Mushtaq Hussain
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View article: From Addiction to Recovery: The Role of Personal Coping Mechanisms in Preventing Relapse Among Recovering Drug Users
From Addiction to Recovery: The Role of Personal Coping Mechanisms in Preventing Relapse Among Recovering Drug Users Open
Substance use disorder (SUD) is a significant public health challenge with multifaceted etiologies and limited effective relapse prevention strategies. For individuals recovering from substance use disorder, self-help or personal coping me…
View article: Integrating genetics into medical curriculum: evaluating a dedicated clinical genetics module at Dow university of health sciences
Integrating genetics into medical curriculum: evaluating a dedicated clinical genetics module at Dow university of health sciences Open
The clinical genetics module at DUHS was well received, effectively enhancing students' understanding of genetic principles and their clinical applications. Students highly rated the module for content clarity, lecture engagement, and rele…
View article: Prevalence of Urinary Tract Infection and Urosepsis Following Transrectal Ultrasound-Guided Prostate Biopsy: Spectrum of Pathogens and Patterns of Antibiotic Resistance
Prevalence of Urinary Tract Infection and Urosepsis Following Transrectal Ultrasound-Guided Prostate Biopsy: Spectrum of Pathogens and Patterns of Antibiotic Resistance Open
Introduction Transrectal ultrasound-guided prostate biopsy (TRUS-Bx) remains the global standard for diagnosing prostate cancer. Despite being a relatively safe procedure, it carries a risk of post-biopsy complications, most notably urinar…
View article: Clinical and Angiographic Profile of Acute Coronary Syndrome: Insights From a Tertiary Care Center in an Industrial Area
Clinical and Angiographic Profile of Acute Coronary Syndrome: Insights From a Tertiary Care Center in an Industrial Area Open
[This corrects the article DOI: 10.7759/cureus.83805.].
View article: Clinical and Angiographic Profile of Acute Coronary Syndrome: Insights From a Tertiary Care Center in an Industrial Area
Clinical and Angiographic Profile of Acute Coronary Syndrome: Insights From a Tertiary Care Center in an Industrial Area Open
Background Acute coronary syndrome (ACS) patterns may be modified by environmental factors in industrial regions. This study examines the clinical and angiographic profile of ACS patients in a polluted industrial area of Eastern India. Met…
View article: Developmental exposure of antibiotics shortens life span and induces teratogenicity in Drosophila melanogaster
Developmental exposure of antibiotics shortens life span and induces teratogenicity in Drosophila melanogaster Open
View article: Energy-Efficient Communication Protocols for Massive IoT Deployments: Green IoT
Energy-Efficient Communication Protocols for Massive IoT Deployments: Green IoT Open
The Internet of Things (IoT) is a rapidly growing technology that connects billions of devices, generating significant energy consumption. However, this energy consumption is a significant concern for the environment. Green IoT aims to red…
View article: Energy-Efficient Communication Protocols for Massive IoT Deployments: Green IoT
Energy-Efficient Communication Protocols for Massive IoT Deployments: Green IoT Open
The Internet of Things (IoT) is a rapidly growing technology that connects billions of devices, generating significant energy consumption. However, this energy consumption is a significant concern for the environment. Green IoT aims to red…
View article: AI in Drug Discovery for Antimicrobial Resistance: Combating the Silent Pandemic
AI in Drug Discovery for Antimicrobial Resistance: Combating the Silent Pandemic Open
Antimicrobial resistance (AMR) is a serious threat to global health and could render efforts aimed at keeping antibiotics working and killing millions of people each year ineffective. The presence of these weaknesses and our deficiencies i…
View article: AI in Drug Discovery for Antimicrobial Resistance: Combating the Silent Pandemic
AI in Drug Discovery for Antimicrobial Resistance: Combating the Silent Pandemic Open
Antimicrobial resistance (AMR) is a serious threat to global health and could render efforts aimed at keeping antibiotics working and killing millions of people each year ineffective. The presence of these weaknesses and our deficiencies i…
View article: Integration of hydro-chemical analysis and GIS for assessment of drinking water quality and health risks of filtration plants in Rawalpindi, Pakistan
Integration of hydro-chemical analysis and GIS for assessment of drinking water quality and health risks of filtration plants in Rawalpindi, Pakistan Open
The present study is about vast domain of water quality analysis, encompassing a comprehensive exploration of physical, chemical parameters and heavy metals i.e., Cadmium and lead, which determined the quality and composition of drinking w…
