Nguyen Quoc Khanh Le
YOU?
Author Swipe
View article: Artificial Intelligence in Proteomics Clinical Applications
Artificial Intelligence in Proteomics Clinical Applications Open
View article: The Art of Nanoimmunobiotechnomedicine in Depression Management
The Art of Nanoimmunobiotechnomedicine in Depression Management Open
Depression is a complex and debilitating disorder requiring innovative therapeutic strategies beyond conventional approaches. This study explores the emerging field of nanoimmunobiotechnomedicine, which integrates nanotechnology, immunobio…
View article: Bioinformatics Analysis of Transcriptomic Data (Bulk and scRNA-Seq) for Immuno-Oncology
Bioinformatics Analysis of Transcriptomic Data (Bulk and scRNA-Seq) for Immuno-Oncology Open
Bioinformatics plays a pivotal role in immunology by enabling the analysis of large-scale datasets generated from high-throughput technologies, such as next-generation sequencing (NGS), single-cell RNA sequencing (scRNA-seq), and mass cyto…
View article: Sex and racial disparities in clinical outcomes and healthcare costs among hospitalized older adult fall patients: A nationwide analysis
Sex and racial disparities in clinical outcomes and healthcare costs among hospitalized older adult fall patients: A nationwide analysis Open
Sex and race are associated with differences in clinical in-hospital outcomes and expenditures in older adult fall hospitalizations, suggesting potential variations in treatment, recovery, and access to care. Further research is needed to …
View article: AI-Driven Deep Learning Approach for Pan-Cancer Immune Profiling
AI-Driven Deep Learning Approach for Pan-Cancer Immune Profiling Open
The tumor immune microenvironment (TME) influences cancer progression and treatment. RNA-Seq has identified six immune subtypes: Wound Healing (WH, C1), IFN- Dominant (IFNG, C2), Inflammatory (INF, C3), Lymphocyte Depleted (LD, C4), Immuno…
View article: A Novel Hypoxia-Immune Signature for Gastric Cancer Prognosis and Immunotherapy: Insights from Bulk and Single-Cell RNA-Seq
A Novel Hypoxia-Immune Signature for Gastric Cancer Prognosis and Immunotherapy: Insights from Bulk and Single-Cell RNA-Seq Open
Background: Hypoxia and immune components significantly shape the tumor microenvironment and influence prognosis and immunotherapy response in gastric cancer (GC). This study aimed to develop hypoxia- and immune-related gene signatures for…
View article: Evaluation of the Timing to Noncardiac Surgery following Cardiac Operations
Evaluation of the Timing to Noncardiac Surgery following Cardiac Operations Open
When feasible, delaying NCS, particularly beyond 100 days, appears to be associated with a reduction in adverse events, suggesting a potential opportunity for optimization of patient outcomes.
View article: Unlocking RNA mysteries: Predicting subcellular localizations with AI
Unlocking RNA mysteries: Predicting subcellular localizations with AI Open
View article: Oncological challenges in GFAP-positive anaplastic meningioma: a case report and literature review
Oncological challenges in GFAP-positive anaplastic meningioma: a case report and literature review Open
Background Meningiomas are typically found in adults, with an average diagnosis age of 66. However, they can occur in children, presenting unique clinical and immunohistochemical characteristics. This report explores a rare pediatric case …
View article: Correction to: Incorporating Natural Language-Based and Sequence-Based Features to Predict Protein Sumoylation Sites
Correction to: Incorporating Natural Language-Based and Sequence-Based Features to Predict Protein Sumoylation Sites Open
View article: KD_MultiSucc: incorporating multi-teacher knowledge distillation and word embeddings for cross-species prediction of protein succinylation sites
KD_MultiSucc: incorporating multi-teacher knowledge distillation and word embeddings for cross-species prediction of protein succinylation sites Open
Protein succinylation is a vital post-translational modification (PTM) that involves the covalent attachment of a succinyl group (-CO-CH2-CH2-CO-) to the lysine residue of a protein molecule. The mechanism underlying the succinylation proc…
View article: Redefining Biomedicine: Artificial Intelligence at the Forefront of Discovery
Redefining Biomedicine: Artificial Intelligence at the Forefront of Discovery Open
The rapid evolution of artificial intelligence (AI) is redefining biomedicine, placing itself at the forefront of groundbreaking discoveries in molecular biology, genomics, drug discovery, diagnostics, and beyond [...]
