Nicholas Au Yong
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View article: Spinal interneuron population dynamics underlying flexible pattern generation
Spinal interneuron population dynamics underlying flexible pattern generation Open
The mammalian spinal locomotor network is composed of diverse populations of interneurons that collectively orchestrate and execute a range of locomotor behaviors. As the number of identified classes of spinal interneurons constituting the…
View article: Preparatory encoding of diverse features of intended movement in the human motor cortex
Preparatory encoding of diverse features of intended movement in the human motor cortex Open
Over the course of a voluntary movement, motor cortical activity exhibits a transition from preparation to execution, with markedly different activity across these phases. Preparatory activity in particular might be used to improve brain-c…
View article: Bilateral Deep Brain Stimulation of the Subthalamic Nucleus or Globus Pallidus Internus Improves Gait Impairment in Parkinson’s Disease
Bilateral Deep Brain Stimulation of the Subthalamic Nucleus or Globus Pallidus Internus Improves Gait Impairment in Parkinson’s Disease Open
Background and objectives The effect of deep brain stimulation (DBS) on gait in patients with Parkinson’s disease (PD) is variable but prospective, long-term studies—especially including globus pallidus interna (GPi) stimulation—remain spa…
View article: An algorithmic procedure for measuring deep brain stimulation-induced capsular activation using motor evoked potentials
An algorithmic procedure for measuring deep brain stimulation-induced capsular activation using motor evoked potentials Open
Objective Effective deep brain stimulation (DBS) treatment for Parkinson’s disease requires careful adjustment of stimulation parameters and targeting to avoid motor side effects caused by activation of the internal capsule. Currently, pat…
View article: Neural pathway activation in the subthalamic region depends on stimulation polarity
Neural pathway activation in the subthalamic region depends on stimulation polarity Open
Deep brain stimulation (DBS) is an effective treatment for Parkinson’s disease; however, there is limited understanding of which subthalamic pathways are recruited in response to stimulation. Here, by focusing on the polarity of the stimul…
View article: Reducing power requirements for high-accuracy decoding in iBCIs
Reducing power requirements for high-accuracy decoding in iBCIs Open
Objective. Current intracortical brain-computer interfaces (iBCIs) rely predominantly on threshold crossings (‘spikes’) for decoding neural activity into a control signal for an external device. Spiking data can yield high accuracy online …
View article: Single-pericyte nanomechanics measured by contraction cytometry
Single-pericyte nanomechanics measured by contraction cytometry Open
Pericytes line the microvasculature throughout the body and play a key role in regulating blood flow by constricting and dilating vessels. However, the biophysical mechanisms through which pericytes transduce microenvironmental chemical an…
View article: GABAergic synaptic scaling is triggered by changes in spiking activity rather than AMPA receptor activation
GABAergic synaptic scaling is triggered by changes in spiking activity rather than AMPA receptor activation Open
Homeostatic plasticity represents a set of mechanisms that are thought to recover some aspect of neural function. One such mechanism called AMPAergic scaling was thought to be a likely candidate to homeostatically control spiking activity.…
View article: Author response: GABAergic synaptic scaling is triggered by changes in spiking activity rather than AMPA receptor activation
Author response: GABAergic synaptic scaling is triggered by changes in spiking activity rather than AMPA receptor activation Open
View article: Spinal interneuron population dynamics underlying flexible pattern generation
Spinal interneuron population dynamics underlying flexible pattern generation Open
The mammalian spinal locomotor network is composed of diverse populations of interneurons that collectively orchestrate and execute a range of locomotor behaviors. Despite the identification of many classes of spinal interneurons constitut…
View article: GABAergic synaptic scaling is triggered by changes in spiking activity rather than AMPA receptor activation
GABAergic synaptic scaling is triggered by changes in spiking activity rather than AMPA receptor activation Open
Homeostatic plasticity represents a set of mechanisms that are thought to recover some aspect of neural function. One such mechanism called AMPAergic scaling was thought to be a likely candidate to homeostatically control spiking activity.…
View article: Reviewer #3 (Public Review): GABAergic synaptic scaling is triggered by changes in spiking activity rather than AMPA receptor activation
Reviewer #3 (Public Review): GABAergic synaptic scaling is triggered by changes in spiking activity rather than AMPA receptor activation Open
Homeostatic plasticity represents a set of mechanisms that are thought to recover some aspect of neural function. One such mechanism called AMPAergic scaling was thought to be a likely candidate to homeostatically control spiking activity.…
View article: Author response: GABAergic synaptic scaling is triggered by changes in spiking activity rather than AMPA receptor activation
Author response: GABAergic synaptic scaling is triggered by changes in spiking activity rather than AMPA receptor activation Open