View article: WHOLE GENOME SEQUENCE OF SARS-COV-2 FROM COVID-19 ACQUIRED HEMOPHILIA PATIENT
WHOLE GENOME SEQUENCE OF SARS-COV-2 FROM COVID-19 ACQUIRED HEMOPHILIA PATIENT Open
Intro: Acquired hemophilia is an atypical pathology of SARS-CoV-2 infection, which could be variant associated. Here, we share a sequence of the SARS-CoV-2 genome from patient with COVID-19 acquired haemophilia. We explore its lineage, gen…
View article: Anatomical transition of trilaminar cerebellar cortex between reptiles and Aves
Anatomical transition of trilaminar cerebellar cortex between reptiles and Aves Open
Background: Motor coordination in vertebrates is primarily regulated by cerebellum. Divergence of aves from reptilian ancestors results in noticeable improvement in the motor coordination. This study aims to explore anatomical innovations …
View article: Inbreeding-Driven Innate Behavioral Changes in Drosophila melanogaster
Inbreeding-Driven Innate Behavioral Changes in Drosophila melanogaster Open
Drosophila melanogaster has long been used to demonstrate the effect of inbreeding, particularly in relation to reproductive fitness and stress tolerance. In comparison, less attention has been given to exploring the influence of inbreedin…
View article: On-Site Sequencing Of Sars-Cov-2 Genomes Identify Two Variant Of Concern Clusters In Pahang, Malaysia
On-Site Sequencing Of Sars-Cov-2 Genomes Identify Two Variant Of Concern Clusters In Pahang, Malaysia Open
Timely variant identification is required in respond to effective public health measures. It has been demonstrated that comprehending genetic epidemiology can be aided by a combination of public health expertise and through viral genomic s…
View article: Comparative Histological Analysis of Cerebellum of Representative Species of Elasmobranchii
Comparative Histological Analysis of Cerebellum of Representative Species of Elasmobranchii Open
In elasmobranch fishes, variations in gross structural organization of cerebellum has been extensively explored. The basic histological features of cerebellum although conserved in the group but the comparative account on subtle cellular v…
View article: Investigating In Situ Expression of c-MYC and Candidate Ubiquitin-Specific Proteases in DLBCL and Assessment for Peptidyl Disruptor Molecule against c-MYC-USP37 Complex
Investigating In Situ Expression of c-MYC and Candidate Ubiquitin-Specific Proteases in DLBCL and Assessment for Peptidyl Disruptor Molecule against c-MYC-USP37 Complex Open
Diffuse Large B-Cell Lymphoma (DLBCL) is the most common form of non-Hodgkin’s lymphoma (NHL). Elevated expression of c-MYC in DLBCL is associated with poor prognosis of the disease. In different cancers, c-MYC has been found regulated by …
View article: The Frequency Of Tibial Shaft Fractures That Fail To Mend Properly Despite The Use Of Locking Plates. A Case Study Series
The Frequency Of Tibial Shaft Fractures That Fail To Mend Properly Despite The Use Of Locking Plates. A Case Study Series Open
BACKGROUND: Fractures of the tibia often result from accidents and falls. Treatment for an open fracture Tibia is challenging for orthopedics and plastic surgeons. Several treatment options are available for tibia fractures, including cons…
View article: Molecular Systems Network Predicts Sars-Cov-2 NSP3 and Orf6 Role in COVID-19 Related Thrombotic Events
Molecular Systems Network Predicts Sars-Cov-2 NSP3 and Orf6 Role in COVID-19 Related Thrombotic Events Open
Background: Pathological advancement of SARS-CoV-2 infection entails engagement of blood related ailment including thrombosis as one of the clinical manifestations. SARS-CoV-2-Human protein-protein and protein-RNA interactomes have been ex…
View article: Aggression Assessment and Plasma Serotonin Level amongst Pakistani Youngsters
Aggression Assessment and Plasma Serotonin Level amongst Pakistani Youngsters Open
Background: Aggressive behavior is a multifaceted construct involving various physiological modulators and genetic factors with a variable frequency in different populations. Of multiple genetic factors, serotonin is known to have profound…
View article: Design and Immunoinformatic Assessment of Candidate Multivariant mRNA Vaccine Construct against Immune Escape Variants of SARS-CoV-2
Design and Immunoinformatic Assessment of Candidate Multivariant mRNA Vaccine Construct against Immune Escape Variants of SARS-CoV-2 Open
To effectively counter the evolving threat of SARS-CoV-2 variants, modifications and/or redesigning of mRNA vaccine construct are essentially required. Herein, the design and immunoinformatic assessment of a candidate novel mRNA vaccine co…
View article: The incidence of fractures in the tibial shaft that do not heal properly despite the use of locking plates.A case series study.
