Kunfu Ouyang
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View article: Targeting adenosine 2A receptor signaling suppresses vascular calcification by restraining smooth muscle osteogenic differentiation
Targeting adenosine 2A receptor signaling suppresses vascular calcification by restraining smooth muscle osteogenic differentiation Open
Vascular calcification (VC) is a major contributor to cardiovascular morbidity and mortality, particularly in patients with chronic kidney disease (CKD). Adenosine 2 A receptor (ADORA2A) is highly expressed in vascular cells and implicated…
View article: NEXN protects against vascular calcification by promoting SERCA2 SUMOylation and stabilization
NEXN protects against vascular calcification by promoting SERCA2 SUMOylation and stabilization Open
Vascular calcification, a key risk factor for cardiovascular diseases, is driven by the phenotypic transition of vascular smooth muscle cells from a contractile to an osteogenic phenotype. NEXN, a protein highly associated with heart funct…
View article: Deletion of Ptpmt1 by αMHC-Cre in Mice Results in Left Ventricular Non-Compaction
Deletion of Ptpmt1 by αMHC-Cre in Mice Results in Left Ventricular Non-Compaction Open
Background: Left ventricular non-compaction cardiomyopathy (LVNC) is a congenital heart disease characterized by abnormal prenatal development of the left ventricle that has an aberrantly thick trabecular layer and a thinner compacted myoc…
View article: The active mechanical characteristics of arterial smooth muscle during aneurysm remodeling
The active mechanical characteristics of arterial smooth muscle during aneurysm remodeling Open
Introduction Abdominal Aortic Aneurysm (AAA) is a common vascular disease characterized by progressive expansion and remodeling of the aortic wall. However, with the gradual expansion of blood vessels, the walls of blood vessels cannot wit…
View article: Deubiquitinase USP9X controls Wnt signaling for CNS vascular formation and barrier maintenance
Deubiquitinase USP9X controls Wnt signaling for CNS vascular formation and barrier maintenance Open
Deubiquitinating enzymes play crucial roles in various cellular activities, yet their involvement in central nervous system (CNS) vascularization and barrier function remains elusive. Canonical Wnt signaling is essential for proper CNS vas…
View article: Ultrasound-Targeted β-Catenin Gene Therapy Improves the Cardiac Function in Mice After Myocardial Infarction
Ultrasound-Targeted β-Catenin Gene Therapy Improves the Cardiac Function in Mice After Myocardial Infarction Open
Gene therapy has received great attention as a therapeutic approach to improve cardiac function post-myocardial infarction (MI), but its limitation lies in the lack of targeting. This study explored the use of ultrasound-targeted microbubb…
View article: Inositol 1,4,5‐Trisphosphate Receptors Regulate Vascular Smooth Muscle Cell Proliferation and Neointima Formation in Mice
Inositol 1,4,5‐Trisphosphate Receptors Regulate Vascular Smooth Muscle Cell Proliferation and Neointima Formation in Mice Open
Background Vascular smooth muscle cell (VSMC) proliferation is involved in many types of arterial diseases, including neointima hyperplasia, in which Ca 2+ has been recognized as a key player. However, the physiological role of Ca 2+ relea…
View article: The ubiquitin E3 ligase APC/CCdc20 mediates mitotic degradation of OGT
The ubiquitin E3 ligase APC/CCdc20 mediates mitotic degradation of OGT Open
O-linked β-N-acetylglucosamine (O-GlcNAc) transferase (OGT) is the sole enzyme that catalyzes all O-GlcNAcylation reactions intracellularly. Previous investigations have found that OGT levels oscillate during the cell division process. Spe…
View article: DEAD-box helicase 17 (DDX17) protects cardiac function by promoting mitochondrial homeostasis in heart failure
DEAD-box helicase 17 (DDX17) protects cardiac function by promoting mitochondrial homeostasis in heart failure Open
DEAD-box helicase 17 (DDX17) is a typical member of the DEAD-box family with transcriptional cofactor activity. Although DDX17 is abundantly expressed in the myocardium, its role in heart is not fully understood. We generated cardiomyocyte…
View article: Myocardin reverses insulin resistance and ameliorates cardiomyopathy by increasing IRS-1 expression in a murine model of lipodystrophy caused by adipose deficiency of vacuolar H<sup>+</sup>-ATPase V0d1 subunit
Myocardin reverses insulin resistance and ameliorates cardiomyopathy by increasing IRS-1 expression in a murine model of lipodystrophy caused by adipose deficiency of vacuolar H<sup>+</sup>-ATPase V0d1 subunit Open
Aim: Adipose tissue (AT) dysfunction that occurs in both obesity and lipodystrophy is associated with the development of cardiomyopathy. However, it is unclear how dysfunctional AT induces cardiomyopathy due to limited animal models availa…
View article: Causal association between self-reported fatigue and coronary artery disease: a bidirectional two-sample Mendelian randomization analysis
Causal association between self-reported fatigue and coronary artery disease: a bidirectional two-sample Mendelian randomization analysis Open
Background Observational studies have reported the association between fatigue and coronary artery disease (CAD), but the causal association between fatigue and CAD is unclear. Method We conducted a bidirectional Mendelian randomization (M…
View article: Identification of the shared mechanisms and common biomarkers between Sjögren’s syndrome and atherosclerosis using integrated bioinformatics analysis