Homeostatic plasticity represents a set of mechanisms that are thought to recover some aspect of neural function. One such mechanism called AMPAergic scaling was thought to be a likely candidate to homeostatically control spiking activity.…
View article: Neural pathway activation in the subthalamic region depends on stimulation polarity
Neural pathway activation in the subthalamic region depends on stimulation polarity Open
Deep brain stimulation (DBS) is an effective treatment for Parkinson’s disease (PD); however, there is limited understanding of which subthalamic pathways are recruited in response to stimulation. Here, by focusing on the polarity of the s…
View article: BRAND: a platform for closed-loop experiments with deep network models
BRAND: a platform for closed-loop experiments with deep network models Open
Objective. Artificial neural networks (ANNs) are state-of-the-art tools for modeling and decoding neural activity, but deploying them in closed-loop experiments with tight timing constraints is challenging due to their limited support in e…
View article: BRAND: A platform for closed-loop experiments with deep network models
BRAND: A platform for closed-loop experiments with deep network models Open
This is the supporting data for "BRAND: A platform for closed-loop experiments with deep network models". It can be analyzed using the code at github.com/brandbci/paper-figures. This dataset contains: Latency measurements from computers ru…
View article: BRAND: A platform for closed-loop experiments with deep network models
BRAND: A platform for closed-loop experiments with deep network models Open
This is the supporting data for "BRAND: A platform for closed-loop experiments with deep network models". It can be analyzed using the code at github.com/brandbci/paper-figures. This dataset contains: Latency measurements from computers ru…
View article: Learning Control Policies of Hodgkin-Huxley Neuronal Dynamics
Learning Control Policies of Hodgkin-Huxley Neuronal Dynamics Open
We present a neural network approach for closed-loop deep brain stimulation (DBS). We cast the problem of finding an optimal neurostimulation strategy as a control problem. In this setting, control policies aim to optimize therapeutic outc…
View article: BRAND: A platform for closed-loop experiments with deep network models
BRAND: A platform for closed-loop experiments with deep network models Open
Artificial neural networks (ANNs) are state-of-the-art tools for modeling and decoding neural activity, but deploying them in closed-loop experiments with tight timing constraints is challenging due to their limited support in existing rea…
View article: GABAergic synaptic scaling is triggered by changes in spiking activity rather than AMPA receptor activation
GABAergic synaptic scaling is triggered by changes in spiking activity rather than AMPA receptor activation Open
Homeostatic plasticity represents a set of mechanisms that are thought to recover some aspect of neural function. One such mechanism called AMPAergic scaling was thought to be a likely candidate to homeostatically control spiking activity.…
View article: Author Response: GABAergic synaptic scaling is triggered by changes in spiking activity rather than transmitter receptor activation
Author Response: GABAergic synaptic scaling is triggered by changes in spiking activity rather than transmitter receptor activation Open
Homeostatic plasticity represents a set of mechanisms that are thought to recover some aspect of neural function. One such mechanism called AMPAergic scaling was thought to be a likely candidate to homeostatically control spiking activity.…
View article: GABAergic synaptic scaling is triggered by changes in spiking activity rather than transmitter receptor activation
GABAergic synaptic scaling is triggered by changes in spiking activity rather than transmitter receptor activation Open
Homeostatic plasticity represents a set of mechanisms that are thought to recover some aspect of neural function. One such mechanism called AMPAergic scaling was thought to be a likely candidate to homeostatically control spiking activity.…
View article: GABAergic synaptic scaling is triggered by changes in spiking activity rather than AMPA receptor activation
GABAergic synaptic scaling is triggered by changes in spiking activity rather than AMPA receptor activation Open
Homeostatic plasticity represents a set of mechanisms that are thought to recover some aspect of neural function. One such mechanism called AMPAergic scaling was thought to be a likely candidate to homeostatically control spiking activity.…
View article: Contralateral C7 Nerve Transfer for Stroke Recovery: New Frontier for Peripheral Nerve Surgery
Contralateral C7 Nerve Transfer for Stroke Recovery: New Frontier for Peripheral Nerve Surgery Open
Ischemic stroke remains a major cause of disability in the United States and worldwide. Following the large-scale implementation of stroke thrombectomy and the optimization of treatment protocols for acute stroke, the reduction in stroke-a…
View article: Cognition in Sensorimotor Control: Interfacing With the Posterior Parietal Cortex
Cognition in Sensorimotor Control: Interfacing With the Posterior Parietal Cortex Open
Millions of people worldwide are afflicted with paralysis from a disruption of neural pathways between the brain and the muscles. Because their cortical architecture is often preserved, these patients are able to plan movements despite an …
View article: Engaging cervical spinal circuitry with non-invasive spinal stimulation and buspirone to restore hand function in chronic motor complete patients
Engaging cervical spinal circuitry with non-invasive spinal stimulation and buspirone to restore hand function in chronic motor complete patients Open