazines as Selective, Potent, and Mutant-Active MET Inhibitors with Intracranial Efficacy Open
Mesenchymal-epithelial transition factor (MET) is a receptor tyrosine kinase that serves a critical function in numerous developmental, morphogenic, and proliferative signaling pathways. If dysregulated, MET has been shown to be involved i…
View article: Electron transport chain inhibition increases cellular dependence on purine transport and salvage
Electron transport chain inhibition increases cellular dependence on purine transport and salvage Open
View article: An interactive web application for exploring human plasma and fibroblast metabolomics data from patients with inborn errors of metabolism
An interactive web application for exploring human plasma and fibroblast metabolomics data from patients with inborn errors of metabolism Open
Metabolomic profiling is instrumental in understanding the systemic and cellular impact of inborn errors of metabolism (IEMs), monogenic disorders caused by pathogenic genomic variants in genes involved in metabolism. This study encompasse…
View article: Electron transport chain inhibition increases cellular dependence on purine transport and salvage
Electron transport chain inhibition increases cellular dependence on purine transport and salvage Open
SUMMARY Cancer cells reprogram their metabolism to support cell growth and proliferation in harsh environments. While many studies have documented the importance of mitochondrial oxidative phosphorylation (OXPHOS) in tumor growth, some can…
View article: Structural basis for gating mechanism of the human sodium-potassium pump
Structural basis for gating mechanism of the human sodium-potassium pump Open
View article: Effect of Prenatal Glucocorticoid Exposure on Circadian Rhythm Gene Expression in the Brains of Adult Rat Offspring
Effect of Prenatal Glucocorticoid Exposure on Circadian Rhythm Gene Expression in the Brains of Adult Rat Offspring Open
Circadian clocks control many vital aspects of physiology from the sleep-wake cycle to metabolism. The circadian clock operates through transcriptional-translational feedback loops. The normal circadian signaling relies on a ‘master clock’…
View article: Identification of MRTX1133, a Noncovalent, Potent, and Selective KRAS <sup>G12D</sup> Inhibitor
Identification of MRTX1133, a Noncovalent, Potent, and Selective KRAS <sup>G12D</sup> Inhibitor Open
KRASG12D, the most common oncogenic KRAS mutation, is a promising target for the treatment of solid tumors. However, when compared to KRASG12C, selective inhibition of KRASG12D presents a significant challe…
View article: Untargeted metabolomics reveals sex-specific differences in lipid metabolism of adult rats exposed to dexamethasone in utero
Untargeted metabolomics reveals sex-specific differences in lipid metabolism of adult rats exposed to dexamethasone in utero Open
View article: TLR9 and beclin 1 crosstalk regulates muscle AMPK activation in exercise
TLR9 and beclin 1 crosstalk regulates muscle AMPK activation in exercise Open
View article: Fetal programming of adrenal PNMT and hypertension by glucocorticoids in WKY rats is dose and sex-dependent
Fetal programming of adrenal PNMT and hypertension by glucocorticoids in WKY rats is dose and sex-dependent Open
Biochemical changes in utero may alter normal fetal development, resulting in disease later in life, a phenomenon known as fetal programming. Recent epidemiological studies link fetal programming to negative health outcomes, such as low bi…
View article: Structures of the <i>Neisseria meningitides</i> methionine‐binding protein MetQ in substrate‐free form and bound to <scp>l</scp>‐ and <scp>d</scp>‐methionine isomers
Structures of the <i>Neisseria meningitides</i> methionine‐binding protein MetQ in substrate‐free form and bound to <span>l</span>‐ and <span>d</span>‐methionine isomers Open
The bacterial periplasmic methionine‐binding protein MetQ is involved in the import of methionine by the cognate MetNI methionine ATP binding cassette (ABC) transporter. The MetNIQ system is one of the few members of the ABC importer famil…
View article: A novel, highly potent and selective phosphodiesterase-9 inhibitor for the treatment of sickle cell disease
A novel, highly potent and selective phosphodiesterase-9 inhibitor for the treatment of sickle cell disease Open
The most common treatment for patients with sickle cell disease (SCD) is the chemotherapeutic hydroxyurea, a therapy with pleiotropic effects, including increasing fetal hemoglobin (HbF) in red blood cells and reducing adhesion of white bl…
View article: Noncanonical role for the binding protein in substrate uptake by the MetNI methionine ATP Binding Cassette (ABC) transporter
