Nianzhuang Qiu
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View article: Mll5 haploinsufficiency attenuates microglial phagocytosis through dysregulated TREM2-SGK3-GSK3β signaling in autism
Mll5 haploinsufficiency attenuates microglial phagocytosis through dysregulated TREM2-SGK3-GSK3β signaling in autism Open
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by persistent deficits in social communication and repetitive behaviors. Recent studies indicated that heterozygous mutations in the mixed lineage leukem…
View article: Cognitive improvement effects of PF-04957325, a phosphodiesterase-8 inhibitor, in mouse models of Alzheimer’s disease via modulating neuroinflammation
Cognitive improvement effects of PF-04957325, a phosphodiesterase-8 inhibitor, in mouse models of Alzheimer’s disease via modulating neuroinflammation Open
Background Alzheimer’s disease (AD) is a neurodegenerative disease characterized by memory deficit and has emerged as a growing global health concern. Phosphodiesterase-8 (PDE8) is a cyclic adenosine monophosphate (cAMP)-specific hydrolase…
View article: Computer-aided discovery of triazolothiadiazoles as DYRK1A-targeted neuroprotective agents
Computer-aided discovery of triazolothiadiazoles as DYRK1A-targeted neuroprotective agents Open
We have discovered a potent DYRK1A inhibitor Y16-5 by virtual screening and in vitro biological evaluation. This compound showed strong in vitro neuroprotective activity and favorable druglikeness.
View article: Discovery of a Novel Chemotype as DYRK1A Inhibitors against Alzheimer’s disease: Computational Modeling and Biological Evaluation
Discovery of a Novel Chemotype as DYRK1A Inhibitors against Alzheimer’s disease: Computational Modeling and Biological Evaluation Open
Dual specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) plays an essential role in tau and Aβ pathology closely related to Alzheimer’s disease (AD). Accumulative evidence has demonstrated DYRK1A inhibition is able to reduce …
View article: Discovery of a novel DYRK1A Inhibitor with neuroprotective activity by virtual screening and in vitro biological evaluation
Discovery of a novel DYRK1A Inhibitor with neuroprotective activity by virtual screening and in vitro biological evaluation Open
Dual specificity tyrosine phosphorylation regulated kinase 1A (DYRK1A) is implicated in accumulation of amyloid β-protein (Aβ), phosphorylation of Tau proteins, and may eventually cause neurodegenerative diseases. Though many DYRK1A inhibi…
View article: Depression-like Behavior and Alterations of Neurotransmitters and the Corresponding Receptors in the Triple Transgenic Mouse Model of Alzheimer's Disease
Depression-like Behavior and Alterations of Neurotransmitters and the Corresponding Receptors in the Triple Transgenic Mouse Model of Alzheimer's Disease Open
Backgrounds: Depression is among the most frequent psychiatric comorbid conditions in Alzheimer’s disease (AD). However, pharmacotherapy for depressive disorders in AD is still a big challenge；current antidepressants used clinically, such …