Nicholas Musinguzi
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View article: Associations of Place-Based Factors with Service Use and Consumer-Reported Unmet Service Needs Among Older Adults Using Publicly Funded Home- and Community-Based Services in the United States
Associations of Place-Based Factors with Service Use and Consumer-Reported Unmet Service Needs Among Older Adults Using Publicly Funded Home- and Community-Based Services in the United States Open
Access to home- and community-based services (HCBS) is critical for aging in place; yet many older adults continue to experience unmet needs. While individual-level factors are better-studied, less is known about how neighborhood-level pla…
View article: Subtypes A1 and D, and recombinant HIV-1 natural polymorphisms associated with lenacapavir drug resistance in Uganda
Subtypes A1 and D, and recombinant HIV-1 natural polymorphisms associated with lenacapavir drug resistance in Uganda Open
Background Lenacapavir, a novel HIV-1 capsid inhibitor, shows promise for treating MDR HIV-1, as well as for pre-exposure prophylaxis (PrEP) in prevention of HIV infection. Its unique mechanism and lack of cross-resistance with other antir…
View article: In-hospital trends of non-communicable disease mortality during the COVID-19 pandemic at a regional referral hospital in southwestern Uganda
In-hospital trends of non-communicable disease mortality during the COVID-19 pandemic at a regional referral hospital in southwestern Uganda Open
Background Non-communicable diseases (NCDs) represent a growing health burden in sub-Saharan Africa. In Uganda, 33% of deaths were attributed to NCDs in 2016 and to-date many health facilities are ill-equipped to properly manage NCDs. The …
View article: Acceptability, feasibility and preliminary effectiveness of the mHealth intervention, InTSHA, on retention in care and viral suppression among adolescents with HIV in South Africa: a pilot randomized clinical trial
Acceptability, feasibility and preliminary effectiveness of the mHealth intervention, InTSHA, on retention in care and viral suppression among adolescents with HIV in South Africa: a pilot randomized clinical trial Open
We describe the results of a pilot randomized clinical trial of a mobile phone-based intervention, InTSHA: Interactive Transition Support for Adolescents with HIV, compared to standard care. Encrypted, closed group chats delivered via What…
View article: Evaluation of the effects of Artemisia Annua L. and Moringa Oleifera Lam. on CD4 count and viral load among PLWH on ART at Mbarara Regional Referral Hospital: a double-blind randomized controlled clinical trial
Evaluation of the effects of Artemisia Annua L. and Moringa Oleifera Lam. on CD4 count and viral load among PLWH on ART at Mbarara Regional Referral Hospital: a double-blind randomized controlled clinical trial Open
Background Initiation of ART among people living with HIV (PLWH) having a CD4 count ≤ 350cells/µl, produces poor immunological recovery, putting them at a high risk of opportunistic infections. To mitigate this, PLWH on ART in Uganda frequ…
View article: Acceptability and feasibility of long-term, real-time electronic adherence monitoring of HIV pre-exposure prophylaxis (PrEP) use among young women in Kenya: A mixed methods study
Acceptability and feasibility of long-term, real-time electronic adherence monitoring of HIV pre-exposure prophylaxis (PrEP) use among young women in Kenya: A mixed methods study Open
Real-time electronic adherence monitoring involves “smart” pill boxes that record and monitor openings as a proxy for pill taking and may be useful in understanding and supporting PrEP use; however, acceptability and/or feasibility for PrE…
View article: My Way: development and preliminary evaluation of a novel delivery system for PrEP and other sexual health needs of young women in Western Kenya
My Way: development and preliminary evaluation of a novel delivery system for PrEP and other sexual health needs of young women in Western Kenya Open
Introduction Young women in sub‐Saharan Africa are a priority population for HIV prevention, yet challenges with adherence and persistence to HIV pre‐exposure prophylaxis (PrEP) are common. This study involved the development and pilot tes…
View article: Social networks and HIV treatment adherence among people with HIV initiating treatment in rural Uganda and peri-urban South Africa
Social networks and HIV treatment adherence among people with HIV initiating treatment in rural Uganda and peri-urban South Africa Open
View article: Effects of Maternal HIV Infection and Alcohol Use in Pregnancy on Birth Outcomes in Uganda
Effects of Maternal HIV Infection and Alcohol Use in Pregnancy on Birth Outcomes in Uganda Open
