Nicholas J. White
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View article: Microbial aerotrophy enables continuous primary production in diverse cave ecosystems
Microbial aerotrophy enables continuous primary production in diverse cave ecosystems Open
Aerated caves receive minimal light energy, yet host diverse microbial communities and the strategies allowing them to meet energy and carbon needs remain unclear. We determined the processes and mediators of primary production in aerated …
View article: Cerebral malaria: of mice and men
Cerebral malaria: of mice and men Open
Background Cerebral malaria is a major cause of death in endemic areas. An animal model of cerebral malaria has been studied widely in which C57BL/6 mice are infected with the Plasmodium berghei ANKA strain. The histopathology and the resp…
View article: Pharmacometric evaluation of sulfadoxine-pyrimethamine- amodiaquine and dihydroartemisinin-piperaquine seasonal malaria chemoprevention in northern Uganda
Pharmacometric evaluation of sulfadoxine-pyrimethamine- amodiaquine and dihydroartemisinin-piperaquine seasonal malaria chemoprevention in northern Uganda Open
Background Seasonal malaria chemoprevention (SMC) using monthly sulfadoxine-pyrimethamine-amodiaquine (SPAQ) is being deployed East Africa, where antimalarial drug resistance levels are high. Dihydroartemisinin-piperaquine (DP) is a potent…
View article: Probabilistic classification of late treatment failure in uncomplicated falciparum malaria
Probabilistic classification of late treatment failure in uncomplicated falciparum malaria Open
View article: <i>Plasmodium vivax</i> malaria relapse risk depends on transmission intensity: evidence from a longitudinal study in northwest Thailand
<i>Plasmodium vivax</i> malaria relapse risk depends on transmission intensity: evidence from a longitudinal study in northwest Thailand Open
Background In northwest Thailand the provision of radical cure to prevent relapses of Plasmodium vivax malaria has decreased P. vivax caseloads and decreased transmission. While malaria control measures were increased, we performed a prosp…
View article: Investigating the Abbott-Bioline™ malaria antigen Pf/Pv rapid diagnostic test
Investigating the Abbott-Bioline™ malaria antigen Pf/Pv rapid diagnostic test Open
The Abbott-Bioline™ Malaria Ag Pf/Pv RDT that were obtained in 2024 failed to detect microscopically confirmed cases of malaria and is not fit for purpose. This test should no longer be used and should be replaced by one with adequate perf…
View article: Population pharmacokinetics of artemether–lumefantrine plus amodiaquine in patients with uncomplicated <i>Plasmodium falciparum</i> malaria
Population pharmacokinetics of artemether–lumefantrine plus amodiaquine in patients with uncomplicated <i>Plasmodium falciparum</i> malaria Open
Aims Resistance to the artemisinins and the artemisinin‐based combination therapy (ACT) partner drugs has developed in Southeast Asia, and artemisinin resistance has also emerged in eastern Africa. Triple ACTs (triple artemisinin‐based com…
View article: Transplacental Transfer of Lumefantrine, Mefloquine, and Piperaquine: A Comparison of Concentrations in Mothers, Neonates, and Cord Blood
Transplacental Transfer of Lumefantrine, Mefloquine, and Piperaquine: A Comparison of Concentrations in Mothers, Neonates, and Cord Blood Open
Background Malaria in pregnancy causes adverse effects on the mother and fetus, requiring effective antimalarial treatment. Understanding the transplacental transfer of antimalarials is vital to assessing fetal safety and the risk of conge…
View article: Antiviral efficacy of oral ensitrelvir versus oral ritonavir-boosted nirmatrelvir in COVID-19 (PLATCOV): an open-label, phase 2, randomised, controlled, adaptive trial
Antiviral efficacy of oral ensitrelvir versus oral ritonavir-boosted nirmatrelvir in COVID-19 (PLATCOV): an open-label, phase 2, randomised, controlled, adaptive trial Open
Wellcome Trust through the COVID-19 Therapeutics Accelerator.
