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View article: PCK1 deficiency promotes MASH-HCC progression by 12-HETE-induced CD8 <sup>+</sup> T cell dysfunction
PCK1 deficiency promotes MASH-HCC progression by 12-HETE-induced CD8 <sup>+</sup> T cell dysfunction Open
Background Metabolic dysfunction-associated steatohepatitis-related hepatocellular carcinoma (MASH-HCC) has been reported to be less responsive to immune checkpoint inhibitors, which may be associated with metabolic reprogramming of tumour…
View article: Mechanistic insights into FUNDC2P4 and HSF1 regulation of EMT in residual hepatocellular carcinoma following insufficient radiofrequency ablation
Mechanistic insights into FUNDC2P4 and HSF1 regulation of EMT in residual hepatocellular carcinoma following insufficient radiofrequency ablation Open
These findings suggest a potential regulatory mechanism involving FUNDC2P4 and HSF1 that may contribute to HCC recurrence and metastasis after IRFA, warranting further in vivo and clinical investigation.
View article: A STUDY ON DEVELOPING AND APPLYING A “THREE-STAGE PROGRESSIVE” MICRO-LESSON MODEL IN ELEMENTARY CHINESE FLIPPED CLASSROOMS
A STUDY ON DEVELOPING AND APPLYING A “THREE-STAGE PROGRESSIVE” MICRO-LESSON MODEL IN ELEMENTARY CHINESE FLIPPED CLASSROOMS Open
This research is situated within the global wave of educational digitalization, which is driving universities to adopt digital teaching models. The Chinese Language Department at Ho Chi Minh City University of Education is pioneering this …
View article: Phosphoglycerate dehydrogenase stabilizes protein kinase C delta type mRNA to promote hepatocellular carcinoma progression
Phosphoglycerate dehydrogenase stabilizes protein kinase C delta type mRNA to promote hepatocellular carcinoma progression Open
Metabolic reprogramming not only reshapes cellular bioenergetics but also profoundly influences RNA metabolism through metabolite signaling and the RNA-binding activities of metabolic enzymes. Emerging evidence highlights that certain meta…
View article: Characterization of Leptin and Leptin Receptor Gene in the Siberian Sturgeon (Acipenser baerii): Molecular Cloning, Tissue Distribution, and Its Involvement in Feeding Regulation
Characterization of Leptin and Leptin Receptor Gene in the Siberian Sturgeon (Acipenser baerii): Molecular Cloning, Tissue Distribution, and Its Involvement in Feeding Regulation Open
Leptin is an adipokine known as a regulator of feeding and metabolism in mammals. Previous studies on fish have revealed its role in food intake regulation in limited teleosts. However, its specific function in Siberian sturgeon, an ancien…
View article: <scp>SPOP</scp> Suppresses Hepatocellular Carcinoma Growth and Metastasis by Ubiquitination and Proteasomal Degradation of <scp>TRAF6</scp>
<span>SPOP</span> Suppresses Hepatocellular Carcinoma Growth and Metastasis by Ubiquitination and Proteasomal Degradation of <span>TRAF6</span> Open
Tumor necrosis factor receptor‐associated factor‐6 (TRAF6) is a well‐established upstream regulator of the IKK complex, essential for the modulation of the NF‐κB (nuclear factor kappa B) signaling pathway. Aberrant activation of TRAF6 has …
View article: Hypoxia reduces SLC27A5 to promote hepatocellular carcinoma proliferation by repressing HNF4A
Hypoxia reduces SLC27A5 to promote hepatocellular carcinoma proliferation by repressing HNF4A Open
Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related mortality globally, with hypoxia recognized as a key factor in its progression. Solute carrier family 27 member 5 (SLC27A5/FATP5), a pivotal enzyme in hepatic …
View article: Imaging Genomics Combined with Machine Learning to Explore the Impact of the Kinase Anchor Protein 12 Gene on Immunity and Survival in Gastric Cancer
Imaging Genomics Combined with Machine Learning to Explore the Impact of the Kinase Anchor Protein 12 Gene on Immunity and Survival in Gastric Cancer Open
Introduction: Kinase anchor protein 12 (AKAP12) has been widely studied and confirmed as a tumor suppressor in various cancers. However, its immune effects on gastric cancer have not been clarified. Therefore, we systematically analyzed th…
View article: SLC27A5 inhibits cancer stem cells by inducing alternative polyadenylation of METTL14 in hepatocellular carcinoma
SLC27A5 inhibits cancer stem cells by inducing alternative polyadenylation of METTL14 in hepatocellular carcinoma Open
Solute carrier family 27 member 5 (SLC27A5/FATP5) is a liver-specific metabolic enzyme that plays a crucial role in fatty acid transport and bile acid metabolism. Deficiency of SLC27A5 promotes the progression of hepatocellular carcinoma (…
View article: Maternal Preconception COVID-19 Vaccination and Its Protective Effect on Infants after a Breakthrough Infection during Pregnancy
Maternal Preconception COVID-19 Vaccination and Its Protective Effect on Infants after a Breakthrough Infection during Pregnancy Open
Background and aims: The transplacental vertical transfer of maternal antibodies was determined to be a crucial factor in conferring protective immunity to infants following delivery, and this study aimed to evaluate the protective effect …
View article: Prophylactic efficacy of an intranasal spray with 2 synergetic antibodies neutralizing Omicron
Prophylactic efficacy of an intranasal spray with 2 synergetic antibodies neutralizing Omicron Open
BACKGROUNDAs Omicron is prompted to replicate in the upper airway, neutralizing antibodies (NAbs) delivered through inhalation might inhibit early-stage infection in the respiratory tract. Thus, elucidating the prophylactic efficacy of NAb…
View article: Construction of a radiomics-based model for predicting the efficacy of radiotherapy and chemotherapy for non-small cell lung cancer
Construction of a radiomics-based model for predicting the efficacy of radiotherapy and chemotherapy for non-small cell lung cancer Open
CT can be used for efficacy prediction after radiotherapy and chemotherapy in NSCLC patients. LR is more suitable for predicting whether NSCLC prognosis is in remission without considering the computing speed.
