Nicholas Kim
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View article: The MR neuroimaging protocol for the Accelerating Medicines Partnership® Schizophrenia Program
The MR neuroimaging protocol for the Accelerating Medicines Partnership® Schizophrenia Program Open
View article: Metabolic reprogramming of the neovascular niche promotes regenerative angiogenesis in proliferative retinopathy
Metabolic reprogramming of the neovascular niche promotes regenerative angiogenesis in proliferative retinopathy Open
View article: The Dynamic Interactions of m6A Modification and R-Loops: Implications for Genome Stability
The Dynamic Interactions of m6A Modification and R-Loops: Implications for Genome Stability Open
R-loops, three-stranded RNA-DNA hybrid nucleic acid structures, are recognized for their roles in both physiological and pathological processes. Regulation of R-loops is critical for genome stability as disruption of R-loop homeostasis can…
View article: The MR neuroimaging protocol for the Accelerating Medicines Partnership® Schizophrenia Program
The MR neuroimaging protocol for the Accelerating Medicines Partnership® Schizophrenia Program Open
Neuroimaging with MRI has been a frequent component of studies of individuals at clinical high risk (CHR) for developing psychosis, with goals of understanding potential brain regions and systems impacted in the CHR state and identifying p…
View article: Shape analysis of the amygdala, hippocampus and thalamus in former American football players
Shape analysis of the amygdala, hippocampus and thalamus in former American football players Open
Repetitive head impacts are common in contact and collision sports and are linked to structural brain changes and an elevated risk of neurodegenerative diseases such as Chronic Traumatic Encephalopathy. Identifying early in vivo structural…
View article: Altered Sulcal Morphology in Former American Football Players.
Altered Sulcal Morphology in Former American Football Players. Open
View article: Epigenetic toxicity of heavy metals − implications for embryonic stem cells
Epigenetic toxicity of heavy metals − implications for embryonic stem cells Open
Exposure to heavy metals, such as cadmium, nickel, mercury, arsenic, lead, and hexavalent chromium has been linked to dysregulated developmental processes, such as impaired stem cell differentiation. Heavy metals are well-known modifiers o…
View article: Brain morphometry in former American football players: findings from the DIAGNOSE CTE research project
Brain morphometry in former American football players: findings from the DIAGNOSE CTE research project Open
Exposure to repetitive head impacts in contact sports is associated with neurodegenerative disorders including chronic traumatic encephalopathy (CTE), which currently can be diagnosed only at post-mortem. American football players are at h…
View article: Metabolic Reprogramming of the Neovascular Niche Promotes Regenerative Angiogenesis in Proliferative Retinopathy
Metabolic Reprogramming of the Neovascular Niche Promotes Regenerative Angiogenesis in Proliferative Retinopathy Open
Healthy blood vessels supply neurons to preserve metabolic function. In blinding proliferative retinopathies (PRs), pathological neovascular tufts often emerge in lieu of needed physiological revascularization of the ischemic neuroretina. …
View article: Metabolic Reprogramming of the Neovascular Niche Promotes Regenerative Angiogenesis in Proliferative Retinopathy
Metabolic Reprogramming of the Neovascular Niche Promotes Regenerative Angiogenesis in Proliferative Retinopathy Open
Healthy blood vessels supply neurons to preserve metabolic function. In blinding ischemic proliferative retinopathies (PRs), pathological neovascular tufts often emerge in lieu of needed physiological neuroretina revascularization. We show…
View article: Nickel-induced transcriptional memory in lung epithelial cells promotes interferon signaling upon nicotine exposure
Nickel-induced transcriptional memory in lung epithelial cells promotes interferon signaling upon nicotine exposure Open
View article: Prorelaxant E-type Prostanoid Receptors Functionally Partition to Different Procontractile Receptors in Airway Smooth Muscle
Prorelaxant E-type Prostanoid Receptors Functionally Partition to Different Procontractile Receptors in Airway Smooth Muscle Open
Prostaglandin E2 imparts diverse physiological effects on multiple airway cells through its actions on four distinct E-type prostanoid (EP) receptor subtypes (EP1-EP4). Gs-coupled EP2 and EP4 receptors are expressed on airway smooth muscle…
View article: Cells in the polyaneuploid cancer cell (PACC) state have increased metastatic potential
Cells in the polyaneuploid cancer cell (PACC) state have increased metastatic potential Open
Although metastasis is the leading cause of cancer deaths, it is quite rare at the cellular level. Only a rare subset of cancer cells (~ 1 in 1.5 billion) can complete the entire metastatic cascade: invasion, intravasation, survival in the…
View article: Rhinovirus C15 Attenuates Relaxation and cAMP Production in Human Airways and Smooth Muscle
Rhinovirus C15 Attenuates Relaxation and cAMP Production in Human Airways and Smooth Muscle Open
Rhinoviruses (RVs) evoke as many as 85% of acute asthma exacerbations in children and 50% in adults and can induce airway hyperresponsiveness and decrease efficacy of current therapeutics to provide symptom relief. Using human precision-cu…
