Nicholas C. Firth
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View article: Music To My Eyes? Exploring the pupil old/new effect to familiar and unfamiliar music in people with logopenic variant Primary Progressive Aphasia
Music To My Eyes? Exploring the pupil old/new effect to familiar and unfamiliar music in people with logopenic variant Primary Progressive Aphasia Open
Background Responses to individualized music in people living with dementia can be indicated by both verbal and non‐verbal cues. Evidence suggests that elevated pupil dilation responses to familiar vs. unfamiliar music are preserved in peo…
View article: Play It Again: Differential pupillometry responses to familiar and unfamiliar music: Findings from typical and atypical Alzheimer’s disease
Play It Again: Differential pupillometry responses to familiar and unfamiliar music: Findings from typical and atypical Alzheimer’s disease Open
Background Music has gained more attention than other art forms as a potent tool in supporting cognitive, emotional and social functioning in dementia populations. Methods for measuring moment‐to‐moment responses ‐ rather than comparing pr…
View article: Play It Again: Differential pupillometry responses to familiar and unfamiliar music: Findings from typical and atypical Alzheimer’s disease
Play It Again: Differential pupillometry responses to familiar and unfamiliar music: Findings from typical and atypical Alzheimer’s disease Open
Background Music has gained more attention than other art forms as a potent tool in supporting cognitive, emotional and social functioning in dementia populations. Methods for measuring moment‐to‐moment responses ‐ rather than comparing pr…
View article: Development of the Video Analysis Scale of Engagement (VASE) for people with advanced dementia
Development of the Video Analysis Scale of Engagement (VASE) for people with advanced dementia Open
Background: The current study sought to develop a valid, reliable and unobtrusive tablet computer-based observational measure to assess engagement of people with advanced dementia. The Video Analysis Scale of Engagement (VASE) was designed…
View article: Development of the Video Analysis Scale of Engagement (VASE) for people with advanced dementia
Development of the Video Analysis Scale of Engagement (VASE) for people with advanced dementia Open
Background: The current study sought to develop a valid, reliable and unobtrusive tablet computer-based observational measure to assess engagement of people with advanced dementia. The Video Analysis Scale of Engagement (VASE) was designed…
View article: Development of the Video Analysis Scale of Engagement (VASE) for people with advanced dementia
Development of the Video Analysis Scale of Engagement (VASE) for people with advanced dementia Open
Background: The current study sought to develop a valid, reliable and unobtrusive tablet computer-based observational measure to assess engagement of people with advanced dementia. The Video Analysis Scale of Engagement (VASE) was designed…
View article: Video Analysis Scale of Engagement (VASE) project: data set
Video Analysis Scale of Engagement (VASE) project: data set Open
This file contains the validity testing and rating data from the Video Analysis Scale of Engagement (VASE) project, published in 2020 by Wellcome Open Research, 5(230).https://wellcomeopenresearch.org/articles/5-230/v2
View article: Video Analysis Scale of Engagement (VASE) project: data set
Video Analysis Scale of Engagement (VASE) project: data set Open
This file contains the validity testing and rating data from the Video Analysis Scale of Engagement (VASE) project, published in 2020 by Wellcome Open Research, 5(230).https://wellcomeopenresearch.org/articles/5-230/v2
View article: Video Analysis Scale of Engagement (VASE) project: data set
Video Analysis Scale of Engagement (VASE) project: data set Open
This file contains the validity testing and rating data from the Video Analysis Scale of Engagement (VASE) project, published in 2020 by Wellcome Open Research, 5(230).https://wellcomeopenresearch.org/articles/5-230/v2
View article: Sequences of cognitive decline in typical Alzheimer's disease and posterior cortical atrophy estimated using a novel event‐based model of disease progression
Sequences of cognitive decline in typical Alzheimer's disease and posterior cortical atrophy estimated using a novel event‐based model of disease progression Open