View article: RNA-ModX: a multilabel prediction and interpretation framework for RNA modifications
RNA-ModX: a multilabel prediction and interpretation framework for RNA modifications Open
Accurate prediction of RNA modifications holds profound implications for elucidating RNA function and mechanism, with potential applications in drug development. Here, the RNA-ModX presents a highly precise predictive model designed to for…
View article: Early Detection of Dementia in Populations With Type 2 Diabetes: Predictive Analytics Using Machine Learning Approach
Early Detection of Dementia in Populations With Type 2 Diabetes: Predictive Analytics Using Machine Learning Approach Open
Background The possible association between diabetes mellitus and dementia has raised concerns, given the observed coincidental occurrences. Objective This study aimed to develop a personalized predictive model, using artificial intelligen…
View article: Disparities in neoadjuvant chemotherapy for pancreatic adenocarcinoma with vascular involvement
Disparities in neoadjuvant chemotherapy for pancreatic adenocarcinoma with vascular involvement Open
View article: Unitig-centered pan-genome machine learning approach for predicting antibiotic resistance and discovering novel resistance genes in bacterial strains
Unitig-centered pan-genome machine learning approach for predicting antibiotic resistance and discovering novel resistance genes in bacterial strains Open
View article: Prevalence and determinants of constipation in children in Asia: a systematic review and meta-analysis
Prevalence and determinants of constipation in children in Asia: a systematic review and meta-analysis Open
View article: Multi-Omics Analysis Reveals the IFI6 Gene as a Prognostic Indicator and Therapeutic Target in Esophageal Cancer
Multi-Omics Analysis Reveals the IFI6 Gene as a Prognostic Indicator and Therapeutic Target in Esophageal Cancer Open
The role of the IFI6 gene has been described in several cancers, but its involvement in esophageal cancer (ESCA) remains unclear. This study aimed to identify novel prognostic indicators for ESCA-targeted therapy by investigating IFI6’s ex…
View article: Multi-Class Deep Learning Model for Detecting Pediatric Distal Forearm Fractures Based on the AO/OTA Classification
Multi-Class Deep Learning Model for Detecting Pediatric Distal Forearm Fractures Based on the AO/OTA Classification Open
View article: Artificial intelligence in time-lapse system: advances, applications, and future perspectives in reproductive medicine
Artificial intelligence in time-lapse system: advances, applications, and future perspectives in reproductive medicine Open
View article: Liver abscess caused by the ingested foreign body without sign of gastrointestinal perforation: A case report
Liver abscess caused by the ingested foreign body without sign of gastrointestinal perforation: A case report Open
View article: Towards Robust Natural-Looking Mammography Lesion Synthesis on Ipsilateral Dual-Views Breast Cancer Analysis
Towards Robust Natural-Looking Mammography Lesion Synthesis on Ipsilateral Dual-Views Breast Cancer Analysis Open
In recent years, many mammographic image analysis methods have been introduced for improving cancer classification tasks. Two major issues of mammogram classification tasks are leveraging multi-view mammographic information and class-imbal…
View article: Predicting Tumor Mutational Burden and Survival in Head and Neck Squamous Cancer Patients Using Machine Learning and Bioinformatics Approaches
Predicting Tumor Mutational Burden and Survival in Head and Neck Squamous Cancer Patients Using Machine Learning and Bioinformatics Approaches Open
Head and neck squamous cancer (HNSC) is a prevalent malignancy with a complex genetic profile. Tumor Mutational Burden (TMB) is an emerging biomarker associated with prognostic and therapeutic implications. In this study, we aimed to devel…
View article: Early Detection of Dementia in Populations With Type 2 Diabetes: Predictive Analytics Using Machine Learning Approach (Preprint)
Early Detection of Dementia in Populations With Type 2 Diabetes: Predictive Analytics Using Machine Learning Approach (Preprint) Open
BACKGROUND The possible association between diabetes mellitus and dementia has raised concerns, given the observed coincidental occurrences. OBJECTIVE This study aimed to develop a personalized predictive model, using artificial intelli…
View article: Identification of a Novel Eight-Gene Risk Model for Predicting Survival in Glioblastoma: A Comprehensive Bioinformatic Analysis
Identification of a Novel Eight-Gene Risk Model for Predicting Survival in Glioblastoma: A Comprehensive Bioinformatic Analysis Open
Glioblastoma (GBM) is one of the most progressive and prevalent cancers of the central nervous system. Identifying genetic markers is therefore crucial to predict prognosis and enhance treatment effectiveness in GBM. To this end, we obtain…
View article: A case report and literature review of myocardial infarction with nonobstructive coronary arteries (MINOCA) possibly due to acute coronary vasospasm induced by misoprostol
A case report and literature review of myocardial infarction with nonobstructive coronary arteries (MINOCA) possibly due to acute coronary vasospasm induced by misoprostol Open
Coronary artery vasospasm (CVS), an uncommon cause of acute chest pain, can be provoked by vasoconstriction-induced medications. Misoprostol, a prostaglandin analog, is a safe medication to terminate a pregnancy. However, misoprostol can c…
View article: The Distribution of Autoantibodies by Age Group in Children with Type 1 Diabetes versus Type 2 Diabetes in Southern Vietnam
The Distribution of Autoantibodies by Age Group in Children with Type 1 Diabetes versus Type 2 Diabetes in Southern Vietnam Open
Asian children are increasingly being diagnosed with type 1 diabetes (T1D) or type 2 diabetes (T2D), and the presence of coexisting islet autoimmune antibodies complicate diagnosis. Here, we aimed to determine the prevalence of islet cell …
View article: Referee report. For: PyRadGUI: A GUI based radiomics extractor software [version 1; peer review: 1 approved with reservations]
Referee report. For: PyRadGUI: A GUI based radiomics extractor software [version 1; peer review: 1 approved with reservations] Open
View article: Development and Validation of Novel Deep-Learning Models Using Multiple Data Types for Lung Cancer Survival
Development and Validation of Novel Deep-Learning Models Using Multiple Data Types for Lung Cancer Survival Open
A well-established lung-cancer-survival-prediction model that relies on multiple data types, multiple novel machine-learning algorithms, and external testing is absent in the literature. This study aims to address this gap and determine th…
View article: Genomic-Analysis-Oriented Drug Repurposing in the Search for Novel Antidepressants
Genomic-Analysis-Oriented Drug Repurposing in the Search for Novel Antidepressants Open
From inadequate prior antidepressants that targeted monoamine neurotransmitter systems emerged the discovery of alternative drugs for depression. For instance, drugs targeted interleukin 6 receptor (IL6R) in inflammatory system. Genomic an…