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View article: Food and hypersensitivity in functional dyspepsia
Food and hypersensitivity in functional dyspepsia Open
It has long been known that stress affects both the stomach and colon, as shown by the very high prevalence of gastrointestinal symptoms among patients with psychiatric illness. The source may be limbic or peripheral, involving encoded mem…
View article: Validation of a specific quality of life questionnaire for functional digestive disorders
Validation of a specific quality of life questionnaire for functional digestive disorders Open
BACKGROUND Dyspepsia and irritable bowel syndrome are suitable conditions for assessment of quality of life. Their similarities justify the elaboration of a single specific questionnaire for the two conditions. AIMS To examine the process …
View article: The role of psychological and biological factors in postinfective gut dysfunction
The role of psychological and biological factors in postinfective gut dysfunction Open
BACKGROUND Both psychological and physiological disturbances have been implicated in the aetiopathogenesis of irritable bowel syndrome (IBS). AIMS To investigate how the psychological factors act, and the involvement of infective and physi…
View article: Alterations in mood after changing to a low-fat diet
Alterations in mood after changing to a low-fat diet Open
The effects on mood of reducing dietary fat while keeping the energy constant were examined in ten male and ten female healthy volunteers aged between 20 and 37 years. Each volunteer consumed a diet containing 41% energy as fat for 1 month…
View article: Acute hyperglycaemia affects anorectal motor and sensory function in normal subjects
Acute hyperglycaemia affects anorectal motor and sensory function in normal subjects Open
Background —The pathogenesis of anorectal dysfunction, which occurs frequently in patients with diabetes mellitus, is poorly defined. Recent studies indicate that changes in the blood glucose concentration have a major reversible effect on…
View article: Influences of dietary and intraduodenal lipid on alertness, mood, and sustained concentration
Influences of dietary and intraduodenal lipid on alertness, mood, and sustained concentration Open
The effects of intraduodenal and dietary lipid on alertness, mood and performance in a task requiring sustained attention were investigated in two studies. The first experiment compared the effect of duodenal infusion of either 100 g/l Int…
View article: Hereditary proctalgia fugax and constipation: report of a second family.
Hereditary proctalgia fugax and constipation: report of a second family. Open
A second family with hereditary proctalgia fugax and internal anal sphincter hypertrophy associated with constipation is described. Anorectal ultrasonography, manometry, and sensory tests were conducted in two symptomatic and one asymptoma…
View article: The effect of liquid fibre on gastric emptying in the rat and humans and the distribution of small intestinal contents in the rat.
The effect of liquid fibre on gastric emptying in the rat and humans and the distribution of small intestinal contents in the rat. Open
A combination of the polysaccharide ethyl-hydroxyethyl-cellulose (EHEC) and the surfactant sodium-dodecylsulphate (SDS) has the extraordinary physical property of being liquid at room temperature but gelling firmly at 37 degrees C. It has …
View article: Effect of food and anti-cholinergic drugs on the pattern of rectosigmoid contractions.
Effect of food and anti-cholinergic drugs on the pattern of rectosigmoid contractions. Open
The colonic response to a meal is often used to test the effect of drugs on colonic motility, but this test is hindered by its inconsistency. This study has used multiple manometric sensors situated in the rectosigmoid region to investigat…
View article: The effect of feeding xanthan gum on colonic function in man: correlation with <i>in vitro</i> determinants of bacterial breakdown
The effect of feeding xanthan gum on colonic function in man: correlation with <i>in vitro</i> determinants of bacterial breakdown Open
Xanthan gum (15 g/d) was given for 10 d to eighteen normal volunteers. In vivo measurements of stool output, transit time, frequency of defaecation and flatulence were compared with a preceding control period of 10 d. At the end of the con…
View article: Anorectal function in patients with complete supraconal spinal cord lesions.
Anorectal function in patients with complete supraconal spinal cord lesions. Open
Anorectal manometry and sphincter electromyography were performed in 23 patients with complete supraconal traumatic spinal injuries and 30 age and sex matched control subjects. Basal pressures in the spinal group were similar to those in n…
View article: Utility of a combined test of anorectal manometry, electromyography, and sensation in determining the mechanism of 'idiopathic' faecal incontinence.
Utility of a combined test of anorectal manometry, electromyography, and sensation in determining the mechanism of 'idiopathic' faecal incontinence. Open
Combined tests of anorectal manometry, sphincter electromyography and rectal sensation were carried out in 302 patients with faecal incontinence (235 women, 67 men). The results obtained were compared with 65 normal subjects (35 women, 30 …
View article: Relation between hysterectomy and the irritable bowel: a prospective study.