View article: Enhancing CYP2D6 genotyping with nanopore sequencing to address allele diversity P. vivax malaria elimination
Enhancing CYP2D6 genotyping with nanopore sequencing to address allele diversity P. vivax malaria elimination Open
The precise profiling of CYP2D6 alleles is critical for identifying patients who are likely to benefit from primaquine therapy, a standard treatment for preventing P. vivax relapse and, as a result, obstacle for malaria elimination. Conven…
View article: Population pharmacokinetic-pharmacodynamic analysis of benznidazole monotherapy and combination therapy with fosravuconazole in chronic Chagas disease (BENDITA)
Population pharmacokinetic-pharmacodynamic analysis of benznidazole monotherapy and combination therapy with fosravuconazole in chronic Chagas disease (BENDITA) Open
Introduction The currently recommended 8-week daily benznidazole regimen for Chagas disease is poorly tolerated. While shorter benznidazole monotherapy and combination regimens have been explored, the pharmacokinetic/pharmacodynamic (PK/PD…
View article: Deaths from febrile coma in African children can be reduced now
Deaths from febrile coma in African children can be reduced now Open
View article: Quantifying anti-trypanosomal treatment effects in chronic indeterminate Chagas disease: a secondary analysis of individual patient data from two proof-of-concept trials
Quantifying anti-trypanosomal treatment effects in chronic indeterminate Chagas disease: a secondary analysis of individual patient data from two proof-of-concept trials Open
Wellcome Trust.
View article: Can malaria rapid diagnostic tests be used to detect simian malaria?
Can malaria rapid diagnostic tests be used to detect simian malaria? Open
The performance of RDTs in detecting simian malaria varies according to RDT brand, infecting Plasmodium species, and parasite density. Most RDT brands show good performance to detect simian Plasmodium species when parasite density exceeds …
View article: Accurate Measurement of Viral Clearance in Early-Phase Antiviral Studies in Coronavirus Disease 2019
Accurate Measurement of Viral Clearance in Early-Phase Antiviral Studies in Coronavirus Disease 2019 Open
View article: Data Assimilation in Large Eddy Simulation: Addressing Model-Observation Mismatch from Navier-Stokes Data
Data Assimilation in Large Eddy Simulation: Addressing Model-Observation Mismatch from Navier-Stokes Data Open
In atmospheric and turbulent flow modeling, Large Eddy Simulation (LES) is often used to reduce computational cost, while observational data typically originates from the underlying physical system. Motivated by this setting, we study a co…
View article: Microhaplotype deep sequencing assays to capture Plasmodium vivax infection lineages
Microhaplotype deep sequencing assays to capture Plasmodium vivax infection lineages Open
View article: In vivo selection and glymphatic delivery of AAV5 capsids engineered to target human glial progenitor cells
In vivo selection and glymphatic delivery of AAV5 capsids engineered to target human glial progenitor cells Open
To establish a means of efficiently transducing human glial progenitor cells (hGPCs) in vivo with therapeutic transgenes, we targeted PDGFRA-driven Cre-recombinase expressing hGPCs in human glial chimeric mice with a library of capsid-modi…
View article: Single low dose primaquine to block the transmission of Plasmodium falciparum—proposed stand-alone and ACT-adapted regimens
Single low dose primaquine to block the transmission of Plasmodium falciparum—proposed stand-alone and ACT-adapted regimens Open
View article: Pharmacometric evaluation of amodiaquine-sulfadoxine-pyrimethamine and dihydroartemisinin-piperaquine seasonal malaria chemoprevention in northern Uganda
Pharmacometric evaluation of amodiaquine-sulfadoxine-pyrimethamine and dihydroartemisinin-piperaquine seasonal malaria chemoprevention in northern Uganda Open
Background Seasonal malaria chemoprevention (SMC) using monthly amodiaquine-sulfadoxine-pyrimethamine (SPAQ) is being deployed East Africa, where antimalarial drug resistance levels are high. Dihydroartemisinin-piperaquine (DP) is a potent…
View article: Does mass chloroquine treatment have any role in the elimination of Plasmodium vivax ?