Introduction This work aims to characterize the sequence in which cognitive deficits appear in two dementia syndromes. Methods Event‐based modeling estimated fine‐grained sequences of cognitive decline in clinically‐diagnosed posterior cor…
View article: O4‐03‐05: LONGITUDINAL COGNITIVE DECLINE AND PRODROMAL STAGING MODEL FOR ALZHEIMER'S DISEASE IN DOWN SYNDROME
O4‐03‐05: LONGITUDINAL COGNITIVE DECLINE AND PRODROMAL STAGING MODEL FOR ALZHEIMER'S DISEASE IN DOWN SYNDROME Open
Down syndrome (DS), caused by chr21 triplication, may be considered a genetic cause of Alzheimer's disease (AD) due to having three copies of the APP gene. The AD in DS population is therefore important for trials to delay or prevent AD. H…
View article: Longitudinal neuroanatomical and cognitive progression of posterior cortical atrophy
Longitudinal neuroanatomical and cognitive progression of posterior cortical atrophy Open
Posterior cortical atrophy is a clinico-radiological syndrome characterized by progressive decline in visual processing and atrophy of posterior brain regions. With the majority of cases attributable to Alzheimer’s disease and recent evide…
View article: Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference
Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference Open
View article: Conceptualising and Understanding Artistic Creativity in the Dementias: Interdisciplinary Approaches to Research and Practise
Conceptualising and Understanding Artistic Creativity in the Dementias: Interdisciplinary Approaches to Research and Practise Open
Creativity research has a substantial history in psychology and related disciplines; one component of this research tradition has specifically examined artistic creativity. Creativity theories have tended to concentrate, however, on creati…
View article: Discovering Highly Potent Molecules from an Initial Set of Inactives Using Iterative Screening
Discovering Highly Potent Molecules from an Initial Set of Inactives Using Iterative Screening Open
The versatility of similarity searching and quantitative structure-activity relationships to model the activity of compound sets within given bioactivity ranges (i.e., interpolation) is well established. However, their relative performance…
View article: P3‐420: AN EVENT BASED MODEL OF ALZHEIMER'S DISEASE IN APOE+ SUBJECTS USING ROBUST BIOMARKERS OF VOLUMETRIC CHANGE IN REGIONAL BRAIN STRUCTURE
P3‐420: AN EVENT BASED MODEL OF ALZHEIMER'S DISEASE IN APOE+ SUBJECTS USING ROBUST BIOMARKERS OF VOLUMETRIC CHANGE IN REGIONAL BRAIN STRUCTURE Open
Computationally driven event-based models (e.g. Young et al., 2014) have broadly confirmed a hypothetical model of Alzheimer's disease progression (Jack et al., 2010). Within this model, brain atrophy occurs after protein abnormalities. Re…
View article: Aging related cognitive changes associated with Alzheimer's disease in Down syndrome
Aging related cognitive changes associated with Alzheimer's disease in Down syndrome Open
Objective Individuals with Down syndrome ( DS ) have an extremely high genetic risk for Alzheimer's disease ( AD ), however, the course of cognitive decline associated with progression to dementia is ill‐defined. Data‐driven methods can es…
View article: Non-Parametric Mixture Modelling and its Application to Disease Progression Modelling
Non-Parametric Mixture Modelling and its Application to Disease Progression Modelling Open
Dementia is characterised by its progressive degeneration of cognitive abilities. In research cohorts, detailed neuropsychological test batteries are often administered to better understand how cognition changes over time. Understanding co…
View article: An image‐based model of brain volume biomarker changes in Huntington's disease
An image‐based model of brain volume biomarker changes in Huntington's disease Open
Objective Determining the sequence in which Huntington's disease biomarkers become abnormal can provide important insights into the disease progression and a quantitative tool for patient stratification. Here, we construct and present a un…
View article: Progression of regional grey matter atrophy in multiple sclerosis
Progression of regional grey matter atrophy in multiple sclerosis Open
See Stankoff and Louapre (doi:10.1093/brain/awy114) for a scientific commentary on this article.Grey matter atrophy is present from the earliest stages of multiple sclerosis, but its temporal ordering is poorly understood. We aimed to dete…
View article: Cognitive Changes associated with Alzheimer’s disease in Down syndrome