Relation between hysterectomy and the irritable bowel: a prospective study. Open
Some women with irritable bowel syndrome date the onset of symptoms to previous hysterectomy. To assess prospectively the incidence of gastrointestinal symptomatology arising de novo after hysterectomy, and to study the effect of surgery o…
View article: Role of gastrointestinal factors in hunger and satiety in man
Role of gastrointestinal factors in hunger and satiety in man Open
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View article: The effect of adrenoceptor antagonists on the ileal brake mechanism in the rat
The effect of adrenoceptor antagonists on the ileal brake mechanism in the rat Open
Studies were carried out in the rat to investigate the effect of adrenoceptor antagonists on stomach to caecum transit time under control conditions and during ileal infusion of Intralipid. Stomach to caecum transit time (SCTT) of the head…
View article: Intermittent rectal motor activity: a rectal motor complex?
Intermittent rectal motor activity: a rectal motor complex? Open
Prolonged nocturnal recordings from multiple sites in the anorectum and duodenum were performed in 12 healthy volunteers to investigate the presence and determine the characteristics of nocturnal rectal motor activity and assess any synchr…
View article: Influence of acid-pepsin secretion on gastric emptying of solids in humans: studies with cimetidine.
Influence of acid-pepsin secretion on gastric emptying of solids in humans: studies with cimetidine. Open
The commonly accepted model for gastric emptying suggests that the 'antral mill' is responsible for the triturition and subsequent emptying of solid food from the stomach. Little is known about the contribution to solid emptying made by ot…
View article: Letters to the editor
Letters to the editor Open
The SARS-CoV-2 pandemic virus is consistently evolving with mutations within the receptor binding domain (RBD)1 being of particular concern2-4. To date, there is little research into protection offered following vaccination or infection ag…
View article: Role of the proximal and distal stomach in mixed solid and liquid meal emptying.
Role of the proximal and distal stomach in mixed solid and liquid meal emptying. Open
The role of the proximal and distal stomach in the emptying of solids and liquids from the stomach remains unclear. We have used a dual isotope technique to quantify proximal and distal stomach emptying of a solid (100 g of 99mTc labelled …
View article: Investigation of normal flatus production in healthy volunteers.
Investigation of normal flatus production in healthy volunteers. Open
Flatulence can cause discomfort and distress but there are few published data of normal patterns and volumes. Twenty four hour collections were made using a rectal catheter in 10 normal volunteers taking their normal diet plus 200 g baked …
View article: Reflex anal dilatation: effect of parting the buttocks on anal function in normal subjects and patients with anorectal and spinal disease.
Reflex anal dilatation: effect of parting the buttocks on anal function in normal subjects and patients with anorectal and spinal disease. Open
Anal dilatation in response to gentle parting of the buttocks has been advocated as a sign of sexual abuse in children, but nothing is known of the physiology of this response or its existence in normal subjects, in patients with spinal di…
View article: Short chain fatty acids in the terminal ileum accelerate stomach to caecum transit time in the rat.
Short chain fatty acids in the terminal ileum accelerate stomach to caecum transit time in the rat. Open
We have previously shown that infusion of triglycerides and long chain fatty acids into the ileum of humans and rats delays small bowel transit time. The present studies have investigated the effect on the stomach to caecum transit time of…
View article: The effect of short-term dietary supplementation with glucose on gastric emptying in humans
The effect of short-term dietary supplementation with glucose on gastric emptying in humans Open
In order to test whether gastric motility can adapt to changes in nutrient load, gastric emptying of hyperosmotic glucose and protein drinks was measured by applied potential tomography in two groups of ten volunteers following dietary sup…
View article: Effect of incorporating fat into a liquid test meal on the relation between intragastric distribution and gastric emptying in human volunteers.
Effect of incorporating fat into a liquid test meal on the relation between intragastric distribution and gastric emptying in human volunteers. Open
The relation between gastric emptying and the intragastric distribution of 300 ml radiolabelled beef consommé with and without 60 g margarine was investigated by performing randomised, paired gammacamera studies in seven healthy male volun…
View article: Relation between rectal sensation and anal function in normal subjects and patients with faecal incontinence.
Relation between rectal sensation and anal function in normal subjects and patients with faecal incontinence. Open
The relation between sensory perception of rapid balloon distension of the rectum and the motor responses of the rectum and external and internal anal sphincters in 27 normal subjects and 16 patients with faecal incontinence who had impair…