Deyou Zheng
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View article: Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer
Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer Open
Castration-resistant prostate cancer (CRPC) is a terminal disease and the molecular underpinnings of CRPC development need to be better understood in order to improve its treatment. Here, we report that a transcription factor Yin Yang 1 (Y…
View article: Immune checkpoint B7x promotes immune evasion and resistance to PD-1/PD-L1 blockade in bladder cancer
Immune checkpoint B7x promotes immune evasion and resistance to PD-1/PD-L1 blockade in bladder cancer Open
View article: shinyUMAP: an online tool for promoting understanding of single cell omics data visualization
shinyUMAP: an online tool for promoting understanding of single cell omics data visualization Open
Visualization is widely used to help explore and interpret high dimensional single cell (sc) omics data, such as scRNA-seq expression data. In particular, uniform manifold approximation and projection (UMAP) has become nearly ubiquitous in…
View article: Survival benefit of perioperative chemoradiotherapy in patients with resectable primary gastric adenosquamous carcinoma: a population-based cohort study
Survival benefit of perioperative chemoradiotherapy in patients with resectable primary gastric adenosquamous carcinoma: a population-based cohort study Open
Background Currently, whether Gastric adenosquamous carcinoma (GASC) can benefit from perioperative chemoradiotherapy (pCRT) remains controversial. The objective of this study was to evaluate the survival benefit of pCRT in resectable GASC…
View article: Facilitate integrated analysis of single cell multiomic data by binarizing gene expression values
Facilitate integrated analysis of single cell multiomic data by binarizing gene expression values Open
View article: Disruption of TAD hierarchy promotes LTR co-option in cancer
Disruption of TAD hierarchy promotes LTR co-option in cancer Open
View article: Publisher Correction: Ageing limits stemness and tumorigenesis by reprogramming iron homeostasis
Publisher Correction: Ageing limits stemness and tumorigenesis by reprogramming iron homeostasis Open
View article: Hematopoietic Single Cell Atlas Reveals a Diverse Repertoire of Lymphoid Cells in Larval Zebrafish
Hematopoietic Single Cell Atlas Reveals a Diverse Repertoire of Lymphoid Cells in Larval Zebrafish Open
SUMMARY During embryogenesis, hematopoietic stem cells (HSC) and HSC-independent progenitor cells form concurrently and produce overlapping and distinct immune cell types. The full repertoire of immune cells generated during development an…
View article: The sotos syndrome gene Nsd1 safeguards developmental gene enhancers poised for transcription by maintaining the precise deposition of histone methylation
The sotos syndrome gene Nsd1 safeguards developmental gene enhancers poised for transcription by maintaining the precise deposition of histone methylation Open
Germline haploinsufficiency of NSD1 is implicated as the etiology of Sotos syndrome; however, the underlying mechanism remains far from being clear. Here, we use mouse embryonic stem cell (mESC) differentiation as a model system to address…
View article: Wireless Channel Measurements and Characterization in Industrial IoT Scenarios
Wireless Channel Measurements and Characterization in Industrial IoT Scenarios Open
Wireless Fidelity (Wi-Fi) communication technologies hold significant potential for realizing the Industrial Internet of Things (IIoT). In this paper, both Single-Input Single-Output (SISO) and polarized Multiple-Input Multiple-Output (MIM…
View article: Six3 and Six6 jointly control diverse target genes in multiple cell populations over developmental trajectories of mouse embryonic retinal progenitor cells
Six3 and Six6 jointly control diverse target genes in multiple cell populations over developmental trajectories of mouse embryonic retinal progenitor cells Open
How tissue-specific progenitor cells generate adult tissues is a puzzle in organogenesis. Using single-cell RNA sequencing of control and Six3 and Six6 compound-mutant mouse embryonic eyecups, we demonstrated that these two closely related…
