Explanipedia

MorPhiC Consortium: towards functional characterization of all human genes Open

Mazhar Adli, Laralynne Przybyla, Tony Burdett, Paul W. Burridge, Pilar Cacheiro , et al. · 2025

Comparative analysis of methodologies for detecting extrachromosomal circular DNA Open

Xiaolian Gao, Ke Liu, Songwen Luo, Meifang Tang, Nianping Liu , et al. · 2024

Extrachromosomal circular DNA (eccDNA) is crucial in oncogene amplification, gene transcription regulation, and intratumor heterogeneity. While various analysis pipelines and experimental methods have been developed for eccDNA identificati…

Application of the Knotting After Half-Side Threaded Anastomosis Method in free anterolateral thigh flap repair Open

Liyu Zhang, Zongcheng Yang, Hui Peng, Guangxing Yan, Yi Wang , et al. · 2024

Backgrounds: The prognosis of free anterolateral thigh (ALT) flap repair is critically tied to the quality of vascular anastomosis. In this study, we introduced Knotting After Half-Side Threaded Anastomosis Method (KAHTAM) and conducted a …

Comparative analysis of methodologies for detecting extrachromosomal circular DNA Open

Xuyuan Gao, Ke Liu, Songwen Luo, Meifang Tang, Nianping Liu , et al. · 2023

Extrachromosomal circular DNA (eccDNA) is crucial in oncogene amplification, gene transcription regulation, and intratumor heterogeneity. While various analysis pipelines and experimental methods have been developed for eccDNA identificati…

Single-cell landscape of primary central nervous system diffuse large B-cell lymphoma Open

Nianping Liu, Chen Jiang, Xinfeng Yao, Minghao Fang, Xiaolong Qiao , et al. · 2023

Understanding tumor heterogeneity and immune infiltrates within the tumor-immune microenvironment (TIME) is essential for the innovation of immunotherapies. Here, combining single-cell transcriptomics and chromatin accessibility sequencing…

Histone lysine methyltransferase SMYD3 promotes oral squamous cell carcinoma tumorigenesis via H3K4me3-mediated HMGA2 transcription Open

Zongcheng Yang, Fen Liu, Li Zongkai, Nianping Liu, Xinfeng Yao , et al. · 2023

Dynamics and regulation of mitotic chromatin accessibility bookmarking at single-cell resolution Open

Qiaoni Yu, Xu Liu, Jingwen Fang, Huihui Wu, Chuang Guo , et al. · 2023

Although mitotic chromosomes are highly compacted and transcriptionally inert, some active chromatin features are retained during mitosis to ensure the proper postmitotic reestablishment of maternal transcriptional programs, a phenomenon t…

Additional file 2 of Histone lysine methyltransferase SMYD3 promotes oral squamous cell carcinoma tumorigenesis via H3K4me3-mediated HMGA2 transcription Open

Zongcheng Yang, Fen Liu, Li Zongkai, Nianping Liu, Xinfeng Yao , et al. · 2023

Additional file 2: Table S1. The results of differential expression analysis on RNA-seq data. Table S2. The results of ChIP-seq. Table S3. The 105-overlapping-gene and 23-gene lists. Table S4. Clinicopathological characteristics of OSCC ti…

Additional file 1 of Histone lysine methyltransferase SMYD3 promotes oral squamous cell carcinoma tumorigenesis via H3K4me3-mediated HMGA2 transcription Open

Zongcheng Yang, Fen Liu, Li Zongkai, Nianping Liu, Xinfeng Yao , et al. · 2023

Additional file 1: Fig. S1. Identification of SMYD3 for diagnosis of OSCC. A–E ROC curve analyses of SMYD3 in TCGA, meta-GEO, TCGA, GSE37991, and GSE30784 datasets. AUC values are shown. Fig. S2. The DNA methylation and genomic mutation pr…

A transcriptome atlas and interactive analysis platform for autoimmune disease Open

Zhuoqiao Shen, Minghao Fang, Wujianan Sun, Meifang Tang, Nianping Liu , et al. · 2022

With the rapid development of next-generation sequencing technology, many laboratories have produced a large amount of single-cell transcriptome data of blood and tissue samples from patients with autoimmune diseases, which enables in-dept…

COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas Open

Xianwen Ren, Wen Wen, Xiaoying Fan, Wenhong Hou, Bin Su , et al. · 2021

Single-cell analysis of COVID-19, sepsis, and HIV infection reveals hyperinflammatory and immunosuppressive signatures in monocytes Open

Nianping Liu, Chen Jiang, Pengfei Cai, Zhuoqiao Shen, Wujianan Sun , et al. · 2021

The mortality risk of coronavirus disease 2019 (COVID-19) patients has been linked to the cytokine storm caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Understanding the inflammatory responses shared between COVID-…

COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas Open

Xianwen Ren, Wen Wen, Xiaoying Fan, Wenhong Hou, Bin Su , et al. · 2021

Large-scale single-cell analysis reveals critical immune characteristics of COVID-19 patients Open

Xianwen Ren, Wen Wen, Xiaoying Fan, Wenhong Hou, Bin Su , et al. · 2020

SUMMARY Dysfunctional immune response in the COVID-19 patients is a recurrent theme impacting symptoms and mortality, yet the detailed understanding of pertinent immune cells is not complete. We applied single-cell RNA sequencing to 284 sa…

WEDGE: imputation of gene expression values from single-cell RNA-seq datasets using biased matrix decomposition Open

Yinlei Hu, Bin Li, Wen Zhang, Nianping Liu, Pengfei Cai , et al. · 2019

The low capture rate of expressed RNAs from single-cell sequencing technology is one of the major obstacles to downstream functional genomics analyses. Recently, a number of imputation methods have emerged for single-cell transcriptome dat…

Fabrication of Microsupercapacitors Based on Horizontally Aligned Carbon Nanotube Arrays Open

Sailei Han, Yufang Zhu, Huang Xu, Nianping Liu, Jianzhen Zhang , et al. · 2019

Nianping Liu YOU? Author Swipe