Nicholas Eriksson
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View article: Genome-wide association study of delay discounting identifies 11 loci and reveals transdiagnostic associations across mental and physical health
Genome-wide association study of delay discounting identifies 11 loci and reveals transdiagnostic associations across mental and physical health Open
Delay discounting (DD), a person’s preference for smaller immediate rewards over larger delayed rewards, is a heritable trait that is associated with psychiatric and physical outcomes, yet the biological mechanisms underlying these links a…
View article: Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression.
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Open
Major depressive disorder (MDD) is a common illness accompanied by considerable morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide association meta-analysis based in 135,458 cases and 344,901 controls a…
View article: Association between polygenic risk and survival in breast cancer patients
Association between polygenic risk and survival in breast cancer patients Open
View article: Bidirectional relationship between olfaction and Parkinson’s disease
Bidirectional relationship between olfaction and Parkinson’s disease Open
View article: The shared genetic architecture and evolution of human language and musical rhythm
The shared genetic architecture and evolution of human language and musical rhythm Open
This study aimed to test theoretical predictions over biological underpinnings of previously documented phenotypic correlations between human language-related and musical rhythm traits. Here, after identifying significant genetic correlati…
View article: Oral and gut microbiome profiles in people with early idiopathic Parkinson’s disease
Oral and gut microbiome profiles in people with early idiopathic Parkinson’s disease Open
View article: Genetic neurodevelopmental clustering and dyslexia
Genetic neurodevelopmental clustering and dyslexia Open
Dyslexia is a learning difficulty with neurodevelopmental origins, manifesting as reduced accuracy and speed in reading and spelling. It is substantially heritable and frequently co-occurs with other neurodevelopmental conditions, particul…
View article: The genetic architecture of dog ownership: large-scale genome-wide association study in 97,552 European-ancestry individuals
The genetic architecture of dog ownership: large-scale genome-wide association study in 97,552 European-ancestry individuals Open
Dog ownership has been associated with several complex traits, and there is evidence of genetic influence. We performed a genome-wide association study of dog ownership through a meta-analysis of 31,566 Swedish twins in 5 discovery cohorts…
View article: Genetic analysis and natural history of Parkinson’s disease due to the <i>LRRK2</i> G2019S variant
Genetic analysis and natural history of Parkinson’s disease due to the <i>LRRK2</i> G2019S variant Open
The LRRK2 G2019S variant is the most common cause of monogenic Parkinson’s disease (PD); however, questions remain regarding the penetrance, clinical phenotype and natural history of carriers. We performed a 3.5-year prospective longitudin…
View article: A phenome-wide association and Mendelian randomisation study of alcohol use variants in a diverse cohort comprising over 3 million individuals
A phenome-wide association and Mendelian randomisation study of alcohol use variants in a diverse cohort comprising over 3 million individuals Open
MVJ, NCK, SBB, SSR and AAP were supported by T32IR5226 and 28IR-0070. SSR was also supported by NIDA DP1DA054394. NCK and RBC were also supported by R25MH081482. ASH was supported by funds from NIAAA K01AA030083. JLMO was supported by VA 1…
View article: MUSSEL: Enhanced Bayesian polygenic risk prediction leveraging information across multiple ancestry groups
MUSSEL: Enhanced Bayesian polygenic risk prediction leveraging information across multiple ancestry groups Open
View article: Analysis of rare Parkinson’s disease variants in millions of people
Analysis of rare Parkinson’s disease variants in millions of people Open
View article: Prospective analysis of incident disease among individuals of diverse ancestries using genetic and conventional risk factors
Prospective analysis of incident disease among individuals of diverse ancestries using genetic and conventional risk factors Open
Background Human genetics provides opportunities for enhancing disease prediction through polygenic risk scores (PRS). Method We used a dataset from 23andMe (6.77M European, 1.30M Latine, and 0.45M African American individuals). Using cros…
View article: A new method for multiancestry polygenic prediction improves performance across diverse populations
A new method for multiancestry polygenic prediction improves performance across diverse populations Open
View article: Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression Open
Major depressive disorder (MDD) is a common illness accompanied by considerable morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide association meta-analysis based in 135,458 cases and 344,901 controls a…
View article: Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infections
Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infections Open
Infectious diseases have a profound impact on our health and many studies suggest that host genetics play a major role in the pathogenesis of most of them. We perform 23 genome-wide association studies for common infections and infection-a…
View article: Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depressive disorder
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depressive disorder Open
Major depressive disorder (MDD) is a notably complex illness with a lifetime prevalence of 14%. 1 It is often chronic or recurrent and is thus accompanied by considerable morbidity, excess mortality, substantial costs, and heightened risk …
View article: A genetic investigation of sex bias in the prevalence of attention deficit hyperactivity disorder
A genetic investigation of sex bias in the prevalence of attention deficit hyperactivity disorder Open
Attention-deficit/hyperactivity disorder (ADHD) shows substantial heritability and is 2-7 times more common in males than females. We examined two putative genetic mechanisms underlying this sex bias: sex-specific heterogeneity and higher …
View article: Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants
Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants Open
View article: Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infections
Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infections Open
We performed 23 genome-wide association studies for common infections, including chickenpox, shingles, cold sores, mononucleosis, mumps, hepatitis B, plantar warts, positive tuberculosis test results, strep throat, scarlet fever, pneumonia…
View article: Germ line variants predispose to both JAK2 V617F clonal hematopoiesis and myeloproliferative neoplasms
Germ line variants predispose to both JAK2 V617F clonal hematopoiesis and myeloproliferative neoplasms Open
Key Points Germ line variants in TERT, SH2B3, TET2, ATM, CHEK2, PINT, and GFI1B are associated with JAK2 V617F clonal hematopoiesis and MPNs. Age-related JAK2 V617F clonal hematopoiesis is found in ∼2 out of 1000 individuals in the general…
View article: GWAS of 89,283 individuals identifies genetic variants associated with self-reporting of being a morning person
GWAS of 89,283 individuals identifies genetic variants associated with self-reporting of being a morning person Open
Circadian rhythms are a nearly universal feature of living organisms and affect almost every biological process. Our innate preference for mornings or evenings is determined by the phase of our circadian rhythms. We conduct a genome-wide a…
View article: Genotype score associated with the risk of androgenetic alopecia.
Genotype score associated with the risk of androgenetic alopecia. Open
Abbreviations: OR, odds ratio; CI, confidence interval.a-The top SNPs from each genome-wide significant loci as shown in Table 2 are used in risk score analysis.
View article: Genome-wide meta-analysis results for AGA in MAAN.
Genome-wide meta-analysis results for AGA in MAAN. Open
(A) Manhattan plot showing the −log10 p value of SNPs against their chromosomal positions. The genome-wide significant SNPs are green (p value<5×10−8). The points with p value <1×10−40 were truncated; the s…
View article: Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine
Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine Open
Migraine is a debilitating neurological disorder affecting around 1 in 7 people worldwide, but its molecular mechanisms remain poorly understood. Some debate exists over whether migraine is a disease of vascular dysfunction, or a result of…
View article: Assessment of the Genetic Basis of Rosacea by Genome-Wide Association Study
Assessment of the Genetic Basis of Rosacea by Genome-Wide Association Study Open
View article: Genetic variants associated with motion sickness point to roles for inner ear development, neurological processes and glucose homeostasis
Genetic variants associated with motion sickness point to roles for inner ear development, neurological processes and glucose homeostasis Open
Roughly one in three individuals is highly susceptible to motion sickness and yet the underlying causes of this condition are not well understood. Despite high heritability, no associated genetic factors have been discovered. Here, we cond…