View article: Bioequivalence of Cefdinir Dispersible Tablets in healthy Chinese subjects under fasting and fed conditions: A Single-Centred, Randomized, Open, Single-Dose, Two-Preparation, Two-Cycle, Two-Sequence, Double-Crossover Trial
Bioequivalence of Cefdinir Dispersible Tablets in healthy Chinese subjects under fasting and fed conditions: A Single-Centred, Randomized, Open, Single-Dose, Two-Preparation, Two-Cycle, Two-Sequence, Double-Crossover Trial Open
Cefdinir is a broad-spectrum antibiotic with good antibacterial activity against gram-positive and gram-negative bacteria, and can be used for the treatment of various sensitive bacterial infections, such as community-acquired pneumonia, u…
View article: H2AK119ub dynamics controls hair follicle stem cell quiescence
H2AK119ub dynamics controls hair follicle stem cell quiescence Open
Summary The transition of stem cells from a quiescent state to an active state is a finely tuned process that requires the dismantling of the quiescence program and the establishment of a cell cycle-promoting transcriptional landscape. Whe…
View article: Deletion of Mgat2 in spermatogonia blocks spermatogenesis
Deletion of Mgat2 in spermatogonia blocks spermatogenesis Open
Identifying factors required for spermatogenesis is important for understanding mechanisms of male fertility. Inactivation of either the Mgat1 or Man2a2 gene leads to a block in spermatogenesis causing infertility in male mice. MGAT1 GlcNA…
View article: scDAPP: a comprehensive single-cell transcriptomics analysis pipeline optimized for cross-group comparison
scDAPP: a comprehensive single-cell transcriptomics analysis pipeline optimized for cross-group comparison Open
Single-cell transcriptomics profiling has increasingly been used to evaluate cross-group (or condition) differences in cell population and cell-type gene expression. This often leads to large datasets with complex experimental designs that…
View article: VISTA Emerges as a Promising Target against Immune Evasion Mechanisms in Medulloblastoma
VISTA Emerges as a Promising Target against Immune Evasion Mechanisms in Medulloblastoma Open
Background: Relapsed medulloblastoma (MB) poses a significant therapeutic challenge due to its highly immunosuppressive tumor microenvironment. Immune checkpoint inhibitors (ICIs) have struggled to mitigate this challenge, largely due to l…
View article: VISTA Emerges as a Promising Target against Immune Evasion Mechanisms in Medulloblastoma
VISTA Emerges as a Promising Target against Immune Evasion Mechanisms in Medulloblastoma Open
Background: Relapsed medulloblastoma (MB) poses a significant therapeutic challenge due to its highly immunosuppressive tumor microenvironment. Immune checkpoint inhibitors (ICIs) have struggled to mitigate this challenge, largely due to l…
View article: Production of high velocity micron-sized ice particles using the NASA Ames Vertical Gun Range for application to missions to icy moons.
Production of high velocity micron-sized ice particles using the NASA Ames Vertical Gun Range for application to missions to icy moons. Open
The Ames Vertical Gun Range (AVGR) is a hypervelocity impact facility hosting a variable angle, two-stage, light-gas gun that can accelerate projectiles up to 7 km s−1. We have used the AVGR to produce impacts into supercooled (73–89 K) sy…
View article: Molecular and network disruptions in neurodevelopment uncovered by single cell transcriptomics analysis of CHD8 heterozygous cerebral organoids
Molecular and network disruptions in neurodevelopment uncovered by single cell transcriptomics analysis of CHD8 heterozygous cerebral organoids Open
View article: Aging limits stemness and tumorigenesis in the lung by reprogramming iron homeostasis
Aging limits stemness and tumorigenesis in the lung by reprogramming iron homeostasis Open
Summary Aging is associated with a decline in the number and fitness of adult stem cells 1–4 . Aging-associated loss of stemness is posited to suppress tumorigenesis 5,6 , but this hypothesis has not been tested in vivo . Here, using physi…
View article: Structure and transcription of integrated HPV DNA in vulvar carcinomas
Structure and transcription of integrated HPV DNA in vulvar carcinomas Open
View article: Fine-tuning spatial-temporal dynamics and surface receptor expression support plasma cell-intrinsic longevity