Does mass chloroquine treatment have any role in the elimination of Plasmodium vivax ? Open
Countries in the Greater Mekong sub-region (GMS) have been encouraged to deploy mass chloroquine treatments given monthly for four months to reduce the burden of vivax malaria. This paper summarizes briefly current knowledge on Plasmodium …
View article: Antiviral efficacy of oral ensitrelvir versus oral ritonavir-boosted nirmatrelvir in COVID-19
Antiviral efficacy of oral ensitrelvir versus oral ritonavir-boosted nirmatrelvir in COVID-19 Open
Background Ensitrelvir is an oral antiviral treatment for COVID-19 with the same molecular target as ritonavir-boosted nirmatrelvir - the current oral first-line treatment. There have been no direct comparisons between the two drugs. Metho…
View article: Onset of strong Iceland-Scotland overflow water 3.6 million years ago
Onset of strong Iceland-Scotland overflow water 3.6 million years ago Open
North Atlantic Deep Water (NADW), the return flow component of the Atlantic Meridional Overturning Circulation (AMOC), is a major inter-hemispheric ocean water mass with strong climate effects but the evolution of its source components on …
View article: A comparison of national seasonal influenza treatment guidelines across the Asia Pacific region
A comparison of national seasonal influenza treatment guidelines across the Asia Pacific region Open
Seasonal influenza leads to 2–3 million infections and up to 650,000 global deaths annually, with particularly high mortality in Asia and relatively low annual vaccination rates for prevention. Relatively lower attention is paid to antivir…
View article: Characterising viral clearance kinetics in acute influenza
Characterising viral clearance kinetics in acute influenza Open
Pharmacometric assessment of antiviral efficacy in acute influenza informs treatment decisions and pandemic preparedness. We characterised natural viral clearance in acute influenza to guide phase II trial design using simulations based up…
View article: Submicroscopic malaria in pregnancy and associated adverse pregnancy events: A case-cohort study of 4,352 women on the Thailand–Myanmar border
Submicroscopic malaria in pregnancy and associated adverse pregnancy events: A case-cohort study of 4,352 women on the Thailand–Myanmar border Open
Background Malaria in pregnancy detected by microscopy is associated with maternal anaemia, reduced fetal growth, and preterm birth, but the effects of lower density (i.e., submicroscopic) malaria infections are poorly characterised. This …
View article: Within-host modeling of primaquine-induced hemolysis in hemizygote glucose-6-phosphate dehydrogenase deficient healthy volunteers
Within-host modeling of primaquine-induced hemolysis in hemizygote glucose-6-phosphate dehydrogenase deficient healthy volunteers Open
Primaquine is the only widely available drug to prevent relapses of Plasmodium vivax malaria. Primaquine is underused because of concerns over oxidant hemolysis in glucose-6-phosphate dehydrogenase (G6PD) deficiency. A pharmacometric trial…
View article: Dose‐Optimization of a Novel Co‐Formulated Triple Combination Antimalarial Therapy: Artemether‐Lumefantrine‐Amodiaquine
Dose‐Optimization of a Novel Co‐Formulated Triple Combination Antimalarial Therapy: Artemether‐Lumefantrine‐Amodiaquine Open
Artemisinin‐based combination therapy (ACT) is the first‐line therapy for uncomplicated falciparum malaria, but artemisinin resistance in Asia and now sub‐Saharan Africa is threatening our ability to control and eliminate malaria. Triple‐A…
View article: Antiviral efficacy of fluoxetine in early symptomatic COVID-19: an open-label, randomised, controlled, adaptive platform trial (PLATCOV)
Antiviral efficacy of fluoxetine in early symptomatic COVID-19: an open-label, randomised, controlled, adaptive platform trial (PLATCOV) Open
View article: A mixed methods study investigating factors affecting adherence to Plasmodium vivax malaria primaquine radical cure regimens among migrants along the Myanmar-Thailand border
A mixed methods study investigating factors affecting adherence to Plasmodium vivax malaria primaquine radical cure regimens among migrants along the Myanmar-Thailand border Open
Background The countries within the Greater Mekong Region of Southeast Asia have pledged to eliminate malaria by 2030. Elimination of Plasmodium vivax malaria is challenging as it requires radical cure to prevent relapse. Understanding and…