Explanipedia

Wafer-Scale Squeezed-Light Chips Open

Shuai Liu, Kailu Zhou, Yuheng Zhang, Abdulkarim Hariri, Nicholas P. Reynolds , et al. · 2025

Squeezed-light generation in photonic integrated circuits (PICs) is essential for scalable continuous-variable (CV) quantum information processing. By suppressing quantum fluctuations below the shot-noise limit, squeezed states enable quan…

Fluorination Induced Inversion of Helicity and Self‐Assembly Into Cross‐α Like Piezoelectric Amyloids by Minimalistic Designer Peptide Open

Sukantha Dey, Emily H. Field, Yuehui Wang, Kyunghoon Han, Rohit Kumar , et al. · 2025

Although initially identified as pathological aggregates, amyloid fibrillar assemblies formed by various proteins and peptides are now known to have crucial physiological roles, carrying out numerous biological functions in almost all orga…

Self-healing, 3D printed bioinks from self-assembled peptide and alginate hybrid hydrogels Open

Emily H. Field, Julian Ratcliffe, Chad Johnson, Katrina J. Binger, Nicholas P. Reynolds · 2024

There is a pressing need for new cell-laden, printable, biomaterials that are rigid and highly biocompatible. These materials can mimic stiffer tissues such as cartilage, fibrotic tissue and cancer microenvironments, and thus have exciting…

Self-healing, biocompatible bioinks from self-assembled peptide and alginate hybrid hydrogels Open

Emily H. Field, Julian Ratcliffe, Chad Johnson, Katrina J. Binger, Nicholas P. Reynolds · 2024

1. Abstract There is a pressing need for new biomaterials that are printable, stiff and highly biocompatible. This is primarily due to the inverse relationship between the printability and viscosity of hydrogels. Cell-laden, printable, rig…

Cell invasive amyloid assemblies from SARS-CoV-2 peptides can form multiple polymorphs with varying neurotoxicity Open

Oana Sanislav, Rina Tetaj, Metali, Julian Ratcliffe, William T. Phillips , et al. · 2024

The neurological symptoms of COVID-19, such as memory loss, cognitive and sensory disruption (neuro-COVID) are well reported. These neurological symptoms frequently persist for months (post-acute sequalae of COVID-19 or PASC). The molecula…

Towards using 3D cellular cultures to model the activation and diverse functions of macrophages Open

Sean W. Cutter, Mark D. Wright, Nicholas P. Reynolds, Katrina J. Binger · 2023

The advent of 3D cell culture technology promises to enhance understanding of cell biology within tissue microenvironments. Whilst traditional cell culturing methods have been a reliable tool for decades, they inadequately portray the comp…

Extensive collagen deposition by mesenchymal stem cells cultured in 3D self-assembled peptide scaffolds as revealed by nanoplasmonic colorimetric histology Open

Christopher J.H. Chong, Vernise J.T. Lim, Mirren Charnley, Julian Ratcliffe, Emily H. Field , et al. · 2022

Self-assembling peptides are promising candidates as scaffolds for 3D cell cultures. These hydrogels offer favourable biocompatibility, nanofibrillar structures that mimic native tissues, and the convenient integration of bioactive peptide…

Neurotoxic amyloidogenic peptides in the proteome of SARS-COV2: potential implications for neurological symptoms in COVID-19 Open

Mirren Charnley, Saba Islam, Guneet K. Bindra, Jeremy Engwirda, Julian Ratcliffe , et al. · 2022

Neurotoxic Amyloidogenic Peptides in the Proteome of SARS-COV2: Potential Implications for Neurological Symptoms in COVID-19 Open

Mirren Charnley, Saba Islam, Guneet K. Bindra, Jeremy Engwirda, Julian Ratcliffe , et al. · 2022

COVID-19 is primarily known as a respiratory disease caused by the virus SARS-CoV-2. However, neurological symptoms such as memory loss, sensory confusion, cognitive and psychiatric issues, severe headaches, and even stroke are reported in…

Neurotoxic Amyloidogenic Peptides Identified in the Proteome of SARS-COV2: Potential Implications for Neurological Symptoms in COVID-19 Open

Saba Islam, Mirren Charnley, Guneet K. Bindra, Julian Ratcliffe, Jiangtao Zhou , et al. · 2021

COVID-19 is primarily known as a respiratory disease caused by the virus SARS-CoV-2. However, neurological symptoms such as memory loss, sensory confusion, cognitive and psychiatric issues, severe headaches, and even stroke are reported in…

CCDC 2008471: Experimental Crystal Structure Determination Open

Santu Bera, Sarah Guerin, Hui Yuan, Joseph O’Donnell, Nicholas P. Reynolds , et al. · 2021

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

Molecular engineering of piezoelectricity in collagen-mimicking peptide assemblies Open

Santu Bera, Sarah Guerin, Hui Yuan, Joseph O’Donnell, Nicholas P. Reynolds , et al. · 2021

Amyloid Evolution: Antiparallel Replaced by Parallel Open

Ali Asghar Hakami Zanjani, Nicholas P. Reynolds, Afang Zhang, Tanja Schilling, Raffaele Mezzenga , et al. · 2020

Rigid Tightly Packed Amino Acid Crystals as Functional Supramolecular Materials Open

Wei Ji, Bin Xue, Zohar A. Arnon, Hui Yuan, Santu Bera , et al. · 2019

The formation of ordered nanostructures by metabolites is gaining increased interest due to the simplicity of the building blocks and their natural occurrence. Specifically, aromatic amino acids possess the ability to form ordered supramol…

Nanomechanical mapping reveals localized stiffening of the basilar membrane after cochlear implantation Open

Jessica Ky-Lee Choong, Amy Hampson, Kate M. Brody, Jonathon Lo, Christofer Bester , et al. · 2019

