Explanipedia

Treatment-resistant DEK::AFF2 sinonasal squamous cell carcinoma: a case report and review of literature Open

Wassim Najjar, Rachel Stemme, Leila J. Mady, Tanguy Y. Seiwert, Harry Quon , et al. · 2025

DEK::AFF2 fusion-associated sinonasal squamous cell carcinoma (SCC) is a rare and recently recognized malignancy, characterized by its deceptively bland histology and aggressive clinical behavior. It is associated with frequent locoregiona…

Molecular patterns and mechanisms of tumorigenesis in HPV-associated and HPV-independent sinonasal squamous cell carcinoma Open

Fernando T. Zamunér, Sreenivasulu Gunti, Gabriel J. Starrett, Farhoud Faraji, Tiffany Toni , et al. · 2025

Mechanisms of tumorigenesis in sinonasal squamous cell carcinoma (SNSCC) remain poorly understood due to its rarity. A subset of SNSCC is associated with human papillomavirus (HPV), but it is unclear whether HPV drives tumorigenesis or act…

Executive Summary of the Clinical Practice Guideline on the Surgical Management of Chronic Rhinosinusitis Open

Jennifer J. Shin, Meghan Wilson, Margo McKenna, Richard M. Rosenfeld, K von Ammon , et al. · 2025

Objective The purpose of this specialty‐specific clinical practice guideline is to identify quality improvement opportunities and provide clinicians with trustworthy, evidence‐based recommendations for the surgical management of chronic rh…

Clinical Practice Guideline: Surgical Management of Chronic Rhinosinusitis Open

Jennifer J. Shin, Meghan Wilson, Margo McKenna, Richard M. Rosenfeld, K von Ammon , et al. · 2025

Objective The purpose of this specialty‐specific clinical practice guideline is to identify quality improvement opportunities and provide clinicians with trustworthy, evidence‐based recommendations for the surgical management of chronic rh…

Factors Associated with Postoperative Complications Following Resection of Sinonasal Tumors: A NSQIP Analysis Open

Raymond J. So, Hannan A. Qureshi, Evelyn M. Leland, Anirudh Saraswathula, Murugappan Ramanathan , et al. · 2025

Background: As the surgical repertoire for the management of sinonasal tumors evolves over time, an improved understanding of risks for postoperative complications is imperative. Objectives: To identify factors associated with 30-day posto…

June 4: International Skull Base Surgery Day Open

David A. Gudis, Benjamin S. Bleier, Jean Anderson Eloy, James J. Evans, Juan C. Fernandez‐Miranda , et al. · 2025

Improving the educational accessibility of sinonasal and skull base anatomy: A novel virtual tool for otolaryngology trainees Open

Anirudh Saraswathula, Emily Y. Huang, Shirley Xin Li, Juan Ruiz-García, Nicholas R. Rowan · 2024

Background Understanding the complex three‐dimensional (3D) anatomy of the nasal cavity, paranasal sinuses, and skull base, is difficult but essential for otolaryngology trainees, especially for endoscopic techniques. There is no effective…

THE ASSOCIATION OF PERIPHERAL AND CENTRAL OLFACTION WITH FRAILTY IN OLDER ADULTS Open

Nicholas R. Rowan, Nimesh Nagururu, Isaac A. Bernstein, Kristin Voegtline, Sarah Olson , et al. · 2024

Olfactory impairment is increasingly recognized as a biomarker of frailty, but the relationship between olfactory subdomains that describe peripheral or central dysfunction and frailty remains unexplored. In this study, we examined 1,160 o…

Neuroimmune interactions in the olfactory epithelium: maintaining a sensory organ at an immune barrier interface Open

Mohammed Ullah, Nicholas R. Rowan, Andrew P. Lane · 2024

Molecular patterns and mechanisms of tumorigenesis in HPV-associated and HPV-independent sinonasal squamous cell carcinoma Open

Fernando T. Zamunér, Sreenivasulu Gunti, Gabriel J. Starrett, Farhoud Faraji, Tiffany Toni , et al. · 2024

Mechanisms of tumorigenesis in sinonasal squamous cell carcinoma (SNSCC) remain poorly described due to its rare nature. A subset of SNSCC are associated with the human papillomavirus (HPV); however, it is unknown whether HPV is a driver o…

Quality of life in chordoma survivors: results from the Chordoma Foundation Survivorship Survey Open

