Nicholas J. Szerlip
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View article: The dynamic nature of frailty in metastatic spine disease patients
The dynamic nature of frailty in metastatic spine disease patients Open
Purpose Frailty measures are critical for predicting outcomes in metastatic spine disease (MSD) patients. This study aimed to evaluate frailty measures throughout the disease process. Methods This retrospective analysis measured frailty in…
View article: Role of epidural disease in local control of spinal metastases treated with stereotactic body radiation therapy
Role of epidural disease in local control of spinal metastases treated with stereotactic body radiation therapy Open
Spinal metastases can be contained in the bone or have epidural spread. Whether the extent of epidural involvement changes tumor response to therapy is unknown. The decision of when to treat disease progression with focal radiation therapy…
View article: Stereotactic body radiotherapy for treatment of spinal metastasis: A systematic review of the literature
Stereotactic body radiotherapy for treatment of spinal metastasis: A systematic review of the literature Open
Background Advances in local and systemic therapies continue to improve overall survival for patients with cancer, increasing the incidence of spine metastases. Up to 15% of patients with solid tumors develop spinal metastases. Spinal meta…
View article: Patients with progression of spinal metastases who present to the clinic have better outcomes compared to those who present to the emergency department
Patients with progression of spinal metastases who present to the clinic have better outcomes compared to those who present to the emergency department Open
Background As cancer therapies have improved, spinal metastases are increasingly common. Resulting complications have a significant impact on patient's quality of life. Optimal methods of surveillance and avoidance of neurologic deficits a…
View article: Editorial. Sacroiliac joint fusion: durability of symptom relief by promoting bone arthrodesis
Editorial. Sacroiliac joint fusion: durability of symptom relief by promoting bone arthrodesis Open
View article: DISP-04. PATIENTS WITH PROGRESSION OF SPINE METASTASES WHO PRESENT TO CLINIC HAVE BETTER OUTCOMES COMPARED TO THOSE WHO PRESENT TO THE EMERGENCY DEPARTMENT
DISP-04. PATIENTS WITH PROGRESSION OF SPINE METASTASES WHO PRESENT TO CLINIC HAVE BETTER OUTCOMES COMPARED TO THOSE WHO PRESENT TO THE EMERGENCY DEPARTMENT Open
As cancer therapies have improved, survival has increased. Spine metastases are becoming more common in the course of oncologic disease. Complications arising from these metastases have a significant impact on patient quality of life and t…
View article: Differential immune landscapes in appendicular versus axial skeleton
Differential immune landscapes in appendicular versus axial skeleton Open
Roughly 400,000 people in the U.S. are living with bone metastases, the vast majority occurring in the spine. Metastases to the spine result in fractures, pain, paralysis, and significant health care costs. This predilection for cancer to …
View article: Pre- and intraoperative thoracic spine localization techniques: a systematic review
Pre- and intraoperative thoracic spine localization techniques: a systematic review Open
OBJECTIVE In the era of modern medicine with an armamentarium full of state-of-the art technologies at our disposal, the incidence of wrong-level spinal surgery remains problematic. In particular, the thoracic spine presents a challenge fo…
View article: Bone Metastases, Skeletal-Related Events, and Survival in Patients With Metastatic Non–Small Cell Lung Cancer Treated With Immune Checkpoint Inhibitors
Bone Metastases, Skeletal-Related Events, and Survival in Patients With Metastatic Non–Small Cell Lung Cancer Treated With Immune Checkpoint Inhibitors Open
Background: Bone metastases and skeletal-related events (SREs) are a frequent cause of morbidity in patients with metastatic non–small cell lung cancer (mNSCLC). Data are limited on bone metastases and SREs in patients with mNSCLC treated …
View article: Survival, fusion, and hardware failure after surgery for spinal metastatic disease
Survival, fusion, and hardware failure after surgery for spinal metastatic disease Open
