Niccolò Arecco
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View article: TAF2 condensation in nuclear speckles links basal transcription factor TFIID to RNA splicing factors
TAF2 condensation in nuclear speckles links basal transcription factor TFIID to RNA splicing factors Open
TFIID is an essential basal transcription factor, crucial for RNA polymerase II (pol II) promoter recognition and transcription initiation. The TFIID complex consists of the TATA binding protein (TBP) and 13 TBP-associated factors (TAFs) t…
View article: Alternative splicing decouples local from global PRC2 activity
Alternative splicing decouples local from global PRC2 activity Open
View article: TAF2 condensation in nuclear speckles links basal transcription factor TFIID to RNA splicing
TAF2 condensation in nuclear speckles links basal transcription factor TFIID to RNA splicing Open
Summary TFIID is an essential basal transcription factor, crucial for RNA polymerase II (pol II) promoter recognition and transcription initiation. The TFIID complex consists of the TATA-binding protein (TBP) and 13 TBP-associated factors …
View article: Alternative splicing decouples local from global PRC2 activity
Alternative splicing decouples local from global PRC2 activity Open
The Polycomb repressive complex 2 (PRC2) mediates epigenetic maintenance of gene silencing in eukaryotes via methylation of histone H3 at lysine 27 (H3K27). This complex interacts with sets of accessory factors to form two distinct subtype…
View article: Controlled X‐chromosome dynamics defines meiotic potential of female mouse <i>in vitro</i> germ cells
Controlled X‐chromosome dynamics defines meiotic potential of female mouse <i>in vitro</i> germ cells Open
The mammalian germline is characterized by extensive epigenetic reprogramming during its development into functional eggs and sperm. Specifically, the epigenome requires resetting before parental marks can be established and transmitted to…
View article: The neurodevelopmental disorder-linked PHF14 complex that forms biomolecular condensates detects DNA damage and promotes repair
The neurodevelopmental disorder-linked PHF14 complex that forms biomolecular condensates detects DNA damage and promotes repair Open
Numerous chromatin-associated proteins have been linked to neurodevelopmental disorders, yet their molecular functions often remain elusive. PHF14, HMG20A, TCF20 and RAI1 are components of a putative chromatin-associated complex and have b…
View article: A temporally controlled sequence of X-chromosome inactivation and reactivation defines female mouse <i>in vitro</i> germ cells with meiotic potential
A temporally controlled sequence of X-chromosome inactivation and reactivation defines female mouse <i>in vitro</i> germ cells with meiotic potential Open
The early mammalian germ cell lineage is characterized by extensive epigenetic reprogramming, which is required for the maturation into functional eggs and sperm. In particular, the epigenome needs to be reset before parental marks can be …
View article: From research to rapid response: mass COVID-19 testing by volunteers at the Centre for Genomic Regulation
From research to rapid response: mass COVID-19 testing by volunteers at the Centre for Genomic Regulation Open
The COVID-19 pandemic has posed and is continuously posing enormous societal and health challenges worldwide. The research community has mobilized to develop novel projects to find a cure or a vaccine, as well as to contribute to mass test…