The incidence of fractures in the tibial shaft that do not heal properly despite the use of locking plates.A case series study. Open
INTRODUCTION: Fractures of the tibia are often the consequence of accidents and falls. Treatment for an open fracture Tibia is a challenging issue for both orthopaedic and plastic surgeons. There are several treatment options available for…
View article: Whole genome sequence analysis showing unique SARS-CoV-2 lineages of B.1.524 and AU.2 in Malaysia
Whole genome sequence analysis showing unique SARS-CoV-2 lineages of B.1.524 and AU.2 in Malaysia Open
SARS-CoV-2 has spread throughout the world since its discovery in China, and Malaysia is no exception. WGS has been a crucial approach in studying the evolution and genetic diversity of SARS-CoV-2 in the ongoing pandemic. Despite considera…
View article: Toronto’s Urban Heat Island : Exploring the Relationship between Land Use and Surface Temperature
Toronto’s Urban Heat Island : Exploring the Relationship between Land Use and Surface Temperature Open
The urban heat island effect is linked to the built environment and threatens human health during extreme heat events. In this study, we analyzed whether characteristic land uses within an urban area are associated with higher or lower s…
View article: Toronto’s Urban Heat Island : Exploring the Relationship between Land Use and Surface Temperature
Toronto’s Urban Heat Island : Exploring the Relationship between Land Use and Surface Temperature Open
The urban heat island effect is linked to the built environment and threatens human health during extreme heat events. In this study, we analyzed whether characteristic land uses within an urban area are associated with higher or lower s…
View article: Immunoinformatic analysis of structural and epitope variations in the spike and Orf8 proteins of SARS‐CoV‐2/B.1.1.7
Immunoinformatic analysis of structural and epitope variations in the spike and Orf8 proteins of SARS‐CoV‐2/B.1.1.7 Open
A newly emerged strain of SARS‐CoV‐2 of B.1.1.7 lineage has caused a significant surge in the SARS‐CoV‐2 infections in the UK. In this study, changes in the epitopes of spike and orf8 proteins in SARS‐CoV‐2 of B.1.1.7 lineage were investig…
View article: Production and antimicrobial activity of silver nanoparticles synthesized from indigenously isolated Pseudomonas aeruginosa from Rhizosphere.
Production and antimicrobial activity of silver nanoparticles synthesized from indigenously isolated Pseudomonas aeruginosa from Rhizosphere. Open
Nanoparticles hold profound biological, pharmaceutical and industrial applications. Green synthesis of nanoparticles is considered amongst the environmentally safe and cost effective method of nanoparticle synthesis. Briefly, Pseudomonas s…
View article: Dataset for homologous proteins in Drosophila melanogaster for SARS-CoV-2/human interactome
Dataset for homologous proteins in Drosophila melanogaster for SARS-CoV-2/human interactome Open
Animal modelling for infectious diseases is critical to understand the biology of the pathogens including viruses and to develop therapeutic strategies against it. Herein, we present the sequence homology and expression data analysis of pr…
View article: Pharmacogenetics of sulfonylurea: Presence of CYP2C9*2, CYP2C9*3 and a novel allele, CYP2C9*61, in Type 2 diabetes patients under sulfonylurea therapy.
Pharmacogenetics of sulfonylurea: Presence of CYP2C9*2, CYP2C9*3 and a novel allele, CYP2C9*61, in Type 2 diabetes patients under sulfonylurea therapy. Open
CYP2C9 is an important member of the cytochrome P450 gene family involved in the metabolism of 15% of the drugs including an oral antidiabetic agent sulfonylurea. This study aims to investigate the frequency of CYP2C9*2 and CYP2C9*3 allele…
View article: Structural Basis of SARS-CoV-2 Spike Protein Priming by TMPRSS2
Structural Basis of SARS-CoV-2 Spike Protein Priming by TMPRSS2 Open
Entry of SARS-CoV-2, etiological agent of COVID-19, in the host cell is driven by the interaction of its spike protein with human ACE2 receptor and a serine protease, TMPRSS2. Although complex between SARS-CoV-2 spike protein and ACE2 has …