Fine-tuning spatial-temporal dynamics and surface receptor expression support plasma cell-intrinsic longevity Open
Durable serological memory following vaccination is critically dependent on the production and survival of long-lived plasma cells (LLPCs). Yet, the factors that control LLPC specification and survival remain poorly resolved. Using intravi…
View article: Author response: Fine-tuning spatial-temporal dynamics and surface receptor expression support plasma cell-intrinsic longevity
Author response: Fine-tuning spatial-temporal dynamics and surface receptor expression support plasma cell-intrinsic longevity Open
View article: Author response: Fine-tuning spatial-temporal dynamics and surface receptor expression support plasma cell-intrinsic longevity
Author response: Fine-tuning spatial-temporal dynamics and surface receptor expression support plasma cell-intrinsic longevity Open
Durable serological memory following vaccination is critically dependent on the production and survival of long-lived plasma cells (LLPCs). Yet, the factors that control LLPC specification and survival remain poorly resolved. Using intra-v…
View article: Reviewer #3 (Public Review): Fine-tuning spatial-temporal dynamics and surface receptor expression support plasma cell-intrinsic longevity
Reviewer #3 (Public Review): Fine-tuning spatial-temporal dynamics and surface receptor expression support plasma cell-intrinsic longevity Open
Durable serological memory following vaccination is critically dependent on the production and survival of long-lived plasma cells (LLPCs). Yet, the factors that control LLPC specification and survival remain poorly resolved. Using intra-v…
View article: TAD hierarchy restricts poised LTR activation and loss of TAD hierarchy promotes LTR co-option in cancer
TAD hierarchy restricts poised LTR activation and loss of TAD hierarchy promotes LTR co-option in cancer Open
Transposable elements (TEs) are abundant in the human genome, and they provide the sources for genetic and functional diversity. The regulation of TEs expression and their functional consequences in physiological conditions and cancer deve…
View article: Comprehensive single cell transcriptomics analysis of murine osteosarcoma uncovers<i>Skp2</i>function in metastasis, genomic instability and immune activation and reveals additional target pathways
Comprehensive single cell transcriptomics analysis of murine osteosarcoma uncovers<i>Skp2</i>function in metastasis, genomic instability and immune activation and reveals additional target pathways Open
Osteosarcoma (OS) is the most common primary pediatric bone malignancy. One promising new therapeutic target is SKP2 , encoding a substrate recognition factor of the SCF E3 ubiquitin ligase responsible for ubiquitination and proteasome deg…
View article: Reviewer #2 (Public Review): Fine-tuning spatial-temporal dynamics and surface receptor expression support plasma cell-intrinsic longevity
Reviewer #2 (Public Review): Fine-tuning spatial-temporal dynamics and surface receptor expression support plasma cell-intrinsic longevity Open
Durable serological memory following vaccination is critically dependent on the production and survival of long-lived plasma cells (LLPCs). Yet, the factors that control LLPC specification and survival remain poorly resolved. Using intra-v…
View article: Reviewer #1 (Public Review): Fine-tuning spatial-temporal dynamics and surface receptor expression support plasma cell-intrinsic longevity
Reviewer #1 (Public Review): Fine-tuning spatial-temporal dynamics and surface receptor expression support plasma cell-intrinsic longevity Open
Durable serological memory following vaccination is critically dependent on the production and survival of long-lived plasma cells (LLPCs). Yet, the factors that control LLPC specification and survival remain poorly resolved. Using intra-v…
View article: Fine-tuning spatial-temporal dynamics and surface receptor expression support plasma cell-intrinsic longevity
Fine-tuning spatial-temporal dynamics and surface receptor expression support plasma cell-intrinsic longevity Open
Durable serological memory following vaccination is critically dependent on the production and survival of long-lived plasma cells (LLPCs). Yet, the factors that control LLPC specification and survival remain poorly resolved. Using intra-v…