Nicholas Hartog
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View article: Estimated annual direct medical costs of manifestations among patients with activated phosphoinositide 3-kinase delta syndrome
Estimated annual direct medical costs of manifestations among patients with activated phosphoinositide 3-kinase delta syndrome Open
View article: Estimated annual direct medical costs of manifestations among patients with activated phosphoinositide 3-kinase delta syndrome
Estimated annual direct medical costs of manifestations among patients with activated phosphoinositide 3-kinase delta syndrome Open
View article: Demographic and Clinical Characteristics of People with Activated Phosphoinositide 3-Kinase Delta Syndrome in the APDS Characterization and Clinical Outcomes Immunologic Registry
Demographic and Clinical Characteristics of People with Activated Phosphoinositide 3-Kinase Delta Syndrome in the APDS Characterization and Clinical Outcomes Immunologic Registry Open
Activated phosphoinositide 3-kinase delta syndrome (APDS) is a rare disorder with autosomal dominant inheritance pattern that leads to immune deficiency and dysregulation. As APDS was first characterized in 2013, there are gaps in knowledg…
View article: From castaways to discoveries: unveiling treasures in skin RNAseq using a novel multidimensional data processing workflow including infection-host dynamics
From castaways to discoveries: unveiling treasures in skin RNAseq using a novel multidimensional data processing workflow including infection-host dynamics Open
Complex bioinformatics mapping to skin RNA sequencing datasets can simultaneously map biological sex, skin-specific genes, bacteria, viruses, protists, and the acquired immune response. The integration of these datasets elucidated bacteria…
View article: Piloting an automated query and scoring system to facilitate APDS patient identification from health systems
Piloting an automated query and scoring system to facilitate APDS patient identification from health systems Open
Introduction Patients with activated PI3Kδ syndrome (APDS) may elude diagnoses for nearly a decade. Methods to hasten the identification of these patients, and other patients with inborn errors of immunity (IEIs), are needed. We sought to …
View article: Comparative immuno-biology at clinical recognition of early multiple organ dysfunction syndrome in pediatric and adult patients using single-cell transcriptomics
Comparative immuno-biology at clinical recognition of early multiple organ dysfunction syndrome in pediatric and adult patients using single-cell transcriptomics Open
Globally, sepsis remains a major health issue, with Multiple Organ Dysfunction Syndrome (MODS) being a leading cause of mortality. MODS, a severe condition often seen in intensive care units, typically results from infections or trauma and…
View article: Comparative Immuno-Biology at Clinical Recognition of Early Multiple Organ Dysfunction Syndrome in Pediatric and Adult Patients Using Single-Cell Transcriptomics
Comparative Immuno-Biology at Clinical Recognition of Early Multiple Organ Dysfunction Syndrome in Pediatric and Adult Patients Using Single-Cell Transcriptomics Open
View article: COVID-19 Vaccination in Patients with Inborn Errors of Immunity Reduces Hospitalization and Critical Care Needs Related to COVID-19: a USIDNET Report
COVID-19 Vaccination in Patients with Inborn Errors of Immunity Reduces Hospitalization and Critical Care Needs Related to COVID-19: a USIDNET Report Open
View article: A systematic review and expert Delphi Consensus recommendation on the use of vaccines in patients receiving dupilumab: A position paper of the American College of Allergy, Asthma and Immunology
A systematic review and expert Delphi Consensus recommendation on the use of vaccines in patients receiving dupilumab: A position paper of the American College of Allergy, Asthma and Immunology Open
View article: COVID-19 Vaccination in Patients with Inborn Errors of Immunity Reduces Hospitalization and Critical Care Needs Related to COVID-19: a USIDNET Report
COVID-19 Vaccination in Patients with Inborn Errors of Immunity Reduces Hospitalization and Critical Care Needs Related to COVID-19: a USIDNET Report Open
View article: Correction to: Clinical Practice Guidelines for the Immunological Management of Chromosome 22q11.2 Deletion Syndrome and Other Defects in Thymic Development
Correction to: Clinical Practice Guidelines for the Immunological Management of Chromosome 22q11.2 Deletion Syndrome and Other Defects in Thymic Development Open
View article: Gene Therapy for Genetic Syndromes: Understanding the Current State to Guide Future Care
Gene Therapy for Genetic Syndromes: Understanding the Current State to Guide Future Care Open
Gene therapy holds promise as a life-changing option for individuals with genetic variants that give rise to disease. FDA-approved gene therapies for Spinal Muscular Atrophy (SMA), cerebral adrenoleukodystrophy, β-Thalassemia, hemophilia A…
View article: Updated guidance regarding the risk of allergic reactions to COVID-19 vaccines and recommended evaluation and management: A GRADE assessment and international consensus approach
Updated guidance regarding the risk of allergic reactions to COVID-19 vaccines and recommended evaluation and management: A GRADE assessment and international consensus approach Open
View article: Editorial Board
Editorial Board Open
View article: Editorial Board
Editorial Board Open
View article: Clinical Practice Guidelines for the Immunological Management of Chromosome 22q11.2 Deletion Syndrome and Other Defects in Thymic Development
Clinical Practice Guidelines for the Immunological Management of Chromosome 22q11.2 Deletion Syndrome and Other Defects in Thymic Development Open