View article: Metabolic Enzyme SLC27A5 Regulates PIP4K2A pre‐mRNA Splicing as a Noncanonical Mechanism to Suppress Hepatocellular Carcinoma Metastasis
Metabolic Enzyme SLC27A5 Regulates PIP4K2A pre‐mRNA Splicing as a Noncanonical Mechanism to Suppress Hepatocellular Carcinoma Metastasis Open
Solute carrier family 27 member 5, a key enzyme in fatty acid transport and bile acid metabolism in the liver, is frequently expressed in low quantities in patients with hepatocellular carcinoma, resulting in poor prognosis. However, it is…
View article: SPOP inhibits HBV transcription and replication by ubiquitination and degradation of HNF1α
SPOP inhibits HBV transcription and replication by ubiquitination and degradation of HNF1α Open
Hepatitis B virus (HBV) infection remains a significant public health burden worldwide. The persistence of covalently closed circular DNA (cccDNA) within the nucleus of infected hepatocytes is responsible for the failure of antiviral treat…
View article: Loss of SLC27A5 Activates Hepatic Stellate Cells and Promotes Liver Fibrosis via Unconjugated Cholic Acid
Loss of SLC27A5 Activates Hepatic Stellate Cells and Promotes Liver Fibrosis via Unconjugated Cholic Acid Open
Although the dysregulation of bile acid (BA) composition has been associated with fibrosis progression, its precise roles in liver fibrosis is poorly understood. This study demonstrates that solute carrier family 27 member 5 (SLC27A5), an …
View article: Signaling metabolite succinylacetone activates HIF-1α and promotes angiogenesis in GSTZ1-deficient hepatocellular carcinoma
Signaling metabolite succinylacetone activates HIF-1α and promotes angiogenesis in GSTZ1-deficient hepatocellular carcinoma Open
Aberrant angiogenesis in hepatocellular carcinoma (HCC) is associated with tumor growth, progression, and local or distant metastasis. Hypoxia-inducible factor 1α (HIF-1α) is a transcription factor that plays a major role in regulating ang…
View article: Nmu receptor of Siberian sturgeon (Acipenser baerii) and its role in food intake
Nmu receptor of Siberian sturgeon (Acipenser baerii) and its role in food intake Open
Neuromedin U (NMU) exerts an annorexigenic role in mammals. In fish, only one study in gold-fish has identified neuromedin U receptors (NMURs), but the information about NMURs in ap-petite regulation is limited. To clarify the response mod…
View article: Real-world effectiveness of an intranasal spray A8G6 antibody cocktail in the post-exposure prophylaxis of COVID-19
Real-world effectiveness of an intranasal spray A8G6 antibody cocktail in the post-exposure prophylaxis of COVID-19 Open
Previously, we identified an antibody combination A8G6 that showed promising efficacy in COVID-19 animal models and favorable safety profile in preclinical models as well as in a first-in-human trial. To evaluate the real-word efficacy of …
View article: High dietary fructose promotes hepatocellular carcinoma progression by enhancing O-GlcNAcylation via microbiota-derived acetate
High dietary fructose promotes hepatocellular carcinoma progression by enhancing O-GlcNAcylation via microbiota-derived acetate Open
Emerging studies have addressed the tumor-promoting role of fructose in different cancers. The effects and pathological mechanisms of high dietary fructose on hepatocellular carcinoma (HCC) remain unclear. Here, we examined the effects of …
View article: PCK1 attenuates tumor stemness via activating the Hippo signaling pathway in hepatocellular carcinoma
PCK1 attenuates tumor stemness via activating the Hippo signaling pathway in hepatocellular carcinoma Open
Liver cancer stem cells were found to rely on glycolysis as the preferred metabolic program. Phosphoenolpyruvate carboxylase 1 (PCK1), a gluconeogenic metabolic enzyme, is down-regulated in hepatocellular carcinoma and is closely related t…
View article: Hypoxia-induced LncRNA CTD-2510F5.4 facilitates hepatocellular carcinoma cell proliferation and invasion, predicts prognosis, tumor microenvironment, and drug efficacy in patients with hepatocellular carcinoma
Hypoxia-induced LncRNA CTD-2510F5.4 facilitates hepatocellular carcinoma cell proliferation and invasion, predicts prognosis, tumor microenvironment, and drug efficacy in patients with hepatocellular carcinoma Open
Purpose Hypoxia induces abnormal expression of various long non-coding RNAs (LncRNAs) highly correlated with tumorigenesis. In this study, we identified CTD-2510F5.4, a hypoxia-induced LncRNA, based on microarray and TCGA analyses, and eva…