Nicholas Nuechterlein
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View article: ANGI-18. DISRUPTING INTEGRIN SIGNALING IMPAIRS MIGRATION, MYC-DRIVEN PURINE BIOSYNTHESIS, AND STEMNESS IN H3K27M DIFFUSE MIDLINE GLIOMAS
ANGI-18. DISRUPTING INTEGRIN SIGNALING IMPAIRS MIGRATION, MYC-DRIVEN PURINE BIOSYNTHESIS, AND STEMNESS IN H3K27M DIFFUSE MIDLINE GLIOMAS Open
Diffuse midline glioma (DMG) is an aggressive pediatric brain tumor driven by the H3K27M histone mutation and represents the leading cause of cancer-related death in children. These tumors are highly infiltrative and can occasionally migra…
View article: Integrated transcriptomic landscape of medulloblastoma and ependymoma reveals novel tumor subtype-specific biology
Integrated transcriptomic landscape of medulloblastoma and ependymoma reveals novel tumor subtype-specific biology Open
Background Medulloblastoma and ependymoma are common pediatric central nervous system tumors with significant molecular and clinical heterogeneity. While molecular subgrouping has enabled classification into molecular subtypes, the extent …
View article: Oligosarcoma uniformly exhibits a HOX gene family hypermethylation signature
Oligosarcoma uniformly exhibits a HOX gene family hypermethylation signature Open
View article: Integrated transcriptomic landscape of medulloblastoma and ependymoma reveals novel tumor subtype-specific biology
Integrated transcriptomic landscape of medulloblastoma and ependymoma reveals novel tumor subtype-specific biology Open
Medulloblastoma and ependymoma are common pediatric central nervous system tumors with significant molecular and clinical heterogeneity. We collected bulk RNA sequencing data from 888 medulloblastoma and 370 ependymoma tumors to establish …
View article: HOXD12 defines an age-related aggressive subtype of oligodendroglioma
HOXD12 defines an age-related aggressive subtype of oligodendroglioma Open
View article: HGG-52. MULTI-INTEGRIN TARGETING EFFECTIVELY SUPPRESSES DIFFUSE MIDLINE GLIOMA MIGRATION
HGG-52. MULTI-INTEGRIN TARGETING EFFECTIVELY SUPPRESSES DIFFUSE MIDLINE GLIOMA MIGRATION Open
Diffuse midline gliomas (DMGs) are aggressive tumors characterized by infiltration into normal midline brain tissue, hindering surgical resection and contributing to overall morbidity and mortality. We established a novel two-step pooled w…
View article: Meningioma transcriptomic landscape demonstrates novel subtypes with regional associated biology and patient outcome
Meningioma transcriptomic landscape demonstrates novel subtypes with regional associated biology and patient outcome Open
Meningiomas, although mostly benign, can be recurrent and fatal. World Health Organization (WHO) grading of the tumor does not always identify high-risk meningioma, and better characterizations of their aggressive biology are needed. To ap…
View article: Ibrutinib disrupts blood-tumor barrier integrity and prolongs survival in rodent glioma model
Ibrutinib disrupts blood-tumor barrier integrity and prolongs survival in rodent glioma model Open
View article: Haploinsufficiency of phosphodiesterase 10A activates PI3K/AKT signaling independent of PTEN to induce an aggressive glioma phenotype
Haploinsufficiency of phosphodiesterase 10A activates PI3K/AKT signaling independent of PTEN to induce an aggressive glioma phenotype Open
Glioblastoma is universally fatal and characterized by frequent chromosomal copy number alterations harboring oncogenes and tumor suppressors. In this study, we analyzed exome-wide human glioblastoma copy number data and found that cytoban…
View article: Meningioma transcriptomic landscape demonstrates novel subtypes with regional associated biology and patient outcome
Meningioma transcriptomic landscape demonstrates novel subtypes with regional associated biology and patient outcome Open
Summary Meningiomas, the most common intracranial tumor, though mostly benign can be recurrent and fatal. WHO grading does not always identify high risk meningioma and better characterizations of their aggressive biology is needed. To appr…
View article: Meningioma Transcriptomic Landscape Demonstrates Novel Subtypes with Regional Associated Biology and Patient Outcome
Meningioma Transcriptomic Landscape Demonstrates Novel Subtypes with Regional Associated Biology and Patient Outcome Open
View article: A road map for the treatment of pediatric diffuse midline glioma
A road map for the treatment of pediatric diffuse midline glioma Open
View article: Whole gain of chromosome 19, not co-gain of chromosomes 19 and 20, characterizes a class of glioblastomas with more favorable outcomes
Whole gain of chromosome 19, not co-gain of chromosomes 19 and 20, characterizes a class of glioblastomas with more favorable outcomes Open
View article: PATH-49. COMPREHENSIVE RNA-SEQ ANALYSIS REVEALS NOVEL SUBTYPES OF MENINGIOMAS AND PREDICTS PATIENT OUTCOME.
