Nicholas A. Clark
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View article: Integration of multi-modal measurements identifies critical mechanisms of tuberculosis drug action
Integration of multi-modal measurements identifies critical mechanisms of tuberculosis drug action Open
View article: Figure S2 from Coordinated Targeting of S6K1/2 and AXL Disrupts Pyrimidine Biosynthesis in PTEN-Deficient Glioblastoma
Figure S2 from Coordinated Targeting of S6K1/2 and AXL Disrupts Pyrimidine Biosynthesis in PTEN-Deficient Glioblastoma Open
Gliomasphere drug responses
View article: Figure S1 from Coordinated Targeting of S6K1/2 and AXL Disrupts Pyrimidine Biosynthesis in PTEN-Deficient Glioblastoma
Figure S1 from Coordinated Targeting of S6K1/2 and AXL Disrupts Pyrimidine Biosynthesis in PTEN-Deficient Glioblastoma Open
Tumor growth and body weight
View article: Supplementary Table S2 from Coordinated Targeting of S6K1/2 and AXL Disrupts Pyrimidine Biosynthesis in PTEN-Deficient Glioblastoma
Supplementary Table S2 from Coordinated Targeting of S6K1/2 and AXL Disrupts Pyrimidine Biosynthesis in PTEN-Deficient Glioblastoma Open
Metabolites
View article: Figure S3 from Coordinated Targeting of S6K1/2 and AXL Disrupts Pyrimidine Biosynthesis in PTEN-Deficient Glioblastoma
Figure S3 from Coordinated Targeting of S6K1/2 and AXL Disrupts Pyrimidine Biosynthesis in PTEN-Deficient Glioblastoma Open
Glucose flux
View article: Supplementary Table S3 from Coordinated Targeting of S6K1/2 and AXL Disrupts Pyrimidine Biosynthesis in PTEN-Deficient Glioblastoma
Supplementary Table S3 from Coordinated Targeting of S6K1/2 and AXL Disrupts Pyrimidine Biosynthesis in PTEN-Deficient Glioblastoma Open
Glucose flux
View article: The 2D Materials Roadmap
The 2D Materials Roadmap Open
Over the past two decades, 2D materials have rapidly evolved into a diverse and expanding family of material platforms. Many members of this materials class have demonstrated their potential to deliver transformative impact on fundamental …
View article: Supplementary Table S4 from Coordinated Targeting of S6K1/2 and AXL Disrupts Pyrimidine Biosynthesis in PTEN-Deficient Glioblastoma
Supplementary Table S4 from Coordinated Targeting of S6K1/2 and AXL Disrupts Pyrimidine Biosynthesis in PTEN-Deficient Glioblastoma Open
Kinativ
View article: Supplementary Table S1 from Coordinated Targeting of S6K1/2 and AXL Disrupts Pyrimidine Biosynthesis in PTEN-Deficient Glioblastoma
Supplementary Table S1 from Coordinated Targeting of S6K1/2 and AXL Disrupts Pyrimidine Biosynthesis in PTEN-Deficient Glioblastoma Open
Key Resources
View article: Figure S4 from Coordinated Targeting of S6K1/2 and AXL Disrupts Pyrimidine Biosynthesis in PTEN-Deficient Glioblastoma
Figure S4 from Coordinated Targeting of S6K1/2 and AXL Disrupts Pyrimidine Biosynthesis in PTEN-Deficient Glioblastoma Open
GSEA, Kinativ
View article: Mind the Value-Action Gap: Do LLMs Act in Alignment with Their Values?
Mind the Value-Action Gap: Do LLMs Act in Alignment with Their Values? Open
Existing research primarily evaluates the values of LLMs by examining their stated inclinations towards specific values. However, the "Value-Action Gap," a phenomenon rooted in environmental and social psychology, reveals discrepancies bet…
View article: Mind the Value-Action Gap: Do LLMs Act in Alignment with Their Values?
Mind the Value-Action Gap: Do LLMs Act in Alignment with Their Values? Open
View article: ValueCompass: A Framework for Measuring Contextual Value Alignment Between Human and LLMs
ValueCompass: A Framework for Measuring Contextual Value Alignment Between Human and LLMs Open
View article: Ensemble-Based Uncertainty Quantification for Reliable Large Language Model Classification in Social Data Applications
Ensemble-Based Uncertainty Quantification for Reliable Large Language Model Classification in Social Data Applications Open
Assessing classification confidence is essential for effectively leveraging Large Language Models (LLMs) in automated data labeling, particularly within the sensitive contexts of Computational Social Science (CSS) tasks. In this study, we …
View article: LLM Confidence Evaluation Measures in Zero-Shot CSS Classification
LLM Confidence Evaluation Measures in Zero-Shot CSS Classification Open
Assessing classification confidence is critical for leveraging large language models (LLMs) in automated labeling tasks, especially in the sensitive domains presented by Computational Social Science (CSS) tasks. In this paper, we make thre…
View article: Integration of multi-modal measurements identifies critical mechanisms of tuberculosis drug action
Integration of multi-modal measurements identifies critical mechanisms of tuberculosis drug action Open
Treatments for tuberculosis remain lengthy, motivating a search for new drugs with novel mechanisms of action. However, it remains challenging to elucidate the direct targets of a drug, and even more so, to determine which disrupted cellul…