OBJECTIVE Decompression with instrumented fusion is commonly employed for spinal metastatic disease. Arthrodesis is typically sought despite limited knowledge of fusion outcomes, high procedural morbidity, and poor prognosis. This study ai…
View article: IMMU-06. DISCERNING THE DIFFERENT BONE MARROW IMMUNE LANDSCAPES
IMMU-06. DISCERNING THE DIFFERENT BONE MARROW IMMUNE LANDSCAPES Open
Roughly 400,000 people have bone metastases in the U.S. with the vast majority of these occurring in the spine. The etiology of bone metastasis still remains to be fully elucidated. This study explored the differences in immune landscape b…
View article: The feasibility of computer-assisted 3D navigation in multiple-level lateral lumbar interbody fusion in combination with posterior instrumentation for adult spinal deformity
The feasibility of computer-assisted 3D navigation in multiple-level lateral lumbar interbody fusion in combination with posterior instrumentation for adult spinal deformity Open
OBJECTIVE The lateral lumbar interbody fusion (LLIF) technique is used to treat many common spinal degenerative pathologies including kyphoscoliosis. The use of spinal navigation for LLIF has not been broadly adopted, especially in adult s…
View article: Association between timing of kyphoplasty and opioid prescribing risk after vertebral fracture
Association between timing of kyphoplasty and opioid prescribing risk after vertebral fracture Open
OBJECTIVE Approximately 550,000 Americans experience vertebral fracture annually, and most receive opioids to treat the resulting pain. Kyphoplasty of the fractured vertebra is a procedural alternative that may mitigate risks of even short…
View article: Utilization of a Resuscitative Care Unit for Initial Triage, Management, and Disposition of Minor Intracranial Hemorrhage
Utilization of a Resuscitative Care Unit for Initial Triage, Management, and Disposition of Minor Intracranial Hemorrhage Open
Objectives: Management of minor intracranial hemorrhage typically involves ICU admission. ICU capacity is increasingly strained, resulting in increased emergency department boarding of critically ill patients. Our objectives were to implem…
View article: Pupillary changes after clinically asymptomatic high-acceleration head impacts in high school football athletes
Pupillary changes after clinically asymptomatic high-acceleration head impacts in high school football athletes Open
OBJECTIVE Previous studies have shown that clinically asymptomatic high-acceleration head impacts (HHIs) may be associated with neuronal and axonal injury, as measured by advanced imaging and biomarkers. Unfortunately, these methods of mea…
View article: GENE-42. EXOME SEQUENCING ANALYSIS TO IDENTIFY POSSIBLE GENOMIC DRIVERS OF METASTATIC INVASION INTO THE SPINE
GENE-42. EXOME SEQUENCING ANALYSIS TO IDENTIFY POSSIBLE GENOMIC DRIVERS OF METASTATIC INVASION INTO THE SPINE Open
The spine is a common site of metastatic spread of many cancers, causing debilitating pain and suffering. Treatment of spinal metastases is limited by resistance to radiation, chemotherapy, and proximity to the spinal cord. It is currently…
View article: GENE-54. INVESTIGATING THE ROLES OF NCOR1 AND NCOR2 IN METASTATIC INVASION INTO THE SPINE
GENE-54. INVESTIGATING THE ROLES OF NCOR1 AND NCOR2 IN METASTATIC INVASION INTO THE SPINE Open
Anywhere from 30–70% of osseous metastatic disease occurs in the spine across many different tumor types. These metastases lead to debilitating pain and neurologic dysfunction significantly reducing patients’ quality of life. Unfortunately…
View article: Detection and isolation of disseminated tumor cells in bone marrow of patients with clinically localized prostate cancer
Detection and isolation of disseminated tumor cells in bone marrow of patients with clinically localized prostate cancer Open
Background Disseminated tumor cells (DTCs) have been reported in the bone marrow (BM) of patients with localized prostate cancer (PCa). However, the existence of these cells continues to be questioned, and few methods exist for viable DTC …
View article: Endoscopic removal of recurrent colloid cysts
Endoscopic removal of recurrent colloid cysts Open
OBJECTIVE Removal of colloid cysts of the third ventricle using a purely endoscopic method has been established as a safe and advantageous technique. It is hypothesized that endoscopic removal in recurrent cases might pose more technical c…
