Nicholas A. Buckley
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View article: The risk of death after hospitalisation following intentional self‐poisoning: a retrospective observational study (<scp>PAVLOVA</scp>‐2)
The risk of death after hospitalisation following intentional self‐poisoning: a retrospective observational study (<span>PAVLOVA</span>‐2) Open
Objectives To estimate the risk of death after hospitalisation with non‐fatal intentional self‐poisoning in New South Wales, and to estimate the associated number of years of life lost. Study design Retrospective observational study; analy…
View article: Post-injection delirium/sedation syndrome from long-acting olanzapine intramuscular injection is rapidly reversed with physostigmine and rivastigmine
Post-injection delirium/sedation syndrome from long-acting olanzapine intramuscular injection is rapidly reversed with physostigmine and rivastigmine Open
Our patients support the hypothesis that post-injection delirium/sedation syndrome includes an antimuscarinic mechanism responsive to acetylcholinesterase inhibitors. Early administration of physostigmine, followed by rivastigmine, may be …
View article: Sex/gender differences in clinical pharmacology: A perspective from the IUPHAR World Smart Medication Day 2025
Sex/gender differences in clinical pharmacology: A perspective from the IUPHAR World Smart Medication Day 2025 Open
View article: Cardiometabolic adverse effects of long-term antipsychotic treatment in children and adolescents with non-psychotic disorders: a systematic review of available evidence
Cardiometabolic adverse effects of long-term antipsychotic treatment in children and adolescents with non-psychotic disorders: a systematic review of available evidence Open
Antipsychotics are known to cause cardiovascular and metabolic adverse effects, but there is less evidence for their use off-label, especially in children and adolescents. Such treatments may be administered over long durations. We conduct…
View article: Balancing Act: Digoxin Antidote Supply and Demand in New South Wales, Australia
Balancing Act: Digoxin Antidote Supply and Demand in New South Wales, Australia Open
Objectives This study aims to evaluate the supply and demand of digoxin antibody (Digoxin‐Fab) in New South Wales (NSW) hospitals before and after the updated Therapeutic Guidelines (TG) for digoxin poisoning introduced in August 2020. We …
View article: Trends in use of sodium-glucose cotransporter 2 inhibitors among people with type 2 diabetes following hospitalisation with heart failure: A population-based study
Trends in use of sodium-glucose cotransporter 2 inhibitors among people with type 2 diabetes following hospitalisation with heart failure: A population-based study Open
While SGLT2i use has increased among people with T2D hospitalised with HF, uptake remains low. Optimising medication use at transitions from hospital to community care may ensure clinical benefits of these medicines are realised.
View article: Disparities in Opioid Agonist Treatment Accessibility for Priority Populations in New South Wales, Australia
Disparities in Opioid Agonist Treatment Accessibility for Priority Populations in New South Wales, Australia Open
Introduction Opioid agonist treatment (OAT) is effective for managing opioid dependence; however, it can be hard to access in some regions. We investigated OAT access for priority populations living in New South Wales, Australia: Aborigina…
View article: Nephrotoxicity biomarkers following propanil (3,4-dichloropropionanilide) self-poisoning
Nephrotoxicity biomarkers following propanil (3,4-dichloropropionanilide) self-poisoning Open
Patients with propanil self-poisoning exhibited reversible kidney injury diagnosable using serum creatinine concentrations within 4 h. Although other biomarkers were increased, they were not effective for early diagnosis.
View article: Patterns of medicine use in the year prior to death by suicide: an Australian population-based case series study
Patterns of medicine use in the year prior to death by suicide: an Australian population-based case series study Open
This study is funded by a grant from the Australian National Health and Medical Research Council (NHMRC) and the Translational Australian Clinical Toxicology Research (TACT) Group.
View article: Restrictions on Pesticides and Deliberate Self-Poisoning in Sri Lanka
Restrictions on Pesticides and Deliberate Self-Poisoning in Sri Lanka Open
Importance Deliberate self-poisoning using pesticides as a means of suicide is an important public health problem in low- and middle-income countries. Three highly toxic pesticides—dimethoate, fenthion, and paraquat—were removed from the m…
View article: Clinical toxicology of acute glyphosate self-poisoning: impact of plasma concentrations of glyphosate, its metabolite and polyethoxylated tallow amine surfactants on the toxicity
Clinical toxicology of acute glyphosate self-poisoning: impact of plasma concentrations of glyphosate, its metabolite and polyethoxylated tallow amine surfactants on the toxicity Open
Plasma concentrations of glyphosate and its metabolite predicted the severity of clinical toxicity in glyphosate poisoning. The co-formulated polyethoxylated tallow amine surfactants were even more strongly predictive of acute kidney injur…
View article: Navigating methotrexate toxicity: Examining the therapeutic roles of folinic acid and glucarpidase
Navigating methotrexate toxicity: Examining the therapeutic roles of folinic acid and glucarpidase Open
Methotrexate (MTX) toxicity varies depending on factors such as dosing frequency (acute or repeated), dosage (low or high) and the administration route (oral, parenteral or intrathecal). Renal impairment can trigger or exacerbate MTX toxic…
View article: Adult Medicine—Aotearoa New Zealand
Adult Medicine—Aotearoa New Zealand Open
View article: Serial repetitive nerve stimulation studies in organophosphorus poisoning indicate two distinct pathophysiological processes occur at the neuromuscular junction in the intermediate syndrome
Serial repetitive nerve stimulation studies in organophosphorus poisoning indicate two distinct pathophysiological processes occur at the neuromuscular junction in the intermediate syndrome Open
There are two easily distinguishable pathophysiological abnormalities in the neuromuscular block in intermediate syndrome. While they often coincide, both may be observed in isolation. The total and rate-dependent block at 30 Hertz are str…
View article: Impact of coordinated care on adherence to antihypertensive medicines among adults experiencing polypharmacy in Australia
Impact of coordinated care on adherence to antihypertensive medicines among adults experiencing polypharmacy in Australia Open
Background: Adherence to antihypertensives is key for blood pressure control. Most people with hypertension have several comorbidities and require multiple medicines, leading to complex care pathways. Strategies for coordinating medicine u…
View article: Correction: Neonatal blood lead concentration predicts medium term lead-related outcomes in children ≤5 years old with congenital lead poisoning: A retrospective cohort study in Northern Nigeria
Correction: Neonatal blood lead concentration predicts medium term lead-related outcomes in children ≤5 years old with congenital lead poisoning: A retrospective cohort study in Northern Nigeria Open
[This corrects the article DOI: 10.1371/journal.pgph.0001644.].