View article: Determinants of health-related quality of life in people with Human Immunodeficiency Virus, failing first-line treatment in Africa
Determinants of health-related quality of life in people with Human Immunodeficiency Virus, failing first-line treatment in Africa Open
View article: Evaluating disparities in code status designation among patients admitted with COVID-19 at a quaternary care center early in the pandemic
Evaluating disparities in code status designation among patients admitted with COVID-19 at a quaternary care center early in the pandemic Open
The COVID-19 pandemic has highlighted disparities in outcomes by social determinants to health. It is unclear how much end-of-life discussions and a patient’s decision about code status (“do not resuscitate,” do not resuscitate, or “comfor…
View article: Table of Contents
Table of Contents Open
View article: Seemingly Unrelated Regression Analysis of the Cost and Health-Related Quality of Life Outcomes of the REVAMP Randomized Clinical Trial
Seemingly Unrelated Regression Analysis of the Cost and Health-Related Quality of Life Outcomes of the REVAMP Randomized Clinical Trial Open
View article: Factors Associated With Changes in Alcohol Use During Pregnancy and the Postpartum Transition Among People With HIV in South Africa and Uganda
Factors Associated With Changes in Alcohol Use During Pregnancy and the Postpartum Transition Among People With HIV in South Africa and Uganda Open
Identifying factors associated with alcohol use changes during pregnancy is important for developing interventions for people with HIV (PWH). Pregnant PWH (n = 202) initiating antiretroviral therapy in Uganda and South Africa completed two…
View article: Evaluation of the effect of Artemisia Annua L. and Moringa Oleifera Lam. on CD4 count and viral load among PLWH on HAART at Mbarara Regional Referral Hospital: A Double-Blind Randomized Controlled Clinical Trial
Evaluation of the effect of Artemisia Annua L. and Moringa Oleifera Lam. on CD4 count and viral load among PLWH on HAART at Mbarara Regional Referral Hospital: A Double-Blind Randomized Controlled Clinical Trial Open
Background Initiation of HAART among people living with HIV (PLWH) having a CD4 count ≤ 350cells/µl, produces poor immunological recovery, putting them at a high risk of opportunistic infections. Artemisia annua and Moringa oleifera are am…
View article: Implementation of Electronic Adherence Monitors and Associated Interventions for Routine HIV Antiretroviral Therapy in Uganda: Promising Findings
Implementation of Electronic Adherence Monitors and Associated Interventions for Routine HIV Antiretroviral Therapy in Uganda: Promising Findings Open
Background High, sustained adherence is critical for achieving the individual and public health benefits of HIV antiretroviral therapy (ART). Electronic monitors provide detailed adherence information and can enable real-time interventions…
View article: Development of a transition readiness score for adolescents living with perinatally-acquired HIV and transitioning to adult care
Development of a transition readiness score for adolescents living with perinatally-acquired HIV and transitioning to adult care Open
We created a transition readiness score for adolescents with perinatally-acquired HIV as they transition from pediatric to adult care. Of the 199 adolescents who transitioned to adult care, 84 (42%) had viral suppression (< 200 copies/ml) …
View article: The structure, function and implementation of an outcomes database at a Ugandan secondary hospital: the Mbarara Surgical Services Quality Assurance Database
The structure, function and implementation of an outcomes database at a Ugandan secondary hospital: the Mbarara Surgical Services Quality Assurance Database Open
View article: Who’s slipping through the cracks? A comprehensive individual, clinical and health system characterization of people with virological failure on first‐line HIV treatment in Uganda and South Africa
Who’s slipping through the cracks? A comprehensive individual, clinical and health system characterization of people with virological failure on first‐line HIV treatment in Uganda and South Africa Open
Objectives HIV virological failure remains a major threat to programme success in sub‐Saharan Africa. While HIV drug resistance (HIVDR) and inadequate adherence are the main drivers of virological failure, the individual, clinical and heal…
View article: Resistance Testing for Management of HIV Virologic Failure in Sub-Saharan Africa
Resistance Testing for Management of HIV Virologic Failure in Sub-Saharan Africa Open
The President's Emergency Plan for AIDS Relief and the National Institute of Allergy and Infectious Diseases.