Adrian E. Jimenez, Kyle V. Cicalese, Miguel A. Jiménez, Sachiv Chakravarti, Cathleen C. Kuo , et al. · 2024

OBJECTIVE Chordomas are rare malignant bone tumors whose location in the skull base or spine, invasive surgical treatment, and accompanying adjuvant radiotherapy may all lead patients to experience poor quality of life (QOL). Limited resea…

Patient Questions Surrounding Posterior Nasal Nerve Ablation for Chronic Rhinitis Open

Daniel Gorelik, Samuel E. Razmi, Robert Kenneth Sims, Aatin K. Dhanda, Masayoshi Takashima , et al. · 2024

Objective In‐office ablation of the posterior nasal nerve (PNN) has emerged as an effective treatment option for chronic rhinitis patients. This study explored questions patients commonly search online regarding this therapy and the qualit…

Modified technique improves efficacy for in‐office posterior nasal nerve ablation Open

Daniel Gorelik, Aatin K. Dhanda, Alexander Choi, Masayoshi Takashima, Najm S. Khan , et al. · 2024

Objectives Posterior nasal nerve (PNN) ablation is a minimally invasive treatment option for patients with chronic rhinitis. Recent evidence shows that parasympathetic innervation of the nasal cavity is more extensive and there are many fi…

Evolution of nasal and olfactory infection characteristics of SARS-CoV-2 variants Open

Mengfei Chen, Andrew Pekosz, Jason Villano, Wenjuan Shen, Ruifeng Zhou , et al. · 2024

SARS-CoV-2 infection of the upper airway and the subsequent immune response are early, critical factors in COVID-19 pathogenesis. By studying infection of human biopsies in vitro and in a hamster model in vivo, we demonstrated a transition…

Operative Corridors in Endoscopic Skull Base Tumor Surgery Open

Ali Ahmed, Nicholas R. Rowan, Debraj Mukherjee · 2024

Advances in technology, instrumentation, and reconstruction have paved the way for extended endoscopic approaches to skull base tumors. In the sagittal plane, the endonasal approach may safely access pathologies from the frontal sinus to t…

Delivering Therapy to the Olfactory Cleft: A Comparison of the Various Methods of Administering Topical Nasal Medications Open

Patricia T. Jacobson, Lucas G. Axiotakis, Brandon J. Vilarello, David A. Gudis, Daniel B. Spielman , et al. · 2024

Physical Function Trajectories and Mortality in Older Adults With Multisensory Impairment Open

Varun Vohra, Eleanor M. Simonsick, Vidyulata Kamath, Karen Bandeen‐Roche, Yuri Agrawal , et al. · 2024

Importance Single sensory impairment is associated with reduced functional resilience and increased mortality, though the effects of multiple sensory deficits are not known. Objective To investigate longitudinal associations of the type, s…

Central Compartment Atopic Disease as a Pathophysiologically Distinct Subtype of Chronic Rhinosinusitis: A Scoping Review Open

Camron Davies, Franklin Wu, Emily Y. Huang, Masayoshi Takashima, Nicholas R. Rowan , et al. · 2023

Central compartment atopic disease (CCAD) is a distinct phenotype within chronic rhinosinusitis with nasal polyps (CRSwNP) with a pathophysiology that bridges the gap between allergy and CRSwNP, an association that was previously ambiguous…

Potential Role for Diet in Mediating the Association of Olfactory Dysfunction and Cognitive Decline: A Nationally Representative Study Open

Varun Vohra, Sahar Assi, Vidyulata Kamath, Zachary M. Soler, Nicholas R. Rowan · 2023

In the context of a growing body of evidence associating olfactory dysfunction (OD) with cognitive decline, this cross-sectional study used data from the 2013–2014 National Health and Nutrition Examination Survey (NHANES) sample in order t…

Accessing the Eustachian tube: Conventional nasal spray vs. exhalation delivery system and the impact of targeted endoscopic sinus surgery on topical distribution patterns Open

Lucas G. Axiotakis, Daniel B. Spielman, David A. Gudis, Nathan Yang, Carol H. Yan , et al. · 2023

Background Eustachian tube dysfunction (ETD) may occur distinct from, or in conjunction with, chronic rhinosinusitis (CRS+ETD). Intranasal corticosteroid sprays are often prescribed for ETD, although ET distribution may be limited. To date…