View article: LBMON186 Beta-agonist Profiling Reveals Novel Biased Signaling Phenotypes For The Beta 2-adrenergic Receptor With Implications In The Treatment Of Asthma
LBMON186 Beta-agonist Profiling Reveals Novel Biased Signaling Phenotypes For The Beta 2-adrenergic Receptor With Implications In The Treatment Of Asthma Open
Asthma involves chronic airway inflammation and airway smooth muscle (ASM) cell contraction. Treatment include agonists of the beta 2-AR, a GPCR that induces the Gs/cAMP pathway leading to ASM relaxation. These agonists can also promote se…
View article: Cells in the Polyaneuploid Cancer Cell (PACC) state have increased metastatic potential
Cells in the Polyaneuploid Cancer Cell (PACC) state have increased metastatic potential Open
Although metastasis is the leading cause of cancer deaths, it is quite rare at the cellular level. Only a rare subset of cancer cells (∼1 in 1.5 billion) can complete the entire metastatic cascade: invasion, intravasation, survival in the …
View article: β<sub>2</sub>‐Adrenoceptor agonist profiling reveals biased signalling phenotypes for the β<sub>2</sub>‐adrenoceptor with possible implications for the treatment of asthma
β<sub>2</sub>‐Adrenoceptor agonist profiling reveals biased signalling phenotypes for the β<sub>2</sub>‐adrenoceptor with possible implications for the treatment of asthma Open
Background and Purpose β‐Adrenoceptor agonists relieve airflow obstruction by activating β 2 ‐adrenoceptors, which are G protein‐coupled receptors (GPCRs) expressed on human airway smooth muscle (HASM) cells. The currently available β‐adre…
View article: Triglyceride-derived fatty acids reduce autophagy in a model of retinal angiomatous proliferation
Triglyceride-derived fatty acids reduce autophagy in a model of retinal angiomatous proliferation Open
Dyslipidemia and autophagy have been implicated in the pathogenesis of blinding neovascular age-related macular degeneration (NV-AMD). VLDL receptor (VLDLR), expressed in photoreceptors with a high metabolic rate, facilitates the uptake of…
View article: Radiation Doses in Patients Undergoing Computed Tomographic Coronary Artery Calcium Evaluation With a 64-Slice Scanner Versus a 256-Slice Scanner
Radiation Doses in Patients Undergoing Computed Tomographic Coronary Artery Calcium Evaluation With a 64-Slice Scanner Versus a 256-Slice Scanner Open
Computed tomographic coronary artery calcium scanning enables cardiovascular risk stratification; however, exposing patients to high radiation levels is an ongoing concern. New-generation computed tomographic systems use lower radiation do…
View article: Identification and characterization of an atypical Gαs-biased β <sub>2</sub> AR agonist that fails to evoke airway smooth muscle cell tachyphylaxis
Identification and characterization of an atypical Gαs-biased β <sub>2</sub> AR agonist that fails to evoke airway smooth muscle cell tachyphylaxis Open
Significance We sought β 2 AR agonists for treating obstructive lung diseases such as asthma, in which this receptor relaxes airway smooth muscle (ASM) cells and opens airways. Agonists favoring Gs coupling (leads to airway relaxation) com…
View article: FFAR1 activation attenuates histamine-induced myosin light chain phosphorylation and cortical tension development in human airway smooth muscle cells
FFAR1 activation attenuates histamine-induced myosin light chain phosphorylation and cortical tension development in human airway smooth muscle cells Open
View article: The odorant receptor OR2W3 on airway smooth muscle evokes bronchodilation via a cooperative chemosensory tradeoff between TMEM16A and CFTR
The odorant receptor OR2W3 on airway smooth muscle evokes bronchodilation via a cooperative chemosensory tradeoff between TMEM16A and CFTR Open
Significance Odorant sensing GPCRs are the largest gene family in the human genome. We previously found multiple olfactory receptors and their obligate downstream effectors expressed in the smooth muscle of human bronchi. However, the exte…
View article: AB038. Pathological neovascularization in retinopathy of prematurity is regulated by heme-derived iron trafficking
AB038. Pathological neovascularization in retinopathy of prematurity is regulated by heme-derived iron trafficking Open
Background: Retinopathy of prematurity (ROP) is an eye disease of the immature newborn characterized by pathological neovascularization (NV). ROP classically arises due to changes in oxygen availability in the retina. However, other factor…
View article: Transgender vaginoplasty: techniques and outcomes
Transgender vaginoplasty: techniques and outcomes Open
Gender affirmation surgery is paramount in the treatment of gender dysphoria for transgender individuals. For transgender women, vaginoplasty offers the opportunity for removal of masculine-appearing genitalia and replacement with a gender…
View article: Abdominal suspension during massive panniculectomy: A novel technique and review of the literature
Abdominal suspension during massive panniculectomy: A novel technique and review of the literature Open
View article: Changing trends in colorectal cancer in the Republic of Korea: contrast with Japan
Changing trends in colorectal cancer in the Republic of Korea: contrast with Japan Open
Colorectal cancer has a high worldwide incidence. Japan, a country that is geographically and culturally similar to the Republic of Korea (here after Korea), has recently reported a decreasing trend in the incidence of colorectal cancer. H…