Noncanonical role for the binding protein in substrate uptake by the MetNI methionine ATP Binding Cassette (ABC) transporter Open
The Escherichia coli methionine ABC transporter MetNI exhibits both high-affinity transport toward l -methionine and broad specificity toward methionine derivatives, including d -methionine. In this work, we characterize the transport of d…
View article: Haptoglobin and hemopexin inhibit vaso-occlusion and inflammation in murine sickle cell disease: Role of heme oxygenase-1 induction
Haptoglobin and hemopexin inhibit vaso-occlusion and inflammation in murine sickle cell disease: Role of heme oxygenase-1 induction Open
During hemolysis, hemoglobin and heme released from red blood cells promote oxidative stress, inflammation and thrombosis. Plasma haptoglobin and hemopexin scavenge free hemoglobin and heme, respectively, but can be depleted in hemolytic s…
View article: Crystal structure of the Escherichia coli ATPgS-bound MetNI methionine ABC transporter in complex with its MetQ binding protein
Crystal structure of the Escherichia coli ATPgS-bound MetNI methionine ABC transporter in complex with its MetQ binding protein Open
The Escherichia coli methionine ABC transporter MetNI exhibits both high-affinity transport toward l-methionine and broad specificity toward methionine derivatives, including d-methionine. In this work, we characterize the transport…
View article: Comparative Analysis of Renin-Angiotensin System (RAS)-Related Gene Expression Between Hypertensive and Normotensive Rats
Comparative Analysis of Renin-Angiotensin System (RAS)-Related Gene Expression Between Hypertensive and Normotensive Rats Open
BACKGROUND The renal renin-angiotensin system (RAS) is physiologically important for blood pressure regulation. Altered regulation of RAS-related genes has been observed in an animal model of hypertension (spontaneously hypertensive rats -…
View article: Control of Oxidative Stress and Inflammation in Sickle Cell Disease with the Nrf2 Activator Dimethyl Fumarate
Control of Oxidative Stress and Inflammation in Sickle Cell Disease with the Nrf2 Activator Dimethyl Fumarate Open
DMF activates Nrf2, enhances antioxidant defenses, and inhibits inflammation and vaso-occlusion in SCD mice. Antioxid. Redox Signal. 26, 748-762.
View article: Hepatic Overexpression of Hemopexin Inhibits Inflammation and Vascular Stasis in Murine Models of Sickle Cell Disease
Hepatic Overexpression of Hemopexin Inhibits Inflammation and Vascular Stasis in Murine Models of Sickle Cell Disease Open
Sickle cell disease (SCD) patients have low serum hemopexin (Hpx) levels due to chronic hemolysis. We hypothesize that in SCD mice, hepatic overexpression of hemopexin will scavenge the proximal mediator of vascular activation, heme, and w…
View article: Prenatal glucocorticoid exposure programs adrenal PNMT expression and adult hypertension
Prenatal glucocorticoid exposure programs adrenal PNMT expression and adult hypertension Open
Prenatal exposure to glucocorticoids (GCs) programs for hypertension later in life. The aim of the current study was to examine the impact of prenatal GC exposure on the postnatal regulation of the gene encoding for phenylethanolamine N -m…
View article: Cardiac phenylethanolamine N-methyltransferase: localization and regulation of gene expression in the spontaneously hypertensive rat
Cardiac phenylethanolamine N-methyltransferase: localization and regulation of gene expression in the spontaneously hypertensive rat Open
Phenylethanolamine N-methyltransferase (PNMT) is the terminal enzyme in the catecholamine biosynthetic pathway responsible for adrenaline biosynthesis. Adrenaline is involved in the sympathetic control of blood pressure; it augments cardia…
View article: The contribution of methionine to the stability of the Escherichia coli MetNIQ ABC transporter-substrate binding protein complex
The contribution of methionine to the stability of the Escherichia coli MetNIQ ABC transporter-substrate binding protein complex Open
Despite the ubiquitous role of ATP-binding cassette (ABC) importers in nutrient uptake, only the Escherichia coli maltose and vitamin B 12 ABC transporters have been structurally characterized in multiple conformations relevant to the alte…
View article: The Fucosylation Inhibitor, 2-Fluorofucose, Inhibits Vaso-Occlusion, Leukocyte-Endothelium Interactions and NF-ĸB Activation in Transgenic Sickle Mice
The Fucosylation Inhibitor, 2-Fluorofucose, Inhibits Vaso-Occlusion, Leukocyte-Endothelium Interactions and NF-ĸB Activation in Transgenic Sickle Mice Open
2-Fluorofucose (2FF) blocks the fucosylation and the tethering of sialyl-Lewisx tetrasaccharide and structural variants on leukocytes and red blood cells to P- and E-selectins on activated endothelial cell surfaces. Because P- and E-select…