Nicholas Schaffer
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View article: The neuronal chaperone proSAAS is highly expressed in the retina
The neuronal chaperone proSAAS is highly expressed in the retina Open
The many layers of the neuroretina contain a complex, interconnected network of specialized neurons that both process visual stimuli and conduct processed information to higher brain areas. Neural networks rely on proteostatic control mech…
View article: ProSAAS is preferentially up‐regulated during homeostatic scaling and reduces amyloid plaque burden in the 5xFAD mouse hippocampus
ProSAAS is preferentially up‐regulated during homeostatic scaling and reduces amyloid plaque burden in the 5xFAD mouse hippocampus Open
The accumulation of β‐amyloid in Alzheimer's disease greatly impacts neuronal health and synaptic function. To maintain network stability in the face of altered synaptic activity, neurons engage a feedback mechanism termed homeostatic scal…
View article: ProSAAS is Preferentially Secreted from Neurons During Homeostatic Scaling and Reduces Amyloid Plaque Size in the 5xFAD Mouse Hippocampus
ProSAAS is Preferentially Secreted from Neurons During Homeostatic Scaling and Reduces Amyloid Plaque Size in the 5xFAD Mouse Hippocampus Open
The accumulation of β-amyloid in Alzheimer’s disease greatly impacts neuronal health and synaptic function. To maintain network stability in the face of altered synaptic activity, neurons engage a feedback mechanism termed homeostatic scal…
View article: Complete genome and characteristics of cluster BC bacteriophage SoJo, isolated using <i>Streptomyces mirabilis</i> NRRL B-2400 in Columbia, MD
Complete genome and characteristics of cluster BC bacteriophage SoJo, isolated using <i>Streptomyces mirabilis</i> NRRL B-2400 in Columbia, MD Open
Here, we present bacteriophage SoJo, a siphovirus infecting Streptomyces mirabilis , with a circularly permuted genome of 39 kbp and GC content of 71.5%. Its genome length and content are similar to that of other phages in the Actinobacter…