View article: High residual inflammation despite HIV viral suppression: Lessons learned from real‐time adherence monitoring among people with HIV in Africa
High residual inflammation despite HIV viral suppression: Lessons learned from real‐time adherence monitoring among people with HIV in Africa Open
This is the accepted manuscript version of the work published in its final form as Castillo‐Mancilla, Jose R.; Musinguzi, Nicholas; Asiimwe, Stephen; Siedner, Mark J.; Orrell, Catherine; Bangsberg, David R.; Haberer, Jessica E.; HIV Medici…
View article: Internalized stigma, depressive symptoms, and the modifying role of antiretroviral therapy: A cohort study in rural Uganda
Internalized stigma, depressive symptoms, and the modifying role of antiretroviral therapy: A cohort study in rural Uganda Open
View article: Treating depression and improving adherence in HIV care with task‐shared cognitive behavioural therapy in Khayelitsha, South Africa: a randomized controlled trial
Treating depression and improving adherence in HIV care with task‐shared cognitive behavioural therapy in Khayelitsha, South Africa: a randomized controlled trial Open
Introduction Major depressive disorder, highly prevalent among people with HIV (PWH) globally, including South Africa, is associated with suboptimal adherence to antiretroviral therapy. Globally, there are insufficient numbers of mental he…
View article: Development and validation of the HIV adolescent readiness for transition scale (HARTS) in South Africa
Development and validation of the HIV adolescent readiness for transition scale (HARTS) in South Africa Open
Introduction Adolescents living with perinatally acquired HIV have low rates of retention in care and viral suppression after the transition from paediatric to adult care. In this study, we developed and validated a tool to identify adoles…
View article: Association between obesity and combination antiretroviral therapy (cART) adherence among persons with early-stage HIV infection initiating cART
Association between obesity and combination antiretroviral therapy (cART) adherence among persons with early-stage HIV infection initiating cART Open
View article: Effect of SMS reminders on PrEP adherence in young Kenyan women (MPYA study): a randomised controlled trial
Effect of SMS reminders on PrEP adherence in young Kenyan women (MPYA study): a randomised controlled trial Open
View article: Pre-treatment integrase inhibitor resistance is uncommon in antiretroviral therapy-naive individuals with HIV-1 subtype A1 and D infections in Uganda
Pre-treatment integrase inhibitor resistance is uncommon in antiretroviral therapy-naive individuals with HIV-1 subtype A1 and D infections in Uganda Open
Objective: Dolutegravir (DTG) is now a preferred component of first-line antiretroviral therapy (ART). However, prevalence data on natural resistance to integrase inhibitors [integrase strand transfer inhibitors (INSTIs)] in circulating no…
View article: Wireless versus routine physiologic monitoring after cesarean delivery to reduce maternal morbidity and mortality in a resource-limited setting: protocol of type 2 hybrid effectiveness-implementation study
Wireless versus routine physiologic monitoring after cesarean delivery to reduce maternal morbidity and mortality in a resource-limited setting: protocol of type 2 hybrid effectiveness-implementation study Open
View article: Brief Report: The Impact of Disease Stage on Early Gaps in ART in the “Treatment for All” Era—A Multisite Cohort Study
Brief Report: The Impact of Disease Stage on Early Gaps in ART in the “Treatment for All” Era—A Multisite Cohort Study Open
Background: Adoption of “Treat All” policies has increased antiretroviral therapy (ART) initiation in sub-Saharan Africa; however, unexplained early losses continue to occur. More information is needed to understand why treatment discontin…
View article: Adherence to recommendations for ART and targeted PrEP use among HIV serodiscordant couples in East Africa: the “PrEP as a bridge to ART” strategy
Adherence to recommendations for ART and targeted PrEP use among HIV serodiscordant couples in East Africa: the “PrEP as a bridge to ART” strategy Open