View article: Coordinated targeting of S6K1/2 and AXL disrupts pyrimidine biosynthesis in PTEN-deficient glioblastoma
Coordinated targeting of S6K1/2 and AXL disrupts pyrimidine biosynthesis in PTEN-deficient glioblastoma Open
Intrinsic resistance to targeted therapeutics in PTEN-deficient glioblastoma (GBM) is mediated by redundant signaling networks that sustain critical metabolic functions. Here we demonstrate that coordinated inhibition of the ribosomal prot…
View article: LLM Confidence Evaluation Measures in Zero-Shot CSS Classification
LLM Confidence Evaluation Measures in Zero-Shot CSS Classification Open
Assessing classification confidence is critical for leveraging large language models (LLMs) in automated labeling tasks, especially in the sensitive domains presented by Computational Social Science (CSS) tasks. In this paper, we make thre…
View article: Supplementary Table S3 from Coordinated Targeting of S6K1/2 and AXL Disrupts Pyrimidine Biosynthesis in PTEN-Deficient Glioblastoma
Supplementary Table S3 from Coordinated Targeting of S6K1/2 and AXL Disrupts Pyrimidine Biosynthesis in PTEN-Deficient Glioblastoma Open
Glucose flux
View article: Supplementary Table S4 from Coordinated Targeting of S6K1/2 and AXL Disrupts Pyrimidine Biosynthesis in PTEN-Deficient Glioblastoma
Supplementary Table S4 from Coordinated Targeting of S6K1/2 and AXL Disrupts Pyrimidine Biosynthesis in PTEN-Deficient Glioblastoma Open
Kinativ
View article: Figure 4 from Coordinated Targeting of S6K1/2 and AXL Disrupts Pyrimidine Biosynthesis in PTEN-Deficient Glioblastoma
Figure 4 from Coordinated Targeting of S6K1/2 and AXL Disrupts Pyrimidine Biosynthesis in PTEN-Deficient Glioblastoma Open
Targeting requirements in the S6K1/S6K2 network. A and B, S6 phosphorylation was reduced only upon genetic silencing of both S6K1 and S6K2 in LN229 GBM cells. C, Combined inactivation of S6K1 and S6K2 via sgRNA and siR…
View article: Figure 5 from Coordinated Targeting of S6K1/2 and AXL Disrupts Pyrimidine Biosynthesis in PTEN-Deficient Glioblastoma
Figure 5 from Coordinated Targeting of S6K1/2 and AXL Disrupts Pyrimidine Biosynthesis in PTEN-Deficient Glioblastoma Open
S6K2 and AXL have an effector—regulator relationship. A, GSEA identified an AXL response signature in RNA sequence analysis of sgS6K2 LN229 GBM cells. B and C, sgNT or sgS6K2 (exon 9) GBM U87MG-GFP-Luc (B) or LN…
View article: Figure S2 from Coordinated Targeting of S6K1/2 and AXL Disrupts Pyrimidine Biosynthesis in PTEN-Deficient Glioblastoma
Figure S2 from Coordinated Targeting of S6K1/2 and AXL Disrupts Pyrimidine Biosynthesis in PTEN-Deficient Glioblastoma Open
Gliomasphere drug responses
View article: Figure S1 from Coordinated Targeting of S6K1/2 and AXL Disrupts Pyrimidine Biosynthesis in PTEN-Deficient Glioblastoma
Figure S1 from Coordinated Targeting of S6K1/2 and AXL Disrupts Pyrimidine Biosynthesis in PTEN-Deficient Glioblastoma Open
Tumor growth and body weight
View article: Supplementary Table S2 from Coordinated Targeting of S6K1/2 and AXL Disrupts Pyrimidine Biosynthesis in PTEN-Deficient Glioblastoma
Supplementary Table S2 from Coordinated Targeting of S6K1/2 and AXL Disrupts Pyrimidine Biosynthesis in PTEN-Deficient Glioblastoma Open
Metabolites
View article: Figure 4 from Coordinated Targeting of S6K1/2 and AXL Disrupts Pyrimidine Biosynthesis in PTEN-Deficient Glioblastoma
Figure 4 from Coordinated Targeting of S6K1/2 and AXL Disrupts Pyrimidine Biosynthesis in PTEN-Deficient Glioblastoma Open
Targeting requirements in the S6K1/S6K2 network. A and B, S6 phosphorylation was reduced only upon genetic silencing of both S6K1 and S6K2 in LN229 GBM cells. C, Combined inactivation of S6K1 and S6K2 via sgRNA and siR…
View article: Supplementary Table S2 from Coordinated Targeting of S6K1/2 and AXL Disrupts Pyrimidine Biosynthesis in PTEN-Deficient Glioblastoma
Supplementary Table S2 from Coordinated Targeting of S6K1/2 and AXL Disrupts Pyrimidine Biosynthesis in PTEN-Deficient Glioblastoma Open
Metabolites
View article: Figure 1 from Coordinated Targeting of S6K1/2 and AXL Disrupts Pyrimidine Biosynthesis in PTEN-Deficient Glioblastoma
Figure 1 from Coordinated Targeting of S6K1/2 and AXL Disrupts Pyrimidine Biosynthesis in PTEN-Deficient Glioblastoma Open
Combination S6K1 and AXL targeting reduces PTEN-deficient glioblastoma tumors in vivo. A, Combination S6K1 and AXL inhibitors, LY-2584702 and BMS-777607, respectively, reduced subcutaneous tumor volumes. Nude mice were implan…
View article: Supplementary Table S1 from Coordinated Targeting of S6K1/2 and AXL Disrupts Pyrimidine Biosynthesis in PTEN-Deficient Glioblastoma
Supplementary Table S1 from Coordinated Targeting of S6K1/2 and AXL Disrupts Pyrimidine Biosynthesis in PTEN-Deficient Glioblastoma Open
Key Resources
View article: Supplementary Table S3 from Coordinated Targeting of S6K1/2 and AXL Disrupts Pyrimidine Biosynthesis in PTEN-Deficient Glioblastoma
Supplementary Table S3 from Coordinated Targeting of S6K1/2 and AXL Disrupts Pyrimidine Biosynthesis in PTEN-Deficient Glioblastoma Open
Glucose flux