PATH-49. COMPREHENSIVE RNA-SEQ ANALYSIS REVEALS NOVEL SUBTYPES OF MENINGIOMAS AND PREDICTS PATIENT OUTCOME. Open
OBJECTIVE Meningiomas are the most common intracranial tumor in humans. While most tumors are benign, some are malignant and ultimately lethal. Current grading systems based on WHO grade do not provide adequate risk stratification, therefo…
View article: MODL-41. LOSS OF DISTAL CHROMOSOME 6Q AND ASSOCIATED <i>PDE10A</i> INDUCES AN AGGRESSIVE GLIOMA PHENOTYPE BY FACILITATING PRONEURAL TO MESENCHYMAL TRANSITION
MODL-41. LOSS OF DISTAL CHROMOSOME 6Q AND ASSOCIATED <i>PDE10A</i> INDUCES AN AGGRESSIVE GLIOMA PHENOTYPE BY FACILITATING PRONEURAL TO MESENCHYMAL TRANSITION Open
Somatic copy number alterations (SCNAs) are common in glioblastoma, with some SCNAs having prognostic implications. Identifying and characterizing SCNA-related genes acting as oncogenes or tumor suppressors may potentially provide new ther…
View article: BIOM-54. VALIDATING MCM2 IMMUNOHISTOCHEMISTRY AS A SURROGATE MARKER FOR AGGRESSIVE MENINGIOMA
BIOM-54. VALIDATING MCM2 IMMUNOHISTOCHEMISTRY AS A SURROGATE MARKER FOR AGGRESSIVE MENINGIOMA Open
Increasing efforts have focused to improve meningioma classification through various multi-omic analyses. One such recent study (Nassiri, et al, Nature, 2021) proposed an integrative molecular classification for meningiomas that included 4…
View article: BIOM-17. WHOLE GAIN OF CHROMOSOME 19, NOT CO-GAIN OF CHROMOSOMES 19 AND 20, IS A FAVORABLE PROGNOSTIC BIOMARKER IN IDH-WILDTYPE GLIOBLASTOMA
BIOM-17. WHOLE GAIN OF CHROMOSOME 19, NOT CO-GAIN OF CHROMOSOMES 19 AND 20, IS A FAVORABLE PROGNOSTIC BIOMARKER IN IDH-WILDTYPE GLIOBLASTOMA Open
BACKGROUND IDH-wildtype glioblastoma carries an abysmal prognosis, but long-term survivors exist. Previous studies have suggested that co-gain of chromosomes 19 and 20 (+19/+20) is a favorable prognostic marker. We sought to validate this …
View article: Validating MCM2 as a clinically relevant surrogate immunohistochemical marker for an aggressive meningioma molecular subtype
Validating MCM2 as a clinically relevant surrogate immunohistochemical marker for an aggressive meningioma molecular subtype Open
View article: Visualizing genomic characteristics across an RNA-Seq based reference landscape of normal and neoplastic brain
Visualizing genomic characteristics across an RNA-Seq based reference landscape of normal and neoplastic brain Open
In order to better understand the relationship between normal and neoplastic brain, we combined five publicly available large-scale datasets, correcting for batch effects and applying Uniform Manifold Approximation and Projection (UMAP) to…
View article: An RNA seq-based reference landscape of human normal and neoplastic brain
An RNA seq-based reference landscape of human normal and neoplastic brain Open
In order to better understand the relationship between normal and neoplastic brain, we combined five publicly available large-scale datasets, correcting for batch effects and applying Uniform Manifold Approximation and Projection (UMAP) to…
View article: An RNA seq-based reference landscape of human normal and neoplastic brain
An RNA seq-based reference landscape of human normal and neoplastic brain Open
In order to better understand the relationship between normal and neoplastic brain, we combined five publicly available large-scale datasets, correcting for batch effects and applying Uniform Manifold Approximation and Projection (UMAP) to…
View article: BIOM-26. GENOME-WIDE SOMATIC COPY NUMBER ALTERATION SIGNATURES HAVE PROGNOSTIC IMPLICATIONS FOR ADULT ASTROCYTIC GLIOMA
BIOM-26. GENOME-WIDE SOMATIC COPY NUMBER ALTERATION SIGNATURES HAVE PROGNOSTIC IMPLICATIONS FOR ADULT ASTROCYTIC GLIOMA Open