Cognitive Changes associated with Alzheimer’s disease in Down syndrome Open
Objective Individuals with Down syndrome (DS) have an extremely high genetic risk for Alzheimer’s disease (AD) however the course of cognitive decline associated with progression to dementia is ill-defined. Data-driven methods can estimate…
View article: Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference
Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference Open
Summary The heterogeneity of neurodegenerative diseases is a key confound to disease understanding and treatment development, as study cohorts typically include multiple phenotypes on distinct disease trajectories. Here we present a new ma…
View article: Data-Driven Sequence of Changes to Anatomical Brain Connectivity in Sporadic Alzheimer’s Disease
Data-Driven Sequence of Changes to Anatomical Brain Connectivity in Sporadic Alzheimer’s Disease Open
Model-based investigations of transneuronal spreading mechanisms in neurodegenerative diseases relate the pattern of pathology severity to the brain's connectivity matrix, which reveals information about how pathology propagates through th…
View article: Preparatory planning framework for Created Out of Mind: Shaping perceptions of dementia through art and science
Preparatory planning framework for Created Out of Mind: Shaping perceptions of dementia through art and science Open
Created Out of Mind is an interdisciplinary project, comprised of individuals from arts, social sciences, music, biomedical sciences, humanities and operational disciplines. Collaboratively we are working to shape perceptions of dementias …
View article: Eyetracking metrics reveal impaired spatial anticipation in behavioural variant frontotemporal dementia
Eyetracking metrics reveal impaired spatial anticipation in behavioural variant frontotemporal dementia Open
Eyetracking technology has had limited application in the dementia field to date, with most studies attempting to discriminate syndrome subgroups on the basis of basic oculomotor functions rather than higher-order cognitive abilities. Eyet…
View article: Progression of regional grey matter atrophy in multiple sclerosis
Progression of regional grey matter atrophy in multiple sclerosis Open
Summary Grey matter atrophy is present from the earliest clinical stages of multiple sclerosis (MS), but the temporal ordering is poorly understood. We aimed to determine the sequence in which grey matter regions become atrophic in MS, and…
View article: Eyetracking Metrics in Young Onset Alzheimer’s Disease: A Window into Cognitive Visual Functions
Eyetracking Metrics in Young Onset Alzheimer’s Disease: A Window into Cognitive Visual Functions Open
Young onset Alzheimer's disease (YOAD) is defined as symptom onset before the age of 65 years and is particularly associated with phenotypic heterogeneity. Atypical presentations, such as the clinic-radiological visual syndrome posterior c…
View article: [P4–257]: ANALYSIS OF THE HETEROGENEITY OF POSTERIOR CORTICAL ATROPHY: DATA‐DRIVEN MODEL PREDICTS DISTINCT ATROPHY PATTERNS FOR THREE DIFFERENT COGNITIVE SUBGROUPS
[P4–257]: ANALYSIS OF THE HETEROGENEITY OF POSTERIOR CORTICAL ATROPHY: DATA‐DRIVEN MODEL PREDICTS DISTINCT ATROPHY PATTERNS FOR THREE DIFFERENT COGNITIVE SUBGROUPS Open
Posterior cortical atrophy (PCA) is a progressive visual syndrome that affects the posterior part of the brain and is most commonly caused by Alzheimer's disease (AD). It has been previously suggested that three main subgroups exist: prima…
View article: [P4–261]: LONGITUDINAL EVALUATION OF NEUROPSYCHOLOGICAL AND NEUROIMAGING PROGRESSION IN POSTERIOR CORTICAL ATROPHY
[P4–261]: LONGITUDINAL EVALUATION OF NEUROPSYCHOLOGICAL AND NEUROIMAGING PROGRESSION IN POSTERIOR CORTICAL ATROPHY Open
Posterior cortical atrophy (PCA) is a clinico-radiological syndrome characterized by progressive decline in visual processing and atrophy of posterior brain regions. With the majority of cases attributable to Alzheimer's disease (AD) and r…
View article: [P2–414]: CHARACTERISING THE PROGRESSION OF ALZHEIMER's DISEASE SUBTYPES USING SUBTYPE AND STAGE INFERENCE (SUSTAIN)
[P2–414]: CHARACTERISING THE PROGRESSION OF ALZHEIMER's DISEASE SUBTYPES USING SUBTYPE AND STAGE INFERENCE (SUSTAIN) Open
Characterising the heterogeneity in the evolution of Alzheimer's disease (AD) biomarkers in different individuals would provide insights into the underlying disease process as well as a mechanism for patient staging and stratification. Her…