Nicholas F. Pearce
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View article: A new synergistic model for simulating exercise incorporating control mechanisms at cellular and organ scales
A new synergistic model for simulating exercise incorporating control mechanisms at cellular and organ scales Open
The physiological response of the cardio-vascular system (CVS) to physical activity is of great importance to those working in sporting research and has profound consequences for the health and well-being of people. Coronary vasodilation a…
View article: Development of a novel low-order model for atrial function and a study of atrial mechano-electric feedback
Development of a novel low-order model for atrial function and a study of atrial mechano-electric feedback Open
Numerical models of the cardiovascular system have largely focused on the function of the ventricles, with atrial function often neglected. Furthermore, the time-varying elastance method that prescribes the pressure-volume relationship rat…
View article: An Investigation of Left Ventricular Valve Disorders and the Mechano-Electric Feedback Using a Synergistic Lumped Parameter Cardiovascular Numerical Model
An Investigation of Left Ventricular Valve Disorders and the Mechano-Electric Feedback Using a Synergistic Lumped Parameter Cardiovascular Numerical Model Open
Cardiac diseases and failure make up one of largest contributions to global mortality and significantly detriment the quality of life for millions of others. Disorders in the valves of the left ventricle are a prominent example of heart di…
View article: Modelling the cardiac response to a mechanical stimulation using a low-order model of the heart
Modelling the cardiac response to a mechanical stimulation using a low-order model of the heart Open
Heart diseases are one of the leading causes of death worldwide, and a dysfunction of the cardiac electrical mechanisms is responsible for a significant portion of these deaths. One of these mechanisms, the mechano-electric feedback (MEF),…