BACKGROUND The molecular landscape of adult diffuse glioma has been extensively characterized by gene expression and DNA methylation profiling, but less attention has been paid to somatic copy number alteration (SCNA) data. This study aime…
View article: BIOM-48. HOXD12 IS AN INDEPENDENTLY PROGNOSTIC AGE-ASSOCIATED INDICATOR FOR POOR SURVIVAL IN OLIGODENDROGLIOMA
BIOM-48. HOXD12 IS AN INDEPENDENTLY PROGNOSTIC AGE-ASSOCIATED INDICATOR FOR POOR SURVIVAL IN OLIGODENDROGLIOMA Open
BACKGROUND Oligodendroglioma, IDH-mutant and 1p/19q-codeleted has variable outcomes that are strongly influenced by patient age. This study aimed to discover novel molecular biomarkers that may characterize an aggressive subgroup of oligod…
View article: Expanded analysis of high-grade astrocytoma with piloid features identifies an epigenetically and clinically distinct subtype associated with neurofibromatosis type 1
Expanded analysis of high-grade astrocytoma with piloid features identifies an epigenetically and clinically distinct subtype associated with neurofibromatosis type 1 Open
View article: Oncogenic role of a developmentally regulated <i>NTRK2</i> splice variant
Oncogenic role of a developmentally regulated <i>NTRK2</i> splice variant Open
Temporally regulated alternative splicing choices are vital for proper development, yet the wrong splice choice may be detrimental. Here, we highlight a previously unidentified role for the neurotrophin receptor splice variant TrkB.T1 in n…
View article: Oncogenic role of a developmentally regulated NTRK2 splice variant
Oncogenic role of a developmentally regulated NTRK2 splice variant Open
Temporally-regulated alternative splicing choices are vital for proper development yet the wrong splice choice may be detrimental. Here we highlight a novel role for the neurotrophin receptor splice variant TrkB.T1 in neurodevelopment, emb…
View article: Oncogenic role of a developmentally regulated NTRK2 splice variant
Oncogenic role of a developmentally regulated NTRK2 splice variant Open
Temporally-regulated alternative splicing choices are vital for proper development yet the wrong splice choice may be detrimental. Here we highlight a novel role for the neurotrophin receptor splice variant TrkB.T1 in neurodevelopment, emb…
View article: Oncogenic role of a developmentally regulated<i>NTRK2</i>splice variant
Oncogenic role of a developmentally regulated<i>NTRK2</i>splice variant Open
Temporally-regulated alternative splicing choices are vital for proper development yet the wrong splice choice may be detrimental. Here we highlight a novel role for the neurotrophin receptor splice variant TrkB.T1 in neurodevelopment, emb…
View article: Machine learning modeling of genome-wide copy number alteration signatures reliably predicts IDH mutational status in adult diffuse glioma
Machine learning modeling of genome-wide copy number alteration signatures reliably predicts IDH mutational status in adult diffuse glioma Open
Knowledge of 1p/19q-codeletion and IDH1/2 mutational status is necessary to interpret any investigational study of diffuse gliomas in the modern era. While DNA sequencing is the gold standard for determining IDH mutational status, genome-w…
View article: NCMP-04. BRAIN-UMAP: THE GENETIC INTERSECTION BETWEEN NEUROSCIENCE, NEUROLOGY, PSYCHIATRY, AND ONCOLOGY
NCMP-04. BRAIN-UMAP: THE GENETIC INTERSECTION BETWEEN NEUROSCIENCE, NEUROLOGY, PSYCHIATRY, AND ONCOLOGY Open
Whole transcriptome sequencing (RNA-seq) is an important tool for understanding genetic mechanisms underlying human diseases and gaining a better insight into complex human diseases. Several ground-breaking projects have uniformly processe…