Nicholas Raun
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View article: The SWI/SNF complex sub-unit Bap60 is required for training-induced gene transcription during long-term memory formation
The SWI/SNF complex sub-unit Bap60 is required for training-induced gene transcription during long-term memory formation Open
Long-term memory (LTM) formation requires tightly regulated gene expression in response to neuronal activity. Chromatin remodeling is thought to play a role in enabling this transcriptional response, but the specific mechanisms remain uncl…
View article: Trithorax regulates long-term memory in Drosophila through epigenetic maintenance of mushroom body metabolic state and translation capacity
Trithorax regulates long-term memory in Drosophila through epigenetic maintenance of mushroom body metabolic state and translation capacity Open
The role of epigenetics and chromatin in the maintenance of postmitotic neuronal cell identities is not well understood. Here, we show that the histone methyltransferase Trithorax (Trx) is required in postmitotic memory neurons of the Dros…
View article: The caterpillar Manduca sexta brain shows changes in gene expression and protein abundance correlating with parasitic manipulation of behaviour
The caterpillar Manduca sexta brain shows changes in gene expression and protein abundance correlating with parasitic manipulation of behaviour Open
View article: The multiple effects of the wasp Cotesia congregata, a parasitic manipulator, on the brain of its host, the caterpillar Manduca sexta.
The multiple effects of the wasp Cotesia congregata, a parasitic manipulator, on the brain of its host, the caterpillar Manduca sexta. Open
The parasitic wasp, Cotesia congregata, manipulates the behaviour of its host, the caterpillar Manduca sexta. The female wasp injects her eggs and a symbiotic virus (i.e. bracovirus, CcBV) into the body of its host. The host’s behaviour re…
View article: <i>Trithorax</i>regulates long-term memory in<i>Drosophila</i>through epigenetic maintenance of mushroom body metabolic identity and translation capacity
<i>Trithorax</i>regulates long-term memory in<i>Drosophila</i>through epigenetic maintenance of mushroom body metabolic identity and translation capacity Open
The role of epigenetics and chromatin in the maintenance of postmitotic neuronal cell identities is not well understood. Here, we show that the histone methyltransferase trithorax (trx) is required in postmitotic memory neurons of the Dros…
View article: A clustering of heterozygous missense variants in the crucial chromatin modifier WDR5 defines a new neurodevelopmental disorder
A clustering of heterozygous missense variants in the crucial chromatin modifier WDR5 defines a new neurodevelopmental disorder Open
View article: Characterization of SETD1A haploinsufficiency in humans and Drosophila defines a novel neurodevelopmental syndrome
Characterization of SETD1A haploinsufficiency in humans and Drosophila defines a novel neurodevelopmental syndrome Open
View article: Characterization of<i>SETD1A</i>haploinsufficiency in humans and<i>Drosophila</i>defines a novel neurodevelopmental syndrome
Characterization of<i>SETD1A</i>haploinsufficiency in humans and<i>Drosophila</i>defines a novel neurodevelopmental syndrome Open
Defects in histone methyltransferases (HMTs) are major contributing factors in neurodevelopmental disorders (NDDs). Heterozygous variants of SETD1A involved in histone H3 lysine 4 (H3K4) methylation were previously identified in individual…
View article: Individual components of the SWI/SNF chromatin remodelling complex have distinct roles in memory neurons of the<i>Drosophila</i>mushroom body
Individual components of the SWI/SNF chromatin remodelling complex have distinct roles in memory neurons of the<i>Drosophila</i>mushroom body Open
Technology has led to rapid progress in the identification of genes involved in neurodevelopmental disorders such as intellectual disability (ID), but our functional understanding of the causative genes is lagging. Here, we show that the S…
View article: The role of H3K4 methyltransferases in Drosophila memory
The role of H3K4 methyltransferases in Drosophila memory Open
Gene transcription required for long-term memory requires the modification of histones. However, there are still many uncertainties about the identity and spatial expression of genes regulated by histone modifications during memory related…
View article: Systematic functional characterization of the intellectual disability-associated SWI/SNF complex reveals distinct roles for the BAP and PBAP complexes in post-mitotic memory forming neurons of the<i>Drosophila</i>mushroom body
Systematic functional characterization of the intellectual disability-associated SWI/SNF complex reveals distinct roles for the BAP and PBAP complexes in post-mitotic memory forming neurons of the<i>Drosophila</i>mushroom body Open
Technology has led to rapid progress in the identification of genes involved in neurodevelopmental disorders like intellectual disability (ID), but our functional understanding of the causative genes is lagging. Here, we show that the SWI/…