Current practices vary widely regarding the immunological work-up and management of patients affected with defects in thymic development (DTD), which include chromosome 22q11.2 microdeletion syndrome (22q11.2del) and other causes of DiGeor…
View article: Editorial Board
Editorial Board Open
View article: Review of Treatment for Adenosine Deaminase Deficiency (ADA) Severe Combined Immunodeficiency (SCID)
Review of Treatment for Adenosine Deaminase Deficiency (ADA) Severe Combined Immunodeficiency (SCID) Open
Adenosine deaminase deficiency (ADA) is a purine salvage pathway deficiency that results in buildup of toxic metabolites causing death in rapidly dividing cells, especially lymphocytes. The most complete form of ADA leads to severe combine…
View article: Understanding patient‐level immune response to COVID‐19 can inform treatment options
Understanding patient‐level immune response to COVID‐19 can inform treatment options Open
COVID‐19 is caused by an evolving pathogen that results in a disease that exhibits variability in progression and treatment response, highlighting the need for developing new and more precise therapies. Over the past two years, we have bui…
View article: CCR5 and Biological Complexity: The Need for Data Integration and Educational Materials to Address Genetic/Biological Reductionism at the Interface of Ethical, Legal, and Social Implications
CCR5 and Biological Complexity: The Need for Data Integration and Educational Materials to Address Genetic/Biological Reductionism at the Interface of Ethical, Legal, and Social Implications Open
In the age of genomics, public understanding of complex scientific knowledge is critical. To combat reductionistic views, it is necessary to generate and organize educational material and data that keep pace with advances in genomics. The …
View article: Cohort experience of second messenger RNA vaccine dose tolerance after an initial-dose reaction
Cohort experience of second messenger RNA vaccine dose tolerance after an initial-dose reaction Open
View article: High-Density Blood Transcriptomics Reveals Precision Immune Signatures of SARS-CoV-2 Infection in Hospitalized Individuals
High-Density Blood Transcriptomics Reveals Precision Immune Signatures of SARS-CoV-2 Infection in Hospitalized Individuals Open
The immune response to COVID-19 infection is variable. How COVID-19 influences clinical outcomes in hospitalized patients needs to be understood through readily obtainable biological materials, such as blood. We hypothesized that a high-de…
View article: Balancing precision versus cohort transcriptomic analysis of acute and recovery phase of viral bronchiolitis
Balancing precision versus cohort transcriptomic analysis of acute and recovery phase of viral bronchiolitis Open
Viral infections affecting the lower respiratory tract place enormous burdens on hospitals. As neither vaccines nor antiviral agents exist for many viruses, understanding risk factors and outcomes in each patient using minimally invasive a…
View article: SARS-CoV-2 infection: molecular mechanisms of severe outcomes to suggest therapeutics
SARS-CoV-2 infection: molecular mechanisms of severe outcomes to suggest therapeutics Open
Introduction:The year 2020 was defined by the 29,903 base pairs of RNA that codes for the SARS-CoV-2 genome. SARS-CoV-2 infects humans to cause COVID-19, spreading from patient-to-patient yet impacts patients very divergently.Are…
View article: Monitoring neutrophil-to-lymphocyte ratio in patients with coronavirus disease 2019 receiving tocilizumab
Monitoring neutrophil-to-lymphocyte ratio in patients with coronavirus disease 2019 receiving tocilizumab Open
View article: Controlled trials needed to prove efficacy and safety of convalescent plasma therapy in coronavirus disease 2019
Controlled trials needed to prove efficacy and safety of convalescent plasma therapy in coronavirus disease 2019 Open
View article: SARS-CoV-2-Encoded Proteome and Human Genetics: From Interaction-Based to Ribosomal Biology Impact on Disease and Risk Processes
SARS-CoV-2-Encoded Proteome and Human Genetics: From Interaction-Based to Ribosomal Biology Impact on Disease and Risk Processes Open
SARS-CoV-2 (COVID-19) has infected millions of people worldwide, with lethality in hundreds of thousands. The rapid publication of information, both regarding the clinical course and the viral biology, has yielded incredible knowledge of t…
View article: <p>Geographic Variability and Pathogen-Specific Considerations in the Diagnosis and Management of Chronic Granulomatous Disease</p>
Geographic Variability and Pathogen-Specific Considerations in the Diagnosis and Management of Chronic Granulomatous Disease Open
Chronic granulomatous disease (CGD) is a rare but serious primary immunodeficiency with varying prevalence and rates of X-linked and autosomal recessive disease worldwide. Functional defects in the phagocyte nicotinamide adenine dinucleoti…
View article: Artificial thymic organoids represent a reliable tool to study T-cell differentiation in patients with severe T-cell lymphopenia
Artificial thymic organoids represent a reliable tool to study T-cell differentiation in patients with severe T-cell lymphopenia Open
The study of early T-cell development in humans is challenging because of limited availability of thymic samples and the limitations of in vitro T-cell differentiation assays. We used an artificial thymic organoid (ATO) platform generated …
View article: Diagnostic assay to assist clinical decisions for unclassified severe combined immune deficiency
Diagnostic assay to assist clinical decisions for unclassified severe combined immune deficiency Open
Key Points 3D organoid T-cell differentiation from a few hundred peripheral blood CD34+ cells was successfully achieved. 3D organoid T-cell differentiation could help physicians distinguish intrinsic from extrinsic defects underlying a cli…