View article: Interventional procedures for chronic spine pain: A systematic review and network meta-analysis of randomised trials
Interventional procedures for chronic spine pain: A systematic review and network meta-analysis of randomised trials Open
View article: A Non-Inferiority Randomised Controlled Trial of a Shorter Acetylcysteine Regimen for Paracetamol Overdose – The SARPO Trial
A Non-Inferiority Randomised Controlled Trial of a Shorter Acetylcysteine Regimen for Paracetamol Overdose – The SARPO Trial Open
View article: Intestinal injury in paracetamol overdose (ATOM‐8)
Intestinal injury in paracetamol overdose (ATOM‐8) Open
Background and Aim Paracetamol, a widely used medication, is known for its delayed hepatotoxicity in cases of overdose. However, the potential for intestinal toxicity resulting from very high paracetamol concentrations during absorption is…
View article: On- and off-label utilisation of antipsychotics in Australia (2000–2021): Retrospective analysis of two medication datasets
On- and off-label utilisation of antipsychotics in Australia (2000–2021): Retrospective analysis of two medication datasets Open
Objective: To determine antipsychotic utilisation patterns in Australian adults from 2005 to 2021, with a focus on on-label and off-label prescriptions. Methods: We examined antipsychotic dispensing trends in adults from 2005 to 2021 using…
View article: Five healthcare trajectories in the year before suicide and what they tell us about opportunities for prevention: a population-level case series study
Five healthcare trajectories in the year before suicide and what they tell us about opportunities for prevention: a population-level case series study Open
Australia's National Health and Medical Research Council.
View article: Substances Detected During Coroner Postmortem Toxicology Analyses in Poisoning- and Nonpoisoning-Related Suicides
Substances Detected During Coroner Postmortem Toxicology Analyses in Poisoning- and Nonpoisoning-Related Suicides Open
Importance Determining the association between drug use and suicide is complicated but can help to inform targeted suicide prevention strategies. Objective To examine the substances prevalent in poisoning- and nonpoisoning-related suicides…
View article: Persistence and Adherence to Cardiovascular Medicines in Australia
Persistence and Adherence to Cardiovascular Medicines in Australia Open
Background The burden of cardiovascular disease is increasing, with many people treated for multiple cardiovascular conditions. We examined persistence and adherence to medicines for cardiovascular disease treatment or prevention in Austra…
View article: Paracetamol (acetaminophen) overdose and hepatotoxicity: mechanism, treatment, prevention measures, and estimates of burden of disease
Paracetamol (acetaminophen) overdose and hepatotoxicity: mechanism, treatment, prevention measures, and estimates of burden of disease Open
Paracetamol is one of the most used medicines worldwide and is the most common important poisoning in high-income countries. In overdose, paracetamol causes dose-dependent hepatotoxicity. Acetylcysteine is an effective antidote, however de…
View article: Neonatal blood lead concentration predicts medium term lead-related outcomes in children ≤5 years old with congenital lead poisoning: A retrospective cohort study in Northern Nigeria
Neonatal blood lead concentration predicts medium term lead-related outcomes in children ≤5 years old with congenital lead poisoning: A retrospective cohort study in Northern Nigeria Open
Mother-to-child-transmission of lead via the placenta is known to result in congenital lead toxicity. Between 2010 and 2021, Médecins Sans Frontières and other stakeholders responded to a severe lead poisoning outbreak related to artisanal…
View article: The Effect of Pesticide Restrictions on Deliberate Self-Poisoning in Sri Lanka
The Effect of Pesticide Restrictions on Deliberate Self-Poisoning in Sri Lanka Open
View article: Epidemiology and renal injury following 2-methyl-4-chlorophenoxyacetic acid (MCPA) poisoning
Epidemiology and renal injury following 2-methyl-4-chlorophenoxyacetic acid (MCPA) poisoning Open
View article: Trends in dispensing and utilisation of sustained-release tapentadol in Australia.
Trends in dispensing and utilisation of sustained-release tapentadol in Australia. Open
ObjectivesTapentadol is a µ-opioid agonist, moderate noradrenaline reuptake inhibitor (NRI) and very weak serotonin reuptake inhibitor. The sustained release (SR) formulation is indicated for relief of chronic moderate to severe pain. We e…
View article: Acute fungicide self-poisoning - a prospective case series
Acute fungicide self-poisoning - a prospective case series Open
Fungicide self-poisoning appears to be less hazardous than insecticide or herbicide self-poisoning, with a substantially lower case fatality in the same cohort. Edifenphos is an exception to this 'less toxic' rule; as a WHO Class Ib highly…
View article: Prescribing trend of tapentadol in a Sydney local health district
Prescribing trend of tapentadol in a Sydney local health district Open
Aims Tapentadol, an opioid with mu‐opioid receptor agonism and noradrenaline reuptake inhibition, has been increasingly used in Australia since 2011. However, data on hospital prescribing trends and indications are scarce. This study aimed…