Exploring Olfactory Dysfunction as a Marker of Frailty and Postoperative Outcomes in Head and Neck Cancer Open

Leila J. Mady, Emma De Ravin, Varun Vohra, Joseph Lu, Jason G. Newman , et al. · 2023

Importance Olfactory dysfunction (OD) is increasingly recognized as a robust marker of frailty and mortality. Despite broad recognition of frailty as a critical component of head and neck cancer (HNC) care, there is no standardized frailty…

The Association of Multiple Sensory Impairment and Telomere Length: The Health <span>ABC</span> Study Open

Varun Vohra, Michael Z. Cheng, Qian‐Li Xue, Eleanor M. Simonsick, Andrew P. Lane , et al. · 2023

Objectives The objective of this study was to characterize the associations of sensory impairments, including olfaction (OI), vision (VI), hearing (HI), and touch (TI), with telomere length (TL) in a group of community‐dwelling older adult…

The NIH pediatric/young adult chordoma clinic and natural history study: Making advances in a very rare tumor Open

Liny John, Hannah Smith, Maran Ilanchezhian, Robin Lockridge, Karlyne M. Reilly , et al. · 2023

Background Chordomas are rare tumors arising from the skull base and spine, with approximately 20 pediatric chordoma cases in the Unitedn States per year. The natural history and optimal treatment of pediatric chordomas, especially poorly …

Reimbursement for Olfactory Testing Open

Anirudh Saraswathula, Rodney J. Schlosser, Nicholas R. Rowan · 2023

This Viewpoint addresses the lack of reimbursement for olfactory testing, which is especially important in a time when the populations of older adults and patients with COVID-19–associated olfactory dysfunction have grown.

Olfactory Dysfunction and Balance Dysfunction are Associated with Increased Falls in Older Adults Open

Lekha V. Yesantharao, Varun Vohra, Michael Cheng, Eleanor M. Simonsick, Yuri Agrawal , et al. · 2023

Objective This study aims to characterize the association between impairments in olfaction and balance, both of which are mediated in part by the cerebellum, and how this relates to prospective incidence of falls in a cohort of aging adult…

Otolaryngology Considerations of Pituitary Surgery: What an Endocrinologist Should Know Open

Michael Z. Cheng, Anirudh Saraswathula, Hannan A. Qureshi, Debraj Mukherjee, Nicholas R. Rowan · 2023

Endoscopic endonasal skull base surgery is the preferred surgical approach for the management of pituitary adenomas. Perioperative management of pituitary lesions requires multidisciplinary care and typically includes a dual surgeon team c…

Quality of Life in Chordoma Co-Survivors: Results from the Chordoma Foundation Survivorship Survey Open

Adrian E. Jimenez, Kyle V. Cicalese, Miguel A. Jiménez, Sachiv Chakravarti, Cathleen C. Kuo , et al. · 2023

Our findings suggest that younger co-survivors are at high risk for adverse emotional QOL outcomes. In addition, more than one third of co-survivors did not know about resources to address their QOL issues. Our study may help guide organiz…

Association between ambient temperature and chronic rhinosinusitis Open

Runming Du, Wangteng Jiao, Junxiong Ma, Qinfeng Zhou, Zhi‐Sheng Liang , et al. · 2023

Background Chronic exposure to particulate matter air pollution (PM 2.5 ) is associated with chronic rhinosinusitis (CRS). Elevated ambient temperature may increase PM 2.5 levels and thereby exacerbate sinonasal symptoms. This study invest…

Management paradigms for chronic rhinosinusitis in individuals with asthma: An evidence‐based review with recommendations Open

Amarbir S. Gill, Jeremiah A. Alt, Kara Y. Detwiller, Nicholas R. Rowan, Stacey T. Gray , et al. · 2022

Background Despite the significant morbidity associated with chronic rhinosinusitis (CRS) in individuals with asthma (CRSwA), there is a paucity of codified, evidence‐based management strategies for CRS in this population. Methods Using Pu…

Quality of Life Considerations in Endoscopic Endonasal Management of Anterior Cranial Base Tumors Open

Anirudh Saraswathula, Jose L. Porras, Debraj Mukherjee, Nicholas R. Rowan · 2022

Considering quality of life (QOL) is critical when discussing treatment options for patients undergoing endoscopic endonasal skull base surgery (EESBS) for cancers at the base of the skull. Several questionnaires have been developed and va…

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