Identification of the shared mechanisms and common biomarkers between Sjögren’s syndrome and atherosclerosis using integrated bioinformatics analysis Open
Background Sjögren’s syndrome (SS) is a chronic autoimmune disease characterized by exocrine and extra-glandular symptoms. The literature indicates that SS is an independent risk factor for atherosclerosis (AS); however, its pathophysiolog…
View article: Transient ischemic attack and coronary artery disease: a two-sample Mendelian randomization analysis
Transient ischemic attack and coronary artery disease: a two-sample Mendelian randomization analysis Open
Background Although observational studies have shown that patients who experienced transient ischemic attacks (TIAs) had a higher risk of coronary artery disease (CAD), the causal relationship is ambiguous. Methods We conducted a two-sampl…
View article: Associations between urine glyphosate and diabetes mellitus in the U.S. general adult: A cross-sectional study from NHANES program
Associations between urine glyphosate and diabetes mellitus in the U.S. general adult: A cross-sectional study from NHANES program Open
Background Glyphosate-based herbicides (GBHs) are used extensively around the world and have become the leading agrochemicals. However, study about the association between glyphosate exposure and diabetes is scarce. This study used four ye…
View article: Glycolytic regulatory enzyme PFKFB3 as a prognostic and tumor microenvironment biomarker in human cancers
Glycolytic regulatory enzyme PFKFB3 as a prognostic and tumor microenvironment biomarker in human cancers Open
The 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFK-2/FBPase-2, PFKFB3) is a glycolysis regulatory enzyme and plays a key role in oncogenesis of several cancers. However, the systematic study of crosstalk between PFKFB3 and Tum…
View article: Non-thyroidal illness syndrome and the prognosis of heart failure: a systematic review and meta-analysis
Non-thyroidal illness syndrome and the prognosis of heart failure: a systematic review and meta-analysis Open
Background Heart failure (HF) is a complex and multifactorial syndrome caused by impaired heart function. The high morbidity and mortality of HF cause a heavy burden of illness worldwide. Non-thyroidal illness syndrome (NTIS) refers to abe…
View article: Suppression of RBFox2 by Multiple MiRNAs in Pressure Overload-Induced Heart Failure
Suppression of RBFox2 by Multiple MiRNAs in Pressure Overload-Induced Heart Failure Open
Heart failure is the final stage of various cardiovascular diseases and seriously threatens human health. Increasing mediators have been found to be involved in the pathogenesis of heart failure, including the RNA binding protein RBFox2. I…
View article: Cardiolipin Regulates Mitochondrial Ultrastructure and Function in Mammalian Cells
Cardiolipin Regulates Mitochondrial Ultrastructure and Function in Mammalian Cells Open
Cardiolipin (CL) is a unique, tetra-acylated diphosphatidylglycerol lipid that mainly localizes in the inner mitochondria membrane (IMM) in mammalian cells and plays a central role in regulating mitochondrial architecture and functioning. …
View article: Identification and Validation of a Ferroptosis-Related Signature for Predicting Prognosis and Immune Microenvironment in Papillary Renal Cell Carcinoma
Identification and Validation of a Ferroptosis-Related Signature for Predicting Prognosis and Immune Microenvironment in Papillary Renal Cell Carcinoma Open
Qingen Da,1,2,* Mingming Ren,2,* Lei Huang,2 Jianhua Qu,1 Qiuhua Yang,3 Jiean Xu,4 Qian Ma,4 Xiaoxiao Mao,4 Yongfeng Cai,4 Dingwei Zhao,4 Junhua Luo,5 Zilong Yan,1 Lu Sun,2 Kunfu Ouyang,2 Xiaowei Zhang,6 Zhen Han,2 Jikui Liu,1 Tao Wang2 1D…
View article: Deficiency of Myeloid Pfkfb3 Protects Mice From Lung Edema and Cardiac Dysfunction in LPS-Induced Endotoxemia
Deficiency of Myeloid Pfkfb3 Protects Mice From Lung Edema and Cardiac Dysfunction in LPS-Induced Endotoxemia Open
Sepsis, a pathology resulting from excessive inflammatory response that leads to multiple organ failure, is a major cause of mortality in intensive care units. Macrophages play an important role in the pathophysiology of sepsis. Accumulati…
View article: Mediator complex proximal Tail subunit MED30 is critical for Mediator core stability and cardiomyocyte transcriptional network
Mediator complex proximal Tail subunit MED30 is critical for Mediator core stability and cardiomyocyte transcriptional network Open
Dysregulation of cardiac transcription programs has been identified in patients and families with heart failure, as well as those with morphological and functional forms of congenital heart defects. Mediator is a multi-subunit complex that…
View article: Cardiolipin Remodeling Defects Impair Mitochondrial Architecture and Function in a Murine Model of Barth Syndrome Cardiomyopathy
Cardiolipin Remodeling Defects Impair Mitochondrial Architecture and Function in a Murine Model of Barth Syndrome Cardiomyopathy Open
Background: Cardiomyopathy is a major clinical feature in Barth syndrome (BTHS), an X-linked mitochondrial lipid disorder caused by mutations in Tafazzin ( TAZ ), encoding a mitochondrial acyltransferase required for cardiolipin remodeling…
View article: Multiple Cytokines Elevated in Patients with Keloids: Is It an Indication of Auto-Inflammatory Disease?
Multiple Cytokines Elevated in Patients with Keloids: Is It an Indication of Auto-Inflammatory Disease? Open
Ferdinand W Nangole,1 Kelsey Ouyang,2 Omu Anzala,3 Julius Ogengo,4 George W Agak2 1Department of Surgery, University of Nairobi, Nairobi, Kenya; 2Division of Dermatology, David Geffen School of Medicine at UCLA, Los Angeles, California, US…