View article: Safety, Efficacy, and Setup Accuracy of Patients Undergoing Multi-Level Spine Stereotactic Radiosurgery
Safety, Efficacy, and Setup Accuracy of Patients Undergoing Multi-Level Spine Stereotactic Radiosurgery Open
View article: Elevated markers of brain injury as a result of clinically asymptomatic high-acceleration head impacts in high-school football athletes
Elevated markers of brain injury as a result of clinically asymptomatic high-acceleration head impacts in high-school football athletes Open
OBJECTIVE This prospective observational cohort study of high-school football athletes was performed to determine if high-acceleration head impacts (HHIs) that do not result in clinically diagnosed concussion still lead to increases in ser…
View article: Dural Cells Release Factors Which Promote Cancer Cell Malignancy and Induce Immunosuppressive Markers in Bone Marrow Myeloid Cells
Dural Cells Release Factors Which Promote Cancer Cell Malignancy and Induce Immunosuppressive Markers in Bone Marrow Myeloid Cells Open
Factors released by primary dural cells induce proliferation of tumor cells and alter bone marrow to create a fertile environment for tumor growth. The dura therefore may play an important role in the increased incidence of metastases to a…
View article: Online postconcussion return-to-play instructions
Online postconcussion return-to-play instructions Open
OBJECTIVE The authors of recent concussion guidelines have sought to form a consensus on injury management, but it is unclear if they have been effective in conveying this information to the public. Many parents and athletes obtain medical…
View article: TMIC-05. THE DURA MATER MODULATES THE SURROUNDING MICROENVIRONMENT TO PROMOTE TUMOR GROWTH AND IMMUNE EVASION
TMIC-05. THE DURA MATER MODULATES THE SURROUNDING MICROENVIRONMENT TO PROMOTE TUMOR GROWTH AND IMMUNE EVASION Open
The dura mater, the outer layer of the protective meninges, lies adjacent to the skull and vertebral bones, and, at specific sites, in direct contact with the bone marrow (BM). During development, the dura regulates morphogenesis in the CN…
View article: The impact of blood pressure management after spinal cord injury: a systematic review of the literature
The impact of blood pressure management after spinal cord injury: a systematic review of the literature Open
OBJECTIVE Spinal cord injury (SCI) results in significant morbidity and mortality. Improving neurological recovery by reducing secondary injury is a major principle in the management of SCI. To minimize secondary injury, blood pressure (BP…
View article: Superiority of CT Myelography over MRI in Delineating the Spinal Cord during Spine Stereotactic Radiosurgery
Superiority of CT Myelography over MRI in Delineating the Spinal Cord during Spine Stereotactic Radiosurgery Open
View article: Anatomic and functional imaging in the diagnosis of spine metastases and response assessment after spine radiosurgery
Anatomic and functional imaging in the diagnosis of spine metastases and response assessment after spine radiosurgery Open
Spine stereotactic radiosurgery (SSRS) has recently emerged as an increasingly effective treatment for spinal metastases. Studies performed over the past decade have examined the role of imaging in the diagnosis of metastases, as well as t…
View article: A Lab Assembled Microcontroller-Based Sensor Module for Continuous Oxygen Measurement in Portable Hypoxia Chambers
A Lab Assembled Microcontroller-Based Sensor Module for Continuous Oxygen Measurement in Portable Hypoxia Chambers Open
We show the kit's utility and stability of data output via a series of hypoxia experiments. The studies also demonstrated the critical need to monitor and adjust gas-phase O2 concentration during hypoxia-based experiments to prevent experi…
View article: Predictors of delayed failure of structural kyphoplasty for pathological compression fractures in cancer patients
Predictors of delayed failure of structural kyphoplasty for pathological compression fractures in cancer patients Open
OBJECT Pathological compression fractures in cancer patients cause significant pain and disability. Spinal metastases affect quality of life near the end of life and may require multiple procedures, including medical palliative care and op…