Cochlear implantation leads to many structural changes within the cochlea which can impair residual hearing. In patients with preserved low-frequency hearing, a delayed hearing loss can occur weeks-to-years post-implantation. We explore wh…

Kinetic Control of Parallel versus Antiparallel Amyloid Aggregation via Shape of the Growing Aggregate Open

Ali Asghar Hakami Zanjani, Nicholas P. Reynolds, Afang Zhang, Tanja Schilling, Raffaele Mezzenga , et al. · 2019

Tunable Chemical and Topographic Patterns Based on Binary Colloidal Crystals (BCCs) to Modulate MG63 Cell Growth Open

Farhana Sharmin Diba, Nicholas P. Reynolds, Helmut Thissen, Peng‐Yuan Wang, Peter Kingshott · 2019

More effective and diversified surface modification strategies are required for materials used in biomedical engineering. Combining surface modification involving bioactive signals or nonfouling polymers with tunable topography has the pot…

Amyloid-like peptide nanofibrils as scaffolds for tissue engineering: Progress and challenges (Review) Open

Nicholas P. Reynolds · 2019

Networks of amyloid-like nanofibrils assembled from short peptide sequences have the ability to form scaffolds that can encapsulate clinically relevant stem cells encouraging their attachment, growth, and differentiation into various linea…

Non-lamellar lyotropic liquid crystalline nanoparticles enhance the antibacterial effects of rifampicin against Staphylococcus aureus Open

Nhiem Tran, Marion Hocquet, Blandine Eon, Parveen Sangwan, Julian Ratcliffe , et al. · 2018

Characterization of Amyloid Fibril Networks by Atomic Force Microscopy Open

Mirren Charnley, Jay Gilbert, Owen G. Jones, Nicholas P. Reynolds · 2018

Dense networks of amyloid nanofibrils fabricated from common globular proteins adsorbed to solid supports can improve cell adhesion, spreading and differentiation compared to traditional flat, stiff 2D cell culture substrates like Tissue C…

Author Correction: Competition between crystal and fibril formation in molecular mutations of amyloidogenic peptides Open

Nicholas P. Reynolds, Jozef Adamčík, Joshua T. Berryman, Stephan Handschin, Ali Asghar Hakami Zanjani , et al. · 2017

The original version of this article contained an error in Fig. 5c. The label for the back series of columns was incorrectly given as ‘1.5 mM pH 2’, rather than the correct ‘1.5 mM pH 7’. This has now been corrected in both the PDF and HTM…

Competition between crystal and fibril formation in molecular mutations of amyloidogenic peptides Open

Nicholas P. Reynolds, Jozef Adamčík, Joshua T. Berryman, Stephan Handschin, Ali Asghar Hakami Zanjani , et al. · 2017

Tuning the Density of Poly(ethylene glycol) Chains to Control Mammalian Cell and Bacterial Attachment Open

Ahmed Al-Ani, Hitesh Pingle, Nicholas P. Reynolds, Peng‐Yuan Wang, Peter Kingshott · 2017

Surface modification of biomaterials with polymer chains has attracted great attention because of their ability to control biointerfacial interactions such as protein adsorption, cell attachment and bacterial biofilm formation. The aim of …

Molecular interactions of amyloid nanofibrils with biological aggregation modifiers: implications for cytotoxicity mechanisms and biomaterial design Open

Durga Dharmadana, Nicholas P. Reynolds, Charlotte E. Conn, Céline Valéry · 2017

Amyloid nanofibrils are ubiquitous biological protein fibrous aggregates, with a wide range of either toxic or beneficial activities that are relevant to human disease and normal biology. Protein amyloid fibrillization occurs via nucleated…

Chitosan-coated amyloid fibrils increase adipogenesis of mesenchymal stem cells Open

Jay Gilbert, Nicholas P. Reynolds, Sarah M. Russell, David N. Haylock, Sally L. McArthur , et al. · 2017

Polymers in the Delivery of siRNA for the Treatment of Virus Infections Open

Nicholas P. Reynolds, Megan Dearnley, Tracey M. Hinton · 2017

Self-assembling peptide and protein amyloids: from structure to tailored function in nanotechnology Open

Gang Wei, Zhiqiang Su, Nicholas P. Reynolds, Paolo Arosio, Ian W. Hamley , et al. · 2017

Self-assembling amyloid materials with various length scales and tailored functions show wide applications in the fields of biomedicine, tissue engineering, energy materials, environmental science, nanodevices, biosensors, optical material…

Dual-modality NIRF-MRI cubosomes and hexosomes: High throughput formulation and in vivo biodistribution Open

Nhiem Tran, Nicole Bye, Bradford A. Moffat, David Wright, Andrew Cuddihy , et al. · 2016

Comparing Gene Silencing and Physiochemical Properties in siRNA Bound Cationic Star-Polymer Complexes Open

Megan Dearnley, Nicholas P. Reynolds, Peter Cass, Xiaohu Wei, Shuning Shi , et al. · 2016

The translation of siRNA into clinical therapies has been significantly delayed by issues surrounding the delivery of naked siRNA to target cells. Here we investigate siRNA delivery by cationic acrylic polymers developed by Reversible Addi…

Microtubule‐Binding R3 Fragment from Tau Self‐Assembles into Giant Multistranded Amyloid Ribbons Open

Jozef Adamčík, Antoni Sánchez‐Ferrer, Nadine Ait‐Bouziad, Nicholas P. Reynolds, Hilal A. Lashuel , et al. · 2015

Tau protein and its fragments self‐assemble into amyloid fibrils in the presence of polyanions, such as heparin. By combining microscopy, scattering, and spectroscopy techniques, we studied the aggregation of the 26‐mer Tau‐derived peptide…

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