Nicholas A. Shaff
YOU?
Author Swipe
View article: Diffusion magnetic resonance spectroscopy captures microglial reactivity related to gut-derived systemic lipopolysaccharide: A preliminary study
Diffusion magnetic resonance spectroscopy captures microglial reactivity related to gut-derived systemic lipopolysaccharide: A preliminary study Open
Neuroinflammation is a key component underlying multiple neurological disorders, yet non-invasive and cost-effective assessment of in vivo neuroinflammatory processes in the central nervous system remains challenging. Diffusion weighted ma…
View article: Abnormal Cerebrovascular Activity, Perfusion, and Glymphatic Clearance in Lewy Body Diseases
Abnormal Cerebrovascular Activity, Perfusion, and Glymphatic Clearance in Lewy Body Diseases Open
Cerebrovascular activity is not only crucial to optimal cerebral perfusion, but also plays an important role in the glymphatic clearance of interstitial waste, including α‐synuclein. This highlights a need to evaluate how cerebrovascular a…
View article: Lesion network mapping of eye-opening apraxia
Lesion network mapping of eye-opening apraxia Open
Apraxia of eyelid opening (or eye-opening apraxia) is characterized by the inability to voluntarily open the eyes because of impaired supranuclear control. Here, we examined the neural substrates implicated in eye-opening apraxia through l…
View article: Is the prefrontal cortex organized by supramodal or modality-specific sensory demands during adolescence?
Is the prefrontal cortex organized by supramodal or modality-specific sensory demands during adolescence? Open
View article: Test–Retest Reliability of a Semi-Structured Interview to Aid in Pediatric Traumatic Brain Injury Diagnosis
Test–Retest Reliability of a Semi-Structured Interview to Aid in Pediatric Traumatic Brain Injury Diagnosis Open
Objective: Retrospective self-report is typically used for diagnosing previous pediatric traumatic brain injury (TBI). A new semi-structured interview instrument (New Mexico Assessment of Pediatric TBI; NewMAP TBI) investigated test–retest…
View article: DNA methylation under the major depression pathway predicts pediatric quality of life four-month post-pediatric mild traumatic brain injury
DNA methylation under the major depression pathway predicts pediatric quality of life four-month post-pediatric mild traumatic brain injury Open
Background Major depression has been recognized as the most commonly diagnosed psychiatric complication of mild traumatic brain injury (mTBI). Moreover, major depression is associated with poor outcomes following mTBI; however, the underly…
View article: The clinical relevance of gray matter atrophy and microstructural brain changes across the psychosis continuum
The clinical relevance of gray matter atrophy and microstructural brain changes across the psychosis continuum Open
View article: Additional file 2 of DNA methylation under the major depression pathway predicts pediatric quality of life four-month post-pediatric mild traumatic brain injury
Additional file 2 of DNA methylation under the major depression pathway predicts pediatric quality of life four-month post-pediatric mild traumatic brain injury Open
Additional file 2. Genes and CpG sites included.
View article: Differing functional mechanisms underlie cognitive control deficits in psychotic spectrum disorders
Differing functional mechanisms underlie cognitive control deficits in psychotic spectrum disorders Open
Background: Functional underpinnings of cognitive control deficits in unbiased samples (i.e., all comers) of patients with psychotic spectrum disorders (PSD) remain actively debated. While many studies suggest hypofrontality in the lateral…
View article: Evidence for asymmetric inhibitory activity during motor planning phases of sensorimotor synchronization
Evidence for asymmetric inhibitory activity during motor planning phases of sensorimotor synchronization Open
View article: Neurosensory Screening and Symptom Provocation in Pediatric Mild Traumatic Brain Injury
Neurosensory Screening and Symptom Provocation in Pediatric Mild Traumatic Brain Injury Open
Objective: To evaluate diagnostic/prognostic implications of neurosensory testing during the subacute stage in patients with pediatric mild traumatic brain injury (pmTBI). Setting: Recruitment from pediatric emergency department and urgent…
View article: Comparison of Methods for Classifying Persistent Post-Concussive Symptoms in Children
Comparison of Methods for Classifying Persistent Post-Concussive Symptoms in Children Open
Pediatric mild traumatic brain injury (pmTBI) has received increased public scrutiny over the past decade, especially regarding children who experience persistent post-concussive symptoms (PPCS). However, several methods for defining PPCS …
View article: Persistent alterations in cerebrovascular reactivity in response to hypercapnia following pediatric mild traumatic brain injury
Persistent alterations in cerebrovascular reactivity in response to hypercapnia following pediatric mild traumatic brain injury Open
Much attention has been paid to the effects of mild traumatic brain injury (mTBI) on cerebrovascular reactivity in adult populations, yet it remains understudied in pediatric injury. In this study, 30 adolescents (12–18 years old) with ped…
View article: Radiologic common data elements rates in pediatric mild traumatic brain injury
Radiologic common data elements rates in pediatric mild traumatic brain injury Open
Collectively, current findings question the trauma-related specificity of certain rCDE, as well how these rCDE are radiologically interpreted. Refinement of rCDE in the context of pmTBI may be warranted, especially as diagnostic schema are…
View article: Proactive inhibition deficits with normal perfusion after pediatric mild traumatic brain injury
Proactive inhibition deficits with normal perfusion after pediatric mild traumatic brain injury Open
Although much attention has been generated in popular media regarding the deleterious effects of pediatric mild traumatic brain injury (pmTBI), a paucity of empirical evidence exists regarding the natural course of biological recovery. Fif…
View article: A comparison of denoising pipelines in high temporal resolution task‐based functional magnetic resonance imaging data
A comparison of denoising pipelines in high temporal resolution task‐based functional magnetic resonance imaging data Open
It has been known for decades that head motion/other artifacts affect the blood oxygen level‐dependent signal. Recent recommendations predominantly focus on denoising resting state data, which may not apply to task data due to the differen…
View article: A symptom-based continuum of psychosis explains cognitive and real-world functional deficits better than traditional diagnoses
A symptom-based continuum of psychosis explains cognitive and real-world functional deficits better than traditional diagnoses Open
View article: Proactive and reactive cognitive control rely on flexible use of the ventrolateral prefrontal cortex
Proactive and reactive cognitive control rely on flexible use of the ventrolateral prefrontal cortex Open
The role of ventral versus dorsolateral prefrontal regions in instantiating proactive and reactive cognitive control remains actively debated, with few studies parsing cue versus probe‐related activity. Rapid sampling (460 ms), long cue–pr…
View article: Advanced biomarkers of pediatric mild traumatic brain injury: Progress and perils
Advanced biomarkers of pediatric mild traumatic brain injury: Progress and perils Open
View article: Disconnected and Hyperactive: A Replication of Sensorimotor Cortex Abnormalities in Patients With Schizophrenia During Proactive Response Inhibition
Disconnected and Hyperactive: A Replication of Sensorimotor Cortex Abnormalities in Patients With Schizophrenia During Proactive Response Inhibition Open
Inhibitory failure represents a core dysfunction in patients with schizophrenia (SP), which has predominantly been tested in the literature using reactive (ie, altering behavior after a stimulus) rather than proactive (ie, purposefully cha…
View article: Impaired Midline Theta Power and Connectivity During Proactive Cognitive Control in Schizophrenia
Impaired Midline Theta Power and Connectivity During Proactive Cognitive Control in Schizophrenia Open
View article: An evaluation of Z-transform algorithms for identifying subject-specific abnormalities in neuroimaging data
An evaluation of Z-transform algorithms for identifying subject-specific abnormalities in neuroimaging data Open