Nicholas E. Bush
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View article: An inspiration-off attractor supports the robust and flexible control of breathing
An inspiration-off attractor supports the robust and flexible control of breathing Open
Summary Breathing is a fundamental motor rhythm necessary to sustain life. The rhythm and pattern of breathing arises from the coordination of a bilaterally symmetric, rostro-caudally extended column of heterogeneous neural populations in …
View article: Biomechanical simplification of the motor control of whisking
Biomechanical simplification of the motor control of whisking Open
1. Summary Animal nervous systems must coordinate the sequence and timing of numerous muscles − a challenging control problem. The challenge is particularly acute for highly mobile sensing structures with many degrees of freedom, such as e…
View article: Modeling Effects of Variable preBötzinger Complex Network Topology and Cellular Properties on Opioid-Induced Respiratory Depression and Recovery
Modeling Effects of Variable preBötzinger Complex Network Topology and Cellular Properties on Opioid-Induced Respiratory Depression and Recovery Open
The preBötzinger complex (preBötC), located in the medulla, is the essential rhythm-generating neural network for breathing. The actions of opioids on this network impair its ability to generate robust, rhythmic output, contributing to lif…
View article: Elevated susceptibility to exogenous seizure triggers and impaired interneuron excitability in a mouse model of Leigh syndrome epilepsy
Elevated susceptibility to exogenous seizure triggers and impaired interneuron excitability in a mouse model of Leigh syndrome epilepsy Open
Mutations in the NADH dehydrogenase (ubiquinone reductase) iron‑sulfur protein 4 (NDUFS4) gene, which encodes for a key structural subunit of the OXFOS complex I (CI), lead to the most common form of mitochondrial disease in children known…
View article: Modeling effects of variable preBötzinger Complex network topology and cellular properties on opioid-induced respiratory depression and recovery
Modeling effects of variable preBötzinger Complex network topology and cellular properties on opioid-induced respiratory depression and recovery Open
The pre-Bötzinger complex (preBotC), located in the medulla, is the essential rhythm-generating neural network for breathing. The actions of opioids on this network impair its ability to generate robust, rhythmic output, contributing to li…
View article: Latent neural population dynamics underlying normal breathing, opioid induced respiratory depression, and gasping
Latent neural population dynamics underlying normal breathing, opioid induced respiratory depression, and gasping Open
Breathing is vital and must be concurrently robust and flexible. This rhythmic behavior is generated and maintained within a rostro-caudally aligned set of medullary nuclei called the Ventral Respiratory Column (VRC). The rhythmic properti…
View article: Inspiratory rhythm generation is stabilized by <i>I<sub>h</sub></i>
Inspiratory rhythm generation is stabilized by <i>I<sub>h</sub></i> Open
The I h current plays multiple roles within the preBötC. This current is important for promoting intrinsic tonic spiking activity in excitatory and inhibitory neurons and for preserving rhythmic function during conditions that dampen netwo…
View article: Latent neural population dynamics underlie normal and disrupted breathing
Latent neural population dynamics underlie normal and disrupted breathing Open
Breathing is a vital rhythmic motor behavior incessant from the first to our last breath. Increasingly refined anatomical, physiological, and genetic methods identified critical neuronal structures for breathing in a rostro-caudally aligne…
View article: Dual mechanisms of opioid-induced respiratory depression in the inspiratory rhythm-generating network
Dual mechanisms of opioid-induced respiratory depression in the inspiratory rhythm-generating network Open
The analgesic utility of opioid-based drugs is limited by the life-threatening risk of respiratory depression. Opioid-induced respiratory depression (OIRD), mediated by the μ-opioid receptor (MOR), is characterized by a pronounced decrease…
View article: Continuous, multidimensional coding of 3D complex tactile stimuli by primary sensory neurons of the vibrissal system
Continuous, multidimensional coding of 3D complex tactile stimuli by primary sensory neurons of the vibrissal system Open
Significance An animal’s primary sensory neurons (PSNs) translate information about the environment into neural signals that allow perception and action. While much is known about visual and auditory PSN responses to complex stimuli, somat…
View article: A dynamical model for generating synthetic data to quantify active tactile sensing behavior in the rat
A dynamical model for generating synthetic data to quantify active tactile sensing behavior in the rat Open
Significance In recent years, increasing effort has been made to study sensorimotor integration within the context of the animal’s body and the environment. However, it is challenging to collect neurophysiological data under naturalistic c…
View article: Purinergic signaling mediates neuroglial interactions to generate sighs
Purinergic signaling mediates neuroglial interactions to generate sighs Open
Sighs prevent the collapse of alveoli in the lungs, initiate arousal under hypoxic conditions, and even express sadness and relief. Sighs are periodically superimposed on normal breaths, known as eupnea. Implicated in the generation of the…
View article: Dual mechanisms of opioid-induced respiratory depression in the inspiratory rhythm-generating network
Dual mechanisms of opioid-induced respiratory depression in the inspiratory rhythm-generating network Open
The analgesic utility of opioid-based drugs is limited by the life-threatening risk of respiratory depression. Opioid-induced respiratory depression (OIRD), mediated by the μ-opioid receptor (MOR), is characterized by a pronounced decrease…
View article: The Pathophysiology of Rett Syndrome With a Focus on Breathing Dysfunctions
The Pathophysiology of Rett Syndrome With a Focus on Breathing Dysfunctions Open
Rett syndrome (RTT), an X-chromosome-linked neurological disorder, is characterized by serious pathophysiology, including breathing and feeding dysfunctions, and alteration of cardiorespiratory coupling, a consequence of multiple interrela…
View article: Continuous, multidimensional coding of 3D complex tactile stimuli by primary sensory neurons of the vibrissal system
Continuous, multidimensional coding of 3D complex tactile stimuli by primary sensory neurons of the vibrissal system Open
To reveal the full representational capabilities of sensory neurons, it is essential to observe their responses to complex stimuli. In the rodent vibrissal system, mechanical information at the whisker base drives responses of primary sens…
View article: Whisker Vibrations and the Activity of Trigeminal Primary Afferents in Response to Airflow
Whisker Vibrations and the Activity of Trigeminal Primary Afferents in Response to Airflow Open
Rodents are the most commonly studied model system in neuroscience, but surprisingly few studies investigate the natural sensory stimuli that rodent nervous systems evolved to interpret. Even fewer studies examine neural responses to these…
View article: Decoupling kinematics and mechanics reveals coding properties of trigeminal ganglion neurons in the rat vibrissal system
Decoupling kinematics and mechanics reveals coding properties of trigeminal ganglion neurons in the rat vibrissal system Open
Tactile information available to the rat vibrissal system begins as external forces that cause whisker deformations, which in turn excite mechanoreceptors in the follicle. Despite the fundamental mechanical origin of tactile information, p…
View article: Author response: Decoupling kinematics and mechanics reveals coding properties of trigeminal ganglion neurons in the rat vibrissal system
Author response: Decoupling kinematics and mechanics reveals coding properties of trigeminal ganglion neurons in the rat vibrissal system Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract Tactile information available to the rat vibris…